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María Daniella Carretta Muñoz

Assistant Professor

Universidad Austral de Chile

valdivia, Chile

My research interest focuses in the role of short-chain free fatty acid receptors and the Hydroxy Carboxylic Acid Receptor in the bovine immune system. My aim is understand the modulation of the innate inmune system in metabolic disorders in cattle.

Sciences, Molecular and Cellular Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2013
Biochemist, UNIVERSIDAD DE CHILE. Chile, 2008
Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2008

Assistant Professor Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Faculty of Veterinary Science

Valdivia, Chile

2014 - At present

Professional Full Time

Universidad Austral de Chile

Valdivia, Chile

2013 - 2014
Assistant Professor Full Time

Universidad Austral de Chile

Valdivia, Chile

2014 - At present

Claudia Mera, Medical Technology student , Tittle " Efecto del ácido D-láctico en la liberación de vesículas secretoras en neutrófilos de bovino y expresión de moléculas de adhesión en células endoteliales de bovino estimuladas con LDBK".


Pro-inflammatory mediators and neutrophils are increased in synovial fluid from heifers with acute ruminal acidosis Hidalgo A.I.; Carretta M.D.; AlarcÃ³n P.; Manosalva C.; MÃ¼ller A.; Navarro M.; Hidalgo M.A.; Kaehne T.; Taubert A.; Hermosilla C.R.; Burgos R.A. Article ISI SCOPUS BMC VETERINARY RESEARCH (2019)
Indirect Measurement of CRAC Channel Activity Using NFAT Nuclear Translocation by Flow Cytometry in Jurkat Cells Carretta M.D.; Hidalgo M. A.; burgos R.A. Article ISI SCOPUS (2018)
Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na+/H+ exchanger 1. Larrazabal CS, Carretta MD; Hidalgo MA, Burgos RA. Article VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2017)
d(-) Lactic Acid-Induced Adhesion of Bovine Neutrophils onto Endothelial Cells Is Dependent on Neutrophils Extracellular Traps Formation and CD11b Expression. Alarcón P, Manosalva C; Conejeros I, Carretta MD; Muñoz-Caro T, Silva LMR; Taubert A, Hermosilla C; Hidalgo MA, Burgos RA Article FRONTIERS IN IMMUNOLOGY (2017)
Plasma and tissue disposition of florfenicol in Escherichia coli lipopolysaccharide-induced endotoxaemic sheep Pérez-Fernández R.; Cazanga V.; Jeldres J.A.; Silva P.P.; riquelme j.; Quiroz F.; Palma C.; Carretta M.D.; Burgos R.A. Article ISI SCOPUS XENOBIOTICA (2017)
Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor Carretta M.D.; Hidalgo A.I.; Burgos, J; Opazo, L; Castro L.; Hidalgo M. A.; Figueroa C.D.; Taubert, A; Hermosilla, C; burgos R.A. Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2016)
Differential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acids Loaiza A.; Carretta, MD; Taubert, A; Hermosilla, C; Hidalgo, MA; Burgos, RA Article ISI SCOPUS BMC VETERINARY RESEARCH (2016)
fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils Hidalgo, MA; Carretta, MD; Teuber, SE; Zárate C.; Cárcamo L.; Concha, II; Burgos, RA Article ISI SCOPUS Journal of Immunology Research (2015)
Decreased cyclooxygenase-2 gene expression and lactoferrin release in blood neutrophils of heifers during the calving period Hidalgo MA, Loncomán CA, Hidalgo AI, Andrade V, Carretta MD, Burgos RA. Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2014)
Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers Concha, Claudia; Carretta, María Daniella; Alarcón, Pablo; Conejeros, Ivan; Gallardo, Diego; Hidalgo, Alejandra Isabel; Tadich, Nestor; Cáceres, Dante Daniel; Hidalgo, María Angélica; Burgos, Rafael Agustín Article ISI SCOPUS JOURNAL OF VETERINARY SCIENCE (2014)
Propionate induces the release of granules from bovine neutrophils Carretta, MD; Conejeros I.; Hidalgo, MA; Burgos, RA Article ISI SCOPUS JOURNAL OF DAIRY SCIENCE (2013)
2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils Conejeros I.; Velasquez Z.D.; Carretta M.D.; Alarcón P.; Hidalgo M. A.; burgos R.A. Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2012)
2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11 b expression, and increases L-selectin shedding in bovine neutrophils Conejeros I.; Jara, E; Carretta M.D.; Alarcón P.; Hidalgo M. A.; burgos R.A. Article ISI SCOPUS RESEARCH IN VETERINARY SCIENCE (2012)
D-Lactic acid interferes with the effects of platelet activating factor on bovine neutrophils Alarcón P.; Conejeros I.; Carretta, MD; Concha, C; Jara, E; Tadich, N; Hidalgo, MA; Burgos, RA Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2011)
Oleic acid induces intracellular calcium mobilization, MAPK phosphorylation, superoxide production and granule release in bovine neutrophils Hidalgo, MA; Nahuelpan, C; Manosalva C.; Jara, E; Carretta, MD; Conejeros I.; Loaiza A.; Chihuailaf, R; Burgos, RA Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Andrographolide reduces IL-2 production in T-cells by interfering with NFAT and MAPK activation Carretta, MD; Alarcón P.; Jara, E; Solís L.; Hancke, JL; Concha, II; Hidalgo, MA; Burgos, RA Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
Propionate induces pH((i)) changes through calcium flux, ERK1/2, p38, and PKC in bovine neutrophils Sandoval A.; Trivinos, E; Sanhueza, A; Carretta, D; Hidalgo, MA; Hancke, JL; Burgos, RA Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2007)
Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils Sandoval, AJ; Riquelme, JP; Carretta, MD; Hancke, JL; Hidalgo, MA; Burgos, RA Article ISI SCOPUS JOURNAL OF LEUKOCYTE BIOLOGY (2007)


PROPIONIC ACID AND D-LACTIC ACID PRODUCED DURING METABOLIC ACIDOSIS INCREASES THE BOVINE BLOOD NEUTROPHILS ACTIVITY Burgos, RA; Carretta, MD; Alarcón P.; Conejeros I.; Concha, C; Jara, E; Tadich, N; Hidalgo, MA Abstract INFLAMMATION RESEARCH (2011)
Andrographolide induces the COX-2 expression in MC3T3-E1 cells via the ERK1/2 pathway Perez T.; Hidalgo, MA; Carretta, MD; Hancke, JL; Burgos, RA Abstract ISI FASEB JOURNAL (2008)


D (-) lactic acid triggers Fibroblast-Like Synoviocytes activity, a hallmark in the pathophysiology of neutrophilic polysynovitis in cattle with acute ruminal acidosis. FONDECYT (1180946) Proyecto 2018-2022 Coinvestigador(a)
Butirato modula la respuesta inflamatoria de la célula endotelial bovina a través de los receptores GPR43 y GPR109A universidad austral de chile (S-2016-41) Proyecto 2016-2018 Inv. Responsable
ROLE OF HCA2 RECEPTOR IN BOVINE NEUTROPHIL CHEMOTAXIS AND ADHESION TO ENDOTHELIAL CELLS FONDECYT (11160676) Proyecto 2016-2019 Inv. Responsable
D-LACTIC ACID INDUCES NEUTROPHIL EXTRACELLULAR TRAPS FORMATION AND IS ASSOCIATED WITH THE ONSET OF INFLAMMATORY PROCESS DURING ACUTE RUMINAL ACIDOSIS IN CATTLE. FONDECYT (1151035) Proyecto 2015-2018 Coinvestigador(a)
Desarrollo de un biomarcador en sangre como indicador de la función metabolica-inmune en vacas lecheras FONDEF (ID14I10050) Proyecto 2015-2017 Investigador(a)
D-lactataemia increases the bovinebloodneutrophil activity and is associated with the early onset of laminitis in heifer with acute ruminal acidosis FONDECYT (1120718) Proyecto 2012-2014 Tesista
Differential effect of nonesterified fatty acids species on the polymorphonuclear leukocyte function in dairy heifers FONDECYT (11100413) Proyecto 2012-2012 Personal técnico y/o de apoyo
Role of neutrophils in the onset of bovine laminitis. Study of acidosis as neutrophils priming inducer agent FONDECYT (1090401) Proyecto 2010-2011 Tesista
Evaluación eficacia inmunomoduladora de una composición de labdanos diterpénicos y desarrollo de nuevos análogos sintéticos FONDEF (D04I1240) Proyecto 2007-2007 Personal técnico y/o de apoyo


Fatty and hydroxycarboxylic acid receptors: The missing link of immune response and metabolism in cattle Alarcon, P; Manosalva C.; Carretta, MD; Hidalgo, AI; Figueroa, CD; Taubert, A; Herrnosilla, C; Hidalgo, MA; Burgos, RA Review ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2018)