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Jaime G. Melendez Rojel

Prof. Asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

Mecanismos moleculares que explican el desarrollo de cáncer colónico ypancreático. Aspectos asociados al uso de nanopartículas como vectores de drug delivery en el control del cáncer.

Cs Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1994
Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2001
Biomedicine, Cincinnati Children´s Hospital Medical Center. Estados Unidos, 2010

Prof. Asistente Full Time

P. Universidad Católica de Chile

Santiago, Chile

2011 - 2019

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New imidoyl-indazole platinum (II) complexes as potential anticancer agents=> Synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies. Cabrera, Alan R; Espinosa-Bustos, Christian; Faúndez, Mario; Meléndez, Jaime; Jaque, Pablo; Daniliuc, Constantin G; Aguirre, Adam; Rojas, Rene S; Salas, Cristian O Article Journal of inorganic biochemistry (2017)
New imidoyl-indazole platinum (II) complexes aspotential anticancer agents=> synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies. Cabrera AR, Espinosa-Bustos Ch; Faúndez M, Meléndez J; Jaque P, Daniliuc C; Aguirre A, Rojas RS Article JOURNAL OF INORGANIC BIOCHEMISTRY (2017)
RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Liu, Ming; Zhang, Zheng; Sampson, Leesa; Zhou, Xuan; Nalapareddy, Kodandaramireddy; Feng, Yuxin; Akunuru, Shailaja; Melendez, Jaime; Davis, Ashley Kuenzi; Bi, Feng; Geiger, Hartmut; Xin, Mei; Zheng, Yi Article Stem cell reports (2017)
Low gene dosage of Cdc42 is not associated with protein dysfunction in patients with colorectal cance González-Quiroz, Matías; Calderón, Ximena; Oyarzún, Ingrid; Hoepfner, Claudia; Azocar, Andrés; Aguirre, Adam; Álvarez, Karin; Quera, Rodrigo; López-Köstner, Francisco; Meléndez, Jaime. Article DNA AND CELL BIOLOGY (2016)
Cdc42 Coordinates Proliferation, Polarity, Migration, and Differentiation of Small Intestinal Epithelial Cells in Mice Meléndez J.; Liu M.; Sampson, L; Akunuru, S; Han, XN; Vallance, J; Witte, D; Shroyer, N; Zheng Y. Article ISI SCOPUS Gastroenterology (2013)
Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation Katayama, KI; Meléndez J.; Baumann, JM; Leslie, JR; Chauhan, BK; Nemkul, N; Lang, RA; Kuan, CY; Zheng Y.; Yoshida Y. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts Meléndez J.; Stengel, K; Zhou, X.; Chauhan, BK; Debidda, M; Andreassen, P; Lang, RA; Zheng Y. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes Foncea, R; Galvez A.; Pérez V; MORALES, MP.; Calixto, A; Meléndez J.; Gonzalez-Jara, F; Diaz-Araya, G; Sapag-Hagar, M; Sugden, PH; et al. Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

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RhoA Is An Essential Regulator of Mitosis and Survival During Hematopoietic Stem Cell Differentiation to Multipotent Progenitors Znou, X; Meléndez J.; Feng, YX; Lang, R; Zheng Y. Abstract BLOOD (2011)

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Liposome-based drug-delivery systems=> Different strategies to evaluate the synergic effect between pro-apoptotic lipids and encapsulated anticancer drug. FONDECYT (1171047) Proyecto 2017-2020 Coinvestigador(a)
Design, synthesis and biological impact of new Smoothened antagonists as potent Hedgehog signaling inhibitors in pancreatic cancer FONDECYT (1161816) Proyecto 2016-2019 Coinvestigador(a)
Expression of orexin receptors during the adenoma to carcinoma progression in human colorectal cancer=> elucidating their role as cell death mediators. FONDECYT (1140012) Proyecto 2014-2017 Coinvestigador(a)
The role of CDC42 of Cdc42-GTPase in mucosal inflammation and colorectal cancer evolution FONDECYT (1120112) Proyecto 2012-2015 Inv. Responsable
Desarrollo de productos de uso tópico para el cuidado de heridas y capilar FONDEF (DO7i1014) Proyecto 2009-2011 Coinvestigador(a)
Disociación de las diferentes vías transduccionales del factor de crecimiento análogo a la insulina tipo-1 (IGF-1) en los procesos de hipertrofia y apoptosis del cardiomiocito FONDECYT (1980908) Proyecto 1998-2000 Coinvestigador(a)
Mecanismos de transduccion y de expresión de la familia B-1 integrina en la hipertrofia del cardiomiocito inducida por estimulos químicos y de estiramiento mecánico FONDECYT (2960046) Proyecto 1996-1999 Inv. Responsable
REGULACION DE LA EXPRESION Y ACTIVIDAD DE LAS INTEGRINAS POR ESTIMULOS FISICOS Y BIOQUIMICOS EN CULTIVOS DE CARDIOMIOCITOS DE RATA FONDECYT (2960046) Proyecto 1996-1999 Inv. Responsable
Hipertrofia ventricular patológica. Participación del sistema renina-angiotensina-aldosterona y actividad adrénergica a través de factores de crecimiento. FONDECYT (1930592) Proyecto 1995-1996 Coinvestigador(a)
HIPERTROFIA VENTRICULAR PATOLOGICA=> PARTICIPACION DEL SISTEMA RENINA-ANGIOTENSINA-ALDOSTERONA Y ACTIVIDAD ADRENERGICA A TRAVES DE FACTORES DE CRECIMIENTO FONDECYT (1930592) Proyecto 1993-1996 Coinvestigador(a)


Signaling Role of Cdc42 in Regulating Mammalian Physiology Meléndez J.; Grogg, M; Zheng Y. Review ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Jaime Melendez

Prof. Asistente

Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

Anita Gálvez

Profesor Asistente

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

Jaime G. Melendez Rojel

Líneas de Investigación

Educación

Cs Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1994

Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2001

Biomedicine, Cincinnati Children´s Hospital Medical Center. Estados Unidos, 2010

Experiencia Profesional

Prof. Asistente Full Time

Article (8)

New imidoyl-indazole platinum (II) complexes as potential anticancer agents=> Synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies.

New imidoyl-indazole platinum (II) complexes aspotential anticancer agents=> synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies.

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance.

Low gene dosage of Cdc42 is not associated with protein dysfunction in patients with colorectal cance

Cdc42 Coordinates Proliferation, Polarity, Migration, and Differentiation of Small Intestinal Epithelial Cells in Mice

Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation

RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts

Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes

Abstract (1)

RhoA Is An Essential Regulator of Mitosis and Survival During Hematopoietic Stem Cell Differentiation to Multipotent Progenitors

Proyecto (10)

Liposome-based drug-delivery systems=> Different strategies to evaluate the synergic effect between pro-apoptotic lipids and encapsulated anticancer drug.

Design, synthesis and biological impact of new Smoothened antagonists as potent Hedgehog signaling inhibitors in pancreatic cancer

Expression of orexin receptors during the adenoma to carcinoma progression in human colorectal cancer=> elucidating their role as cell death mediators.

The role of CDC42 of Cdc42-GTPase in mucosal inflammation and colorectal cancer evolution

Desarrollo de productos de uso tópico para el cuidado de heridas y capilar

Disociación de las diferentes vías transduccionales del factor de crecimiento análogo a la insulina tipo-1 (IGF-1) en los procesos de hipertrofia y apoptosis del cardiomiocito

Mecanismos de transduccion y de expresión de la familia B-1 integrina en la hipertrofia del cardiomiocito inducida por estimulos químicos y de estiramiento mecánico

REGULACION DE LA EXPRESION Y ACTIVIDAD DE LAS INTEGRINAS POR ESTIMULOS FISICOS Y BIOQUIMICOS EN CULTIVOS DE CARDIOMIOCITOS DE RATA

Hipertrofia ventricular patológica. Participación del sistema renina-angiotensina-aldosterona y actividad adrénergica a través de factores de crecimiento.

HIPERTROFIA VENTRICULAR PATOLOGICA=> PARTICIPACION DEL SISTEMA RENINA-ANGIOTENSINA-ALDOSTERONA Y ACTIVIDAD ADRENERGICA A TRAVES DE FACTORES DE CRECIMIENTO

Review (1)

Signaling Role of Cdc42 in Regulating Mammalian Physiology

SERGIO LAVANDERO

Jaime Melendez

Anita Gálvez