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Alexsandra Beatriz Espejo Lataillade

Research Scientist

The University of Texas M.D. Anderson Cancer Center

Houston, Estados Unidos

Tumor immune monitoring in human cancers prior and post therapy using single and quantitative multiplex immunohistochemistry. In vitro Screening for drug discovery, protein to protein interactions, posttranslational modifications and histone code.

Marine biologist, UNIVERSIDAD DE CONCEPCION. Chile, 2000
Doctor of Philosophy (Epigenetics and Molecular Carcinogenesis), UNIV TEXAS M.D. ANDERSON CANCER CENTER. Estados Unidos, 2016
Bachelor in Marine Biology, UNIVERSIDAD DE CONCEPCION. Chile, 1999

Research Investigator Full Time

UNIV TEXAS M.D. ANDERSON CANCER CENTER

Department of Carcinogenesis.

Smithville, Estados Unidos

2001 - 2010
Graduate Research Assistant Full Time

UNIV TEXAS M.D. ANDERSON CANCER CENTER

Department of Epigenetics and Molecular Carcinogenesis.

Smithville, Estados Unidos

2010 - 2016
Postdoctoral Fellow Full Time

UNIV TEXAS M.D. ANDERSON CANCER CENTER

Department of Pediatric Research

Houston, Estados Unidos

2016 - 2017
Research Scientist Full Time

UNIV TEXAS M.D. ANDERSON CANCER CENTER

Department of Immunology

Houston, Estados Unidos

2017 - A la fecha

CPRTP Postdoctoral Fellowship in Cancer Prevention

UNIV TEXAS M.D. ANDERSON CANCER CENTER

Estados Unidos, 2017

The Cancer Prevention Research Training Program at MD Anderson prepares scientists and clinicians to achieve leadership roles as research investigators in the field of cancer prevention and control.


PRMT5 C-terminal Phosphorylation Modulates a 14-3-3/PDZ Interaction Switch Espejo, Alexsandra B.; Gao, Guozhen; Black, Karynne; Gayatri, Sitaram; Veland, Nicolas; Kim, Jeesun; Chen, Taiping; Sudol, Marius; Walker, Cheryl; Bedford, Mark T. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills Napoli, Eleonora; Song, Gyu; Liu, Siming; Espejo, Alexsandra; Perez, Carlos J.; Giulivi, Cecilia Article ISI SCIENTIFIC REPORTS (2017)
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation Metzger, Eric; Willmann, Dominica; McMillan, Joel; Metzger, Philipp; Gerhardt, Stefan; Petroll, Kerstin; von Maessenhausen, Anne; Urban, Sylvia; Schott, Anne-Kathrin; Eberlin, Adrien; et al. Article ISI NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene Mecklenburg, Lars; Jaubert, Jean; Martinez-Santamaria, Lucia; Iritani, Brian M.; DiGiovanni, John; Dent, Sharon Y. R.; Wood, Richard D.; Kusewitt, Donna F.; Guenet, Jean-Louis; Conti, Claudio J. Article ISI JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)
Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex Kapoor, Prabodh; Bao, Yunhe; Xiao, Jing; Yang, Lin; Peng, Guang; Shen, Xuetong Article ISI MOLECULAR CELL (2015)
Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2 Hadjikyriacou, Andrea; Yang, Yanzhong; Clarke, Steven G. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Methyllysine Reader Plant Homeodomain ( PHD) Finger Protein 20-like 1 ( PHF20L1) Antagonizes DNA ( Cytosine-5) Methyltransferase 1 ( DNMT1) Proteasomal Degradation Esteve, Pierre-Olivier; Terragni, Jolyon; Deepti, Kanneganti; Chin, Hang Gyeong; Dai, Nan; Correa, Ivan R., Jr.; Pradhan, Sriharsa Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Protein arginine methyl transferases-3 and-5 increase cell surface expression of cardiac sodium channel Beltran-Alvarez, Pedro; Schmauder, Ralf; Mrowka, Ralf; Linke, Thomas; Batlle, Montserrat; Perez-Villa, Felix; Perez, Guillermo J.; Scornik, Fabiana S.; Benndorf, Klaus; Pagans, Sara; et al. Article ISI FEBS LETTERS (2013)
Interaction of Proliferation Cell Nuclear Antigen (PCNA) with c-Abl in Cell Proliferation and Response to DNA Damages in Breast Cancer Zhao, Huajun; Ho, Po-Chun; Lo, Yuan-Hung; Hung, Mien-Chie; Wang, Shao-Chun Article ISI PLOS ONE (2012)
Methylation by Set9 modulates FoxO3 stability and transcriptional activity Calnan, Daniel R.; Webb, Ashley E.; White, Jamie L.; Stowe, Timothy R.; Goswami, Tapasree; Shi, Xiaobing; Gozani, Or; Gygi, Steven P.; Brunet, Anne Article ISI AGING-US (2012)
Lysine methylation of the NF-kappa B subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappa B signaling Levy, Dan; Kuo, Alex J.; Schaefer, Uwe; Kitson, Christopher; Cheung, Peggie; Zee, Barry M.; Liu, Chih Long; Tangsombatvisit, Stephanie; Tennen, Ruth I.; Kuo, Andrew Y.; et al. Article ISI NATURE IMMUNOLOGY (2011)
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a Chang, Yanqi; Sun, Lidong; Kokura, Kenji; Horton, John R.; Fukuda, Mikiko; Izumi, Victoria; Koomen, John M.; Shinkai, Yoichi; Fang, Jia Article ISI NATURE COMMUNICATIONS (2011)
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics Quinn, Amy M.; Spannhoff, Astrid; Austin, Christopher P.; Oppermann, Udo; Simeonov, Anton Article ISI NUCLEIC ACIDS RESEARCH (2010)
Mouse Models for the p53 R72P Polymorphism Mimic Human Phenotypes Zhu, Feng; Dolle, Martijn E. T.; Berton, Thomas R.; Kuiper, Raoul V.; Capps, Carrie; McArthur, Mark J.; van Steeg, Harry; de Vries, Annemieke; Johnson, David G. Article ISI CANCER RESEARCH (2010)
TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks Lu, Yue; Wu, Jiacai; Xu, Wei; Liang, Shoudan Article ISI MOLECULAR CELL (2010)
Crystal Structure of the Three Tandem FF Domains of the Transcription Elongation Regulator CA150 Lu, Ming; Yang, Jun; Ren, Zhiyong; Sabui, Subir; Jacobson, Raymond H.; Jeruzalmi, David; McMurray, John S.; Chen, Xiaomin Article ISI JOURNAL OF MOLECULAR BIOLOGY (2009)
Epigenome Microarray Platform for Proteome-Wide Dissection of Chromatin-Signaling Networks Bua, Dennis J.; Migliori, Valentina; Casadio, Fabio; Bassi, Christian; Amati, Bruno; Guccione, Ernesto Article ISI PLOS ONE (2009)
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse Schotta, Gunnar; Sengupta, Roopsha; Kubicek, Stefan; Malin, Stephen; Kauer, Monika; Callen, Elsa; Celeste, Arkady; Pagani, Michaela; Opravil, Susanne; De La Rosa-Velazquez, Inti A.; et al. Article ISI GENES & DEVELOPMENT (2008)
Arginine methylation of the histone H3 tail impedes effector binding Iberg, Aimee N.; Cheng, Donghang; Kim, Daehoon; Michaud-Levesque, Jonathan; Richard, Stephane Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
p53 is regulated by the lysine demethylase LSD1 Huang, Jing; Lee, Min Gyu; Dorsey, Jean A.; Richter, Mario; Berger, Shelley L. Article ISI NATURE (2007)
Tudor, MBT and chromo domains gauge the degree of lysine methylation Daniel J.; Lake, A; Bedford, MT Article ISI EMBO REPORTS (2006)
14-3-3 Interacts with the Tumor Suppressor Tuberin at Akt Phosphorylation Site(s) Liu, Matt Y; Cai, Shengli Article CANCER RESEARCH (2002)
A protein-domain microarray identifies novel protein-protein interactions Cote, J; Bednarek, A Article ISI BIOCHEMICAL JOURNAL (2002)


Methyl-Arginine Recognition by Tudor Domains BookSection (2015)
System-Oriented Proteomics Using Protein-Domain Microarrays Dr. Mark Schena BookSection (2005)
Isozyme Analysis in the Sea Urchin Loxechinus albus John M. Lawrence and Oscar Guzman BookSection (2004)
Protein-Domain Microarrays Eric T. Fung BookSection (2004)

Alexsandra Espejo

Research Scientist

Department of Immunology

The University of Texas M.D. Anderson Cancer Center

Houston, Estados Unidos

Alexsandra Beatriz Espejo Lataillade

Líneas de Investigación

Educación

Marine biologist, UNIVERSIDAD DE CONCEPCION. Chile, 2000

Doctor of Philosophy (Epigenetics and Molecular Carcinogenesis), UNIV TEXAS M.D. ANDERSON CANCER CENTER. Estados Unidos, 2016

Bachelor in Marine Biology, UNIVERSIDAD DE CONCEPCION. Chile, 1999

Experiencia Académica

Research Investigator Full Time

Graduate Research Assistant Full Time

Postdoctoral Fellow Full Time

Research Scientist Full Time

Premios y Distinciones

CPRTP Postdoctoral Fellowship in Cancer Prevention

Article (23)

BookSection (4)