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Irmgadt Annelise Goecke Sariego

Mèdico Jefe Secciòn Reumatología

Hospital Clínico,UNIVERSIDAD DE CHILE

Santiago, Chile

Autoimmune Diseases.; Acute Inflammation; Glucocorticoid receptors; Rheumatoid Arthritis; Spondiloarthropaties

Ciencias Biologicas Mencion Fisiologia y Biofisica, UNIVERSIDAD DE CHILE. Chile, 2009
Medico, UNIVERSIDAD DE VALPARAISO. Chile, 2006
Especialista en Medicina interna, UNIVERSIDAD DE CHILE. Chile, 2013
Especialista en reumatología, UNIVERSIDAD DE CHILE. Chile, 2015

Profesor asociado Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1994 - A la fecha

Dirección de tesis de Magíster:

Alumno: Sr Ricardo Henriquez, Programa de Magister en Fisiología, Escuela de Postgrado, Facultad de Medicina,Universidad de Chile. Titulo de la tesis: “efectos de la coestimulacion con corticoides e IL6 sobre la expresión de VGF-A en condrocitos hipertróficos murinos” 2013-2015

Alumno: Sr Christian Urzúa, Programa de Magister en inmunología, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile.Titulo de la tesis: “Expresión de Isoformas del receptor de Glucocorticoides en pacientes con Enfermedad de Vogt-Koyanagi-Harada” 2012-2014.

Alumna: Srta. Juliana bedoya, Programa de Magister en Ciencias médicas, mención inmunología, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Titlo de la Tesis: “Rol del TLR4 en la modulación de la expresión de las isoformas alfa y beta del RGC inducida por LPS” 2009-2013.

Alumna Sra. Rossana Mamani, Programa de Magister en Ciencias médicas, mención inmunología, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Titulo tesis: “modulación de la expresión de las isoformas alfa y beta del receptor de GC en lactantes con sibilancias post bronquiolitis por VSR” 2010

Alumna: Srta. María Luisa Molina, Programa de Magíster en ciencias Biológícas, mención Fisiopatología, Escuela de Postgrado, Facultad de Medicina, univerwsidad de Chile. Título de la Tesis: “LPS in vitro (como modelo de inflamación aguda) modula la expresión de las distintas isoformas del receptor de glucocorticoides” 2005-2007.

Alumna: Sra. Barbara Fertilio, Programa de Magíster en ciencias Biológicas, mención Morfología, Escuela de Postgrado, Facultad de Medicina, universidad de Chile. Título de la Tesis: “Efectos morfológicos de bloqueadores de canales de calcio tipo L en cartílago de crecimiento de rudimentos oseos” 2005-2006.

Dirección tesis de Doctorado:

Alumno: Sr Claudio Karsulovic, Programa de Doctorado en ciencias médicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. 2016 a la fecha.

Alumno: Sr Rafael Martinez, Programa de Doctorado en ciencias médicas, Escuela de Postgrado, Facultad de Medicina,Pontificia Universidad Católica de Chile. Título de la Tesis: “Rol del cotransportador de fosfato inorgánico PIT-1 en la hipertrofia condroídea de células ATDC5 expuestas a líquido sinovial de pacientes con osteoartritis” 2007-2012.

Alumna: Srta Julia guerrero, Programa de Doctorado en ciencias biomédicas, Escuela de Postgrado, Facultad de Medicina, universidad de Chile. Título de la Tesis: Isoformas del receptor de glucocorticoides en inflamación aguda severa. 2005-2007.


Determinación de niveles de vitamina D en pacientes con fibromialgia. Estudio de casos y controles Lanas, A; Cordero, F; Pino, S; Soto, L; Goecke, A; Romero, C; Caamaño, E; Pineda, P. Article Rev. Chil. Endocrinol. diabetes (2017)
Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease. Urzua CA, Guerrero J; Gatica H, Velasquez V Article Invest Ophthalmol Vis Sci. (2017)
LPS regulates the expression of glucocorticoid receptor alpha and beta isoforms and induces a selective glucocorticoid resistance in vitro Molina, Maria Luisa; Guerrero, Julia; Cidlowski, John A.; Gatica, Héctor; Goecke, Annelise Article ISI SCOPUS Journal of Inflammation (United Kingdom) (2017)
Tofacitinib, an oral Janus kinase inhibitor, for the treatment of Latin American patients with rheumatoid arthritis=> Pooled efficacy and safety analyses of Phase 3 and long-term extension studies Radominski, SC; Cardiel, MH; Citera, G; Goecke, A; Jaller, JJ; Lomonte, ABV; Miranda, P; Velez P, Xibillé; D, Kwok; K, Rojo; R, García Article Reumatologia Clinica (2017)
A phase III randomized study to evaluate the efficacy and safety of CT-P13 compared with reference infliximab in patients with active rheumatoid arthritis=> 54-week results from the PLANETRA study Dae Hyun Yoo, Artur Racewicz; Jan Brzezicki, Roman Yatsyshyn; Edgardo Tobias Arteaga, Asta Baranauskaite; Carlos Abud-Mendoza, Sandra Navarra; Vladimir Kadinov, Irmgadt Goecke Sariego; Seung Suh Hong, Sung Young Lee Article Arthritis Res Ther (2016)
Comparable long-term efficacy, as assessed by patient-reported outcomes, safety and pharmacokinetics, of CT-P13 and reference infliximab in patients with ankylosing spondylitis=> 54-week results from the randomized, parallel-group PLANETAS study. Won Park, Dae Hyun Yoo; corresponding author Janusz Jaworski, Jan Brzezicki; Andriy Gnylorybov, Vladimir Kadinov; Irmgadt Goecke Sariego, Carlos Abud-Mendoza; William Jose Otero Escalante, Seong Wook Kang; Daina Andersone, Francisco Blanco Article Arthritis Res Ther. (2016)
Earlier immunomodulatory treatment is associated with better visual outcomes in a subset of patients with Vogt-Koyanagi-Harada disease. Urzua, Cristhian A; Velasquez, Victor; Sabat, Pablo; Berger, Osvaldo; Ramirez, Sebastian; Goecke, Annelise; Vásquez, Darío H; Gatica, Hector; Guerrero, Julia Article Acta ophthalmologica (2015)
Recomendaciones sobre el manejo del compromiso renal del lupus eritematoso sistémico=> Documento de Consenso de las Sociedades Chilenas de Nefrología y Reumatología Verónica Aguirre, Miriam Alvo; Leopoldo Ardiles, J. Daniel Carpio; Carolina Foster, Annelise Goecke; Roberto Jalil, Loreto Massardo; Sergio Palma, Emilio Roessler Article Revista Médica de Chile (2015)
Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay. Guerrero, Julia; Gatica, Héctor A; Rodríguez, Margarita; Estay, Roberto; Goecke, Irmgadt Annelise Article Critical care (London, England) (2013)
Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations Sanchez E.; Rasmussen A.; Riba, L; Acevedo-Vasquez, E; Kelly J.A.; Langefeld C.D.; Williams A.H.; Ziegler J.T.; Comeau M.E.; Marion M.C.; Garcia De La Torre I.; Maradiaga-Cecena M.A.; Cardiel M.H.; Esquivel-Valerio J.A.; Rodriguez-Amado J.; Moctezuma J.F.; Miranda, P.; Perandones C.E.; Castel C.; Laborde H.A.; Alba, P; Musuruana J.L.; Goecke I.A.; Anaya J.-M.; Kaufman K.M.; Adler A.; Glenn S.B.; Brown E.E.; Alarcón G.S.; Kimberly R.P.; Edberg J.C.; Vila L.M.; Criswell L.A.; Gilkeson G.S.; Niewold T.B.; Martin J.; Vyse T.J.; Boackle S.A.; Ramsey-Goldman R.; Scofield R.H.; Petri M.; Merrill J.T.; Reveille J.D.; Tsao B.P.; Orozco, L.; Baca V.; Moser K.L.; Gaffney P.M.; James J.A.; Harley J.B.; Tusie-Luna, T; Pons-Estel B.A.; Jacob C.O.; Alarcon-Riquelme M.E. Article ISI SCOPUS Arthritis and Rheumatism (2012)
Increased expression of the glucocorticoid receptor Î² in infants with RSV bronchiolitis. Diaz, Patricia V; Pinto, Ricardo A; Mamani, Rossana; Uasapud, Paola A; Bono, Maria R; Gaggero, Aldo A; Guerrero, Julia; Goecke, Annelise Article Pediatrics (2012)
Effects of methotrexate on the expression of the translational isoforms of glucocorticoid receptors Î± and Î²: correlation with methotrexate efficacy in rheumatoid arthritis patients. Gatica, Héctor; Aliste, Marta; Guerrero, Julia; Goecke, Irmgadt Annelise Article Rheumatology (Oxford, England) (2011)
L-type calcium channels in growth plate chondrocytes participate in endochondral ossification Mancilla, EE; Galindo, M; Fertilio, B; Herrera, M; Salas K.; Gatica H.; Goecke A. Article JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
L-type calcium channels in growth plate chondrocytes participate in endochondral ossification. Mancilla, Edna E; Galindo, Mario; Fertilio, Barbara; Herrera, Mario; Salas, Karime; Gatica, Hector; Goecke, Annelise Article Journal of cellular biochemistry (2007)
Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro. Goecke, I Annelise; Alvarez, Claudia; Henríquez, Juan; Salas, Karime; Molina, María Luisa; Ferreira, Arturo; Gatica, Héctor Article Molecular immunology (2007)
Glucocorticoid receptor beta in acute and chronic inflammatory conditions: clinical implications. Goecke, Annelise; Guerrero, Julia Article Immunobiology (2006)
[Detection of malignancy markers in thyroid nodules by reverse transcriptase polymerase chain reaction (RT-PCR)]. Pineda, Pedro; Rojas, Paula; Liberman, Claudio; Moyano, Leonor; Goecke, Irmgadt Article Revista mÃ©dica de Chile (2003)
Reduced Na-K pump but increased Na-K-2Cl cotransporter in aorta of streptozotocin-induced diabetic rat. Michea, L; Irribarra, V; Goecke, I A; Marusic, E T Article American journal of physiology. Heart and circulatory physiology (2001)
[Comparison of the efficacy of intraarticular and intraarterial injections of two betamethasone preparations in patients with osteoarthritis or epicondilytis]. Oksenberg, D; Cuchacovich, M; Alamo, M; Goecke, A; Contreras, L; Catalán, J; Saavedra, I; Gaete, L; Gatica, H Article Revista mÃ©dica de Chile (1998)
Increased Na,K,Cl cotransporter and Na, K-ATPase activity of vascular tissue in two-kidney Goldblatt hypertension. Goecke, A; Kusanovic, J P; Serrano, M; Charlin, T; Zuñiga, A; Marusic, E T Article Biological research (1998)
Tissue-specific modulation of Na, K-ATPase alpha-subunit gene expression in uremic rats. Bofill, P; Goecke, I A; Bonilla, S; Alvo, M; Marusic, E T Article Kidney international (1994)
Comparison of fluid absorption by bovine and ovine descending colon in vitro. McKie, A T; Goecke, I A; Naftalin, R J Article The American journal of physiology (1991)
Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle. Bonilla, S; Goecke, I A; Bozzo, S; Alvo, M; Michea, L; Marusic, E T Article The Journal of clinical investigation (1991)
Enhanced insulin sensitivity in extrarenal potassium handling in uremic rats. Goecke, I A; Bonilla, S; Marusic, E T; Alvo, M Article Kidney international (1991)

Irmgadt Goecke

Mèdico Jefe Secciòn Reumatología

Medicina

Hospital Clínico,UNIVERSIDAD DE CHILE

Santiago, Chile

Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Irmgadt Annelise Goecke Sariego

Líneas de Investigación

Educación

Ciencias Biologicas Mencion Fisiologia y Biofisica, UNIVERSIDAD DE CHILE. Chile, 2009

Medico, UNIVERSIDAD DE VALPARAISO. Chile, 2006

Especialista en Medicina interna, UNIVERSIDAD DE CHILE. Chile, 2013

Especialista en reumatología, UNIVERSIDAD DE CHILE. Chile, 2015

Experiencia Académica

Profesor asociado Part Time

Formación de Capital Humano

Article (24)

Determinación de niveles de vitamina D en pacientes con fibromialgia. Estudio de casos y controles

Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease.

LPS regulates the expression of glucocorticoid receptor alpha and beta isoforms and induces a selective glucocorticoid resistance in vitro

Tofacitinib, an oral Janus kinase inhibitor, for the treatment of Latin American patients with rheumatoid arthritis=> Pooled efficacy and safety analyses of Phase 3 and long-term extension studies

A phase III randomized study to evaluate the efficacy and safety of CT-P13 compared with reference infliximab in patients with active rheumatoid arthritis=> 54-week results from the PLANETRA study

Comparable long-term efficacy, as assessed by patient-reported outcomes, safety and pharmacokinetics, of CT-P13 and reference infliximab in patients with ankylosing spondylitis=> 54-week results from the randomized, parallel-group PLANETAS study.

Earlier immunomodulatory treatment is associated with better visual outcomes in a subset of patients with Vogt-Koyanagi-Harada disease.

Recomendaciones sobre el manejo del compromiso renal del lupus eritematoso sistémico=> Documento de Consenso de las Sociedades Chilenas de Nefrología y Reumatología

Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay.

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations

Increased expression of the glucocorticoid receptor Î² in infants with RSV bronchiolitis.

Effects of methotrexate on the expression of the translational isoforms of glucocorticoid receptors Î± and Î²: correlation with methotrexate efficacy in rheumatoid arthritis patients.

L-type calcium channels in growth plate chondrocytes participate in endochondral ossification

L-type calcium channels in growth plate chondrocytes participate in endochondral ossification.

Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro.

Glucocorticoid receptor beta in acute and chronic inflammatory conditions: clinical implications.

[Detection of malignancy markers in thyroid nodules by reverse transcriptase polymerase chain reaction (RT-PCR)].

Reduced Na-K pump but increased Na-K-2Cl cotransporter in aorta of streptozotocin-induced diabetic rat.

[Comparison of the efficacy of intraarticular and intraarterial injections of two betamethasone preparations in patients with osteoarthritis or epicondilytis].

Increased Na,K,Cl cotransporter and Na, K-ATPase activity of vascular tissue in two-kidney Goldblatt hypertension.

Tissue-specific modulation of Na, K-ATPase alpha-subunit gene expression in uremic rats.

Comparison of fluid absorption by bovine and ovine descending colon in vitro.

Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle.

Enhanced insulin sensitivity in extrarenal potassium handling in uremic rats.

Irmgadt Goecke

Julia Guerrero