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Antonio . Garcia de Herreros Madueno

Senior Scientist and Full Professor

Hospital del Mar

Barcelona, España

Characterization of the mechanisms controlling E-cadherin gene expression in tumor cells. The factors repressing E-cadherin transcription in invasive cells. Analysis of the elements involved in thetranscription of mesenchymal genes during EMT.

PhD in Biochemistry, Universidad Autonoma de Madrid. España, 1985
Licenciatura en Ciencias Quimicas, UNIVERSIDAD COMPLUTENSE DE MADRID. España, 1980

Ph.D Thesis Director

Number of thesis accomplished: 20; A. Skoudy (1995), E. Batlle (1999), M. M. Llosas (2000), S. Roura (2001), J. A. Piedra (2003), D. Domínguez (2003), S. Miravet (2003), I. Puig (2005), S. Guaita (2005), J. Castaño ( 2005); B. Montserrat (2006); M. Escrivà (2008); A. Virgós (2008); P. Villagrasa (2010), M. Beltran (2010), N. Herranz (2011), R. Batlle (2011), R. Viñas (2013), A. Millanes (2014), E. Aparicio (2014).


Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6. VINYOLES, M., DEL VALLE-PÉREZ, B., CURTO, J., VIÑAS-CASTELLS, R., ALBA-CASTELLÓN, L., GARCÍA DE HERREROS, A. , DUÑACH, M. Article ISI Mol Cell, 53, 444-457 (2014)
Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. VIÑAS-CASTELLS, R., ROBLES, E. FRÍAS, A., ZHANG, K., LONGMORE, G.D. GARCÍA DE HERREROS, A., DÍAZ, V.M. Article ISI Nucleic Acids Res, 42, 1079-1094 (2014)
Snail1 expression is required for sarcomagenesis ALBA-CASTELLÓN, L., BATLLE, R., FRANCÍ, C., FERNÁNDEZ-ACEÑERO, M.J., MAZZOLINI, R., PEÑA, R., LOUBAT, J., ALAMEDA, F., RODRÍGUEZ, R., CURTO, J.,ALBANELL, J., MUÑOZ, A., BONILLA, F., CASAL, J.I., ROJO, F., GARCÍA DE HERREROS, A Article ISI NEOPLASIA (2014)
Snail1 controls TGF- responsiveness and differentiation of Mesenchymal Stem Cells. BATLLE, R., ALBA, L., LOUBAT-CASANOVAS, J., STANISAVLJEVIC, J., ARMENTEROS, E., FRANCI, C., MARTIN-CABALLERO, J., BONILLA, F., BAULIDA, J., GRIDLEY, T., GARCIA DE HERREROS A Article ISI Oncogene 32, 3381-3389. (2013)
Akt2 interacts with Snail1 in E-cadherin promoter VILLAGRASA, P., DIAZ, V.M., VIÑAS-CASTELLS, R., PEIRÓ, S., DEL VALLE-PÉREZ, B., DAVE, N., RODRIGUEZ-ASIAIN, A., CASAL, J. I., LIZCANO, J.M., DUÑACH, M., GARCIA DE HERREROS, A. Article ISI Oncogene.31, 4022-4033 (2012)
Cooperation, amplification, and feed-back in epithelial-mesenchymal GARCIA DE HERREROS, A., BAULIDA, J. Article ISI BBA - Reviews on Cancer (2012)
Rac1 activation upon Wnt stimulation requires Rac1 and Vav2 binding to p120-catenin. VALLS., G., CODINA, M., MILLER, R., DEL VALLE-PÉREZ, B., VINYOLES, M., CAELLES, C., McCREA, P., GARCÍA DE HERREROS, A., DUÑACH, M. Article ISI J. Cell Sci. 125, 5288-5301. (2012)
A coordinated action of CK1 isoforms in Wnt signaling. DEL VALLE-PÉREZ, B., ARQUÉS, O., VINYOLES, M., GARCÍA DE HERREROS, A., DUÑACH, M Article ISI Mol Cel Biol. (2011)
Functional cooperation between Snail1 and Twist in the regulation of Zeb1 expression during epithelial-to-mesenchymal transition. DAVE, N., GUAITA-ESTERUELAS, S., GUTARRA, S., FRIAS, A., BELTRAN, M., PEIRO, S., GARCIA DE HERREROS, A Article ISI J. Biol. Chem. (2011)
Wnt controls Kaiso transcriptional factor activity through CK1- dependent phosphorylation of p120-catenin. . DEL VALLE-PEREZ, B., CASAGOLDA, D., VALLS, G., LUGILDE, E., DAVE, N., CODINA, M., GARCÍA DE HERREROS, A.*, DUÑACH, M Article ISI J. Cell Sci. (2011)
A p120-catenin/CK1 complex regulates Wnt signalling CASAGOLDA, D., DEL VALLE, B., VALLS, G., LUGILDE, E., CASADO-VELA, J., SOLANAS, G., BATLLE, E., REYNOLDS, A.B., CASAL, J.I., GARCÍA DE HERREROS, A., DUÑACH, M. Article Journal Cell Science (2010)
Snail family regulation and epithelial mesenchymal transitions in breast cancer progression. GARCIA DE HERREROS , A, PEIRO, S. NASSOUR, M., SAVAGNER, P. Article ISI J. Mammary Gland Biol. Neoplasia (2010)
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition BELTRAN, M., PUIG, I., PEÑA, C., GARCIA, J.M., ALVAREZ, A.B., PEÑA, R., BONILLA, F., GARCIA DE HERREROS, A. Article ISI Genes Dev. (2008)
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor HERRANZ, N., PASINI, D., DIAZ, V.M., FRANCÍ, C., GUTIÉRREZ, A., DAVE, N., ESCRIVÀ, M., HERNÁNDEZ-MUÑOZ, I., DI CROCE, L., HELIN, K., GARCÍA DE HERREROS, A. *, PEIRÓ, S. Article ISI Mol. Cel. Biol. (2008)
Expression of Snail protein in tumor-stroma interface. FRANCI, C., TAKKUNEN, M., DAVE, D., ALAMEDA, F., GÓMEZ, S., RODRIGUEZ, R., ESCRIVÀ, M., MONTSERRAT-SENTÍS, B., BARÓ, T., GARRIDO, M., BONILLA, F., VIRTANEN, I., GARCIA DE HERREROS, A. Article ISI ONCOGENE (2006)
Regulation of Snail transcription during epithelial to mesenchymal-transition of tumor cells. BARBERÀ, M.J., PUIG, I., DOMINGUEZ, D., JULIEN-GRILLE, S., GUAITA-ESTERUELAS, S., PEIRÓ, S., BAULIDA, J., FRANCI, C., DEDHAR, S., LARUE, L., GARCIA DE HERREROS, A Article ISI ONCOGENE (2004)
) p120-catenin-associated Fer and Fyn tyrosine kinases regulate -catenin Tyr-142 phosphorylation and -catenin--catenin interaction PIEDRA, J.A., MIRAVET, S., CASTAÑO, C., PALMER, H.G., HEISTERKAMP, N., GARCIA DE HERREROS, A., DUÑACH, M Article ISI Mol. Cell. Biol. 23, 2287-2297 (2003)
Phosphorylation regulates nuclear export and activity of Snail transcriptional repressor DOMINGUEZ, D. MONTSERRAT-SENTIS, B., VIRGOS-SOLER, A., GUAITA, S., GRUESO, J., PORTA, M., PUIG, I., BAULIDA, J., FRANCI, C., GARCIA DE HERREROS, A. Article ISI Mol. Cel. Biol. (2003)
Snail induction of epithelial-to-mesenchymal transition in tumor cells is accompanied by MUC-1 repression and ZEB1 expression GUAITA, S., PUIG, I., FRANCI, C., GARRIDO, M., DOMINGUEZ, D., BATLLE, E., SANCHO, E., DEDHAR, S., GARCÍA DE HERREROS, A., BAULIDA, J. Article ISI J. Biol. Chem. (2002)
Regulation of -catenin structure and function by tyrosine phosphorylation PIEDRA, J., MARTÍNEZ, D., CASTAÑO, J., MIRAVET, S., DUÑACH, M., GARCÍA DE HERREROS, A Article ISI J. Biol. Chem. 276: 20436-20443. (2001)
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. BATLLE, E., SANCHO, E., FRANCÍ, C., DOMÍNGUEZ, D., MONFAR, M., BAULIDA, J., GARCÍA DE HERREROS, A. Article ISI Nature Cell. Biol. (2000)
Regulation of E-cadherin/catenin association by tyrosine phosphorylation ROURA, S., MIRAVET, S., PIEDRA, J., GARCÍA DE HERREROS, A., DUÑACH, M.* Article ISI Journal Biological Chemistry (1999)

Antonio Garcia de Herreros

Senior Scientist and Full Professor

Parc de Recerca Biomèdica de Barcelona

Hospital del Mar

Barcelona, España

Antonio . Garcia de Herreros Madueno

Líneas de Investigación

Educación

PhD in Biochemistry, Universidad Autonoma de Madrid. España, 1985

Licenciatura en Ciencias Quimicas, UNIVERSIDAD COMPLUTENSE DE MADRID. España, 1980

Formación de Capital Humano

Article (22)

Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.

Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability.

Snail1 expression is required for sarcomagenesis

Snail1 controls TGF- responsiveness and differentiation of Mesenchymal Stem Cells.

Akt2 interacts with Snail1 in E-cadherin promoter

Cooperation, amplification, and feed-back in epithelial-mesenchymal

Rac1 activation upon Wnt stimulation requires Rac1 and Vav2 binding to p120-catenin.

A coordinated action of CK1 isoforms in Wnt signaling.

Functional cooperation between Snail1 and Twist in the regulation of Zeb1 expression during epithelial-to-mesenchymal transition.

Wnt controls Kaiso transcriptional factor activity through CK1- dependent phosphorylation of p120-catenin.

A p120-catenin/CK1 complex regulates Wnt signalling

Snail family regulation and epithelial mesenchymal transitions in breast cancer progression.

A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition

Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor

Expression of Snail protein in tumor-stroma interface.

Regulation of Snail transcription during epithelial to mesenchymal-transition of tumor cells.

) p120-catenin-associated Fer and Fyn tyrosine kinases regulate -catenin Tyr-142 phosphorylation and -catenin--catenin interaction

Phosphorylation regulates nuclear export and activity of Snail transcriptional repressor

Snail induction of epithelial-to-mesenchymal transition in tumor cells is accompanied by MUC-1 repression and ZEB1 expression

Regulation of -catenin structure and function by tyrosine phosphorylation

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells.

Regulation of E-cadherin/catenin association by tyrosine phosphorylation

Antonio Garcia de Herreros