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Sergio Quezada

Professiorial Research Fellow

UCL Cancer Institute

London, Reino Unido

Immunology, anti-CTLA-4, anti-PD-1 and other immune-modulatory antibodies targering co-inhibitory and co-stimulatory pathway

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999
Immunology, Dartmouth Medical School. Estados Unidos, 2004

Postdoc Full Time

Dartmouth Medical School, New Hampshire

New Hampshire, Estados Unidos

2004 - 2004
Postdoc Full Time

Memorial Sloan-Kettering Cancer Center

New York, Chile

2005 - 2010

Professorial Research Fellow and Group Leader Other

University College London Cancer Institute.

London, Reino Unido

2010 - A la fecha
Adjunct investigator Other

The Royal Marsden, NHS Foundation Trust.

London, Chile

2012 - A la fecha
Immunology Lead Other

UCL/Manchester CRUK Lung Cancer Centre of Excellence

Manchester, Reino Unido

2014 - A la fecha


Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade Mcgranahan, N; Furness, A. J. S.; Ramskov, S.; Lyngaa, R.; Saini, S. K.; Jamal-Hanjani, M.; Wilson, G. A.; Birkbak, N. J.; Hiley, C. T.; Watkins, T. B. K.; et al. Article SCIENCE (2016)
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes Bentzen, Amalie Kai; Marquard, Andrea Marion; Lyngaa, Rikke; Saini, Sunil Kumar; Ramskov, Sofie; Donia, Marco; Such, Lina; Furness, Andrew J S; McGranahan, Nicholas; Rosenthal, Rachel; et al. Article Nature Biotechnology (2016)
TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors Menger, Laurie; Sledzinska, Anna; Bergerhoff, Katharina; Vargas, Frederick Arce; Smith, Julianne; Poirot, Laurent; Pule, Martin; Herrero, Javier; Peggs, Karl S. Article CANCER RESEARCH (2016)
Anti-programmed cell death-1 therapy and insulin-dependent diabetes: a case report Martin-Liberal, Juan; Furness, Andrew JS; Joshi, Kroopa; Peggs, Karl S.; Larkin, James Article Cancer Immunology, Immunotherapy (2015)
CMV promotes recipient T-cell immunity following reduced-intensity T-cell-depleted HSCT, significantly modulating chimerism status Sellar, R. S.; Vargas, F. A.; Henry, J. Y.; Verfuerth, S.; Charrot, S.; Beaton, B.; Chakraverty, R.; Quezada, S. A.; Mackinnon, S.; Thomson, K. J.; et al. Article BLOOD (2015)
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity Zelenay, Santiago; van der Veen, Annemarthe G.; Böttcher, Jan P.; Snelgrove, Kathryn J.; Rogers, Neil; Acton, Sophie E.; Chakravarty, Probir; Girotti, Maria Romina; Marais, Richard; Quezada, Sergio A.; et al. Article Cell (2015)
Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure Funes, J. M.; Limia, C. M.; Mesa M.; Quezada, S. A. Article CANCER RESEARCH (2015)
TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells Menger, L.; Gouble, A.; Marzolini, M. A. V.; Pachnio, A.; Bergerhoff, K.; Henry, J. Y.; Pule, M.; Riddell, S. R.; Quezada, S. A.; Peggs, K. S. Article BLOOD (2015)
Translational Implications of Tumor Heterogeneity Jamal-Hanjani, M.; Quezada, S. A. Article CLINICAL CANCER RESEARCH (2015)
A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy Philip, B.; Kokalaki, E.; Mekkaoui, L.; Straathof, K.; Flutter, B.; Marafioti, T.; Chakraverty, R.; Linch, D.; Quezada, S. A.; Peggs, K. S.; et al. Article BLOOD (2014)
An antitumor boost to TH9 cells Quezada, Sergio A Article NATURE IMMUNOLOGY (2014)
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy Fan, Xiaozhou; Sepulveda, Manuel A.; Sharma, Padmanee; Allison, James P. Article JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies Vargas, Frederick Arce; Peggs, Karl S. Article Trends in Immunology (2014)
Resolution of acute inflammation bridges the gap between innate and adaptive immunity Newson, J.; Stables, M.; Karra, E.; Arce-Vargas, F.; Motwani, M.; Mack, M; Yona, S.; Audzevich, T.; Gilroy, D. W. Article BLOOD (2014)
Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study Jamal-Hanjani, Mariam; Hackshaw, Alan; Ngai, Yenting; Shaw, Jacqueline; Dive, Caroline; Middleton, Gary; de Bruin, Elza; Le Quesne, John; Shafi, Seema; Falzon, Mary; et al. Article PLOS BIOLOGY (2014)
Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer Article BRITISH JOURNAL OF CANCER (2013)
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma Simpson, Tyler R.; Li, Fubin; Montalvo-Ortiz, Welby; Sepulveda, Manuel A.; Bergerhoff, Katharina; Arce, Frederick; Roddie, Claire; Henry, Jake Y.; Yagita, Hideo; Wolchok, Jedd D.; et al. Article JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Tumour heterogeneity and immune-modulation Jamal-Hanjani, Mariam; Thanopoulou, Eirini; Quezada, Sergio A; Swanton, Charles Article Current Opinion in Pharmacology (2013)
Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas Gerlinger, Marco; Quezada, Sergio A; Furness, Andrew JS; Fisher, Rosalie; Marafioti, Teresa; Shende, Vishvesh H; McGranahan, Nicholas; Rowan, Andrew J; Hazell, Steven; Hamm, David; et al. Article Journal of Pathology (2013)
PD-1 blockade: promoting endogenous anti-tumor immunity Quezada, Sergio A Article Expert Review of Anticancer Therapy (2012)
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication Peggs, Karl S.; Simpson, Tyler R.; Allison, James P. Article Immunological Reviews (2011)
Tumor-reactive CD4 + T cells: plasticity beyond helper and regulatory activities Quezada, Sergio A Article IMMUNOTHERAPY (2011)
Ipilimumab: attenuation of an inhibitory immune checkpoint improves survival in metastatic melanoma Quezada, Sergio A Article Expert Review of Anticancer Therapy (2010)
Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS) Quezada, Sergio A Article Current Opinion in Immunology (2010)
Tumor-reactive CD4 + T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts Simpson, Tyler R.; Peggs, Karl S.; Merghoub, Taha; Vider, Jelena; Fan, Xiaozhou; Blasberg, Ronald; Yagita, Hideo; Muranski, Pawel; Antony, Paul A.; Restifo, Nicholas P.; et al. Article JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies Peggs, Karl S.; Chambers, Cynthia A.; Korman, Alan J.; Allison, James P. Article JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists Peggs, K. S.; Quezada, S. A.; Allison, J. P. Article Clinical and Experimental Immunology (2009)
Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy Peggs, Karl S.; Allison, James P. Article Immunological Reviews (2008)
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma Peggs, Karl S.; Simpson, Tyler R.; Shen, Yuelei; Littman, Dan R.; Allison, James P. Article JOURNAL OF EXPERIMENTAL MEDICINE (2008)
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells Quezada, S. A. Article JOURNAL OF CLINICAL INVESTIGATION (2006)
Principles and use of anti-CTLA4 antibody in human cancer immunotherapy Quezada, Sergio A Article Current Opinion in Immunology (2006)
Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation Quezada, S. A., K. Bennett, B. R. Blazar, A. Y. Rudensky, S. Sakaguchi, and R. J. Noelle Article J. Immunol. (2005)
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism Gondek, D. C., L. F. Lu, S. A. Quezada, S. Sakaguchi, and R. J. Noelle Article J. Immunol. (2005)
Distinct mechanisms of action of anti-CD154 in early versus late treatment of murine lupus nephritis Eckert, Maria; Adeyi, Oyedele A.; Schned, Alan R.; Noelle, Randolph J.; Burns, Christopher M. Article Arthritis & Rheumatism (2003)
Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation Quezada, S. A. Article BLOOD (2003)
The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning Quezada, S. A., Gonzalez, M., B. R. Blazar, A. Panoskaltsis-Mortari, A. Y. Rudensky, and R. J. Noelle Article J. Immunol. (2002)


Combination immunotherapy for the treatment of cancer James Allison; Padmanee Sharma; Sergio A. Quezada; Tihui Fu Patent
Regulatory t cell mediator proteins and uses thereof Randolph J Noelle; Li-Fan Lu; Sergio Quezada; David Gondek Patent Application


Cancer Immunotherapy Catalyst Network Proyecto (2015)
Testing bi-specific antibodies in syngeneic mouse models Proyecto (2015)
Evaluation Of Immunomodulatory Bispecific Antibodies In Murine Models Proyecto (2014)
ERC- FP7 Health 2013 Innovation Proyecto (2013)
Exploring And Exploiting Mechanisms Of Response And Resistance To Ipilimumab And Other Novel Immune Modulatory Antibodies For Therapeutic Gain Proyecto (2013)
Deciphering the immune and neoantigenic landscape of lung cancer and their relevance to cancer immunotherapy Proyecto (0)
Development and evaluation of check-point-targeting antibodies with enhanced activity based on Fc interactions and tumour microenvironment Proyecto (0)

Sergio Quezada

Professiorial Research Fellow

UCL Cancer Institute

London, Reino Unido

Sergio Quezada

Líneas de Investigación

Educación

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999

Immunology, Dartmouth Medical School. Estados Unidos, 2004

Experiencia Académica

Postdoc Full Time

Postdoc Full Time

Experiencia Profesional

Professorial Research Fellow and Group Leader Other

Adjunct investigator Other

Immunology Lead Other

Article (36)

Patent (2)

Proyecto (7)