
Brigitte Adriana Johanna van Zundert Mathyssen
Full Professor
UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS
Santiago, Chile
neuronal plasticity; learning and memory; neurodegeneration; amyotrophic lateral sclerosis (ALS); Frontotemporal dementia (FTD)
-
Molecular and Cell Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2002
-
Biochemistry, Hogeschool West-Brabant. Holanda, 1993
-
Master in Science, University of Utrecht. Chile, 1996
-
postdoctoral fellow Full Time
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Biology
Boston, Estados Unidos
2002 - 2005
-
postdoctoral fellow Full Time
HARVARD UNIVERSITY
Boston, Chile
2002 - 2005
-
Assistent Professor Full Time
UNIVERSIDAD DE CONCEPCION
Biological Sciences
Concepcion, Chile
2005 - 2009
-
Associate Professor Full Time
UNIVERSIDAD DE CONCEPCION
Concepcion, Chile
2010 - 2010
-
Full Professor Full Time
Universidad Andres Bello
Biological Sciences
Santiago, Chile
2015 - At present
-
Associate Professor Full Time
Universidad Andres Bello
Biological sciences
Santiago, Chile
2010 - 2015
-
Associate Professor Full Time
Universidad Andres Bello
Santiago, Chile
2010 - 2015
-
Associate Professor Full Time
Universidad de Concepcion
Concepcion, Chile
2010 - 2010
-
Assistent Professor Full Time
Universidad de Concepcion
Concepcion, Chile
2005 - 2010
-
Full Professor Full Time
Universidad Andres Bello
Santiago, Chile
2015 - At present
-
Full Professor Full Time
Universidad Andres Bello
Santiago, Chile
2015 - At present
DIRECTION OF POSTDOCTORAL FELLOWS: Supervising in last 5 years (2012-current): 6.
1. Berta Henríquez (PhD from UDEC); Postdoc co-directed with Dr. Montecino (2011-2013). Project “Expression of plasticity genes regulating dendritogenesis by epigenetic mechanisms: participation of covalent histone H3 modifications and polycomb proteins” has been financed by Postdoctoral Project FONDECYT N° 3110138.
2. Estibaliz Ampuero (PhD from UChile); Postdoc (2012-2014). Project “Participation of NMDARs and extracellular matrix components in the reactivation of dendritogenesis and synaptogenesis in mature hippocampal neurons” has been financed by Postdoctoral Project FONDECYT N° 3130582
3. Agnieszka Dyrda (PhD from U. de Rennes, France); Postdoc (2012-2015). Project “Role of PolyP in the pathogenesis and death of motoneuron death in ALS” has been financed by the RING/Anillo grant (BvZ).
4. Mario Sanchez (PhD from UChile); Postdoc co-directed with Dr. Montecino (2015-2018). Project “Epigenetic regulation of memory formation and maintenance” is being financed by Postdoctoral Project FONDECYT N° 316022.
5. Claudio Capelli (PhD from UChile); Postdoc (2016). Project “Identification of epi-drugs to increase the expression of the gene C9orf72 in FTD” is being financed by ATA grant (to BvZ).
6. Christian Arredondo (PhD from PUC-Chile); Postdoc (2015-2017). Project “Identification of the toxic factor(s) released by ALS astrocytes” is being financed by ATA grant (to BvZ).
PhD THESIS STUDENTS: Supervising in last 5 years (2012-current): 5.
1. Eveling Inostroza: “Role of the association of NR2B containing NMDARs with RasGRF1 and CaMKII in neuronal plasticity in vitro”, PhD Program in Biological Sciences, UDEC (Terminated, 2014).
2. Fernando Bustos (co-tutor Dr. Montecino): “Role of anchoring protein PSD95 in the regulation of the dendritic architecture: define epigenetic mechanisms controlling the expression of PSD95 during brain development”, PhD Program in Biological Sciences, UDEC (Terminated, 2014).
3. David Gonzalez (co-tutor Dr. Brandan at PUC): “Role of the pro-fibrotic factors and extracellular matrix components in the progression of ALS”, PhD Program in Cellular and Molecular Biological Sciences (in Thesis since 2013).
4. Sebastian Abarzua (co-tutor Dr. Montecino): “Altered chromatin remodeling and changes in gene expression in ALS astrocytes”, PhD Program in Molecular Biosciences (in Thesis since 2016).
5. Pablo Martínez: “Identification of the toxic factor released from skeletal muscles in ALS and its role in pathogenesis in motoneuron degeneration” PhD Program in Molecular Biosciences (in Thesis since 2016).
MASTER THESIS STUDENTS: Supervising in last 5 years (2012-current): 11.
1. Elsa Fritz: “Analysis of the mechanisms underlying cell death and hyperexcitability in diverse ALS models”. Master Program in Science, UDEC. (Terminated, 2014)
2. Matias Campos: “Role of NR1NR2B NMDARs and CaMKII in the dendritic arborization in hippocampal neurons in vitro”. Master Program in Science, UNAB. (Terminated, 2014)
3. David González: “Role of the NR2A/PSD-95 and NR2B/SAP102 complexes in dendritogenesis and neuronal plasticity in the developing and mature brain”. Master in Science, UNAB. (Terminated, 2015)
4. Paulina Nuñez (co-tutor Dr. Stehberg): “Effect of the binding of Runx1 to the promoter of the P2X3 receptor on inflammatory pain”. Master Program in Science, UNAB. (Terminated, 2015)
5. Sebastián Abarzúa: “Generation of superoxide in structural plasticity through the NR2B-NMDAR/ RasGRF1/NOX2 signaling pathway in neurons in vitro”. Master Program in Science, UNAB. (Terminated, 2015)
6. Nicole Cortes: “Role of intracellular calcium in the production of ROS in diverse models of ALS and FTD in vitro”. Master in Science, UNAB. (Terminated, 2017)
7. Patricia Valentina Jorquera (co-tutor Dr. Varela-Nallar): “Role of PSD-95 in the formation of glutamatergic synapses of newborn neurons in the adult brain”. Master Program in Science, UNAB (Terminated, 2017)
8. Ivan Diaz: “Role of ROS in epigenetic changes in ALS astrocytes in vivo”. Master in Science, UNAB. (Ongoing since 2016)
9. Paula Cubillos: “Stability of epigenetic changes in vitro induced by epigenome editing tools”. Master in Science, UNAB. (Ongoing since 2016)
10. Esteban Quezada (co-tutor Dr. Montecino): “Identifying of beneficial epidrugs in an ALS/FTD model in vitro”. Master in Science, UNAB. (Ongoing since 2016)
11. Patricio Garcia: “Set-up of a high-throughput screening for drug discovery in diverse models of ALS and FTD in vitro”. Master in Science, UNAB. (Ongoing since 2017)
UNDERGRADUATE THESIS STUDENTS: Supervising in last 5 years (2012-current): 3.
1. Martin Oude Alink “Transfection and Perfection: Regulating de origins of pain perception”. Bachelor Program in Medicine. U. of Groningen, the Netherlands (Terminated, 2013).
2. Nur Jury: “Altered PSD95 expression by epigenetic mechanisms: effect on the neuronal architecture en hippocampal neurons in vivo”. Bachelor Program in Biochemistry, PUCV (Terminated, 2016).
3. Claudio Salas: “Long-term memory consolidation in a conditioned fear model; role of PSD95”. Bachelor Program in Biotechnology, UNAB (Terminated, 2016).
INTERNATIONAL STUDENTS AND POSTDOCS:
BvZ is coordinator of an international program called International Research Staff Exchange Scheme (IRES) “EULAMDIMA” between U. of Groningen (the Netherlands), U. of Heidelberg (Germany), UNAM (Mexico), and UNAB (Chile), that involves the training and recipocal exchange of 23 students, young scientists, and PIs from and to Chile for 4 years (2012-2016).
-
The most outstanding young scientists 2010
Chilean Society for Biology
Chile, 2010
Awarded by the "Chilean Society for Biology" and "Grupo BIOS S.A."
-
The best Doctoral Thesis 2004
Chilean Foundation for Cell Biology
Chile, 2004
Awarded by the "Chilean Foundation for Cell Biology"
-
Postdoctoral fellowship “Pierre de Bourknecht ALS Research Fund”
International Pierre de Bourknecht ALS Research Fund
Estados Unidos, 2003
Awared while being a Postdoctoral fellowship at MIT and Harvard/MGH (2003-2005).

Brigitte van Zundert
Full Professor
UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS
Santiago, Chile

Rodrigo Aguilar
Assistant Professor
Institute for Biomedical Sciences
Universidad Andrés Bello
Santiago, Chile

Juan Carcamo
Profesor Titular
Instituto de Bioquímica y Microbiología
Universidad Austral de Chile
Valdivia, Chile

Claudio Hetz
Deputy Director
INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE
SANTIAGO, Chile

Felipe Court
Full Professor and Director
Center for Integrative Biology
Universidad Mayor
Huechuraba, Chile

Nicole Cortés
Coordinadora de Estudios Clínicos
Laboratorio de Biología Celular, Molecular y Neurociencias, Corporación Centro Internacional de Biomedicina, ICC
Santiago, Chile

Viviana Montecinos
Assistant Professor
Hematology Oncology
Pontificia Universidad Catolica de Chile
Santiago, Chile
.jpg_thumb90.png?1522943358)
Magdalena Cuevas
Profesor Asistente
Departamento de Fisiología
Universidad de Concepción
Concepción, Chile

Enrique Brandan
Profesor Titular
Biología Celular y Molecular
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Melissa Calegaro
Principal Investigator, head lab
Research Vice Presidency
Universidad Mayor
Santiago, Chile

Maria Paz Marzolo
Profesor Titular
Departamento de Biología Celular y Molecular
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA
Santiago, Chile

David González
Investigador postdoctoral
Institut des Neurosciences de Montpellier (INM)
Montpellier, Francia

Ute Wohlbier
Associate Professor
Center for Integrative Biology
Universidad Mayor de Chile
Santiago, Chile

Fabián Segovia
Associate professor
Department of Cell Biology
Universidad de Concepción
Concepción, Chile

Felipe Zuñiga
Profesor Asistente
Bioquimica Clinica e Inmunologia
UNIVERSIDAD DE CONCEPCION
Concepcion, Chile

Catherine Andreu
Estudiante de Doctorado
Escuela de Psicología
Pontificia Universidad Católica de Chile
Santiago, Chile

estibaliz ampuero
Profesor Asistente
Facultad de Química y Biología
Universidad de Santiago de Chile
Santiago, Chile

Alvaro Elorza
FULL PROFESSOR
INSTITUTE OF BIOMEDICAL SCIENCES
UNIVERSIDAD ANDRES BELLO
Santiago, Chile

JUAN PABLO HENRIQUEZ
Associate Professor
Cell Biology
UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR
Concepción, Chile

Pablo Henny
Profesor Asociado
Anatomía Normal
Pontificia Universidad Católica de Chile
Santiago, Chile

Ricardo Armisen
Associate Professor
Centro de Genética y Genómica
Universidad del Desarrollo
Santiago, Chile
-chica.jpg_thumb90.png?1616028404)
Alicia Colombo
Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile
Departamento de Anatomía Patológica
Universidad de Chile
Santiago, Chile

Jorge Ojeda
Académico investigador
Ciencias Básicas y Morfología
Universidad Católica de la Santisima Concepción
Concepción, Chile

Alejandro Godoy
Associate Professor
Centro de Biología Celular y Biomedicina
Universidad San Sebastián
Santiago, Chile

PAULA GUZMÁN
Profesional Bioquímico
Laboratorio Clínico
Hospital Clínico Regional de Concepción Guillermo Grant Benavente
Concepción, Chile

Felipe Simon
Profesor Titular
Department of Biological Sciences
UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS
Santiago, Chile

Karina Palma
Postdoctorado
Instituto de Neurociencia Biomédica BNI
Universidad de Chile
Santiago, Chile

Rodolfo Madrid
Full Professor
Departamento de Biología
UNIVERSIDAD DE SANTIGO DE CHILE
Santiago, Chile

Patricio Rojas
Assistant Professor
Departamento de Biologia
UNIVERSIDAD DE SANTIAGO DE CHILE
Santiago, Chile

Karen Castillo
Académica Investigadora
,Centro de Investigación de Estudios Avanzados del Maule (CIEAM)
Universidad Catolica del Maule
Talca, Chile

Mauricio Sáez
Profesor Asistente
Centro de Genómica y Bioinformática
Universidad Mayor
Santiago, Chile

Sergio Onate
Associate Professor
Medical Specialties
UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA
concepcion, Chile

Marcelo Bustamante
Director
Basisc Sciences
UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN
CONCEPCIÓN, Chile

Lorena Mardones
ASSOCIATED PROFESSOR
BASIC SCIENCES AND MORPHOLOGY
UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION
CONCEPCION, Chile

Gloria Arriagada
Profesor Asociado-Investigador Principal
Instituto de Ciencias Biomédicas
UNIVERSIDAD ANDRES BELLO
Santiago, Chile

Juan Espinoza
Encargado de Cultivo Celular y Bioterio
Universidad Bernardo O'Higgins
Santiago, Chile

Alexis Martinez
Investigador postdoctoral senior
Facultad de medicina
Instituto de Neurcoeincia Biomedica
Santiago, Chile