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Pamela Joselyn Urrutia Vargas

Profesor Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Estrés Oxidativo; Neurodegeneración; Neuroinflamación; Desarrollo Neuronal; Trafico Celular; Disfunción mitocondrial

Educación

  •  Licenciatura en Ingeniería en Biotecnología , UNIVERSIDAD DE CHILE. Chile, 2009
  •  Doctorado en Ciencias mención Biología Molecular, Celular y Neurociencias, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Ingenieria en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2015

Experiencia Académica

  •   Docente Biología Celular Part Time

    UNIVERSIDAD DIEGO PORTALES

    Salud y Odontología

    Chile

    2013 - 2015

  •   Docente Biología Celular Part Time

    UNIVERSIDAD DE LAS AMERICAS

    Instituto de Ciencias Naturales

    Santiago, Chile

    2020 - 2020

  •   Docente invitada de curso postgrado: Bases moleculares de la Respuesta al estrés oxidativo Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias

    Santiago, Chile

    2020 - 2020

  •   Profesor Asistente Full Time

    Universidad San Sebastián

    Medicina y Ciencia

    Santiago, Chile

    2021 - At present

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Instituto de Nutrición y Tecnología de los Alimentos (INTA)

    Santiago, Chile

    2023 - At present

Experiencia Profesional

  •   Tesista Pregrado Full Time

    Instituto Milenio de Dinámica Celular y Biotecnología (ICDB), Universidad de Chile

    Santiago, Chile

    2008 - 2009

  •   Tesista de Doctorado Part Time

    Facultad de Ciencias, Universidad de Chile

    Santiago, Chile

    2010 - 2015

  •   Investigador Postdoctoral Full Time

    Centro FONDAP de Gerociencia, Salud Mental y Metabolismo (GERO), Universidad de Chile

    Santiago, Chile

    2015 - 2019

  •   Investigador Adjunto Part Time

    Universidad de Chile

    Chile

    2020 - At present


 

Article (15)

A Role for Second Messengers in Axodendritic Neuronal Polarity.
On the Chemical and Biological Characteristics of Multifunctional Compounds for the Treatment of Parkinson's Disease
Iron, the endolysosomal system and neuroinflammation: a matter of balance
New Players in Neuronal Iron Homeostasis: Insights from CRISPRi Studies
Inflaming the Brain with Iron
Tuba Activates Cdc42 during Neuronal Polarization Downstream of the Small GTPase Rab8a
Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth
Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1
Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia
Dissecting the role of redox signaling in neuronal development
The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death.
The interplay between iron accumulation, maochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders
Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells.
Iron toxicity in neurodegeneration.
The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1.

BookSection (3)

The APP intracellular domain (AICD) interactome: connecting APP and Alzheimer's disease pathologic features
Iron Neurotoxicity in Parkinson’s Disease
The Execution Step in Parkinson’s Disease – On the Vicious Cycle of Mitochondrial Complex I Inhibition, Iron Dishomeostasis and Oxidative Stress

Errata (1)

The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death (vol 463, pg 787, 2015)

Proyecto (6)

Neuronal iron homeostasis maintenance under oxidative/nitrosative stress
Neuronal iron homeostasis maintenance under oxidative/nitrosative stress through mitoNEET-mediated IRP1 cluster repair
Rab8 regula el establecimiento de la polaridad neuronal a través de activación de Cdc42
Rab8 regula el establecimiento de la polaridad neuronal a través de activación de Cdc42.
Apoyo a la realización de Tesis Doctoral
Beca de Doctorado Nacional 2010

Review (1)

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders
20
Pamela Urrutia

Profesor Asistente

Universidad de Chile

Santiago, Chile

4
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

3
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

2
Daniel Bórquez

Profesor asociado

Facultad de Medicina

Universidad Diego Portales

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile