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Alejandro Francisco Alvarez Lueje

Académico

UNIVERSIDAD DE CHILE

Santiago, Chile

BioelelectroquÃmica; AnÃ¡lisis de Medicamentos; Obtention of new nanobiomaterials: peptides and metal nanoparticles; Synthesis and Structure of peptides; Nanobiomaterials for biomedical applications; Ciencia de Materiales, Material Granular; FisicoquÃmica de Superficies; BiofÃsica: Microscopia de Fuerza AtÃ³mica; EstrÃ©s y depresiÃ³n; Neuroplasticidad neuronal; FarmacogenÃ³mica y FarmacogenÃ©tica de la depresiÃ³n

Análisis de medicamentos/Bioelectroquímica, UNIVERSIDAD DE CHILE. Chile, 1999

Profesor Titular/Académico Full Time

UNIVERSIDAD DE CHILE

Ciencias Químicas y Farmacéuticas

Santiago, Chile

1987 - A la fecha

1. Dirección/ patrocinio de Tesis de Postgrado
2 Tesis para optar al Grado de Magister en Química (Universidad de Chile)
2 Tesis para optar al Grado de Doctor en Química (Universidad de Chile)
3 Tesis para optar al Grado de Doctor en Ciencias Farmacéuticas (Universidad de Chile)

2. Dirección/ patrocinio de Memorias/Tesis de Pregrado
44 Memorias conducentes al Título de Químico Farmacéutico (Universidad de Chile)
1 Tesis conducente al Título de Químico Farmacéutico (Pontificia Universidad Católica de Chile)
1 Tesis conducente al Título de Químico Industrial (Universidad Tecnológica Metropolitana)
1 Tesis conducente al Título de Bioquímico (Pontificia Universidad Católica de Valparaíso)
1 Tesis conducente al Título de Ingeniero Químico (Universidad Tecnológica Metropolitana)


Application of Switchable Hydrophobicity Solvents for Extraction of Emerging Contaminants in Wastewater Samples Article Science Citation Index Expanded (Web of Science), MEDLINE (PubMed), Scopus and other databases. Molecules (2020)
CARBON NANOTUBES-IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS P. Pizarro Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2019)
Electrocatalytic oxidation and voltammetric determination of sulfamethazine using a modified carbon electrode with ionic liquid L. Urzúa, M. Pérez-Ortiz Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2018)
Gold nanoparticles as an efficient drug delivery system for GLP-1 peptides M. Pérez-Ortiz, C. Zapata-Urzúa; G.A. Acosta, A. Álvarez-Lueje; F. Albericio, M.J. Kogan Article COLLOIDS AND SURFACES B-BIOINTERFACES (2017)
Heterologous Expression of an α-Amylase Inhibitor from Common Bean (Phaseolus vulgaris) in Kluyveromyces lactis and Saccharomyces cerevisiae S. Brain-Isasi, A. Álvarez-Lueje Article MICROBIAL CELL FACTORIES (2017)
New approach for determination of flumequine and oxolinic acid in aqueous samples by Ionic liquid-based dispersive liquid-liquid microextraction and high-performance liquid chromatography–fluorescence detection C. Toledo-Neira, M. Bravo Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2016)
Hantzsch Dihydropyridines=> Privileged Structures for the Formation of Well-Defined Gold Nanostars C. Zapata-Urzúa, M. Pérez-Ortiz; G.A. Acosta, J. Mendoza; L. Yedra, S. Estradé; A. Álvarez-Lueje, L.J. Núñez-Vergara; F. Albericio, R. Lavilla Article JOURNAL OF COLLOID AND INTERFACE SCIENCE (2015)
Ionic liquids for improving the extraction of NSAIDs in water samples using dispersive liquid-liquid microextraction by high performance liquid chromatography-diode array-fluorescence detection C. Toledo-Neira, A. Álvarez-Lueje Article TALANTA (2015)
Development of a modified carbon electrode with ionic liquid and its application for electrocatalytic oxidation and voltammetric determination of levodopa V. Moncada, A. Álvarez-Lueje Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2014)
Electrooxidation of DNA at glassy carbon electrodes modified with multi-walled carbon nanotubes with different oxidation degree P. Cañete-Rosales, A. Álvarez-Lueje Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2014)
Ethylendiamine-functionalized multi-walled carbon nanotubes prevent cationic dispersant use in the electrochemical detection of dsDNA Canete-Rosales, P; Alvarez-Lueje, A; Bollo, S Article SENSORS AND ACTUATORS B-CHEMICAL (2014)
Ion Pair Method to Determine the CTAB Content in Gold Nanorods Samples C. Adura, F. Guzmán; A. Álvarez-Lueje, M.J. Kogan Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2014)
Development of a Carbon Nanotube Modified Ionic Liquid Electrode for the Voltammetric Determination of Methyldopa Levels in Urine Perez-Mella, B; Alvarez-Lueje, A Article ELECTROANALYSIS (2013)
Electrochemical Analysis of Nitrofurans Based on Flow Injection Analysis on Pretreated Commercial Carbon Nanofiber Screen Printed Electrodes=> Determination in Chicken Muscle Samples Salgado-Figueroa, P; Jara-Ulloa, P; Alvarez-Lueje, A; Nunez-Vergara, LJ; Squella, JA Article JOURNAL OF THE ELECTROCHEMICAL SOCIETY (2013)
Sensitive Determination of Nitrofurantoin by Flow Injection Analysis Using Carbon Nanofiber Screen Printed Electrodes Salgado-Figueroa, P; Jara-Ulloa, P; Alvarez-Lueje, A; Squella, JA Article ELECTROANALYSIS (2013)
Influence of size and oxidative treatments of multi-walled carbon nanotubes on their electrocatalytic properties P. Cañete-Rosales, V. Ortega; A. Álvarez-Lueje, S. Bollo; M. Gonzalez, A. Ansón Article Electrochimica Acta (2012)
Voltammetric Study and Direct Analytical Determination of the Antiparkinson Drug Benserazide Perez-Ortiz M., Bollo; S, Zapata-Urzua C.; Yanez, C; Alvarez-Lueje, A Article ANALYTICAL LETTERS (2011)
Electrochemical behavior of atomoxetine and its voltammetric determination in capsules Perez-Ortiz M., Munoz; C, Zapata-Urzua C.; Alvarez-Lueje, A Article TALANTA (2010)
Electrochemistry of interaction of 2-(2-nitrophenyl)-benzimidazole derivatives with DNA M. Catalán, A. Álvarez-Lueje Article Bioelectrochemistry (2010)
Simultaneous voltammetric determination of levodopa, carbidopa and benserazide in pharmaceuticals using multivariate calibration C. Zapata-Urzúa, M. Pérez-Ortiz; M. Bravo, A.C. Olivieri Article Talanta (2010)
Stability and drug metabolism assessed by electrochemical methods A. Álvarez-Lueje, S. Bollo Article Combinatorial Chemistry & High Throughput Screening (2010)
Voltammetric behavior of naratriptan and its determination in tablets Velasco-Aguirre C., Alvarez-Lueje Article TALANTA (2010)
Electrochemical study and analytical applications for new biologically active 2-nitrophenylbenzimidazole derivatives Alvarez-Lueje, A; Zapata-Urzua C., Brain-Isasi S.; Perez-Ortiz M., Barros; L, Pessoa-Mahana; H, Kogan Article TALANTA (2009)
Determination and characterization of new benzimidazoles with activity against Trypanosoma cruzi by UV spectroscopy and HPLC Stephanie Brain-Isasi, Cristián Quezada; Hernán Pessoa, Antonio Morello; Marcelo J. Kogan, Alejandro Álvarez-Lueje Article Bioorganic & Medicinal Chemistry (2008)
How changes in the sequence of the peptide CLPFFD-NH(2) can modify the conjugation and stability of gold nanoparticles and their affinity for beta-amyloid fibrils Olmedo, I; Araya E., Sanz F.; Medina, E; Arbiol, J; Toledo, P; Alvarez-Lueje, A; Giralt, E; Kogan, MJ Article BIOCONJUGATE CHEMISTRY (2008)
Voltammetric reduction of finasteride at mercury electrode and its determination in tablets A. Álvarez-Lueje, S. Brain-Isasi; L.J. Núñez-Vergara, J.A. Squella Article Talanta (2008)
Voltammetric behaviour of bromhexine and its determination in pharmaceuticals Turchan M., Jara-Ulloa; P, Bollo; S, Nunez-Vergara; LJ, Squella; JA, Alvarez-Lueje Article TALANTA (2007)
Assessment of the hydrolytic degradation of lovastatin by HPLC Alvarez-Lueje, A; Pastine J., Squella; JA, Nunez-Vergara Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2005)
Voltammetric behavior of zaleplon and its differential pulse polarographic determination in capsules Larenas G., Bollo; S, Rodriguez; M, Lemus I.; Nunez-Vergara, LJ; Squella, JA; Alvarez-Lueje, A Article JOURNAL OF AOAC INTERNATIONAL (2005)
Differential pulse voltammetric assay of lercanidipine in tablets Alvarez-Lueje, A; Pujol S., Nunez-Vergara; LJ, Squella Article JOURNAL OF AOAC INTERNATIONAL (2002)
Voltammetric behaviour of clonixin and its differential pulse polarographic determination in tablets Alvarez-Lueje, A; Sturm, JC; Nunez-Vergara, LJ; Carbajo J., Squella Article ANALYTICAL LETTERS (2000)


IONIC LIQUIDS/CARBON BASED COMPOSITES TO DEVELOP MODIFIED ELECTRODES FOR ITS APPLICATION IN DRUG ANALYSIS FONDECYT (1150861) Proyecto 2015-2019 Inv. Responsable
LIQUIDOS IONICOS COMO DISOLVENTES VERDES DE ULTIMA GENERACION APLICADOS AL DESARROLLO DE METODOS ANALITICOS PARALA DETERMINACION DE CONTAMINANTES EMERGENTES EN MUESTRAS AMBIENTALES FONDECYT (3140459) Proyecto 2013-2016 Inv. Patrocinante
The multifunctionalization of gold nanoparticles with peptides to improve their penetration through biological barriers and for to increase their affinity for beta-amyloid aggregates FONDECYT (1130425) Proyecto 2013-2015 Coinvestigador(a)
Ionic liquid modified electrodes to drug analysis FONDECYT (1110182) Proyecto 2011-2014 Inv. Responsable
Creación de un Laboratorio de nanobiotecnología para el desarrollo de nuevas técnicas para diagnóstico y terapia de enfermedades de interés regional Agencia Española de Cooperación Internacional para el Desarrollo (D/025188/09) Proyecto 2010-2012 Investigador(a)
New approach to the electrochemistry of some nitrocompounds of biological significance=> from mercury to carbon nanotube electrodes FONDECYT (1090120) Proyecto 2009-2012 Coinvestigador(a)
Desarrollo de metodologías analíticas para la cuantificación y caracterización de la serie homóloga 2-(o-nitrofenil)-benzimidazol N-sustituida FONDECYT (1061144) Proyecto 2006-2009 Inv. Responsable
Desarrollo de nuevos nanomateriales=> manipulación de la autoagregación y de la conformación de proteínas para reducir su toxicidad FONDECYT (1061142) Proyecto 2006-2009 Coinvestigador(a)

Alejandro Alvarez

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE

Santiago, Chile

Alejandro Francisco Alvarez Lueje

Líneas de Investigación

Educación

Análisis de medicamentos/Bioelectroquímica, UNIVERSIDAD DE CHILE. Chile, 1999

Experiencia Académica

Profesor Titular/Académico Full Time

Formación de Capital Humano

Article (31)

Proyecto (8)

IONIC LIQUIDS/CARBON BASED COMPOSITES TO DEVELOP MODIFIED ELECTRODES FOR ITS APPLICATION IN DRUG ANALYSIS

LIQUIDOS IONICOS COMO DISOLVENTES VERDES DE ULTIMA GENERACION APLICADOS AL DESARROLLO DE METODOS ANALITICOS PARALA DETERMINACION DE CONTAMINANTES EMERGENTES EN MUESTRAS AMBIENTALES

The multifunctionalization of gold nanoparticles with peptides to improve their penetration through biological barriers and for to increase their affinity for beta-amyloid aggregates

Ionic liquid modified electrodes to drug analysis

Creación de un Laboratorio de nanobiotecnología para el desarrollo de nuevas técnicas para diagnóstico y terapia de enfermedades de interés regional

New approach to the electrochemistry of some nitrocompounds of biological significance=> from mercury to carbon nanotube electrodes

Desarrollo de metodologías analíticas para la cuantificación y caracterización de la serie homóloga 2-(o-nitrofenil)-benzimidazol N-sustituida

Desarrollo de nuevos nanomateriales=> manipulación de la autoagregación y de la conformación de proteínas para reducir su toxicidad