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Pamela Romanque Ulloa

Residente

Hospital Clínico Universidad de Chile

Santiago, Chile

Dano hepatico, regeneracion hepatica, dano por isquemia-reperfusion, trasplante hepatico. Fisiopatologia. Imagenologia.

Médico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1999
Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2007
Medicina, UNIVERSIDAD DE CHILE. Chile, 1997

Profesor Asistente Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2009 - 2017

Profesor Asistente Part Time

Programa de Fisiopatología, Facultad de Medicina, Universidad de Chile

Santiago, Chile

2009 - 2017
Profesor Asistente Part Time

Facultad de Medicina, Universidad Diego Portales

Santiago, Chile

2005 - 2013
Médico de Urgencias Part Time

Hospital del Salvador

Santiago, Chile

2014 - 2015
Médico Part Time

Vitaclinic

Santiago, Chile

2013 - 2014
Médico Residente Full Time

Servicio de Imagenología, Hospital Clínico Universidad de Chile

Santiago, Chile

2017 - At present

TESIS DE PREGRADO:
- “Evaluación del daño oxidativo al DNA hepático post perfusión en el sistema de hígado perfundido aislado” Carolina López Valdés. Medical Technology thesis. Facultad de Medicina, Universidad Pedro de Valdivia. Finalizada

TESIS DE MAGÍSTER:
- “Influencia de las células de Küpffer sobre la activación del factor de transcripción nuclear NRF2”. Bárbara Núñez Valdovinos. Pharmacology and Medical Sciences Master Degree. Faculty of Medicine, Universidad de Chile.
- “Efecto del pretratamiento hormonal con triyodotironina y metilprednisolona sobre la regeneración hepática post hepatectomía parcial“. Amanda D’Espessailles Tapia. Biological Sciences Master Degree, Sciences Faculty, Universidad de Chile.
- “Efecto del pretratamiento con t3 sobre el daño hepático luego de un período de preservación e isquemia fría en un modelo experimental en ratas”. María Kelly Riquelme. Veterinarian Sciences Degree. Veterinarian Sciences Faculty. Universidad Santo Tomás.
- “Efecto del pretratamiento con metilprednisolona sobre el daño y la capacidad de regeneración del injerto hepático luego de un período de isquemia fría en un modelo experimental en ratas”. Paula Araya P. Veterinarian Sciences Degree. Veterinarian Sciences Faculty. Universidad Santo Tomás.
“Efecto del protocolo de resucitación hormonal combinado sobre parámetros de estrés oxidativo y daño hepático en un modelo de hígado perfundido aislado. Luis Gómez G. Pharmacology and Medical Sciences Master Degree. Faculty of Medicine, Universidad de Chile.

TESIS DE DOCTORADO:
“Effect of inflammatory and metabolic status of the brain dead donor over kidney and liver graft quality”. Rolando Rebolledo. Medical Sciences and Surgery PhD., Faculty of Medicine, Universidad de Chile in collaboration with University Medical Center Groningen, Groningen, Netherlands.
“Metabolic control of liver regeneration after ALPPS: AMPK/mTOR pathway”. Carlos Mandiola B. Medical Sciences and Surgery PhD., Faculty of Medicine, Universidad de Chile.

Beca de Doctorado CONICYT

UNIVERSIDAD DE CHILE

Chile, 2002

Beca para la realización de Doctorado de CONICYT
MECESUP UCH0306. Beca de entrenamiento predoctoral

UNIVERSIDAD DE CHILE

Chile, 2005

Beca para estadía en el extranjero, dentro del contexto de entrenamiento predoctoral, financiada por MECESUP
Beca Fulbright

COMISION FULBRIGHT-CHILE

Chile, 2006

Beca para estadía doctoral en el extranjero, Comisión Fulbright
ESKAS Bundesstipendium

Gobierno Suizo

Suiza, 2008

Beca de excelencia de la Confederación Helvética para entrenamiento postdoctoral
ESOT-STALYC Travel grant

European Society for Organ Transplantation

Holanda, 2013

Estadía como Profesor Visitante en UMCG, Gröningen, Holanda


Insight on ALPPS - Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy - mechanisms: activation of mTOR pathway Uribe, Mario; Uribe-Echevarría, Sebastián; Mandiola, Carlos; Zapata, María I.; Riquelme, Francisco; Romanque, Pamela Article ISI SCOPUS HPB (2018)
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): Preliminary results of a single center experience in Santiago, Chile Uribe-Echevarría, S.A.; Uribe M., M.; Riquelme M., F.; Mandiola B., C.; Zapata F., M.I.; Romanque, P. Article HPB (2016)
Anti-Apoptotic Effects of 3,3 ',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats Rebolledo RA; Van Erp, AC; Ottens, PJ; Wiersema-Buist, J; Leuvenink, HGD; Romanque, P. Article ISI SCOPUS PLOS ONE (2015)
Asociación de la partición hepática y ligadura de la vena portal para hepatectomía por etapas, un nuevo procedimiento en cirugía hepática Uribe, M., Uribe-Echevarría, S., Núñez, J., Martínez, W., Paqui, L., Camacho, J., Romanque, P. Article Revista Chilena de Cirugia (2015)
N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-alpha upregulation and NF-kappa B DNA binding abrogation Tapia, G; Valenzuela R.; Espinosa, A.; Romanque, P.; Dossi, C; Gonzalez-Manan, D; Videla LA.; D'Espessailles A. Article ISI SCOPUS MOLECULAR NUTRITION & FOOD RESEARCH (2014)
Hormonal pretreatment preserves liver regenerative capacity and minimizes inflammation after partial hepatectomy D'Espessailles A.; Dossi, C; Intriago, G; Leiva P.; Romanque, P. Article ISI SCOPUS Annals of Hepatology (2013)
Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol Mardones, M; Valenzuela R.; Romanque, P.; Covarrubias, N; Anghileri F.; Fernández V.; Videla, L.A.; Tapia, G Article ISI SCOPUS Journal of Nutritional Biochemistry (2012)
Thyroid Hormone-Induced Cytosol-to-Nuclear Translocation of Rat Liver Nrf2 Is Dependent on Kupffer Cell Functioning Videla, L.A.; Cornejo P.; Romanque, P.; Santibáñez C.; Castillo I.; Vargas R. Article ISI SCOPUS The Scientific World Journal (2012)
Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning Videla LA, Cornejo P, Romanque P, Santibáñez C, Castillo I, Vargas R. Article ScientificWorldJournal (2012)
Ablation of the Tumor Suppressor Histidine Triad Nucleotide Binding Protein 1 is Protective Against Hepatic Ischemia/Reperfusion Injury Martin J.; Romanque, P.; Maurhofer O.; Schmitter K.; Hora, C; Ferrand, G.; Dufour, JF Article ISI SCOPUS Hepatology (2011)
Effect of Sorafenib on Murine Liver Regeneration Hora, C; Romanque, P.; Dufour J.-F.F. Article ISI SCOPUS Hepatology (2011)
Thyroid Hormone Administration Induces Rat Liver Nrf2 Activation: Suppression by N-Acetylcysteine Pretreatment Romanque, P.; Valdes, S; Videla, L.A.; Cornejo P. Article ISI SCOPUS Thyroid (2011)
Delayed Ischemic Preconditioning Protects Against Liver Ischemia-Reperfusion Injury In Vivo Romanque, P.; Diaz A.; Tapia, G; Uribe-Echevarria, S; Videla LA.; Fernández V. Article ISI SCOPUS Transplantation Proceedings (2010)
Disproportionally high results of transient elastography in patients with autoimmune hepatitis. Romanque P, Stickel F, Dufour JF Article Liver International (2008)
Targeting vessels to treat hepatocellular carcinoma Romanque P, Piguet AC, Dufour JF. Article Clinical Sciences (2008)
Involvement of Kupffer cell-dependent signaling in T-3-induced hepatocyte proliferation in vivo Fernández V.; Reyes, S; Bravo S.; sepulveda, r; Romanque, P.; Santander, G.; Castillo I.; Varela, P; Tapia, G; Videla LA. Article ISI SCOPUS BIOLOGICAL CHEMISTRY (2007)
Thyroid hormone preconditioning: Protection against ischemia-reperfusion liver injury in the rat Fernández V.; Castillo I.; Tapia, G; Romanque, P.; Uribe-Echevarria, S; Uribe M.; Cartier-Ugarte, D; Santander, G.; Vial, MT; Videla LA. Article ISI SCOPUS HEPATOLOGY (2007)
Early histological and functional effects of chronic copper exposure in rat liver Cisternas, FA; Tapia, G; Arredondo M.; Cartier-Ugarte, D; Romanque, P.; Sierralta WD; Vial, MT; Videla LA.; Araya M. Article ISI SCOPUS BIOMETALS (2005)
Molecular mechanisms in liver ischemic-reperfusion injury and ischemic preconditioning Romanque U P, Uribe M M, Videla LA. Article Revista Médica de Chile (2005)
Thyroid hormone-induced oxidative stress in rodents and humans: a comparative view and relation to redox regulation of gene expression Fernández V, Tapia G, Varela P, Romanque P, Cartier-Ugarte D, Videla LA. Article Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology (2005)
Effects of acute lindane intoxication and thyroid hormone administration in relation to nuclear factor-kappa B activation, tumor necrosis factor-alpha expression, and Kupffer cell function in the rat Valencia, C; Cornejo P.; Romanque, P.; Tapia, G; Varela, P; Videla LA.; Fernández V. Article ISI SCOPUS TOXICOLOGY LETTERS (2004)
Kupffer cell stimulation in the isolated perfused rat liver triggers nuclear factor-kappa B DNA binding activity Romanque, P.; Tapia, G; Videla LA. Article ISI SCOPUS REDOX REPORT (2003)


Anti-Apoptotic But Not Mitotic Effects of 3,3 ', 5-triiodo-l-thyronine in the Liver of Brain Dead Rats van Erp, A; Rebolledo R.; Wiersema-Buist, J; Ottens, P; Leuvenink, H; Romanque, P. Abstract ISI AMERICAN JOURNAL OF TRANSPLANTATION (2015)
ANTI-APOPTOTIC EFFECTS OF 3,30,5-TRIIODO-LTHYRONINE IN THE LIVER OF BRAIN-DEAD RATS Rebolledo RA; Van Erp, AC; Wiersema-Buist, J; Leuvenink, HGD; Romanque, P. Abstract ISI TRANSPLANT INTERNATIONAL (2014)
THE EFFECT OF THE beta-HUMAN CHORIONIC GONADOTROPIN-RELATED PEPTIDE (AQGV) ON A BRAIN DEATH MODEL van Erp, A; Rebolledo R.; Ottens, PJ; Veldhuis, S; Leuvenink, HGD; Romanque, P. Abstract ISI TRANSPLANT INTERNATIONAL (2013)
SORAFENIB AND LIVER REGENERATION Hora, C; Romanque, P.; Ledermann, M; Wilhelm, S; Dufour, JF Abstract ISI JOURNAL OF HEPATOLOGY (2010)
SORAFENIB TREATMENT FOR ADVANCED HCC PRIOR TO SURGERY: WHEN SHOULD WE STOP? Romanque, P.; Wilhelm, S; Dufour, JF Abstract ISI HEPATOLOGY (2008)
Chronic copper overload: Kupffer cell function and NF-kappa B activity Cartier, D; Tapia, G; Romanque, P.; Araya M.; Videla LA. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2004)
Activation of NF kappa B in carbon infusion activated liver macrophages Romanque, P.; Cornejo P.; Tapia, G; Fernández V.; Videla LA. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2003)


Disproportionally high results of transient elastography in patients with autoimmune hepatitis Romanque, P.; Stickel, F; Dufour, JF Letter ISI LIVER INTERNATIONAL (2008)


Targeting vessels to treat hepatocellular carcinoma Romanque, P.; Piguet, AC; Dufour, JF Review ISI CLINICAL SCIENCE (2008)
Thyroid hormone-induced oxidative stress in rodents and humans: A comparative view and relation to redox regulation of gene expression Fernández V.; Tapia, G; Varela, P; Romanque, P.; Cartier-Ugarte, D; Videla LA. Review ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY PHARMACOLOGY (2006)
Molecular mechanisms in liver ischemic-reperfusion injury and ischemic preconditioning Romanque, P.; Uribe M.; Videla LA. Review ISI REVISTA MEDICA DE CHILE (2005)