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David Adrián Sáez San Martín

Investigador Postdoctoral

Universidad de Concepción

Concepción, Chile

Líneas de Investigación


Molecular Dynamics, Enzymatic Catalysis, Enzymatic Design

Educación

  •  Química, UNIVERSIDAD DE CONCEPCION. Chile, 2017
  •  Química y Farmacia, UNIVERSIDAD DE CONCEPCION. Chile, 2012

Experiencia Académica

  •   Colaborador Docente Part Time

    UNIVERSIDAD DE CONCEPCION

    Farmacia

    Concepcion, Chile

    2018 - A la fecha


 

Article (8)

Covalent Adduct Formation as a Strategy for Efficient CO2 Fixation in Crotonyl-CoA Carboxylases/Reductases



Article ISI
ACS CATALYSIS  (2023)

Atom-Condensed Fukui Function in Condensed Phases and Biological Systems and Its Application to Enzymatic Fixation of Carbon Dioxide

Oller J.

Article ISI SCOPUS
JOURNAL OF PHYSICAL CHEMISTRY A  (2020)

Awakening the Sleeping Carboxylase Function of Enzymes: Engineering the Natural CO2-Binding Potential of Reductases

Bernhardsgrütter I.; Schell K.; Peter D.M.; Borjian F.

Article ISI SCOPUS
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  (2019)

Electronic structure benchmark calculations of inorganic and biochemical carboxylation reactions



Article ISI SCOPUS
JOURNAL OF COMPUTATIONAL CHEMISTRY  (2019)

Four amino acids define the CO2 binding pocket of enoyl-CoA carboxylases/reductases

Stoffel G.M.M.; Saez D.A.; DeMirci H.; Vögeli B.; Zarzycki J.; Yoshikuni Y.; Wakatsuki S.; Erb T.J.

Article ISI SCOPUS
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  (2019)

Catalytic Reaction Mechanism in Native and Mutant Catechol-O-methyltransferase from the Adaptive String Method and Mean Reaction Force Analysis

Zinovjev, K; Tunon, I; Voringer-Martinez, E

Article ISI SCOPUS
JOURNAL OF PHYSICAL CHEMISTRY B  (2018)

The effect of the environment on the methyl transfer reaction mechanism between trimethylsulfonium and phenolate

Saez, David Adrian; Vogt-Geisse, Stefan; Inostroza-Rivera, Ricardo; Kuba?, Tomáš; Elstner, Marcus

Article ISI SCOPUS
PHYSICAL CHEMISTRY CHEMICAL PHYSICS  (2016)

A consistent S-Adenosylmethionine force field improved by dynamic Hirshfeld-I atomic charges for biomolecular simulation



Article ISI SCOPUS
Journal of Computer-Aided Molecular Design  (2015)

Proyecto (7)

Mechanisms Governing CO2/ O2 Specificity in RuBisCO from Multiscale Computer Simulations



Proyecto
 (2024)

NADPH, 1,4-Dihydropyridines and Unsaturated Compounds: Exploring the Main Reducing Strategy of Nature.

David Adrian Saez; Stefan Vogt-Geisse

Proyecto
 (2019)

REDCO2:Rational Enzyme Design for CO2 fixation

Stefan Vogt-Geisse; David Adrian Saez; Rodrigo Recabarren

Proyecto
 (2019)

Max Planck Partner Group=> A mechanistic model for CO2 fixation of Ccr enzymes from QM/MM simulations and mutational studies.

Max Planck Society (0)

Proyecto
2017-2019
Postdoctorado

Núcleo Milenio Procesos Químicos y Catálisis

Iniciativa Científica Milenio (110082)

Proyecto
2015-2016
Personal técnico y/o de apoyo

ON THE TRACK OF ENZYMES' FUNCTION=> NEW INSIGHTS FROM THE MEAN REACTION FORCE

FONDECYT (11121179)

Proyecto
2012-2015
Personal técnico y/o de apoyo

ON THE TRACK OF ENZYMES' FUNCTION=> NEW INSIGHTS FROM THE MEAN REACTION FORCE

FONDECYT (11121179)

Proyecto
2012-2015
Tesista

7
Esteban Vohringer-Martinez

Profesor Asociado

Físico-Química

FACULTAD DE CIENCIAS QUÍMICAS

Concepción, Chile

1
Oscar Douglas

Profesor Auxiliar

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Alejandro Toro

PROFESOR TITULAR

Química Física

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

11
David Sáez

Investigador Postdoctoral

Universidad de Concepción

Concepción, Chile

1
Javier Oller

Investigador Postdoctoral

Universidad de Chile

Santiago de Chile, Chile

1
Aharon Gomez

Docente

Departamento de Ciencias Biológicas y Químicas

Universidad San Sebastián

Concepción, Chile