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Fabián Josué Segovia Miranda

Associate professor

Universidad de Concepción

Concepción, Chile

Líneas de Investigación


Cell and tissue architecture, deep tissue imaging, 3D tissue reconstructions, liver, regeneration, non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma.

Educación

  •  Bachelor in Medical Technology, UNIVERSIDAD DE TALCA. Chile, 2006
  •  Master in Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  PhD in Biological Sciences specializing in Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
  •  Postdoctoral fellow, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2014
  •  Postdoctoral fellow, MAX-PLANCK INSTITUT FUR MOLEKULARE ZELLBIOLOGIE UN GENETIK (MPI-CBG). Alemania, 2019

Experiencia Académica

  •   Professor of Hematology Laboratory Other

    UNIVERSIDAD DE TALCA

    Faculty of Health Sciences

    Talca, Chile

    2006 - 2007

  •   Assistant professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Faculty of Biological Sciences

    Concepción, Chile

    2019 - At present

  •   Associate professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Faculty of Biological Sciences

    Concepción, Chile

    2024 - At present

Experiencia Profesional

  •   Tecnólogo Médico Laboratorio de Parasitología Full Time

    Servicio de Laboratorios Clínicos de la Pontificia Universidad Católica de Chile

    Santiago, Chile

    2006 - 2006

Formación de Capital Humano


GRADUATE THESIS ADVISOR
• 2023 – current: Dilan Martinez. Doctorado en Ciencias Biológicas Area Biología Celular y Molecular, Universidad de Concepción.
• 2023 – current: Cristian Perez. Doctorado en Ciencias Biológicas Area Biología Celular y Molecular, Universidad de Concepción.

UNDERGRADUATE THESIS ADVISOR
• 2023: Isidora Sovino. Bioingeniería, Universidad de Concepción.
• 2023: Valentina Maldonado. Bioingeniería, Universidad de Concepción.
• 2022: Boris Vega. Ingeniería civil biomédica, Universidad de Concepción.
• 2022: Dilan Martinez. Bioingeniería, Universidad de Concepción.
• 2021: Rodrigo Yañez. Biología, Universidad de Concepción.


Premios y Distinciones

  •   Henri Nestlé Award

    NESTLE CHILE S.A.

    Chile, 2009

    Thirdly by the research article (Biol Trace Elem Res 125: 109-119, 2008).

  •   CONICYT scholarship

    CONICYT

    Chile, 2007

    CONICYT scholarship for doctoral studies in Chile

  •   Best graduated

    UNIVERSIDAD DE TALCA

    Chile, 2006

    Best graduated. Bachelor of Medical Technology

  •   Cuadro de Honor

    UNIVERSIDAD DE TALCA

    Chile, 2003

    Given to the best student of the entire undergraduate Medical Technology program.


 

Article (18)

Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas

Martinez-Torres, Dilan; Maldonado, Valentina; Perez-Gallardo, Cristian; Yanez, Rodrigo; Candia, Valeria; Kalaidzidis, Yannis; Zerial, Marino; Morales-Navarrete, Hernan; Segovia-Miranda, Fabian

Article ISI
SCIENTIFIC REPORTS  (2024)

Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

Espinoza, Sofia; Arredondo, Sebastian B.; Barake, Francisca; Carvajal, Francisco; Guerrero, Fernanda G.; Segovia-Miranda, Fabian; Valenzuela, David M.; Wyneken, Ursula; Rojas-Fernandez, Alejandro; Cerpa, Waldo; Massardo, Loreto; Varela-Nallar, Lorena; Gonzalez, Alfonso

Article ISI
BMC BIOLOGY  (2020)

Quantification of nematic cell polarity in three-dimensional tissues

Scholich, Andre; Syga, Simon; Morales-Navarrete, Hernan; Segovia-Miranda, Fabian; Nonaka, Hidenori; Meyer, Kirstin; de Back, Walter; Brusch, Lutz; Kalaidzidis, Yannis; Zerial, Marino; Juelicher, Frank; Friedrich, Benjamin M.

Article ISI
PLOS COMPUTATIONAL BIOLOGY  (2020)

Liquid-crystal organization of liver tissue

Morales-Navarrete, Hernan; Nonaka, Hidenori; Scholich, Andre; Segovia-Miranda, Fabian; de Back, Walter; Meyer, Kirstin; Bogorad, Roman L.; Koteliansky, Victor; Brusch, Lutz; Kalaidzidis, Yannis; Juelicher, Frank; Friedrich, Benjamin M.; Zerial, Marino

Article ISI
ELIFE  (2019)

PREDICTION OF MULTIPLE 3D TISSUE STRUCTURES BASED ON SINGLE-MARKER IMAGES USING CONVOLUTIONAL NEURAL NETWORKS

Morales-Navarrete, Hernan; Segovia-Miranda, Fabian; Zerial, Marino; Kalaidzidis, Yannis; IEEE

Article ISI
2019 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP)  (2019)

Three-dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression

Segovia-Miranda, Fabian; Morales-Navarrete, Hernan; Kuecken, Michael; Moser, Vincent; Seifert, Sarah; Repnik, Urska; Rost, Fabian; Brosch, Mario; Hendricks, Alexander; Hinz, Sebastian; Roecken, Christoph; Luetjohann, Dieter; Kalaidzidis, Yannis; Schafmayer, Clemens; Brusch, Lutz; Hampe, Jochen; Zerial, Marino

Article ISI
NATURE MEDICINE  (2019)

Content-aware image restoration: pushing the limits of fluorescence microscopy

Weigert, Martin; Schmidt, Uwe; Boothe, Tobias; Mueller, Andreas; Dibrov, Alexandr; Jain, Akanksha; Wilhelm, Benjamin; Schmidt, Deborah; Broaddus, Coleman; Culley, Sian; Rocha-Martins, Mauricio; Segovia-Miranda, Fabian; Norden, Caren; Henriques, Ricardo; Zerial, Marino; Solimena, Michele; Rink, Jochen; Tomancak, Pavel; Royer, Loic; Jug, Florian; Myers, Eugene W.

Article ISI
NATURE METHODS  (2018)

Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse

Obino D.; Fetler L.; Soza A.; Malbec O.; Saez J.J.; Labarca M.; Oyanadel, C; Del Valle Batalla F.; Goles N.; Chikina A.; Lankar D.; Segovia-Miranda F.; Garcia C.; Léger T.; Gonzalez A.; Espéli M.; Lennon-Duménil A.-M.; Yuseff M.-I.

Article ISI SCOPUS
CELL REPORTS  (2018)

A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule

Meyer, Kirstin; Ostrenko, Oleksandr; Bourantas, Georgios; Morales-Navarrete, Hernan; Porat-Shliom, Natalie; Segovia-Miranda, Fabian; Nonaka, Hidenori; Ghaemi, Ali; Verbavatz, Jean-Marc; Brusch, Lutz; Sbalzarini, Ivo; Kalaidzidis, Yannis; Weigert, Roberto; Zerial, Marino

Article ISI
CELL SYSTEMS  (2017)

Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis

Pardo, Evelyn; Cárcamo, Claudia; Uribe-San Martín, Reinaldo; Ciampi, Ethel; Segovia-Miranda, Fabián; Curkovic-Peña, Cristobal; Montecino, Fabián; Holmes, Christopher; Tichauer, Juan Enrique; Acuña, Eric; Osorio-Barrios, Francisco; Castro, Marjorie; Cortes, Priscilla; Oyanadel, Claudia; Valenzuela, David M.; Pacheco, Rodrigo; Naves, Rodrigo; Soza, Andrea; González, Alfonso; Klein, Robyn S

Article ISI SCOPUS
PLOS ONE  (2017)

AUTOMATIC RECOGNITION AND CHARACTERIZATION OF DIFFERENT NON-PARENCHYMAL CELLS IN LIVER TISSUE

Morales-Navarrete, Hernan; Nonaka, Hidenori; Segovia-Miranda, Fabian; Zerial, Marino; Kalaidzidis, Yannis; IEEE

Article ISI
2016 IEEE 13TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI)  (2016)

A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

Morales-Navarrete, Hernan; Segovia-Miranda, Fabian; Klukowski, Piotr; Meyer, Kirstin; Nonaka, Hidnori; Marsico, Giovanni; Chernykh, Mikhail; Kalaidzidis, Alexander; Zerial, Marino; Kalaidzidis, Yannis

Article ISI
ELIFE  (2015)

Anti-Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice

Bravo-Zehnder, M; Toledo E.M.; Segovia-Miranda, F; Serrano, F.G.; Benito M.J.; Metz, C; Retamal, C; Alvarez A.; Massardo, L; Inestrosa, N. C.; González A

Article ISI SCOPUS
ARTHRITIS & RHEUMATOLOGY  (2015)

Pathogenicity of Lupus Anti-Ribosomal P Antibodies: Role of Cross-Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model

Segovia-Miranda, F; Serrano, F; Dyrda A; Ampuero E.; Retamal, C; Bravo-Zehnder, M; Parodi, J; Zamorano P.; Valenzuela, D; Massardo, L; van Zundert, B; Inestrosa, NC; González A

Article ISI SCOPUS
Arthritis and Rheumatology  (2015)

Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome

Palomo IG; Gutierrez, CL; Alarcon ML; Jaramillo, JC; Segovia FM; Leiva, EM; Mujica VE; Icaza, GN; Diaz, NS; Moore-Carrasco, R

Article ISI SCOPUS
MOLECULAR MEDICINE REPORTS  (2009)

Increased concentrations of soluble vascular cell adhesion molecule-1 and soluble CD40L in subjects with metabolic syndrome

Palomo IG; Jaramillo, JC; Alarcon ML; Gutierrez, CL; Moore-Carrasco, R; Segovia FM; Leiva, EM; Mujica VE; Icaza G.; Diaz, NS

Article ISI SCOPUS
MOLECULAR MEDICINE REPORTS  (2009)

Low prevalence of Factor V Leiden and the prothrombin G20210A mutation in a healthy population from the central-south region of Chile Baixa prevalência do Fator V Leiden e da mutação da protrombina g20210a em uma população sã da região centro-sul do Chile

Palomo I.; Segovia F.; Parra D.; Alarcon M.; Rojas E.

Article SCOPUS
Revista Brasileira de Hematologia e Hemoterapia  (2009)

Heme iron uptake by Caco-2 cells is a saturable, temperature sensitive and modulated by extracellular pH and potassium

Arredondo M.; Kloosterman, J.; Nunez, S; Segovia, F; Candia, V; Flores, S; Le Blanc, S; Olivares M.; Pizarro, F

Article ISI SCOPUS
BIOLOGICAL TRACE ELEMENT RESEARCH  (2008)

Abstract (1)

Anti-P Autoantibodies Enhance Cytosolic Calcium and Neurotransmission in Hippocampal Neurons by Cross-Reacting with Cell Surface NSPA

Segovia-Miranda, F; Parodi, J; Serrano, F; Escobedo N; Bravo-Zehnder, M; Larrain, J; Massardo, L; Valenzuela, D; Zamorano P.; Inestrosa, N; González A

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2011)

Review (1)

An insight into the pathophysiology of thrombosis in antiphospholipid syndrome

Palomo IG; Segovia FM; Alarcon ML; Fuentes BY; Pereira JG; Rojas A.; Forastiero R

Review ISI
FRONTIERS IN BIOSCIENCE-LANDMARK  (2007)

20
Fabián Segovia

Associate professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

5
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

4
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

4
Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

3
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

2
veronica mujica

2
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

1
Reinaldo Uribe

Instructor Adjunto

Neurología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Edgardo Rojas

Académico e Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo OHiggins

Santiago, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

1
Fabian Montecino

Asistente de investigación

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudia Oyanadel

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
CLAUDIA CARCAMO

Profesor Asociado

neurology

PONTIFICIA UNIVERSIDADA CATÓLICA DE CHILE. DEPARTAMENTO DE NEUROLOGÍA

Santiago, Chile

1
Juan Agustín Larraín

Profesor Titular

Biologia Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Fernando Pizarro

Profesor Titular

INTA-UNIVERSIDAD DE CHILE

Santiago, Chile

1
Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile