Man

Juan Carlos Casar Leturia

Profesor Asistente Adjunto

Escuela de Medicina, Pontificia Universidad Catolica de Chile

Santiago, Chile

Líneas de Investigación


Neuromuscular disorders; Myogenic progenitors/ cell-based therapy (Progenitores Musculares/Terapia Celular); Therapies for Muscular Dystrophy (Terapias para Distrofias Musculares); Palliative Care for ALS (Cuidados Paliativos en ELA)

Educación

  •  Licenciado en Medicina, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1995
  •  Doctorado en Ciencias Médicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003
  •  Médico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998
  •  Especialista en Neurología de adultos, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesor Asistente Adjunto Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2007 - A la fecha

Experiencia Profesional

  •   Profesor asistente adjunto Full Time

    Depto. de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile

    Santiago, Chile

    2007 - A la fecha

  •   Research Fellow Full Time

    Children's Hospital Boston/Harvard Medical School

    Boston, Estados Unidos

    2007 - 2011


 

Article (16)

Ganglionopatía Autonómica Autoinmune crónica. Una causa rara de disautonomia Chronic Autoimmune Autonomic Ganglionopathy. A rare case of dysautonomia

Idiáquez; Riquelme, Julio; Casar, Juan Carlos

Article
Revista Neurolo  (2020)

Non-dystrophic Myotonia Chilean Cohort With Predominance of the SCN4A Gly1306Glu Variant

Vargas Leal, Carmen Paz; Cortés-Zepeda, Rocía; Lagos Lucero, Marcela; Avaria Benapres. María de los Ángeles; Casar Leturia, Juan Carlos; Mellado Sagredo; Sternberg, Damien

Article
NEUROMUSCULAR DISORDER  (2020)

Stem Cell Diferentiation and Therapeutic Use

Alexander, Mathew; Casar, Juan Carlos; Motohashi, Norio

Article
Stem Cells International  (2015)

Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis.

Cabrera, Daniel; Gutiérrez, Jaime; Cabello-Verrugio, Claudio; Morales, Maria Gabriela; Mezzano, Sergio; Fadic, Ricardo; Casar, Juan Carlos; Hancke, Juan L; Brandan, Enrique

Article
Skeletal muscle  (2014)

MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms.

Alexander, Matthew S; Casar, Juan Carlos; Motohashi, Norio; Vieira, Natássia M; Eisenberg, Iris; Marshall, Jamie L; Gasperini, Molly J; Lek, Angela; Myers, Jennifer A; Estrella, Elicia A; Kang, Peter B; Shapiro, Frederic; Rahimov, Fedik; Kawahara, Genri; Widrick, Jeffrey J; Kunkel, Louis M

Article
The Journal of clinical investigation  (2014)

MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation.

Alexander, M S; Kawahara, G; Motohashi, N; Casar, J C; Eisenberg, I; Myers, J A; Gasperini, M J; Estrella, E A; Kho, A T; Mitsuhashi, S; Shapiro, F; Kang, P B; Kunkel, L M

Article
Cell death and differentiation  (2013)

beta 4 Integrin Marks Interstitial Myogenic Progenitor Cells in Adult Murine Skeletal Muscle

Liadaki K.; Wessen M.; Jun S.; Gussoni E.

Article ISI SCOPUS
Journal of Histochemistry and Cytochemistry  (2012)

Identification of a novel microRNA that regulates the proliferation and differentiation in muscle side population cells.

Motohashi, Norio; Alexander, Matthew S; Casar, Juan Carlos; Kunkel, Louis M

Article
Stem cells and development  (2012)

Regulation of DMD pathology by an ankyrin-encoded miRNA.

Alexander, Matthew S; Casar, Juan Carlos; Motohashi, Norio; Myers, Jennifer A; Eisenberg, Iris; Gonzalez, Robert T; Estrella, Elicia A; Kang, Peter B; Kawahara, Genri; Kunkel, Louis M

Article
Skeletal muscle  (2011)

Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism.

Osses, Nelson; Casar, Juan Carlos; Brandan, Enrique

Article
BMC cell biology  (2009)

Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation.

Casar, Juan Carlos; Cabello-Verrugio, Claudio; Olguin, Hugo; Aldunate, Rebeca; Inestrosa, Nibaldo C; Brandan, Enrique

Article
Journal of cell science  (2004)

Structural and functional organization of synaptic acetylcholinesterase.

Aldunate, Rebeca; Casar, Juan Carlos; Brandan, Enrique; Inestrosa, Nibaldo C

Article
Brain research. Brain research reviews  (2004)

Transient up-regulation of biglycan during skeletal muscle regeneration: delayed fiber growth along with decorin increase in biglycan-deficient mice.

Casar, Juan Carlos; McKechnie, Beth A; Fallon, Justin R; Young, Marian F; Brandan, Enrique

Article
Developmental biology  (2004)

Extracellular matrix histone H1 binds to perlecan, is present in regenerating skeletal muscle and stimulates myoblast proliferation.

Henriquez, Juan Pablo; Casar, Juan Carlos; Fuentealba, Luis; Carey, David J; Brandan, Enrique

Article
Journal of cell science  (2002)

Reduced natriuresis after oral sodium load in cholestatic rats: role of compartment volumes and ANP.

Casar, J C; Valdivieso, A; Bravo, J A; Chacón, C; Boric, M P

Article
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)  (2000)

Synthesis of proteoglycans is augmented in dystrophic mdx mouse skeletal muscle.

Cáceres, S; Cuellar, C; Casar, J C; Garrido, J; Schaefer, L; Kresse, H; Brandan, E

Article
European journal of cell biology  (2000)

BookSection (2)

Capítulo 7. Semiología de las enfermedades de la motoneurona

Mellado, Patricio

BookSection
 (2020)

Parte VIII. Neurología. Capítulos 37-47

Juri, Carlos; Godoy, Jaime; Kuntsmann, Sonia

BookSection
 (2019)

Proyecto (4)

ROLE OF THE LPA/LPARs AXIS IN SKELETAL MUSCLE FIBROSIS

Brandan

Proyecto
 (2019)

Participation of mesenchymal progenitors in the initiation of skeletal muscle fibrosis=> Effect of TGFβ/CTGF/PDGF and co-factors on fibroblasts’ ability to modulate myogenesis

FONDECYT (1150106)

Proyecto
2015-2018
Coinvestigador(a)

MYOGENIC PRECURSOR TRANSPLANTATION AND DIRECT IN VIVO GENE TRANSFER TO MURINE SKELETAL MUSCLE

Howard Hughes Medical Institute (-)

Proyecto
2007-2009
Postdoctorado

PARTICIPACION DE PROTEOGLICANES EN LA REGENERACION MUSCULAR ESQUELETICA EN EL RATON.

FONDECYT (2000113)

Proyecto
2000-2002
Inv. Responsable

6
Juan Casar

Profesor Asistente Adjunto

Departamento de Neurología

Escuela de Medicina, Pontificia Universidad Catolica de Chile

Santiago, Chile