Man

Diana Fernandes de Sousa Rafael

Investigador Post-Doctoral

Vall D' Hebron Research Insititute

Barcelona, España

Líneas de Investigación


Design of drug and gene delivery formulations for different diseases (cancer, HIV, bacterial infections, cirrhosis), ii) in vitro and in vivo preclinical validation of the developed products, iii) study of the molecular pathways involved in cancer.

Educación

  •  Tecnología Farmacéutica, UNIVERSIDADE DE LISBOA. Portugal, 2017
  •  Ciencias Farmacéuticas, UNIVERSIDADE DE LISBOA. Portugal, 2010

 

Article (20)

Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells
The Biological Potential Hidden in Inclusion Bodies
Zileuton (TM) loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells
Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells
Simvastatin-loaded nanoparticles are more effective and less toxic than conventional statins in a pre-clinical model of advanced chronic liver disease
Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications
AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells
Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells
Efficient EFGR mediated siRNA delivery to breast cancer cells by Cetuximab functionalized Pluronic (R) F127/Gelatin
Micellar-Based Nanoparticles for Cancer Therapy and Bioimaging
Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets
Simvastatin-loaded polymeric micelles are a new, safe and effective drug delivery system targeting liver sinusoidal endothelial cells
Cancer stem cells and personalized cancer nanomedicine
Self-assembly PEGylation assists SLN-paclitaxel delivery inducing cancer cell apoptosis upon internalization
EMT Blockage Strategies: Targeting Akt Dependent Mechanisms for Breast Cancer Metastatic Behaviour Modulation
Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells
TARGETING AKT2 SIGNALLING EVENTS: IMPROVING THERAPEUTIC OUTCOMES THROUGH CANCER STEMNESS MODULATION
Preclinical development of siRNA therapeutics: Towards the match between fundamental science and engineered systems
Gene Therapy for Advanced Melanoma: Selective Targeting and Therapeutic Nucleic Acids
Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases

BookSection (3)

The Emerging Role of Nanomedicine in the Advances of Oncological Treatment
Amphiphilic Polymers: Drug Delivery
Lipoplexes and Polyplexes: Gene Delivery Applications

Patent (1)

Actively targeted polymeric micelles for drug and gene delivery

Proyecto (1)

SAFETY TESTING IN THE LIFE CYCLE OF NANOTECHNOLOGY-ENABLED MEDICAL TECHNOLOGIES FOR HEALTH.
25
Diana Fernandes

Investigador Post-Doctoral

CIBBIM-Nanomedicine

Vall D' Hebron Research Insititute

Barcelona, España

9
Fernanda da Silva

Post-doctoral Researcher

CIBBIM-Nanomedicine

Vall d'Hebron Instituto de Recerca

Barcelona, España

4
Sara Montero

Estudiante de Doctorado

CIBBIM-Nanomedicine

Vall D'Hebron Research Institute

Barcelona, España