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Nibaldo Manuel Inestrosa Cantin

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Discipline: Cellular and Molecular Biology / Molecular Neurobiology. Wnt Signaling and Synaptic function; Neuroprotection against amyloid-promoting damage at the synaptic level; Use of dual-AChE inhibitors with anti-Alzheimer.

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1979
Biologist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1974

Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Santiago, Chile

1983 - At present

Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1983 - At present

Postgraduate

1. Enrique Brandan Siques. Title: Anchorage of the Acetylcholinesterase to the basal lamina. Year: 1985.

2. Mª Elena Fuentes L. Title: The acetylcholinesterase in the mammalina central nervous system: Structural characterization of the enzyme and its expresión during the neuronal differentiation. Year: 1990.

3. Ricardo Moreno Mauro. Title: Study of the acetylcholinesterase during the development of the mammalian nervous system. Year: 1996.

4. Alejandra Alvarez Rojas. Title: Acetylcholinesterase promotes fibrilogenesis of the ?-amyloid peptide. Year: 1998.

5. Frances Calderón Hafon. Title: Efectos neurotóxicos del péptido ?-Amiloide (A?) y la acetilcolinesterasa (AChE). Year: 1999.

6. Ariel Reyes Zambrano. Title: Caracterización de nuevos modelos animales para el estudio de la enfermedad de Alzheimer. Year: 2000.

7. Francisca Bronfman Cáceres. Title: Amyloidogenesis and the Cholinergic System in Alzheimer’s disease: from in vitro análisis to Transgenic Mice Models” Co-Promotor Thesis. Doctor in Medical Sciences, Katholieke Univesiteit, Leuven, Belgium. Year: 2000.

8. Paola Deprez Mateljan. Title: Characterization of collagenous tail of the asymmetric acetylcholinesterase and its interaction with the basal lamina. Year: 2000.

9. Sandra Luza Cornejo. Title: Effect of the CGRP peptide derived from the clacitonin gene, on neuronal cells: Regulation of the molecular forms of Acetylcholinesterase (Universidad de Chile; Facultad de Ciencias Químicas y Farmaceúticas). Year: 2000.

10. Giancarlo De Ferrari Valentini. Title: Identification and characterization of the polypeptide domains that allows the interaction between acetylcholinesterase and the -amyloid peptide.
Year: 2001.

11. Carlos Opazo Martínez. Title: Neuroprotective effect of proteins from the central nervous system over the -amyloid fibrils toxicity. Year: 2002.

12. Carlos Morgan Sabat. Title: Laminine inhibits -amyloid deposition in vitro. Implicances for Alzheimer´s disease. Year: 2002.

13. Rebeca Aldunate Magalhaes. Title: Study of the role of CGRP in the expression of the enzyme acetylcholinesterase neuromuscular junction in culture. Year: 2002.

14. Rodrigo Fuentealba Alday. Title: Participación de la vía de transducción de señales Wnt en la toxicidad del péptido ?-amiloide en modelos celulares de la enfermedad de Alzheimer.
Year: 2005.

15. Lorena Varela Nallar. Title: Efectos del cobre sobre la expresión génica y propiedades de la proteína prion celular (PrPc) en células neuronales. Year: 2005.

16. Marcelo Chacón. Title: Papel de los receptores Frizzled en la Neuroprotección frente a la Toxicidad inducida por el péptido-b-amiloide. Year: 2007.

17. Mary Carmen Vázquez. Title: Modulación de la Actividad Celular del Fragmento AICD por la quinasa c-Abl en presencia de la Proteína Adaptadora Fe65. Co-tutoría con Dr. Alejandra Alvarez. Year: 2008.

18. Marcela Colombres. Title: La Vía de señalización Wnt modula la adehesión sináptica mediada por N-cadherina. Year: 2009.

19. Enrique Toledo. Title: Protección contra la neurotoxicidad del peptido ?-Amiloide en un modelo doble transgénico de la enfermedad de Alzheimer. Year: 2009.

20. Ginny Farias. Title: La Vía de Señalización Wnt promueve la organización del terminal pre-sináptico en el SNC maduro: Papel de APC en la localización sináptica de los receptores nicotinicos ?7. Year: 2009.

21 Waldo Cerpa Nebott. Title: Participación de la vía Wnt en la sinopsis CA3-ca1 del hipocampo de rata: efecto de los oligómeros del péptido ? amiloide. Year: 2009.

22. Margarita Dinamarca. Title: La proteína neuroligina es un agente nucleador del péptido ?-amiloide in vitro y une los oligómeros de A? a la sinápsis neuronal. Year: 2009.

23. Jessica Scheu. Title: Disabled-2 (Dab-2) Regula la Señalización Wnt en un Modelo Neuronal. Co-tutoría Dr. María Paz Marzolo. Year: 2009.

24. Ivan Alfaro. Title: Papel de la vía de señalización Wnt no canónica en la morfogénesis y plasticidad estructural de espinas dendríticas en neuronas hipocampales de rata. Year: 2011.

25. Loreto Cuitiño. Title: Modulación de la sinapsis inhibitoria GABAérgica por la vía de señalización Wnt. Year: 2011.

26. Claudio Allard. Title: Papel de la proteína SIRT 1 en la sinapsis neuronal: Protección contra los oligómeros del péptido A? en la enfermedad de Alzheimer. Year: 2013.

27. Daniela Rebolledo. Title: Restoration of nNOSµ Function in the mdx Mouse Model of Duchenne Muscular Drystrophy. Year: 2013.

28. Macarena Arrazola. Title: Efectos de la Vía de Señalizacion Wnt sobre la permeabilidad mitocondrial inducida por oligómetros del Péptido b-Amiloide. Year: 2014.

29. Juan Francisco Codocedo. Title: Estudio del papel de microRNAs sobre la remodelacion post-sináptica inducida por el ligando Wnt-5a. Year: 2014.

30. Jessica Vargas. Title: Involvement of Wnt Signaling Pathway in the adult hippocampal Synapses: Role in Neuroprotection. Year: 2014.

31. Valerie Ramirez. Title: Estudio de los mecanismos celulares del ligando Wnt-5A en neuronas hipocampales: Identificación del receptor Frizzled y rol de las proteínas G triméricas. Year: 2015.

32. Catherina Cuevas. Title: Regulación de la Via de señalización Wnt por Angiotensina II y Angiotensina-(1-7): Participación en la fibrosis renal. Co-tutela Dr. Carlos Vío. Year: 2016.

33. Cheryl Tapia. Title: Implicancias de la pérdida de la señalización Wnt canónica en etapas pre-sintomáticas de la Enfermedad de Alzheimer sobre el desarrollo de la patología. Year: 2016.

34. Juvenal Rios. Title: Implicancias de la vía de señalización Wnt en funciones del metabolismo neuronal. Year: 2017.

35. Carla Montecinos. Title: El ligando Wnt5a promueve la formación del complejo trimérico PSD95-Stargazin-receptor AMPA, generando neuroprotección contra oligómeros A?1-42. In progress.

Postdoctoral training

1. Dr. Jack Yamuy, MD, 1984, Universidad de la República, Uruguay.
2. Dr. Ricardo Fadic, MD, 1988-1989, Universidad Católica de Chile.
3. Dr. Claudio Soto, PhD, 1995-1996, Universidad de Chile.
4. Dr. Francisco José Muñoz, PhD, 1997-1999, España.
5. Dr. Maria Paz Marzolo Ph.D. (1998-1999), Universidad Católica de Chile.
6. Dr. Alejandra Alvarez, PhD, 2000, Universidad Católica de Chile.
7. Dr. Alicia Minniti, PhD, (2000-2003), Universidad de Rosario, Argentina.
8. Dr. Rodrigo Quintanilla, PhD, (2004-2005), Universidad de Chile.
9. Dr. Rodrigo Fuentealba, PhD, (2005-2006) Universidad Católica de Chile.
10. Dr. Lorena Varela, PhD, (2005-2006), Universidad Católica de Chile.
11. Dr. Rebeca Aldunate, PhD, (2007-2008), Universidad Católica de Chile.
12. Dr. Rosana Mesa, PhD, (2007 - 2008), Universidad Nacional de San Luis, Argentina.
13. Dr. Gesa Consiglieri, PhD, (2007 - 2008), Universidad de Berlín, Alemania.
14. Dr. Christopher Adams, PhD, (2008 - 2008), PUC-Univ. Paul Sabatier, Francia.
15. Dr. Rebecca Graumann, PhD, (2008 –2009), Universidad de Chile.
16. Dr. Mary Carmen Vazquez, PhD, (2008 -2009), Universidad Católica de Chile.
17. Dr. Ivan Neira, PhD, (2009 -2010), Univ. de Antofagasta, Chile.
18. Dr. Lorena Varela-Nallar, PhD, (2009 -2012), Universidad Católica de Chile.
19. Dr. Jorge Parodi, PhD, (2009 -2011), Universidad de Concepción, Chile.
20. Dr. Andrea Calixto, PhD, (2009 -2012), Columbia University, New York, USA.
21. Dr. Carla Calderon, PhD, (2011-2012), University of Lund, Sweden.
22. Dr. Carolina Oliva, PhD, (2010- ), Univ. Valparaiso-University of Yale.
23. Dr. Juan Zolezzi, PhD, (2011-2012), University of Bologna, Italy.
24. Dr. Pedro Cisternas, PhD, (2012- ), Universidad de Concepcion, Chile.
25. Dr. Carmen Silva, PhD, (2012-2016), Universidad de Concepcion, Chile.
26. Dr. Ting Cao, PhD, (2013), University of Milan, Milan, Italy.
27. Dr. Claudio Pinto, (2013- 2015 ), Universidad Católica de Chile.
28. Dr. Macarena Arrazola, (2014 - 2015 ), Universidad Católica de Chile.
29. Dr. Juan Francisco Codocedo, (2014-2016), Universidad Católica de Chile.
30. Dr. Eva Ramos PhD, (2013- ), Universidad Pompeu Fabra, Barcelona, España.
31. Dr. Catherine Lambert, (2013- ), Universidad de Paris, Francia.
32. Dr. Daniela Vallejo, (2016- ), Universidad de Valladolid, España.
33. Dr. Daniela Rivera, (2016- ), Universidad Católica de Chile.

National and International collaborations

- CEBIMA: During the last years, the permanent development of the main research line, has allowed the establishment of a formal collaboration between the Universidad Católica de Chile, specifically through CARE Chile - UC, with the Universidad de Magallanes for the constitution of the Center of Excellence in Biomedicine Research of Magallanes (CEBIMA). The main scope of this center is the identification and development of new compounds potentially useful as therapeutical agents against chronic diseases, using the knowledge obtained from basic research focused to investigate the aquatic and terrestrial ecosystems of the Magallanes region and the chilean Antartica.

- We have developed several international collaborations with remarkable scientist all over the world

Dr. Michael Bader, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Dr. Daniel Choquet, Director Interdisciplinary Institute of Neuroscience, University of Bordeaux, France.
Dr. Hollis Cline, Scripps Institute, La Jolla, San Diego, CA, USA. Current President of the Society for Neuroscience.
Dr. David Sabatini, New York University Medical Center, NY, USA.
Dr. Freda Miller, Sick Children´s Hospital, Toronto, Canada.
Dr. Robson Santos, Director NanoBioPharm Institute, Universidade Federal do Minas Gerais, Belo Horizonte, Brazil.
Dr. Ariel Feldstein, University of California (UCSD) San Diego, CA, USA.
Dr. Giampietro Schiavo, Institute of Neurology, University College London (UCL), UK.

Symposia and Seminars

1. Leighton, F., Bronfman, M. and Inestrosa, N.C. (1977) Peroxisomes and hypolipidemic agents. In Symposium "Biotransformation of drugs". II Meet. Latinoamerican Assoc. Pharmacol. Viña Del Mar, Chile.

2. Leighton, F., Bronfman, M. and Inestrosa, N.C. (1979) Organization of the system of fatty acid oxidation peroxisomes. Proposition of a model. In Symposium "Biochemistry of Lipids and Isoprenoids". II Meet Southern Cone, Panamerican Biochem. Soc. Chile. Viña del Mar, P. 241.

3. Hall, Z.W., Silberstein, L., Inestrosa N.C., Sanes, J. and Weinberg, C. (1981) Synapse-specific componentes of the neuro-muscular junction. INC-UCLA Symposia "Cellular Recognition", USA., Colorado, Keystone J. Supra Mol. Struct. Cell Biochem. Suppl. 5, P. 248 (Abstract 672).

4. Inestrosa, N.C., Maldonado, M. and Garrido, J. (1984) Direct connection between extracellular basal lamina and cytoplasmic filaments. ICN-UCLA Symposia "Extracellular Matrix: structure and function", April 22.-29, 1984, Colorado, USA., J. Cell Biochem. Suppl. 8b, Abstract N° 1608.

5. Maldonado, M., Torres, J.C., Garrido, J., Brandan, E. and Inestrosa, N.C. (1984) The anchorage of acetylcholinesterase to the synaptic basal lamina is mediated by heparin-like macromolecules. ICN-UCLA Symposia "Extracellular matrix: structure and function", April 22-29, 1984, Colorado, USA. J. Cell Biochem. Suppl. 8b, Abstract N° 1599.

6. Inestrosa, N.C. (1989) Dinámica de la sinapsis colinérgica: Singer Symposium. XXXII Reunión Anual Sociedad de Biología de Chile. Viña del Mar, Noviembre.

7. Inestrosa, N.C. (1990) Aspectos biotecnológicos en biología marina. En: Simposio "Demandas de investigacion básica sobre recursos marinos: Un desafío para el desarrollo Ecónomico sostenido nacional". XXXIII Reunión Anual Sociedad de Biología de Chile. Punta de Tralca, Noviembre. Arch. Biol. Med. Expt. 23: R.200.

8. Inestrosa, N.C., Palma, V. and Godoy, J. (1991) Expression of Beta-amyloid precursos protein in cell lines and blood cells of alzheimer patients. Internatl. Symposium "The cytoskeleton in cell differentiation, Santiago, 3-4 Diciembre.

9. Inestrosa N.C., “Envejecimiento Cerebral y Estrógenos”, Symposium Estrógenos y Condición Mental de la Mujer. . Santiago – Chile (Junio 02 – 1995).

10. Inestrosa N.C., “Enfermedad de Alzheimer: Diferencias entre el hombre y la mujer”. Efectos de la THR. II Simposio Internacional de Menopausia y Envejecimiento. Impacto del Climaterio en la Salud Mental. Santiago – Chile (Dic. 06 - 1996).

11. Pérez, D., Alarcón, R., and Inestrosa, N.C. (1998) Kinetic and thermodynamic effects of acetylcholinesterase on the solubility of A?-peptide. Xth Internat. Symp. on Cholinergic Mechanisms. 1-5 September, Arcachon, France. J. Physiol (Paris) 92: 479.

12. Deprez, P., Krejci, E., Massoulié, J. and Inestrosa, N.C. (1998) Dissection of the heparin-binding domains present in the collagenic tail of mammalian acetylcholinesterase. Xth Internatl. Symp. on Cholinergic Mechanisms. 1-5 September, Arcachon, France. J. Physiol (Paris) 92: 425 (Abstr. 26).

13. Inestrosa, N.C. (1995) “Oxidative Stress Impact in Alzheimer Disease”, Simposio Biology and Pathology of free radicals: Plant and Wine Polyphenol Antioxidants. Santiago, Chile (Julio 29 – 30).

14. Ruiz, F.H., Silva, E., and Inestrosa, N.C. (1999) Prion protein (PrP59-61) has the ability to reduce copper (II): Role of Tryptophan. The Protein Society. Third European Symposium. 19-22 September. Garmisch Partenkirchen, Germany. PROTEIN SCIENCE 8: p. 68 Abstr.194.

15. Inestrosa, N.C. and Morgan, C., (2000) Interaction of laminin-1 with amyloid ?-peptide. Implications for Alzheimer’s Disease. Intl. Symposium on Extracellular Matrix. Angra dos Reis, Río de Janeiro, September 24-27, (Abs. S-119).

16. De Ferrari, G.V. e Inestrosa N.C. (2000) Acetylcholinesterase induced ?-Amyloid and Neurotoxicity. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, Sweden (April 05 – 08).

17. Inestrosa N.C. “Role of Copper in Alzheimer’s and Prion Diseases” NIH Chile research cooperation Workshop inhealth and environment. Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago – Chile (April 04 – 06, 2001).

18. N.C. Inestrosa and G.V. De Ferrari. Therapy-"Cholinesterase Inhibitors with Anti-Amyloid properties"-.International Geneva/Springfield Symposium on Advances in Alzheimer .Ginebra-Suiza-7th, 3 al 8 de Abril, 2002.

19. Inestrosa, G.V. De Ferrari, J.L. Garrido, A. Alvarez, M. Bronfman. "Neurodegenerative Processes in Alzheimer´s Disease"- International Symposium on Cholinergic Mechanisms-St. Moritz-Switzerland-XI, 5 al 9 de Mayo 2002.

20. Inestrosa NC. “AChE inhibitors, properties of AChE/Ab complexes and the Wnt pathway” 8th International Montreal/Springfield, Symposium on Advances in Alzheimer Therapy, Montreal, Quebec, Canada del 13 al 17 de Abril 2004.

21. Inestrosa NC. “Wnt Signaling in Synaptic Function: Specific A? Effects”. First Chilean International Symposium on Neurodegenerative Diseases, Santiago Chile, November 21 al 25 de 2005.

22. Fuentealba R, Retamal C, Bu G, Inestrosa NC and Marzolo MP. “ApoER2 Modulates A? Levels and Interacts with app in Cultured cell lines”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 81, Santiago Chile, November 21 al 25 de 2005.

23. Parodi J, Sepúlveda F, Godoy J, Inestrosa NC and Aguayo LG. “Nanomolar Concentrations of ?-amyloid Aggregates Reduce Spontaneous Synaptic Activity in Hippocampal Neurons”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 84, Santiago Chile, Noviembre 21 al 25 de 2005.

24. Pérez de Arce K, Inestrosa NC and Alvarez A. “c-Abl Kinase Interacts with Proteins of Synaptic Structures and its Effect is Modulated by Lithium”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 85, Santiago Chile, Noviembre 21 al 25 de 2005.

25. Vázquez MC, Alvarez A and Inestrosa NC. “APP Swedish Expresión in N2A Cell Induces Neprylisin expression: Possible Role of the AICD/FE65/c-Abl Complex”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 86, Santiago Chile, Noviembre 21 al 25 de 2005.

26. Lazo O, Manuna J, Inestrosa NC and Bronfman FC. “Neurotrophic Retrograde Signaling of Septohippocampal Pathway Supports Phenotypic Differentiation but not Survival of Cholinergic Neurons”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 86, Santiago Chile, Noviembre 21 al 25 de 2005.

27. Inestrosa NC. “Cellular Signalling Pathways on ?-amyloid Peptide Neurodegeneration”. 13th International Symposium on Chromaffin Cell Biology, (pag. 56), Pucón - Chile (Enero 07 – 12 de 2006).

28. Farías G and Inestrosa NC. “?7-Nicotinic Acetylcholine Receptor Interacts With Tumor Suppressor APC in Presynaptic Regions of Hippocampal Neurons: Effect of Wnt.7a Ligand”. 13th International Symposium on Chromaffin Cell Biology, (pag. 92) Pucón - Chile (Enero 07 – 12 de 2006).

29. Dinamarca M, Cerpa W and Inestrosa NC. “?-Amyloid and Hydrogen Peroxide Neurotoxicity, Dissecting the Molecular Mechanisms”. 13th International Symposium on Chromaffin Cell Biology, (pag. 104) Pucón - Chile (Enero 07 – 12 de 2006).

30. Inestrosa N.C., “Wnt and calcium signaling in synaptic defferentiation and A? neuroprotection: role of CaMKIV. 13th. International Symposium on Chromaffin cell Biology. Pucón-Chile. (Enero 07 – 12, 2006).

31. Inestrosa NC. “Wnt Signaling Pathway and Synapse Differentiation” Spring Meeting 2006: “Symposium & Workshop on MOLECULAR AND CELLULAR BASIS OF NEUROCONNECTIVITY”, (L-7) Leuven – Belgium (Mayo 04 – 06 de 2006).

32. Fuentealba R, Inestrosa NC and Marzolo MP. “Trafficking and Functional Aspects of ApoER2: Its Role as a Regulator of APP Processing”. Spring Meeting 2006: “Symposium & Workshop on MOLECULAR AND CELLULAR BASIS OF NEUROCONNECTIVITY”, (L-13) Leuven – Belgium (Mayo 04 – 06 de 2006).

33. Inestrosa N.C. “Mecanismos de Daño Neuronal en la Enfermedad de Alzheimer” Simposio Internacional: “Neuropsiquiatría y función gonadal”. Santiago – Chile (28 – 29 Marzo 2008).

34. Inestrosa N.C., , “Enfermedad de Alzheimer: Papel de la via Wnt” Ciclo de Conferencias “Topicos selectos en Biología y Biomedicina” Universidad de Antofagasta, Antofagasta – Chile (12 de Diciembre 2008).

35. Inestrosa N.C “Vía Wnt de Señalización Modula la Maduración de las Regiones Pre- y Postsinápticas del Sistema Nervioso de Vertebrados” V Reunión Sociedad Chilena de Neurociencias, Coquimbo, Chile (Septiembre 23 – 25, 2009).

36. Inestrosa N.C. “Regulation of central synapses by Wnt signaling” Chilean Science Meets the Max Planck Institutes, Max Planck-Conicyt – Centro Interdiciplinario de la Universidad de Valparaíso (CINV) Valparaíso-Chile (January 11 - 13 de 2010).

37. Calderón F.H., De Mello F.G. and Campos E.O. Inestrosa N.C., “The Response of Retina to Biological Insults”. “Neurotoxicity of ?-Amyloid Aggregates and Ache-A Complexes in Avian Retina Cell Cultures”. Simposio Third IBRO Regional Meeting, San – Sabro 1998. Puerto Iguazú, Argentina (Nov. 30 – Dic. 03, 2008).

38. Inestrosa, N.C., Canales, M., Alarcón, R. & De Ferrarri G.V. “Acetylcholinesterase Promotes Amyloid Fibril Formation”, Fifth Ibro World Congress of Neuroscience. Jerusalem, Israel. (July 11 – 15, 1999).

39. Inestrosa N.C. and G.V De Ferrari.. “Acetylcholinesterase induced ?-Amyloid and Neurotoxicity”, Sixth International Stockholm / Springfield Symposium on advances in Alzheimer Therapy. Stockholm, Sweden (April 05 – 08, 2000).

40. Inestrosa, N.C., “Acetylcholinesterase and -amyloid interactions”. Esn Conference on: Advances in Molecular Mechanisms of Neurological Disorders ESN Conference on: “Advances in Molecular Mechanisms of Neurological Disorders. Perugia, Italy, (May 22-25, 2001).

41. Inestrosa, N.C., “Wnt Pathway Mediates Amyloid Neurotoxicity”. ISN Satellite Meeting: Cell Communication in the Nervous System-Function and Dysfunction. Río de Janeiro, Brasil, (August 22-24, 2001).

42. Inestrosa, N.C., “The Wnt signalling Patchway in Neuronal developmet” University of texas medical branch, dep. of physiology and biophysics, Galveston Texas, USA, (June, 27 – 29, 2002).

43. Inestrosa, N.C., Conferencia H. Niemeyer “Función de la Vía Wnt en el Sistema Nervioso” iv Jornadas de Bioinformatica y XXVI Congreso, organizado por la Sociedad Española de Bioquímica y Biología Celular SEBBM, La Coruña, España (Septiembre 15 – 18, 2003).

44. Inestrosa, N.C., AChE inhibitors, properties of AChE/A? complexes and the Wnt pathway. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, Quebec, Canada. (Abril 14 – 19, 2004).

45. Inestrosa, N.C., “Activation of WNT signaling protects from A? neurotoxicity”. Alzheimer’s and Parkinson’s diseases: new perspectives 7th International Conference,. Sorrento, Italy (March 8-12, 2005).

46. Inestrosa N.C., “Wnt Signaling Pathway and Synapse Differentiation” Spring Meeting 2006: “Symposium & Workshop on Molecular and Cellular Basis of Neuroconnectivity”, Leuven – Bélgica (Mayo 04 – 06, 2006).

47. Inestrosa N.C., “The Wnt Signaling Pathway and Its Relevance to Alzheimer Disease”. The 10th. International Conference on Alzheimer’s Disease and Related Disorders, Madrid – España (Julio 15 – 20, 2006).

48. Inestrosa N.C., “Activation of Wnt signaling protects from: Amyloid neurodegeneration” Alzheimer’s & Parkinson Diseases: Advances, Concepts & New Challenges 9TH International Conference AD/PD 2009, Prague, Czech Republic (March 11 – 15, 2009).

49. Inestrosa N.C., “Amyloid beta oligomers at brain synapses” 11th International Geneva/Springfield Simposium on Advances in Alzheimer Therapy. Geneva – Switzerland, March 24 – 27, 2010.

50. Inestrosa N.C., “Role of Wnt signaling in synaptic function and neurodegeneration.” V Neurotoxicity Society Meeting. Uspallata, Mendoza – Argentina (Abril 7 – 10 de 2011).

51. Inestrosa NC,. “Activation of brain Wnt signaling in vivo: effect on LTP and spontaneous network activity” AD/PD 2013 The 11th International Conference on Alzheimer‘s & Parkinson’s Diseases. 2013 Florence, Italy. (March 6-10 de 2013).

52.- Inestrosa NC. Posibles Blancos Moleculares del Litio en el Sistema Nervioso Central. Simposio “Potasio y litio, desde la biología a la medicina”. Santiago – Chile. (Noviembre 27, 2015).

53. Inestrosa NC. Effects of Wnt on Synaptic Structure and Function. Simposio “Synaptic Basis of Cognitive Dysfunction”. Valparaiso – Chile (October 23 – 24, 2014).

54. Inestrosa NC. “Wnt signaling and Alzheimer ?s disease”. International Symposium Biology of Neuropsychiatric Disorders. Valparaiso - Chile Nibaldo Inestrosa (Abril 27 – 28, 2016).

55. Inestrosa NC. “Neuroprotection of AD in Octodon degus: Role of WNT pathway”. AD/PD 2017 Meeting, Vienna, April, 2017.

Outreach communications

1997: Inestrosa, N.C., Conferencia “Estrógenos y Alzheimer”, JORNADA ANUAL DE ENDOCRINOLOGÍA Y METABOLISMO 1997 Olmué, Chile (Octubre 17 – 18)

2005: Inestrosa, N.C. “Papel de la Vía Wnt en la Función Sináptica, y en el Alzheimer”, XXII CONGRESO NACIONAL DE ESTUDIANTES DE BIOQUÍMICA, Universiad Nacional Andrés Bello. Santiago – Chile. (Agosto 3)

2005: Inestrosa NC. “¿Porqué la Vía de Señalización Wnt es Importante en Neurociencia?” Conferencia Plenaria. 1er Congreso de la Sociedad Chilena de Neurociencia, (Abst P2) Santiago Chile, (Diciembre 1 – 2)

2007: Inestrosa N.C., XV CONGRESO CHILENO DE QUÍMICA CLÍNICA,”Las Incomunicaciones del Alzheimer”. Pucón – Chile (Octubre 04 – 06).

2008: Inestrosa N.C. “Wnt signaling Pathway: from Alzheimer’s disease to synaptic function”, XVIII Congreso de la Asociación Latinoamericana de Farmacología, Coquimbo – Chile (Octubre 12 – 16).

2011: Inestrosa NC, Aldunate R, Minniti A On the function of copper in s-IBM. IV International Workshop on Iron and Copper Homeostasis. Pucón Chile, Nov 30 – Dec 3,

2013: Inestrosa NC, “Un científico nace o se hace: el camino al Alzheimer”. Feria Científica y Tecnológica. Osorno Chile, Agosto 12-13.

2013: Inestrosa NC, “Degú como un modelo de AD estudios recientes en cerebro, incluyendo la presencia de componentes de la vía Wnt”. Conferencia en el Instituto Brain Science de Australia. Sidney – Australia, Octubre 14.

2013: Inestrosa NC, “Porque Perdemos la Memoria: La enfermedad de Alzheimer”. Ciclo de Charlas Explora. Puerto Montt-Chile, Noviembre 21-22.

2013: Inestrosa NC, “Productos naturales para combatir la enfermedad de alzheimer”. Ciclo Charlas Universidad Santo Tomas. Santiago – Chile. Noviembre 27.

2013: Inestrosa NC, “Investigaciones en la enfermedad de Alzheimer”. Primer encuentro Vasco-Chileno de Investigación Biomédica. Santiago – Chile, Diciembre 02.

2013: Inestrosa NC, “Incomunicaciones del Alzehimer”. Charla en el Instituto Instituto de Sistemas Complejos. Valparaiso – Chile. Diciembre 15.

2014: Inestrosa NC, “Determinantes biológicos asociados a la longevidad”. El Congreso Nacional de Geriatría y Gerontología de Chile. Santiago – Chile. Junio 30.

2014: Inestrosa NC, “¿Por qué Investigar? O ¿Por qué Investigo?. Charla hospital Sotero del Rios. Santiago – Chile. Agosto 21.

2017: Inestrosa NC, “Papel de la Via Wnt en la Enfermedad de Alzheimer: Rol del Litio” Facultad de Ciencias, Universidad de Chile, 23 de Agosto.

PLOS ONE Article in the Top 10% Most Cited

PLoS One

Estados Unidos, 2017

PLOS ONE Article in the Top 10% Most Cited
Scopus-Elsevier Prize in Medical Science for ISI citations.

Scopus-Elsevier

Chile, 2013

Number of publications and citations
Top-3 cited paper FEBS Journal

FEBS Journal

Chile, 2010

Highly cited paper
Faculty of 1000-Medicine

Faculty of 1000 members

Estados Unidos, 2009

Scientific Career award
Premio Nacional de Ciencias

Chilean Government

Chile, 2008

Outstanding career award
Beca UNESCO Curso “Aspectos Químicos y Eléctricos de la Neurotransmisión”

IVICS Venezuela

Venezuela, 1977

To study the Chemistry and Electrical properties of Neurotransmission.
Postdoctoral grant

MUSCULAR DYSTROPHY ASSOCIATION OF AMERICA

Estados Unidos, 1980

Neurochemical and neurobiological approach to muscular dystrophy
Course grant

European Molecular Biology Organization

España, 1982

Course on Developmental Genetics of Drosophila.
Premio en Ciencia y Tecnología “Manuel Noriega Morales”

Consejo Interamericano para la Educación, la Ciencia y la Cultura (OEA)

Chile, 1986

Significant contribution to Biochemistry and Neurobiology fields.
BERNARDO HOUSSAY del Consejo Nacional de Investigación Científica de Argentina

Asociación Latinoamericana de Ciencias Fisiológicas

Argentina, 1988

Gold medal and plenary conference for young scientist in the field of physiology.
CATEDRA PRESIDENCIAL DE CIENCIA

Gobierno de Chile

Chile, 1996

Study of Synaptic Acetylcholinesterase
fellowship

JOHN SIMON GUGGENHEIM MEMORIAL FOUNDATION

Estados Unidos, 1999

A study of the interaction of cholinesterases with the amyloid-b-peptide
CATEDRA PRESIDENCIAL DE CIENCIA

Gobierno de Chile

Chile, 1999

Molecular Basis of the Amyloid Deposits and Neurotoxicity
Academic Degree Professor Emerito

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2018

Academic Degree Award Ceremony, Professor emerito


"Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress. Rivera DS, Lindsay CB, Oliva CA, Bozinovic F, Inestrosa NC. Article SCOPUS NEUROBIOLOGY OF STRESS (2021)
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sánchez-López E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Pérez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, García ML, Camins A, Silman I, Jean Article SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2021)
Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus. Lindsay CB, Zolezzi JM, Rivera DS, Cisternas P, Bozinovic F, Inestrosa NC. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2020)
Andrographolide restores glucose uptake in rat hippocampal neurons Gherardelli C, Cisternas P, Gutiérrez J, Martinez M, Inestrosa NC. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2020)
Canonical Wnt Signaling Modulates the Expression of Pre- and Postsynaptic Components in Different Temporal Patterns. Martínez M, Torres VI, Vio CP, Inestrosa NC. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2020)
Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus Rivera Daniela S.; Lindsay, Carolina B.; Oliva, Carolina A; Francisco Codocedo, Juan; Bozinovic, Francisco; Inestrosa, Nibaldo C. Article ISI SCIENTIFIC REPORTS (2020)
Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus Chang, Lily Y-L.; Ardiles O. Álvaro; Tapia-Rojas Cheril; Araya Joaquín; Inestrosa C Nibaldo; Palacios G Adrian; Acosta L Mónica Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2020)
Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex. Lira M, Mira RG, Carvajal FJ, Zamorano P, Inestrosa NC, Cerpa W. Article ISI SCOPUS Cells (2020)
Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation. Montecinos-Oliva C, Arrázola MS, Jara C, Tapia-Rojas C, Inestrosa NC. Article ISI SCOPUS PHARMACEUTICALS (2020)
Potential Role of Autonomic Dysfunction in Covid-19 Morbidity and Mortality. Del Rio R, Marcus NJ, Inestrosa NC. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2020)
Wnt Signaling Pathway Dysregulation in the Aging Brain: Lesson From the Octodon Degus Inestrosa, Nibaldo C; Tapia-Rojas Cheril; Lindsay, Carolina B; Zolezzi, Juan Manuel Article ISI SCOPUS Frontiers in Cell and Developmental Biology (2020)
Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling. Article ISI SCOPUS STEM CELLS (2020)
Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus Toledo, Camilo; Lucero, Claudia; Andrade, David C.; Diaz, Hugo S.; Schwarz, Karla G.; Pereyra, Katherin V.; Arce-Alvarez, Alexis; Lopez, Nicolas A.; Martinez, Milka; Inestrosa, Nibaldo C.; del Rio, Rodrigo Article ISI SCOPUS AGING-US (2019)
Diterpenes and the crosstalk with the arachidonic acid pathways, relevance in neurodegeneration. Zolezzi JM, Inestrosa NC Article ISI SCOPUS NEURAL REGENERATION RESEARCH (2019)
Fructose and prostate cancer: toward an integrated view of cancer cell metabolism. Carreño D, Corro N, Torres-Estay V, Véliz LP, Jaimovich R, Cisternas P, San Francisco IF, Sotomayor PC, Tanasova M, Inestrosa NC , Godoy AS Article ISI SCOPUS Prostate Cancer Prostatic Disease (2019)
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies Pardo, E.; Barake F; Tapia C.; Soza A.; Gonzalez, A Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus Salech, Felipe; Varela-Nallar, Lorena; Arredondo, Sebastian B.; Bustamante, Daniel B.; Andaur, Gabriela A.; Cisneros, Rodrigo; Ponce, Daniela P.; Ayala, Patricia; Inestrosa, Nibaldo C.; Valdes, Jose L.; Behrens, Maria I.; Couve, Andres Article ISI SCOPUS JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)
Modulating Wnt signaling at the root: Porcupine and Wnt acylation Torres V.I.; Godoy, J.A.; Inestrosa, N. C. Article ISI SCOPUS PHARMACOLOGY THERAPEUTICS (2019)
Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment. Toledo C, Andrade DC, Díaz HS, Inestrosa NC, Del Rio R. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia -Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC , Gonzalez-Billau Article ISI SCOPUS Nature Cell Biology (2019)
Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer's Disease Cisternas P.; Oliva C.A.; Torres V.I.; Barrera D.P.; Inestrosa N.C. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2. Article ISI SCOPUS (2019)
Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk Bastías-Candia, S; Martinez, M; Zolezzi, JM; Inestrosa, NC Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2019)
Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling Ramos-Fernández, Eva; Tapia-Rojas, Cheril; Ramírez, Valerie T; Inestrosa, Nibaldo C Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
APP/Go protein Gb gamma-complex signaling mediates A beta degeneration and cognitive impairment in Alzheimers disease models Bignante, Elena Anahi; Ponce, Nicolás Eric; Heredia, Florencia.; Musso, Juliana; Krawczyk, María C.; Millán, Julieta; Pigino, Gustavo F.; Inestrosa, Nibaldo C; Boccia, Mariano M.; Lorenzo, Alfredo Article ISI SCOPUS NEUROBIOLOGY OF AGING (2018)
Hypothyroidism and Cognitive Disorders during Development and Adulthood: Implications in the Central Nervous System Salazar P.; Cisternas P.; Martinez M.; Inestrosa, N. C. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2018)
Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus Rivera Daniela S.; Lindsay, Carolina B.; Codocedo, Juan F.; Carreño, Laura E.; Cabrera, Daniel; Arrese, Marco A.; Vio, Carlos P; Bozinovic, Francisco; Inestrosa, Nibaldo C Article ISI SCOPUS Molecular Neurobiology (2018)
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease. Tapia-Rojas, Cheril; Inestrosa, Nibaldo C Article Neural regeneration research (2018)
Modulation of Glucose Metabolism in Hippocampal Neurons by Adiponectin and Resistin Cisternas P.; Martinez M.; Ahima R.S.; William Wong G.; Inestrosa, N. C. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2018)
Neuroprotective Effects of Ferruginol, Jatrophone, and Junicedric Acid Against Amyloid-beta Injury in Hippocampal Neurons Zolezzi, Juan M.; Lindsay, Carolina B.; Serrano, Felipe G.; Ureta, Roxana C.; THEODULOZ, CRISTINA; Schmeda-Hirschmann, Guillermo; Inestrosa, Nibaldo C Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2018)
New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-? Peptide Aggregation and Age-Related Amyloid Pathology Cisternas P.; Zolezzi J.M.; Lindsay C.; Rivera D.S.; Martinez A.; Bozinovic F.; Inestrosa, N. C. Article ISI SCOPUS (2018)
Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons Godoy, Juan A; Valdivieso, Angel G.; Inestrosa, Nibaldo C Article ISI SCOPUS Molecular Neurobiology (2018)
The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons Lira M.; Arancibia D.; Orrego P.R.; Montenegro-Venegas C.; Cruz Y.; GarcÃa J.; Leal-Ortiz S.; Godoy, J.A.; Gundelfinger E.D.; Inestrosa, N. C.; Garner C.C.; Zamorano P.; Torres V.I. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2018)
Wnt Signaling in the Central Nervous System=> New Insights in Health and Disease. Oliva, Carolina A; Montecinos-Oliva, Carla; Inestrosa, Nibaldo C Article Progress in molecular biology and translational science (2018)
Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimers disease in J20-APP transgenic and wild-type mice Tapia-Rojas, Cheril; Inestrosa, Nibaldo C Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2018)
Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease Cisternas P.; Zolezzi J.M.; Martinez M.; Torres V.I.; Wong G.W.; Inestrosa, N. C. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2018)
Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3 beta-AMPK axis Ríos, Juvenal A.; Godoy, Juan A; Inestrosa, Nibaldo C Article ISI SCOPUS CELL COMMUNICATION AND SIGNALING (2018)
Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer’s disease Cisternas, Pedro; Inestrosa, Nibaldo C. Article SCOPUS Neuroscience and Biobehavioral Reviews (2017)
CDK5 downregulation enhances synaptic plasticity Posada-Duque, Rafael; Ramirez, Omar; Hartel, Steffen; Inestrosa, Nibaldo C; Bodaleo, Felipe; González-Billault, Christian; Kirkwood, Alfredo; Cardona-Gómez, Gloria Patricia Article ISI SCOPUS CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders Torres, Viviana I.; Vallejo, Daniela; Inestrosa, Nibaldo C. Article ISI SCOPUS NEURAL PLASTICITY (2017)
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice Bustos, Fernando J; Ampuero, Estibaliz; Jury, Nur; Aguilar, Rodrigo; Falahi, Fahimeh; Toledo, Jorge; Ahumada, Juan; Lata, Jaclyn; Cubillos, Paula; Henríquez, Berta; Guerra, Miguel V; Stehberg, Jimmy; Neve, Rachael L; Inestrosa, Nibaldo C; Wyneken, Ursula; Fuenzalida, Marco; Härtel, Steffen; Sena-Esteves, Miguel; Varela-Nallar, Lorena; Rots, Marianne G; Montecino, Martin; van Zundert, Brigitte Article ISI SCOPUS Brain (2017)
Identification of Cerebral Metal Ion Imbalance in the Brain of Aging Octodon degus Braidy, Nady; Poljak, Anne; Marjo, Chris; Rutlidge, Helen; Rich, Anne; Jugder, Bat-Erdene; Jayasena, Tharusha; Inestrosa, Nibaldo C.; Sachdev, Perminder S. Article ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2017)
Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity Salazar, Paulina; Cisternas, Pedro; Codocedo, Juan Francisco; Inestrosa, Nibaldo C. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)
INT131 increases dendritic arborization and protects against A beta toxicity by inducing mitochondrial changes in hippocampal neurons Godoy, Juan A.; Zolezzi, Juan M.; Inestrosa, Nibaldo C. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation Zolezzi, Juan M.; Santos, Manuel J.; Bastías-Candia, Sussy; Pinto, Claudio; Godoy, Juan A.; Inestrosa, Nibaldo C. Article ISI SCOPUS BIOLOGICAL REVIEWS (2017)
Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and A beta Aggregates in Hippocampal Neurons: the Role of Mitochondria Godoy J.A.; Lindsay C.B.; Quintanilla R.A.; Carvajal F.J.; Cerpa W.; Inestrosa N.C. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2017)
Vertebrate Presynaptic Active Zone Assembly: a Role Accomplished by Diverse Molecular and Cellular Mechanisms Torres V.I.; Inestrosa N.C. Article SCOPUS Molecular Neurobiology (2017)
Wnt Signaling Prevents the A beta Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons Arr?zola, Macarena S.; Ramos-Fern?ndez, Eva; Cisternas, Pedro; Ordenes, Daniela; Inestrosa, Nibaldo C.; Thomas, Bobby Article ISI SCOPUS PLOS ONE (2017)
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease Zolezzi, Juan M.; Inestrosa, Nibaldo C. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2017)
Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis Cisternas, Pedro; Salazar, Paulina; Silva-Álvarez, Carmen; Barros, L. Felipe; Inestrosa, Nibaldo C. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Amyloid-beta Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity Guivernau, Biuse; Bonet, Jaume; Valls-Comamala, Vict?ria; Bosch-Morat?, M?nica; Godoy, Juan A.; Inestrosa, Nibaldo C.; Per?lvarez-Mar?n, Alex; Fern?ndez-Busquets, Xavier; Andreu, David; Oliva, Baldomero; Mu?oz, Francisco J. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2016)
Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) Rivera, Daniela S.; Lindsay, Carolina; Codocedo, Juan Francisco; Morel, Isidora; Pinto, Claudio; Cisternas, Pedro; Bozinovic, Francisco; Inestrosa, Nibaldo C. Article ISI SCOPUS NEUROBIOLOGY OF AGING (2016)
Frizzled-1 receptor regulates adult hippocampal neurogenesis Mardones M.D.; Andaur G.A.; Varas-Godoy, M; Henriquez J.F.; Salech, F; Behrens, M. I.; couve, a; Inestrosa, N. C.; Varela-Nallar L. Article ISI SCOPUS MOLECULAR BRAIN (2016)
Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-beta (A beta)(42) peptides Tapia-Rojas, Cheril; Burgos, Patricia V.; Inestrosa, Nibaldo C. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2016)
Modulation of the NMDA Receptor Through Secreted Soluble Factors Cerpa, W.; Ramos-Fernandez, E; Inestrosa, NC Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2016)
On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae) Daniela S. Rivera; Nibaldo C. Inestrosa; Francisco Bozinovic Article ISI SCIELO BIOLOGICAL RESEARCH (2016)
Posttranslational Modifications Regulate the Postsynaptic Localization of PSD-95 Vallejo D.; Codocedo J.F.; Inestrosa, N. C. Article SCOPUS Molecular Neurobiology (2016)
Recent advances in neuroinflammation therapeutics: PPARs/LXR as neuroinflammatory modulators Bastías-Candia S.; Nicolás G.A.; Zolezzi J.M.; Inestrosa, N. C. Article SCOPUS CURRENT PHARMACEUTICAL DESIGN (2016)
Reduction of Blood Amyloid-beta Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition Estrada, Lisbell D.; Chamorro, David; Ya?ez, Mar?a Jos?; González, Marcelo; Leal, Nancy; von Bernhardi, Rommy; Dulcey, Andr?s E.; Marugan, Juan; Ferrer, Marc; Soto, Claudio; Zanlungo, Silvana; Inestrosa, Nibaldo C.; Alvarez, Alejandra R. Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2016)
Regulation of Memory Formation by the Transcription Factor XBP1 Martinez, G; Vidal, RL; Mardones P.; Serrano, FG; Ardiles AO; Wirth C.; Valdés P.; Thielen P; Schneider, BL; Kerr, B.; Valdes, JL; Palacios, AG; Inestrosa, NC; Glimcher, LH; hetz C. Article ISI SCOPUS CELL REPORTS (2016)
Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in A beta PPswe/PS-1 Mice of Different Ages Serrano, Felipe; Tapia-Rojas, Cheril; Carvajal, Francisco; Cisternas, Pedro; Viayna, Elisabet; Sola, Irene; Munoz-Torrero, Diego; Inestrosa, Nibaldo Article ISI CURRENT ALZHEIMER RESEARCH (2016)
Rhein-huprine derivatives reduce cognitive impairment, synaptic failure and amyloid pathology in A?PPswe/PS-1 mice of different ages Serrano F.G.; Tapia-Rojas C.; Carvajal F.J.; Cisternas P.; Viayna E.; Sola I.; Muñoz-Torrero D.; Inestrosa N.C. Article SCOPUS CURRENT ALZHEIMER RESEARCH (2016)
The G alpha(o) Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons Ramirez, VT; Ramos-Fernandez, E; Inestrosa, NC Article ISI SCOPUS NEURAL PLASTICITY (2016)
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease Tapia-Rojas, C; Aranguiz, F; Varela-Nallar, L; Inestrosa, NC Article ISI SCOPUS Brain Pathology (2016)
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy Fuenzalida, M; Espinoza, C.; Perez, MA; Tapia-Rojas, C; Cuitino, L; Brandan, E.; Inestrosa, NC Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2016)
Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons Juan Francisco Codocedo; Nibaldo C. Inestrosa Article ISI SCIELO BIOLOGICAL RESEARCH (2016)
Wnt-5a/Frizzled9 Receptor Signaling through the G alpha(o)-G beta gamma Complex Regulates Dendritic Spine Formation Ram?rez, Valerie T.; Ramos-Fern?ndez, Eva; Henr?quez, Juan Pablo; Lorenzo, Alfredo; Inestrosa, Nibaldo C. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons Cisternas, Pedro; Salazar, Paulina; Silva-Álvarez, Carmen; Barros, L. Felipe; Inestrosa, Nibaldo C. Article ISI SCOPUS NEURAL PLASTICITY (2016)
A novel function for Wnt signaling modulating neuronal firing activity and the temporal structure of spontaneous oscillation in the entorhinal-hippocampal circuit Oliva, CA; Inestrosa, NC Article ISI SCOPUS Experimental Neurology (2015)
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease Inestrosa, NC; Rios, JA; Cisternas P.; Tapia-Rojas, C; Rivera, DS; Braidy, N; Zolezzi, JM; Godoy JA; Carvajal, FJ; Ardiles AO; Bozinovic F.; Palacios, AG; Sachdev, PS Article ISI SCOPUS Brain Pathology (2015)
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus Du, Lucia Y.; Chang, Lily Y-L.; Ardiles, Alvaro O; Tapia-Rojas, Cheril; Araya, Joaquin; Inestrosa, Nibaldo C; Palacios, Adrian G; Acosta, Monica L.; Padmanabhan, Jaya Article ISI SCOPUS PLOS ONE (2015)
Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3 beta: autoregulation of GSK-3 beta in vivo Tapia-Rojas, C; Schuller, A; Lindsay C.B.; Ureta R.C.; Mejias-Reyes C.; Hancke, J; Melo F.; Inestrosa, N. C. Article ISI SCOPUS BIOCHEMICAL JOURNAL (2015)
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus Varela-Nallar, L; Arredondo, SB; Tapia-Rojas, C; Hancke, J; Inestrosa, NC Article ISI SCOPUS Neural Plasticity (2015)
Angiotensin II increases fibronectin and collagen I through the beta-catenin-dependent signaling in mouse collecting duct cells Cuevas C.A.; González A.A.; Inestrosa, N. C.; Vio C.P.; Prieto M.C. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)
Anti-Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice Bravo-Zehnder, M; Toledo E.M.; Segovia-Miranda, F; Serrano, F.G.; Benito M.J.; Metz, C; Retamal, C; Alvarez A.; Massardo, L; Inestrosa, N. C.; González A Article ISI SCOPUS ARTHRITIS & RHEUMATOLOGY (2015)
beta-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats Cuevas CA; Tapia-Rojas, C; Cespedes, C; Inestrosa, NC; Vio, CP Article ISI SCOPUS BioMed Research International (2015)
Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance Cisternas P.; salazar, P; Serrano, FG; Montecinos-Oliva, C; Arredondo, SB; Varela-Nallar, L; Barja S.; Vio, CP; Gomez-Pinilla, F; Inestrosa, NC Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2015)
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in A beta oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice Tapia-Rojas, C; Lindsay, CB; Montecinos-Oliva, C; Arrazola, MS; Retamales, RM; Bunout, D; Hirsch, S; Inestrosa, NC Article ISI SCOPUS Molecular Neurodegeneration (2015)
Monitoring mitochondrial membranes permeability in live neurons and mitochondrial swelling through electron microscopy analysis. Arrázola, Macarena S; Inestrosa, Nibaldo C Article Methods in molecular biology (Clifton, N.J.) (2015)
Pathogenicity of Lupus Anti-Ribosomal P Antibodies: Role of Cross-Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model Segovia-Miranda, F; Serrano, F; Dyrda A; Ampuero E.; Retamal, C; Bravo-Zehnder, M; Parodi, J; Zamorano P.; Valenzuela, D; Massardo, L; van Zundert, B; Inestrosa, NC; González A Article ISI SCOPUS Arthritis and Rheumatology (2015)
Teneurins and Alzheimer's disease: A suggestive role for a unique family of proteins Bastias-Candia, S; Braidy, N; Zolezzi, JM; Inestrosa, NC Article ISI SCOPUS Medical Hypotheses (2015)
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy Cavieres, Viviana A.; Gonzlez, Alexis; Muoz, Vanessa C.; Yefi, Claudia P.; Bustamante, Hianara A.; Barraza, Rafael R.; Tapia-Rojas, Cheril; Otth, Carola.; Barrera, Mara Jos; Gonzlez, Carlos; Mardones, Gonzalo A.; Inestrosa, Nibaldo C; Burgos, Patricia, V; Lakshmana, Madepalli K. Article ISI SCOPUS PLOS ONE (2015)
Tetrahydrohyperforin: a neuroprotective modified natural compound against Alzheimer's disease Montecinos-Oliva, C; Schuller, A; Inestrosa, NC Article ISI SCOPUS Neural Regeneration Research (2015)
The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease Cisternas P.; Lindsay, CB; salazar, P; Silva-Alvarez, C; Retamales, RM; Serrano, FG; Vio, CP; Inestrosa, NC Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2015)
The Protein Oxidation Repair Enzyme Methionine Sulfoxide Reductase A Modulates A beta Aggregation and Toxicity In Vivo Minniti A.N.; Arrázola M.S.; Bravo-Zehnder, M; Ramos, F; Inestrosa, N. C.; Aldunate, R Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2015)
The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons alfaro ie; Varela-Nallar, L; Varas-Godoy, M; Inestrosa, NC Article ISI SCOPUS Molecular and Cellular Neuroscience (2015)
The soluble extracellular fragment of neuroligin-1 targets A beta oligomers to the postsynaptic region of excitatory synapses Dinamarca, MC; Di Luca M.; Godoy JA; Inestrosa, NC Article ISI SCOPUS Biochemical and Biophysical Research Communications (2015)
WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by A beta oligomers Vargas J.Y.; Ahumada, J; Arrázola M.S.; Fuenzalida, M; Inestrosa, N. C. Article ISI SCOPUS EXPERIMENTAL NEUROLOGY (2015)
Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against AO oligomers Codocedo JF; Montecinos-Oliva, C; Inestrosa, NC Article ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production Parodi, Jorge; Montecinos-Oliva, Carla; Varas, Rodrigo; Alfaro, Iván E.; Serrano, Felipe G.; Varas-Godoy, Manuel; Muñoz, Francisco J.; Cerpa, Waldo; Godoy, Juan A; Inestrosa, Nibaldo C Article ISI SCOPUS Molecular and Cellular Neuroscience (2015)
Andrographolide reduces cognitive impairment in young and mature A beta PPswe/PS-1 mice Serrano, FG; Tapia-Rojas, C; Carvajal, FJ; Hancke, J; Cerpa, W.; Inestrosa, NC Article ISI MOLECULAR NEURODEGENERATION (2014)
Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons Braidy, N; Brew BJ; Inestrosa, NC; Chung R; Sachdev P; Guillemin GJ. Article ISI METABOLIC BRAIN DISEASE (2014)
Chronic hypoxia induces the activation of the Wnt/beta-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1 Delta E9 transgenic mice in vivo Varela-Nallar, L; Rojas-Abalos, M; Abbott AC; Moya, EA; Iturriaga R.; Inestrosa, NC Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Effects of Tetrahydrohyperforin in Mouse Hippocampal Slices: Neuroprotection, Long-term Potentiation and TRPC Channels Montecinos-Oliva, C.; Schueller, A.; Parodi, J.; Melo, F.; Inestrosa, N. C. Article ISI CURRENT MEDICINAL CHEMISTRY (2014)
EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-beta Oligomers M. Vargas, Lina; Leal, Nancy.; Estrada, Lisbell D.; Gonzlez, Adrian; Serrano, Felipe; Araya, Katherine; Gysling, Katia; Inestrosa, Nibaldo C; Pasquale, Elena B.; Alvarez, Alejandra R.; Arendt, Thomas Article ISI SCOPUS PLOS ONE (2014)
In vivo Activation of Wnt Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model Vargas JY; Fuenzalida, M; Inestrosa, NC Article ISI JOURNAL OF NEUROSCIENCE (2014)
Phosphorylated tau potentiates A beta-induced mitochondrial damage in mature neurons Quintanilla, RA; von Bernhardi R.; Godoy JA; Inestrosa, NC; Johnson, GVW Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2014)
PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors Bustos, Fernando J.; Varela-Nallar, Lorena; Campos, Matias; Henriquez, Berta; Phillips, Marnie; Opazo, Carlos; Aguayo, Luis G.; Montecino, Martin; Constantine-Paton, Martha; Inestrosa, Nibaldo C.; van Zundert, Brigitte Article ISI SCOPUS PLOS ONE (2014)
Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain Godoy, J.A.; Zolezzi J.M.; Braidy, N; Inestrosa, N. C. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2014)
Role of Wnt Signaling in Tissue Fibrosis, Lessons from Skeletal Muscle and Kidney Cisternas P.; Vio, CP; Inestrosa, NC Article ISI CURRENT MOLECULAR MEDICINE (2014)
Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents Viayna E; Sola I.; Bartolini, M; De Simone A; Tapia-Rojas, C; Serrano, FG; Sabaté R; Juarez-Jimenez, J; Pérez B; Luque, FJ; Andrisano, V; Clos MV; Inestrosa, NC; Munoz-Torrero, D Article ISI SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2014)
Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis Cisternas P.; Henriquez, JP; Brandan, E.; Inestrosa, NC Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2014)
Wnt signalling in neuronal differentiation and development Inestrosa, N. C.; Varela-Nallar L. Article ISI SCOPUS Cell and Tissue Research (2014)
Wnt-5 alpha increases NO and modulates NMDA receptor in rat hippocampal neurons Muñoz FJ.; Godoy JA; Cerpa, W.; Poblete IM; Huidobro-Toro, JP; Inestrosa, NC Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Wnt-5a Ligand Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons Godoy, J.A.; Arrázola M.S.; Ordenes, D; Silva-Alvarez, C; Braidy, N; Inestrosa, N. C. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
ATP Induces NO Production in Hippocampal Neurons by P2X(7) Receptor Activation Independent of Glutamate Signaling Codocedo, Juan Francisco; Godoy, Juan Alejandro; Poblete, Maria Ines; Inestrosa, Nibaldo C; HUIDOBRO-TORO, Juan Pablo; Mongin, Alexander A. Article ISI SCOPUS PLOS ONE (2013)
Canonical Wnt signaling protects hippocampal neurons from A beta oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics Silva-Alvarez, C; Arrazola, MS; Godoy JA; Ordenes, D; Inestrosa, NC Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2013)
Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons Slater, Paula G.; Ramirez, Valerie T.; Gonzalez-Billault, Christian; Varela-Nallar, Lorena; Inestrosa, Nibaldo C; Katoh, Masaru Article ISI SCOPUS PLOS ONE (2013)
Nicotine Prevents Synaptic Impairment Induced by Amyloid-beta Oligomers Through alpha 7-Nicotinic Acetylcholine Receptor Activation Inestrosa, NC; Godoy JA; Vargas JY; Arrazola, MS; Rios, JA; Carvajal, FJ; Serrano, FG; Farias GG. Article ISI SCOPUS NEUROMOLECULAR MEDICINE (2013)
Peroxisome Proliferator-Activated Receptor (PPAR) gamma and PPAR alpha Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders? Zolezzi, Juan M.; Silva-Alvarez, Carmen; Ordenes, Daniela; Godoy, Juan A; Carvajal, Francisco J.; Santos, Manuel J.; Inestrosa, Nibaldo C; Ferreira, Sergio T. Article ISI SCOPUS PLOS ONE (2013)
Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease Inestrosa, NC; Carvajal, FJ; Zolezzi, JM; Tapia-Rojas, C; Serrano, F; Karmelic D; Toledo EM; Toro, A.; Toro, J.; Santos MJ Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice Carvajal, FJ; Zolezzi, JM; Tapia-Rojas, C; Godoy JA; Inestrosa, NC Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Tetrahydrohyperforin Increases Adult Hippocampal Neurogenesis in Wild-Type and APPswe/PS1 Delta E9 Mice Abbott AC; Toledo, CC; Aranguiz FC; Inestrosa, NC; Varela-Nallar, L Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Tetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca2+ Overload after A beta and A beta-AChE Complex Challenge in Rat Hippocampal Neurons Zolezzi, JM; Carvajal, FJ; Rios, JA; Ordenes, D; Silva-Alvarez, C; Godoy JA; Inestrosa, NC Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway Quintanilla, Rodrigo A.; Godoy, Juan A; Alfaro, Ivan; Cabezas, Deny; Bernhardi, Rommy von; Bronfman, Miguel; Inestrosa, Nibaldo C; Allinquant, Bernadette Article ISI SCOPUS PLOS ONE (2013)
Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease Cabeza, C; Figueroa, A; Lazo O.M.; Galleguillos, C; Pissani C.; Klein, A.; Gonzalez-Billault, C; Inestrosa, N. C.; Alvarez, A.R.; Zanlungo S.; Bronfman F.C. Article ISI SCOPUS Molecular Neurodegeneration (2012)
Frizzled Receptors in Neurons: From Growth Cones to the Synapse Varela-Nallar, L; Ramirez V.T.; Gonzalez-Billault, C; Inestrosa, N. C. Article ISI SCOPUS Cytoskeleton (2012)
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease Ardiles, A. O.; Tapia-Rojas C.C.; Mandal M; Alexandre F; Kirkwood A.; Inestrosa, N. C.; Palacios A.G. Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2012)
Reusing and composing models of cell fate regulation of human bone precursor cells Assar, R; Leisewitz A.V.; Garcia, A.; Inestrosa, N. C.; Montecino M.A.; Sherman D.J. Article ISI SCOPUS BioSystems (2012)
SIRT1 Regulates Dendritic Development in Hippocampal Neurons Codocedo, Juan F.; Allard, Claudio; Godoy, Juan A; Varela-Nallar, Lorena; Inestrosa, Nibaldo C; Allinquant, Bernadette Article ISI SCOPUS PLOS ONE (2012)
Synaptic defects associated with s-inclusion body myositis are prevented by copper Aldunate, R; Minniti A.N.; Rebolledo, D; Inestrosa, N. C. Article ISI SCOPUS BIOMETALS (2012)
Wnt-5a Is a Synaptogenic Factor with Neuroprotective Properties against A beta Toxicity Varela-Nallar, L; Parodi, J; Farias G.G.; Inestrosa, N. C. Article ISI SCOPUS Neurodegenerative Diseases (2012)
Copper Reduces A beta Oligomeric Species and Ameliorates Neuromuscular Synaptic Defects in a C. elegans Model of Inclusion Body Myositis Rebolledo, DL; Aldunate, R; Kohn R.; Neira, I; Minniti AN; Inestrosa, NC Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2011)
HID-1, a New Component of the Peptidergic Signaling Pathway Mesa R; Luo, S; Nonet M.L.; Hoover C.M.; Miller K.; Minniti A; Inestrosa, N Article ISI SCOPUS Genetics (2011)
Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling Cerpa, W.; Gambrill A; Inestrosa, NC; Barría A. Article ISI SCOPUS Journal of Neuroscience (2011)
Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1 Delta E9 model of Alzheimer's disease: a possible effect on APP processing Inestrosa, NC; Tapia-Rojas, C; Griffith TN; Carvajal, FJ; Benito MJ; Rivera-Dictter, A; Alvarez, AR; Serrano, FG; Hancke, JL; Burgos, PV; Parodi, J; Varela-Nallar, L Article ISI SCOPUS Translational Psychiatry (2011)
The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2 X4 Receptors Lorca, Ramn A.; Varela-Nallar, Lorena; Inestrosa, Nibaldo C; Huidobro-Toro, J. Pablo Article SCOPUS International Journal of Alzheimer's Disease (2011)
The GABA(A)rho receptors in hippocampal spontaneous activity and their distribution in hippocampus, amygdala and visual cortex Rosas-Arellano A.; Parodi, J; Machuca-Parra, AI; Sanchez-Gutierrez A.; Inestrosa, NC; Miledi R; Martinez-Torres, A Article ISI SCOPUS Neuroscience Letters (2011)
The Synaptic Protein Neuroligin-1 Interacts with the Amyloid beta-Peptide. Is There a Role in Alzheimer's Disease? Dinamarca, MC; Weinstein D.; Monasterio O.; Inestrosa, NC Article ISI SCOPUS Biochemistry (2011)
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1 Delta E9 mouse model of Alzheimer's disease Toledo EM; Inestrosa, NC Article ISI SCOPUS MOLECULAR PSYCHIATRY (2010)
Amyloid-beta Peptide Fibrils Induce Nitro-Oxidative Stress in Neuronal Cells ILL-Raga G.; Ramos-Fernandez, E; Guix FX; Tajes M.; Bosch-Morato M.; Palomer E.; Godoy, J; Belmar S; Cerpa, W.; Simpkins, JW; Inestrosa, NC; Munoza, FJ Article ISI SCOPUS Journal of Alzheimer's Disease (2010)
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the A beta peptide. Implications for the pathogenesis of Alzheimer's disease Dinamarca, MC; Sagal, JP; Quintanilla, RA; Godoy JA; Arrazola, MS; Inestrosa, NC Article ISI SCOPUS Molecular Neurodegeneration (2010)
Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons Lazo OM; Mauna, JC; Pissani CA; Inestrosa, NC; Bronfman, FC Article ISI SCOPUS Molecular Neurodegeneration (2010)
beta-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure Parodi, J; Sepulveda, FJ; Roa, J; Opazo C.; Inestrosa, NC; Aguayo, LG Article ISI SCOPUS Journal of Biological Chemistry (2010)
Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method Hodar, C; Assar, R; Colombres M.; Aravena, A.; Pavez, L.; Gonzalez, M.; Martínez, S.; Inestrosa, NC; Maass A. Article ISI SCOPUS BMC Genomics (2010)
Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Griffith TN; Varela-Nallar L.; Dinamarca, MC; Inestrosa, NC Article ISI CURRENT MEDICINAL CHEMISTRY (2010)
Neuroinflammation, AD, and Dementia Reale, Marcella; Brenner, Talma; Greig, Nigel H.; Inestrosa, Nibaldo; Paleacu, Diana Article SCOPUS International Journal of Alzheimer's Disease (2010)
Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation de Arce KP; Varela-Nallar, L; Farias O.; Cifuentes, A.; Bull, P; Couch BA; Koleske AJ; Inestrosa, NC; Alvarez, AR Article ISI SCOPUS Journal of Neuroscience (2010)
The Hyperforin Derivative IDN5706 Occludes Spatial Memory Impairments and Neuropathological Changes in a Double Transgenic Alzheimer's Mouse Model Cerpa, W.; Hancke, JL; Morazzoni, P.; Bombardelli, E.; Riva, A; Marin, PP; Inestrosa, NC Article SCOPUS Current alzheimer Research (2010)
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses Varela-Nallar, L; alfaro ie; Serrano, FG; Parodi, J; Inestrosa, NC Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2010)
Wnt signaling activation reduces neuropathological markers in a mouse model of Alzheimer's disease Toledo E.M.; Inestrosa, N. C. Article SCOPUS MOLECULAR PSYCHIATRY (2010)
Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons Cuitino, L; Godoy JA; Farias GG.; couve, a; Bonansco, C.; Fuenzalida, M; Inestrosa, NC Article ISI SCOPUS Journal of Neuroscience (2010)
Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons Cerpa, W.; Farias GG.; Godoy JA; Fuenzalida, M; Bonansco, C.; Inestrosa, NC Article ISI SCOPUS Molecular Neurodegeneration (2010)
c-Abl Modulates AICD Dependent Cellular Responses: Transcriptional Induction and Apoptosis Vázquez MC; Vargas LM; Inestrosa, NC; Alvarez, AR Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway Arrazola, MS; Varela-Nallar, L; Colombres M.; Toledo EM; Cruzat F.; Pavez, L.; Assar, R; Aravena, A.; Gonzalez, M.; Montecino, M.; Maass A.; Martínez, S.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Intracellular amyloid formation in muscle cells of A beta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification Minniti AN; Rebolledo, DL; Grez, PM; Fadic, R; Aldunate, R; Volitakis I.; Cherny, RA; Opazo C.; Masters C.; Bush, AI; Inestrosa, NC Article ISI SCOPUS MOLECULAR NEURODEGENERATION (2009)
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans Minniti AN; Cataldo, R; Trigo, C; Vásquez, L.; Mujica, P.; Leighton F.; Inestrosa, NC; Aldunate, R Article ISI SCOPUS AGING CELL (2009)
Overexpression of amyloid precursor protein increases copper content in HEK293 cells Suazo M.; Hodar, C; Morgan C.; Cerpa, W.; Cambiazo, V; Inestrosa, NC; Gonzalez, M. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function Varela-Nallar, L; Grabowski CP; alfaro ie; Alvarez, AR; Inestrosa, NC Article ISI SCOPUS NEUROSCIENCE LETTERS (2009)
THE ROLE OF WNT SIGNALING IN NEUROPROTECTION Cerpa, W.; Toledo EM; Varela-Nallar, L; Inestrosa, NC Article ISI DRUG NEWS PERSPECTIVES (2009)
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons Farias GG.; alfaro ie; Cerpa, W.; Grabowski CP; Godoy JA; Bonansco, C.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
beta-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway Dinarnarca, MC; Colombres M.; Cerpa, W.; Bonansco, C.; Inestrosa, NC Article ISI NEURODEGENERATIVE DISEASES (2008)
Circadian stress tolerance in adult Caenorhabditis elegans Simonetta, SH; Romanowski A; Minniti AN; Inestrosa, NC; Golombek, DA Article ISI SCOPUS JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY (2008)
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against a beta oligomers Chacón MA; Varela-Nallar, L; Inestrosa, NC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Heparin activates Wnt signaling for neuronal morphogenesis Colombres M.; Henriquez, JP; Reig, GF; Scheu J.; Calderôn R.; Alvarez A.; Brandan, E.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Release of acetylcholinesterase (ACH) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice Dinamarca, MC; Arrazola M; Toledo, E.; Cerpa, WF; Hancke, J; Inestrosa, NC Article ISI SCOPUS CHEMICO-BIOLOGICAL INTERACTIONS (2008)
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits Cancino, GI; Toledo EM; Leal, NR; Hernández DE; Yevenes, LF; Inestrosa, NC; Alvarez, AR Article ISI SCOPUS BRAIN (2008)
Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Cerpa, W.; Dinamarca, MC; Inestrosa, NC Article ISI CURRENT ALZHEIMER RESEARCH (2008)
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons Cerpa, W.; Godoy JA; Alfaro I.; Farlas, GG; Metcalfe MJ; Fuentealba, R; Bonansco, C.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
ApoER2 expression increases A beta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity Fuentealba, RA; Barría MI; Lee, J; Cam, J; Araya C.; Escudero, CA; Inestrosa, NC; Bronfman, FC; Bu, GJ; Marzolo, MP Article ISI SCOPUS MOLECULAR NEURODEGENERATION (2007)
Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis Fuenzalida K.; Quintanilla R.; Ramos, P; Piderit, D; Fuentealba, RA; Martinez, G; Inestrosa, NC; Bronfman, M Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Synaptotoxicity in Alzheimer's disease: The Wnt signaling pathway as a molecular target Inestrosa, NC; Varela-Nallar, L; Grabowski CP; Colombres M. Article ISI IUBMB LIFE (2007)
Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons Farias GG.; Valles, AS; Colombres M.; Godoy JA; Toledo EM; Lukas, RJ; Barrantes, FJ; Inestrosa, NC Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2007)
Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits Dinamarca, MC; Cerpa, W.; Garrido, J.; Hancke, JL; Inestrosa, NC Article ISI SCOPUS MOLECULAR PSYCHIATRY (2006)
Induction of cellular prion protein gene expression by copper in neurons Varela-Nallar, L; Toledo EM; Larrondo, LF; Cabral, ALB; Martins, VR; Inestrosa, NC Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
Localization, specific activity, and molecular forms of acetylcholinesterase in developmental stages of the cestode Mesocestoides corti Kemmerling U.; Cabrera G.; CAMPOS, EO; Inestrosa, NC; Galanti N. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)
The functional links between prion protein and copper Varela-Nallar, L; Toledo EM; Chacón MA; Inestrosa, NC Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its rafts' association Cuitino, L; Matute, R.; Retamal, C; Bu, GJ; Inestrosa, NC; Marzolo, MP Article ISI SCOPUS TRAFFIC (2005)
Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia von Bernhardi R.; Alarcon, R; Mezzano D.; Fuentes P.; Inestrosa, NC Article ISI SCOPUS DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2005)
Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu Inestrosa, NC; Reyes, AE; Chacón MA; Cerpa, W.; Villalon A.; Montiel, J; Merabachvili, G; Aldunate, R; Bozinovic F.; Aboitiz F. Article ISI SCOPUS NEUROBIOLOGY OF AGING (2005)
Peroxisomal proliferation protects from beta-amyloid neurodegeneration Santos MJ; Quintanilla, RA; Toro, AS; Grandy, R; Dinamarca, MC; Godoy JA; Inestrosa, NC Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling Inestrosa, NC; Godoy JA; Quintanilla, RA; Koenig, CS; Bronfman, M Article ISI SCOPUS EXPERIMENTAL CELL RESEARCH (2005)
The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components Farias GG.; Godoy JA; Vázquez MC; Adani, R; Meshulam, H; Avila J.; Amitai, G; Inestrosa, NC Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2005)
Acetylcholinesterase (AChE)--amyloid-beta-peptide complexes in Alzheimer's disease. the Wnt signaling pathway. Inestrosa, NC; Urra S; Colombres M. Article ISI CURRENT ALZHEIMER RESEARCH (2004)
Acetylcholinesterase-A beta complexes are more toxic than A beta fibrils in rat hippocampus - Effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss Reyes, AE; Chacon, MA; Dinamarca, MC; Cerpa, W; Morgan, C; Inestrosa, NC Article ISI AMERICAN JOURNAL OF PATHOLOGY (2004)
beta-sheet breaker peptide prevents A beta-induced spatial memory impairments with partial reduction of amyloid deposits Chacón MA; Barría MI; Soto C.; Inestrosa, NC Article ISI SCOPUS MOLECULAR PSYCHIATRY (2004)
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation Casar, JC; Cabello-Verrugio, C; Olguin, H; Aldunate, R; Inestrosa, NC; Brandan, E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2004)
M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway Farias GG.; Godoy JA; Hernández F.; Avila J.; Fisher, A; Inestrosa, NC Article ISI NEUROBIOLOGY OF DISEASE (2004)
Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease Fuentealba, RA; Farías G.; Scheu J.; Bronfman, M; Marzolo, MP; Inestrosa, NC Article ISI BRAIN RESEARCH REVIEWS (2004)
Stepwise construction of triple-helical heparin binding sites using peptide models Doss-Pepe, E; Deprez, P.; Silva, T; Inestrosa, NC; Kirkpatrick, A; Ramshaw, JAM; Brodsky, B Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Structural and functional organization of synaptic acetylcholinesterase Aldunate, R; Casar, JC; Brandan, E.; Inestrosa, NC Article ISI BRAIN RESEARCH REVIEWS (2004)
The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo Cerpa, WF; Barría MI; Chacón MA; Suazo M.; Gonzalez, M.; Opazo C.; Bush, AI; Inestrosa, NC Article ISI SCOPUS FASEB JOURNAL (2004)
Wnt-3a overcomes ?-amyloid toxicity in rat hippocampal neurons Alvarez, A.R.; Godoy, J.A.; Mullendorff, K; Olivares G.H.; Bronfman, M; Inestrosa, N. C. Article SCOPUS EXPERIMENTAL CELL RESEARCH (2004)
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons Alvarez, AR; Godoy JA; Mullendorff, K; Olivares, GH; Bronfman, M; Inestrosa, NC Article ISI EXPERIMENTAL CELL RESEARCH (2004)
A human prion protein peptide (PrP59-91) protects against copper neurotoxicity Chacón MA; Barría MI; Lorca, R; Huidobro-Toro, JP; Inestrosa, NC Article ISI SCOPUS MOLECULAR PSYCHIATRY (2003)
Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus Chacón MA; Reyes, AE; Inestrosa, NC Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2003)
Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture von Bernhardi R.; Ramirez G.; De Ferrari, GV; Inestrosa, NC Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2003)
Activation of Wnt signaling and behavioral impairments rescues neurodegeneration induced by beta-amyloid fibrils De Ferrari, GV; Chacón MA; Barría MI; garrido, JL; Godoy JA; Olivares, G; Reyes, AE; Alvarez A.; Bronfman, M; Inestrosa, NC Article ISI SCOPUS MOLECULAR PSYCHIATRY (2003)
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases Opazo C.; Barría MI; Ruiz, FH; Inestrosa, NC Article ISI BIOMETALS (2003)
Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells Leisewitz AV.; Jung JE; Perez-Alzola, P; Fuenzalida, KM; Roth, A.; Inestrosa, NC; Bronfman, M Article ISI JOURNAL OF NEUROCHEMISTRY (2003)
PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes Roth AD; Leisewitz AV.; Jung JE; Cassina, P; Barbeito, L; Inestrosa, NC; Bronfman, M Article ISI SCOPUS JOURNAL OF NEUROSCIENCE RESEARCH (2003)
The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X(4) receptor without modifying the zinc action Lorca RA; Chacon M.; Barría MI; Inestrosa, NC; Huidobro-Toro, JP Article ISI JOURNAL OF NEUROCHEMISTRY (2003)
Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase Deprez, P.; Inestrosa, NC; Krejci, E Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Laminin affects polymerization, depolymerization and neurotoxicity of A beta peptide Morgan C.; Bugueno, MP; Garrido, J.; Inestrosa, NC Article ISI SCOPUS PEPTIDES (2002)
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid - Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2 Opazo C.; Huang, XD; Cherny, RA; Moir, RD; Roher, AE; White, AR; Cappai, R; Masters, CL; Tanzi, RE; Inestrosa, NC; Bush, AI Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Protein kinase C inhibits amyloid beta-peptide neurotoxicity by acting on members of the Wnt pathway garrido, JL; Godoy, J; Alvarez A.; Bronfman, M; Inestrosa, NC Article ISI FASEB JOURNAL (2002)
Vitamin E but not 17 beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant Muñoz FJ.; Opazo C.; Gil-Gomez G.; Tapia, G; Fernández V.; Valverde, MA; Inestrosa, NC Article ISI JOURNAL OF NEUROSCIENCE (2002)
Wnt signaling involvement in beta-amyloid-dependent neurodegeneration Inestrosa, NC; De Ferrari, GV; garrido, JL; Alvarez A.; Olivares, GH; Barría MI; Bronfman, M; Chacón MA Article ISI SCOPUS NEUROCHEMISTRY INTERNATIONAL (2002)
A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation De Ferrari, GV; Canales, MA; Shin, I; Weiner, LM; SILMAN, I; Inestrosa, NC Article ISI BIOCHEMISTRY (2001)
Interactions of laminin with the amyloid beta peptide. Implications for Alzheimer's disease Morgan C.; Inestrosa, NC Article ISI BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2001)
Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites De Ferrari, GV; Mallender, WD; Inestrosa, NC; ROSENBERRY, TL Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Acetylcholinesterase-amyloid-beta-peptide interaction and Wnt signaling involvement in A beta neurotoxicity Inestrosa, NC; Alvarez A.; Godoy, J; Reyes A.; De Ferrari, GV Article ISI ACTA NEUROLOGICA SCANDINAVICA (2000)
Amyloid-beta-peptide reduces copper(II) to copper(I) independent of its aggregation state Opazo C.; Ruiz, FH; Inestrosa, NC Article ISI BIOLOGICAL RESEARCH (2000)
Expression of alpha(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells Marzolo, MP; von Bernhardi R.; Bu, GJ; Inestrosa, NC Article ISI SCOPUS JOURNAL OF NEUROSCIENCE RESEARCH (2000)
Interaction of collagen-like peptide models of asymmetric acetylcholinesterase with glycosaminoglycans: Spectroscopic studies of conformational changes and stability Doss-Pepe, E; Deprez, P.; Inestrosa, NC; Brodsky, B Article ISI SCOPUS BIOCHEMISTRY (2000)
Interaction of the collagen-like tail of asymmetric acetylcholinesterase with heparin depends on triple-helical conformation, sequence and stability Deprez, P.; Doss-Pepe, E; Brodsky, B; Inestrosa, NC Article ISI SCOPUS BIOCHEMICAL JOURNAL (2000)
Molecular modeling of the collagen-like tail of asymmetric acetylcholinesterase Deprez, P.; Inestrosa, NC Article ISI SCOPUS PROTEIN ENGINEERING (2000)
The N-terminal tandem repeat region of human prion protein reduces copper: Role of tryptophan residues Ruiz, FH; Silva, E.; Inestrosa, NC Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein Ruiz, FH; Gonzalez, Y; Bodini, M; Opazo, C; Inestrosa, NC Article ISI JOURNAL OF NEUROCHEMISTRY (1999)
Mannose receptor is present in a functional state in rat microglial cells Marzolo M.P.; Inestrosa, N. C.; von Bernhardi R. Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1999)
Molecular modeling of the amyloid-beta-peptide using the homology to a fragment of triosephosphate isomerase that forms amyloid in vitro Contreras, CF; Canales, MA; Alvarez, A; De Ferrari, GV; Inestrosa, NC Article ISI PROTEIN ENGINEERING (1999)
Neurotoxicity of acetylcholinesterase amyloid beta-peptide aggregates is dependent on the type of A beta peptide and the AChE concentration present in the complexes Munoz, FJ; Inestrosa, NC Article ISI FEBS LETTERS (1999)
Neurotoxicity of acetylcholinesterase amyloid β-peptide aggregates is dependent on the type of Aβ peptide and the AChE concentration present in the complexes Muñoz, Francisco J.; Inestrosa, Nibaldo C. Article ISI FEBS LETTERS (1999)
PC12 and neuro 2a cells have different susceptibilities to acetylcholinesterase-amyloid complexes, amyloid25-35 fragment, glutamate, and hydrogen peroxide Calderón, Frances H.; Bonnefont, Andrea; Muñoz, Francisco J.; Fernández, Virginia; Videla, Luis A.; Inestrosa, Nibaldo C. Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1999)
Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase Munoz, FJ; Aldunate, R; Inestrosa, NC Article ISI NEUROREPORT (1999)
A major portion of synaptic basal lamina acetylcholinesterase is detached by high salt- and heparin-containing buffers from rat diaphragm muscle and Torpedo electric organ Casanueva, OI; Garcia-Huidobro, T; Campos, EO; Aldunate, R; Garrido, J; Inestrosa, NC Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (1998)
At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ Casanueva, OI; Deprez, P; Garcia-Huidobro, T; Inestrosa, NC Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1998)
Brain acetylcholinesterase promotes amyloid-beta-peptide aggregation but does not hydrolyze amyloid precursor protein peptides Campos, EO; Alvarez, A; Inestrosa, NC Article ISI NEUROCHEMICAL RESEARCH (1998)
Cellular and molecular basis of estrogen's neuroprotection - Potential relevance for Alzheimer's disease Inestrosa, NC; Marzolo, MP; Bonnefont, AB Article ISI MOLECULAR NEUROBIOLOGY (1998)
Crosslinking of amyloid-beta peptide to brain acetylcholinesterase Opazo, C; Inestrosa, NC Article ISI MOLECULAR AND CHEMICAL NEUROPATHOLOGY (1998)
Developmental regulation of mouse brain monomeric acetylcholinesterase Moreno, RD; Campos, EO; Dajas, F; Inestrosa, NC Article ISI INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (1998)
Estrogen protects neuronal cells from the cytotoxicity induced by acetylcholinesterase-amyloid complexes Bonnefort, AB; Munoz, FJ; Inestrosa, NC Article ISI FEBS LETTERS (1998)
Laminin blocks the assembly of wild type A beta and the Dutch variant peptide into Alzheimer's fibrils Bronfman, FC; Alvarez, A; Morgan, C; Inestrosa, NC Article ISI AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (1998)
Responses induced by tacrine in neuronal and non-neuronal cell lines De Ferrari, GV; von Bernhardi, R; Calderon, FH; Luza, SC; Inestrosa, NC Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1998)
Responses induced by tacrine in neuronal and non-neuronal cell lines. De Ferrari GV, von Bernhardi R, Calderón FH, Luza SC, Inestrosa NC. Article ISI J Neurosci Res (1998)
Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils Alvarez, Alejandra; Alarcón, Rodrigo; Opazo, Carlos; Campos, Eliseo O.; Muñoz, Francisco José; Calderón, Frances H.; Dajas, Federico; Gentry, Mary K.; Doctor, Bhupendra P.; De Mello, Fernando G.; Inestrosa, Nibaldo C. Article JOURNAL OF NEUROSCIENCE (1998)
Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro Calderon, FH; von Bernhardi, R; De Ferrari, G; Luza, S; Aldunate, R; Inestrosa, NC Article ISI MOLECULAR PSYCHIATRY (1998)
A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme Reyes, AE; Perez, DR; Alvarez, A; Garrido, J; Gentry, MK; Doctor, BP; Inestrosa, NC Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1997)
Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils Alvarez, A; Opazo, C; Alarcon, R; Garrido, J; Inestrosa, NC Article ISI JOURNAL OF MOLECULAR BIOLOGY (1997)
Abnormal development of the locomotor activity in yellow larvae of Drosophila: A cuticular defect? Inestrosa, NC; Sunkel, CE; Arriagada, J; Garrido, J; GodoyHerrera, R Article ISI GENETICA (1996)
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme Inestrosa, NC; Alvarez, A; Perez, CA; Moreno, RD; Vicente, M; Linker, C; Casanueva, OI; Soto, C; Garrido, J Article ISI NEURON (1996)
Amyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neuronal cell line Bronfman, FC; Fernandez, HL; Inestrosa, NC Article ISI EXPERIMENTAL CELL RESEARCH (1996)
Extracellular matrix regulates the amount of the ?-amyloid precursor protein and its amyloidogenic fragments Bronfman F.C.; Soto C.; Tapia L.; Tapia, V; Inestrosa, N. C. Article ISI JOURNAL OF CELLULAR PHYSIOLOGY (1996)
Laminin inhibits amyloid-beta-peptide fibrillation Bronfman, FC; Garrido, J; Alvarez, A; Morgan, C; Inestrosa, NC Article ISI NEUROSCIENCE LETTERS (1996)
Laminin inhibits amyloid-β-peptide fibrillation Bronfman, Francisca C.; Garrido, Jorge; Alvarez, Alejandra; Morgan, Carlos; Inestrosa, Nibaldo C. Article ISI Neuroscience Letters (1996)
Sprouting and abnormal contacts of nonmedullated axons, and deposition of extracellular material induced by the amyloid precursor protein (APP) and other protease inhibitors Moreno, R.D.; Inestrosa, N. C.; Alvarez J.; Culwell A.R. Article ISI BRAIN RESEARCH (1996)
Tetrameric (G4) acetylcholinesterase: structure, localization, and physiological regulation Fernandez, HL; Moreno, RD; INESTROSA, NC Article ISI JOURNAL OF NEUROCHEMISTRY (1996)
2 HEPARIN-BINDING DOMAINS ARE PRESENT ON THE COLLAGENIC TAIL OF ASYMMETRIC ACETYLCHOLINESTERASE DEPREZ, PN; INESTROSA, NC Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (1995)
Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-beta-peptides Alvarez, A; Bronfman, F; Perez, CA; Vicente, M; Garrido, J; Inestrosa, NC Article ISI NEUROSCIENCE LETTERS (1995)
Behavioral responses of Concholepas concholepas (Bruguiere, 1789) larvae to natural and artificial settlement cues and microbial films Rodriguez, SR; Riquelme, C; Campos, EO; Chavez, P; Brandan, E; Inestrosa, NC Article ISI BIOLOGICAL BULLETIN (1995)
EARLY AXONAL REGENERATION - REPRESSION BY SCHWANN-CELLS AND A PROTEASE TAPIA, M; INESTROSA, NC; ALVAREZ, J Article ISI EXPERIMENTAL NEUROLOGY (1995)
EFFECT OF PROTAMINE ON THE SOLUBILIZATION OF COLLAGEN-TAILED ACETYLCHOLINESTERASE - POTENTIAL HEPARIN-BINDING CONSENSUS SEQUENCES IN THE TAIL OF THE ENZYME DEPREZ, PN; SIGNORELLI, J; INESTROSA, NC Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (1995)
Mitosis of Schwann cells and demyelination are induced by the amyloid precursor protein and other protease inhibitors in the rat sciatic nerve Alvarez, J; Moreno, RD; INESTROSA, NC Article ISI The European Journal of Neuroscience (1995)
MITOSIS OF SCHWANN-CELLS AND DEMYELINATION ARE INDUCED BY THE AMYLOID PRECURSOR PROTEIN AND OTHER PROTEASE INHIBITORS IN THE RAT SCIATIC-NERVE ALVAREZ, J; MORENO, RD; INESTROSA, NC Article ISI EUROPEAN JOURNAL OF NEUROSCIENCE (1995)
PLATELETS ARE THE PRIMARY SOURCE OF AMYLOID BETA-PEPTIDE IN HUMAN BLOOD CHEN, M; INESTROSA, NC; ROSS, GS; FERNANDEZ, HL Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1995)
Platelets Are the Primary Source of Amyloid β-Peptide in Human Blood Chen, M.; Inestrosa, N.C.; Ross, G.S.; Fernandez, H.L. Article ISI Biochemical and Biophysical Research Communications (1995)
The -Helical to -Strand Transition in the Amino-terminal Fragment of the Amyloid -Peptide Modulates Amyloid Formation Soto, Claudio; Castaño, Eduardo M.; Frangione, Blas; Inestrosa, Nibaldo C. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (1995)
THE ALPHA-HELICAL TO BETA-STRAND TRANSITION IN THE AMINO-TERMINAL FRAGMENT OF THE AMYLOID BETA-PEPTIDE MODULATES AMYLOID FORMATION SOTO, C; CASTANO, EM; FRANGIONE, B; INESTROSA, NC Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (1995)
Two heparin-binding domains are present on the collagenic tail of asymmetric acetylcholinesterase Deprez, PN; INESTROSA, NC Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (1995)
BLOOD MARKERS IN ALZHEIMER-DISEASE - SUBNORMAL ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN LYMPHOCYTES AND ERYTHROCYTES INESTROSA, NC; ALARCON, R; ARRIAGADA, J; DONOSO, A; ALVAREZ, J; CAMPOS, EO Article ISI JOURNAL OF THE NEUROLOGICAL SCIENCES (1994)
METAMORPHOSIS OF LABORATORY-REARED LARVAE OF CONCHOLEPAS-CONCHOLEPAS (MOLLUSCA, GASTROPODA) INESTROSA, NC; Bustos, E; CAMPOS, EO; RODRIGUEZ, SR; PINTO, A Article ISI AQUACULTURE (1994)
MONOMERIC AMPHIPHILIC FORMS OF ACETYLCHOLINESTERASE APPEAR EARLY DURING BRAIN-DEVELOPMENT AND MAY CORRESPOND TO BIOSYNTHETIC PRECURSORS OF THE AMPHIPHILIC G(4) FORMS INESTROSA, NC; MORENO, RD; FUENTES, ME Article ISI NEUROSCIENCE LETTERS (1994)
SENSITIVITY OF ACETYLCHOLINESTERASE MOLECULAR-FORMS TO INHIBITION BY HIGH MGCL2 CONCENTRATION INESTROSA, NC; PEREZ, CA; SIMPFENDORFER, RW Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (1994)
Structural Determinants of the Alzheimer's Amyloid β-Peptide Soto, Claudio; Brañes, María Cecilia; Alvarez, Jaime; Inestrosa, Nibaldo C. Article ISI JOURNAL OF NEUROCHEMISTRY (1994)
A NEUROFILAMENT POLYPEPTIDE AND THE GLIAL FIBRILLARY ACIDIC PROTEIN SHARE COMMON EPITOPES IN THE VARIABLE REGION KRAUSS, RY; ALVAREZ, J; INESTROSA, NC Article ISI NEUROSCIENCE LETTERS (1993)
ACETYLCHOLINESTERASE CHANGES IN HEARTS WITH SINUS RHYTHM AND ATRIAL-FIBRILLATION GONZALEZ, RA; CAMPOS, EO; KARMELIC, C; MORAN, S; INESTROSA, NC Article ISI GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM (1993)
EXTRACELLULAR-MATRIX COMPONENTS AND AMYLOID IN NEURITIC PLAQUES OF ALZHEIMERS-DISEASE BRANDAN, E; INESTROSA, NC Article ISI GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM (1993)
NERVE REGENERATION IS IMPROVED BY INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND BASIC FIBROBLAST GROWTH-FACTOR (BFGF) VERGARA, J; MEDINA, L; MAULEN, J; INESTROSA, NC; ALVAREZ, J Article ISI RESTORATIVE NEUROLOGY AND NEUROSCIENCE (1993)
PLATELET OF ALZHEIMER PATIENTS - INCREASED COUNTS AND SUBNORMAL UPTAKE AND ACCUMULATION OF [C-14] 5-HYDROXYTRYPTAMINE INESTROSA, NC; ALARCON, R; ARRIAGADA, J; DONOSO, A; ALVAREZ, J Article ISI NEUROSCIENCE LETTERS (1993)
Platelet of Alzheimer patients: Increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine Inestrosa, Nibaldo C.; Alarcón, Rodrigo; Arriagada, Jorge; Donoso, Archibaldo; Alvarez, Jaime Article ISI Neuroscience Letters (1993)
A HIGH-MOLECULAR-WEIGHT PROTEOGLYCAN IS DIFFERENTIALLY EXPRESSED DURING DEVELOPMENT OF THE MOLLUSK CONCHOLEPAS-CONCHOLEPAS (MOLLUSCA, GASTROPODA, MURICIDAE) BRANDAN, E; GONZALEZ, M; INESTROSA, NC; TREMBLAY, C; URREA, R Article ISI JOURNAL OF EXPERIMENTAL ZOOLOGY (1992)
AMPHIPHILIC BEHAVIOR OF A BRAIN TETRAMERIC ACETYLCHOLINESTERASE FORM LACKING THE PLASMA-MEMBRANE ANCHORING DOMAIN FUENTES, ME; INESTROSA, NC Article ISI BRAIN RESEARCH (1992)
AXONAL SPROUTING INDUCED IN THE SCIATIC-NERVE BY THE AMYLOID PRECURSOR PROTEIN (APP) AND OTHER ANTIPROTEASES ALVAREZ, J; MORENO, RD; LLANOS, O; INESTROSA, NC; BRANDAN, E; COLBY, T; ESCH, FS Article ISI NEUROSCIENCE LETTERS (1992)
ISOLATION OF PROTEOGLYCANS SYNTHESIZED BY RAT-HEART - EVIDENCE FOR THE PRESENCE OF SEVERAL DISTINCT FORMS GONZALEZ, R; URREA, R; GONZALEZ, M; INESTROSA, NC; BRANDAN, E Article ISI GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM (1992)
A COMPARISON OF THE XENOPUS-LAEVIS OOCYTE ACETYLCHOLINESTERASE WITH THE MUSCLE AND BRAIN ENZYME SUGGESTS VARIATIONS AT THE POSTTRANSLATIONAL LEVEL MOYA, MA; FUENTES, ME; INESTROSA, NC Article ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY PHARMACOLOGY (1991)
CHARACTERIZATION OF ACETYLCHOLINESTERASE FROM HUMAN HEART AURICLES - EVIDENCE FOR THE PRESENCE OF A G-FORM SENSITIVE TO PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C GONZALEZ, R; CAMPOS, EO; MORAN, S; INESTROSA, NC Article ISI GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM (1991)
ASSOCIATION OF ACETYLCHOLINESTERASE WITH THE CELL-SURFACE INESTROSA, NC; PERELMAN, A Article ISI JOURNAL OF MEMBRANE BIOLOGY (1990)
CARRAGEENANS SOLUBILIZE ASYMMETRIC ACETYLCHOLINESTERASE FROM NICOTINIC CHOLINERGIC SYNAPSES VONBERNHARDI, R; AYAL, H; INESTROSA, NC Article ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY ENDOCRINOLOGY (1990)
DERMATAN SULFATE AND DE-SULFATED HEPARIN SOLUBILIZED COLLAGEN-TAILED ACETYLCHOLINESTERASE FROM THE RAT NEUROMUSCULAR-JUNCTION VONBERNHARDI, R; INESTROSA, NC Article ISI BRAIN RESEARCH (1990)
Motor nerve regulates muscle extracellular matrix proteoglycan expression Fadic, R; Brandan, E; Inestrosa, NC Article JOURNAL OF NEUROSCIENCE (1990)
PROTEOGLYCAN PRODUCTION IN DROSOPHILA EGG DEVELOPMENT - EFFECT OF BETA-D-XYLOSIDE ON PROTEOGLYCAN SYNTHESIS AND LARVAE MOTILITY CAMBIAZO, V; INESTROSA, NC Article ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (1990)
A SIMPLE ASSAY TO ESTIMATE THE ACETYLCHOLINESTERASE MOLECULAR-FORMS IN CRUDE EXTRACTS OF RAT SKELETAL-MUSCLE PERELMAN, A; INESTROSA, NC Article ISI ANALYTICAL BIOCHEMISTRY (1989)
ANTI-200 KDA NEUROFILAMENT ANTIBODY CROSS-REACTS WITH MICROTUBULE-ASSOCIATED PROTEIN-2 (MAP-2) ALLENDE, ML; KRAUSS, RY; TREMBLAY, C; ALVAREZ, J; INESTROSA, NC Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1989)
DISTRIBUTION AND ANCHORING OF MOLECULAR-FORMS OF ACETYLCHOLINESTERASE INESTROSA, NC; PERELMAN, A Article ISI TRENDS IN PHARMACOLOGICAL SCIENCES (1989)
NERVE REGULATION OF CLASS-I AND CLASS-II-ASYMMETRIC FORMS OF ACETYLCHOLINESTERASE IN RAT SKELETAL-MUSCLES FADIC, R; INESTROSA, NC Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1989)
PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C SOLUBILIZED G2 ACETYLCHOLINESTERASE FROM PLASMA-MEMBRANES OF CHROMAFFIN CELLS PRIETO, AL; FUENTES, ME; ARQUEROS, L; INESTROSA, NC Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1989)
A 13 KDA FRAGMENT IS RESPONSIBLE FOR THE HYDROPHOBIC AGGREGATION OF BRAIN G4 ACETYLCHOLINESTERASE FUENTES, ME; ROSENBERRY, TL; INESTROSA, NC Article ISI BIOCHEMICAL JOURNAL (1988)
A MEMBRANE-ASSOCIATED DIMER OF ACETYLCHOLINESTERASE FROM XENOPUS SKELETAL-MUSCLE IS SOLUBILIZED BY PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C INESTROSA, NC; FUENTES, ME; ANGLISTER, L; FUTERMAN, AH; SILMAN, I Article ISI NEUROSCIENCE LETTERS (1988)
AXONS GROW IN THE AGING RAT BUT FAST TRANSPORT AND ACETYLCHOLINESTERASE CONTENT REMAIN UNCHANGED INESTROSA, NC; ALVAREZ, J Article ISI BRAIN RESEARCH (1988)
CHANGES IN CONTRALATERAL SYNAPTIC ACETYLCHOLINESTERASE FOLLOWING MOTOR-NERVE SECTION IN RATS FADIC, R; SOZA, MA; INESTROSA, NC Article ISI NEUROSCIENCE LETTERS (1988)
Characterization of a tetrameric G4 form of acetylcholinesterase from bovine brain: a comparison with the dimeric G2 form of the electric organ Fuentes, MariaElena; Inestrosa, NibaldoC. Article Molecular and Cellular Biochemistry (1988)
BIOSYNTHESIS OF THE NEUROFILAMENT HEAVY SUBUNIT IN XENOPUS OOCYTES MICROINJECTED WITH RAT-BRAIN POLY(A)+ RNA CROSS, D; ALLENDE, ML; KRAUSS, RY; FUENTES, ME; KALTWASSER, G; ALVAREZ, J; INESTROSA, NC Article ISI MOLECULAR BIOLOGY REPORTS (1987)
CO-SOLUBILIZATION OF ASYMMETRIC ACETYLCHOLINESTERASE AND DERMATAN SULFATE PROTEOGLYCAN FROM THE EXTRACELLULAR-MATRIX OF RAT SKELETAL-MUSCLES BRANDAN, E; INESTROSA, NC Article ISI FEBS LETTERS (1987)
EFFECT OF PHENYTOIN ON CYTOSKELETAL PROTEIN-PHOSPHORYLATION AND NEURONAL STRUCTURE IN THE RAT SENSORY CORTEX RUIZ, G; FLORES, OG; GONZALEZPLAZA, R; INESTROSA, NC Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1987)
GLYCOSAMINOGLYCAN COMPOSITION OF ELECTRIC ORGAN BASEMENT-MEMBRANES INESTROSA, NC; NADER, HB; GARRIDO, J; SAMPAIO, LO; BRANDAN, E; DIETRICH, CP Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1987)
ISOLATION OF THE HEPARAN-SULFATE PROTEOGLYCANS FROM THE EXTRACELLULAR-MATRIX OF RAT SKELETAL-MUSCLE BRANDAN, E; INESTROSA, NC Article ISI JOURNAL OF NEUROBIOLOGY (1987)
SYNTHESIS AND EXPRESSION OF FUNCTIONAL ANGIOTENSIN-II RECEPTORS IN XENOPUS OOCYTES INJECTED WITH RAT-BRAIN MESSENGER-RNA CROSS, D; CIFUENTES, F; HUIDOBROTORO, JP; VIO, CP; INESTROSA, NC Article ISI MOLECULAR BRAIN RESEARCH (1987)
THE SENSORY PROJECTIONS OF DROSOPHILA MUTANTS WHICH SHOW ABNORMAL WING FORMATION OR FLYING BEHAVIOR INESTROSA, NC; SUNKEL, C; ARRIAGADA, J Article ISI BRAIN RESEARCH (1987)
HEPARIN-ACETYLCHOLINESTERASE INTERACTION - SPECIFIC DETACHMENT OF CLASS I-A FORMS AND BINDING OF CLASS I AND CLASS-II-A FORMS TO HEPARIN-AGAROSE BRANDAN, E; LLONA, I; INESTROSA, NC Article ISI NEUROCHEMISTRY INTERNATIONAL (1986)
PUTATIVE GLUTAMATE RECEPTORS IN MEMBRANES OBTAINED FROM HEADS OF DROSOPHILA-MELANOGASTER FIEDLER, JL; INESTROSA, NC; BUSTOS, G Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1986)
The synaptic form of acetylcholinesterase binds to cell-surface heparan sulfate proteoglycans Brandan, E.; Inestrosa, N. C. Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1986)
THE SYNAPTIC FORM OF ACETYLCHOLINESTERASE BINDS TO CELL-SURFACE HEPARAN-SULFATE PROTEOGLYCANS BRANDAN, E; INESTROSA, NC Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (1986)
ANCHORAGE OF COLLAGEN-TAILED ACETYLCHOLINESTERASE TO THE EXTRACELLULAR-MATRIX IS MEDIATED BY HEPARAN-SULFATE PROTEOGLYCANS BRANDAN, E; MALDONADO, M; GARRIDO, J; INESTROSA, NC Article ISI JOURNAL OF CELL BIOLOGY (1985)
ATYPICAL DISTRIBUTION OF ASYMMETRIC ACETYLCHOLINESTERASE IN MUTANT PC12 PHEOCHROMOCYTOMA CELLS LACKING A CELL-SURFACE HEPARAN-SULFATE PROTEOGLYCAN INESTROSA, NC; MATTHEW, WD; REINESS, CG; HALL, ZW; REICHARDT, LF Article ISI JOURNAL OF NEUROCHEMISTRY (1985)
INTERACTION OF HEPARIN WITH MULTIMOLECULAR AGGREGATES OF ACETYLCHOLINESTERASE TORRES, JC; INESTROSA, NC Article ISI CELLULAR AND MOLECULAR NEUROBIOLOGY (1985)
MEMBRANE-BOUND FORM OF ACETYLCHOLINESTERASE ACTIVATED DURING POSTNATAL-DEVELOPMENT OF THE RAT SOMATOSENSORY CORTEX INESTROSA, NC; RUIZ, G Article ISI DEVELOPMENTAL NEUROSCIENCE (1985)
16S-ACETYLCHOLINESTERASE OF THE EXTRACELLULAR-MATRIX IS ASSEMBLED WITHIN MOUSE MUSCLE-CELLS IN CULTURE INESTROSA, NC Article ISI BIOCHEMICAL JOURNAL (1984)
ACETYLCHOLINESTERASE IS FUNCTIONAL IN EMBRYONIC RAT MUSCLE BEFORE ITS ACCUMULATION AT THE SITES OF NERVE MUSCLE CONTACT ZISKINDCONHAIM, L; INESTROSA, NC; HALL, ZW Article ISI DEVELOPMENTAL BIOLOGY (1984)
Acetylcholinesterase is functional in embryonic rat muscle before its accumulation at the sites of nerve-muscle contact Ziskind-Conhaim, Lea; Inestrosa, Nibaldo C.; Hall, Zach W. Article ISI Developmental Biology (1984)
ACYL-COA SYNTHETASE AND THE PEROXISOMAL ENZYMES OF BETA-OXIDATION IN HUMAN-LIVER - QUANTITATIVE-ANALYSIS OF THEIR SUBCELLULAR-LOCALIZATION BRONFMAN, M; INESTROSA, NC; NERVI, FO; LEIGHTON, F Article ISI BIOCHEMICAL JOURNAL (1984)
AGE-RELATED RESPONSES OF SKELETAL-MUSCLE AFTER ECTOPIC INNERVATION, WITH PARTICULAR REFERENCE TO 16S ACETYLCHOLINESTERASE, IN ADULT-RATS MALDONADO, M; RAMIREZ, BU; RUIZ, G; YAMUY, J; INESTROSA, NC Article ISI JOURNAL OF NEUROCHEMISTRY (1984)
BINDING OF THE ASYMMETRIC FORMS OF ACETYLCHOLINESTERASE TO HEPARIN BRANDAN, E; INESTROSA, NC Article ISI BIOCHEMICAL JOURNAL (1984)
SUBCELLULAR-LOCALIZATION OF ACETYLCHOLINESTERASE MOLECULAR-FORMS IN ENDPLATE REGIONS OF ADULT MAMMALIAN SKELETAL-MUSCLE FERNANDEZ, HL; INESTROSA, NC; STILES, JR Article ISI NEUROCHEMICAL RESEARCH (1984)
THE ELECTRIC ORGAN OF DISCOPYGE-TSCHUDII - ITS INNERVATED FACE AND THE BIOLOGY OF ACETYLCHOLINESTERASE MENDEZ, B; GARRIDO, J; MALDONADO, M; JAKSIC, FM; INESTROSA, NC Article ISI CELLULAR AND MOLECULAR NEUROBIOLOGY (1984)
DEVELOPMENTAL REGULATION OF 16S-ACETYLCHOLINESTERASE AND ACETYLCHOLINE-RECEPTORS IN A MOUSE MUSCLE-CELL LINE INESTROSA, NC; MILLER, JB; SILBERSTEIN, L; ZISKINDCONHAIM, L; HALL, ZW Article ISI EXPERIMENTAL CELL RESEARCH (1983)
HEPARIN SOLUBILIZES ASYMMETRIC ACETYLCHOLINESTERASE FROM RAT NEUROMUSCULAR-JUNCTION TORRES, JC; INESTROSA, NC Article ISI FEBS LETTERS (1983)
INCREASE OF MUSCLE PEROXISOMAL ENZYMES AND MYOTONIA INDUCED BY NAFENOPIN, A HYPOLIPIDEMIC DRUG BEHRENS, MI; SOZA, MA; INESTROSA, NC Article ISI MUSCLE NERVE (1983)
NEURAL 16S ACETYLCHOLINESTERASE IS SOLUBILIZED BY HEPARIN TORRES, JC; BEHRENS, MI; INESTROSA, NC Article ISI BIOCHEMICAL JOURNAL (1983)
THE A12 ACETYLCHOLINESTERASE AND POLYPEPTIDE COMPOSITION OF ELECTRIC ORGAN BASAL LAMINA OF ELECTROPHORUS AND SOME TORPEDINAE FISHES INESTROSA, NC; MENDEZ, B Article ISI CELL BIOCHEMISTRY AND FUNCTION (1983)
ANEURAL MUSCLE-CELL CULTURES MAKE SYNAPTIC BASAL LAMINA COMPONENTS SILBERSTEIN, L; INESTROSA, NC; HALL, ZW Article ISI NATURE (1982)
ASSOCIATION OF THE SYNAPTIC FORM OF ACETYLCHOLINESTERASE WITH EXTRACELLULAR-MATRIX IN CULTURED MOUSE MUSCLE-CELLS INESTROSA, NC; SILBERSTEIN, L; HALL, ZW Article ISI CELL (1982)
GANGLIOSIDES AND SIALOGLYCOPROTEINS IN NORMAL AND DENERVATED RAT DIAPHRAGM MUSCLE INESTROSA, NC; FERNANDEZ, HL Article ISI MUSCLE NERVE (1982)
ACETYLCHOLINESTERASE AGGREGATES IN A NEWLY FORMED MOTOR-NERVE SMOOTH-MUSCLE JUNCTION MENDEZ, B; INESTROSA, NC Article ISI BRAIN RESEARCH BULLETIN (1981)
Cellular localization of the molecular forms of acetylcholinesterase in rat pheochromocytoma PC12 cells treated with nerve growth factor Inestrosa, NC; Reiness, CG; Reichardt, LF; Hall, ZW Article JOURNAL OF NEUROSCIENCE (1981)
Purification of the peroxisomal fatty acyl-CoA oxidase from rat liver Inestrosa, Nibaldo C.; BRONFMAN, Miguel; Leighton, Federico Article ISI Biochemical and Biophysical Research Communications (1980)
PURIFICATION OF THE PEROXISOMAL FATTY ACYL-COA OXIDASE FROM RAT-LIVER INESTROSA, NC; BRONFMAN, M; LEIGHTON, F Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1980)
ACETYLCHOLINESTERASE LIKE THAT OF SKELETAL-MUSCLE IN SMOOTH-MUSCLE RE-INNERVATED BY A MOTOR-NERVE INESTROSA, NC; MENDEZ, B; LUCO, JV Article ISI NATURE (1979)
DETECTION OF PEROXISOMAL FATTY ACYL-COENZYME-A OXIDASE ACTIVITY INESTROSA, NC; BRONFMAN, M; LEIGHTON, F Article ISI BIOCHEMICAL JOURNAL (1979)
FATTY-ACID OXIDATION BY HUMAN-LIVER PEROXISOMES BRONFMAN, M; INESTROSA, NC; LEIGHTON, F Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1979)
PROPERTIES OF FATTY ACYL-COA OXIDASE FROM RAT-LIVER, A PEROXISOMAL FLAVOPROTEIN INESTROSA, NC; BRONFMAN, M; LEIGHTON, F Article ISI LIFE SCIENCES (1979)
EFFECT OF DENERVATION AND OF AXOPLASMIC-TRANSPORT BLOCKAGE ON INVITRO RELEASE OF MUSCLE ENDPLATE ACETYLCHOLINESTERASE INESTROSA, NC; RAMIREZ, BU; FERNANDEZ, HL Article ISI JOURNAL OF NEUROCHEMISTRY (1977)
IS THERE A CORRESPONDENCE BETWEEN HALF-LIVES OF MOTOR ENDPLATE ACETYLCHOLINESTERASE AND JUNCTIONAL ACETYLCHOLINE RECEPTORS INESTROSA, NC; FERNANDEZ, HL Article ISI NEUROSCIENCE LETTERS (1977)
ACTIN-LIKE FILAMENTS IN SYNAPTOSOMES DETECTED BY HEAVY-MEROMYOSIN BINDING INESTROSA, NC; FERNANDEZ, HL; GARRIDO, J Article ISI NEUROSCIENCE LETTERS (1976)
Muscle enzymatic changes induced by blockage of axoplasmic transport Inestrosa, N. C.; Fernandez, H. L. Article JOURNAL OF NEUROPHYSIOLOGY (1976)
ROLE OF AXOPLASMIC-TRANSPORT IN NEUROTROPHIC REGULATION OF MUSCLE END PLATE ACETYLCHOLINESTERASE FERNANDEZ, HL; INESTROSA, NC Article ISI NATURE (1976)
Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model. Bastías-Candia S, Zolezzi JM, Inestrosa NC. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY


The activation of the(Pro)renin receptor (PRR) stimulates fibrotic factors expression independent of b-catenin signaling pathway in collecting duct cells Cuevas, C; González A; Inestrosa, N; Vio, C; Prieto, M Abstract ISI FASEB JOURNAL (2015)
Andrographolide activates the Wnt pathway and modulates the APP processing by direct inhibiton of GSK3 beta Tapia, CC; Mejías C.; Bustamante, H; Burgos P.; Inestrosa, NC Abstract ISI FASEB JOURNAL (2013)
Effect of hydrogen peroxide on apoptosis in Caenorhabditis elegans dopaminergic neurons Gorenberg, E; Roadcloud, E; Quinn, T; Ortiz J.; Minniti A; Inestrosa, NC; Kohn, RE Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
Activation of Brain Wnt signaling in vivo: Effect on LTP and Neurogenesis Inestrosa, NC Abstract ISI FASEB JOURNAL (2012)
Frizzled receptors mediate the postsynaptic effects of Wnt-5a in hippocampal neurons Ramirez, VT; Varela-Nallar, L; Inestrosa, NC Abstract ISI JOURNAL OF NEUROCHEMISTRY (2012)
Nicotine prevents synaptic impairment induced by A beta oligomers through alpha 7-nicotinic ACh receptor activation Aranguiz, F; Farías G.; Inestrosa, NC Abstract ISI JOURNAL OF NEUROCHEMISTRY (2012)
Role of Wnt signaling in the postsynaptic development in hippocampal neurons Inestrosa, NC; Varela-Nallar, L Abstract ISI JOURNAL OF NEUROCHEMISTRY (2012)
Anti-P Autoantibodies Enhance Cytosolic Calcium and Neurotransmission in Hippocampal Neurons by Cross-Reacting with Cell Surface NSPA Segovia-Miranda, F; Parodi, J; Serrano, F; Escobedo N; Bravo-Zehnder, M; Larrain, J; Massardo, L; Valenzuela, D; Zamorano P.; Inestrosa, N; González A Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2011)
c-Abl inhibition decreases the levels of Amyloid beta peptide in plasma of Alzheimer transgenic mice. Estrada, LD; Chamorro, D; Inestrosa, NC; Alvarez, AR Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2011)
Role of hippocampal P2X7 receptors in the release of NO by ATP and related nucleotides Wilson, IMP; Godoy, J; Inestrosa, N; Huidobro-Toro, JP Abstract ISI PURINERGIC SIGNALLING (2010)
Anti-P antibodies impair memory in mice Bravo-Zehnder, M; Achurra P.; Toledo, E.; Segovia, F; Inestrosa, N; Massardo, L; González A Abstract ISI ARTHRITIS AND RHEUMATISM (2008)
Peroxisomal proliferation prevents beta-amyloid-neurotoxicity in rat hippocampal neurons Quintanilla, RA; Godoy JA; Toro, A.; Santos MJ; Inestrosa, NC Abstract ISI JOURNAL OF NEUROCHEMISTRY (2005)
AChE inhibitors, amyloid-induced neurotoxicity and the Wnt pathway Inestrosa, NC; Colombres M. Abstract ISI NEUROBIOLOGY OF AGING (2004)
ApoER2 associates to different lipid rafts depending on the cell context and is endocytosed by a clathrin-mediated process involving Dab2 Cuitino, L; Matute, R.; Erranz B.; Guojun, B; Inestrosa, NC; Marzolo, M Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2004)
Selective M1 muscarinic agonists as potential disease modifiers for Alzheimer disease (AD) Fisher, A; Brandeis, R; Pittel, Z; Inestrosa, N; Farías G.; Sparks, DL; Hartmann T.; Bons, N Abstract ISI NEUROBIOLOGY OF AGING (2004)
The therapeutic potential of MI muscarinic agonists in Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) Fisher, A; Pittel, Z; Brandeis, R; Beach, TG; Sparks, DL; Hartmann T.; Farias GG.; Bons, N; Bar-Ner, N; Inestrosa, NC Abstract ISI NEUROBIOLOGY OF AGING (2004)
Ethanol specifically decreases PPAR beta MRNA and protein in B12 oligodendrocyte-like cells Leisewitz AV.; Jung JE; Perez-Alzola, P; Fuenzalida, KM; Inestrosa, NC; Bronfman, M Abstract ISI JOURNAL OF NEUROCHEMISTRY (2002)
Neuroprotective properties of copper binding fragments of amyloid precursor protein and prion Inestrosa, NC; Chacon M.; Barría MI; Varela-Nallar, L; Opazo C. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2002)
Neuroprotective properties of copper binding fragments of APP and PrP against copper toxicity Chacon M.; Barría MI; Inestrosa, N Abstract ISI NEUROBIOLOGY OF AGING (2002)
PPAR gamma activators induce differentiation of B12 oligodendrocyte-like cells and rat spinal cord oligodendrocytes Roth AD; Leisewitz AV.; Inestrosa, NC; Bronfman, M Abstract ISI JOURNAL OF NEUROCHEMISTRY (2002)
Regulation of prion protein gene expression by heavy metals Varela-Nallar, L; Cuitino, L; Sagal, JP; Inestrosa, NC Abstract ISI JOURNAL OF NEUROCHEMISTRY (2002)
Acetylcholinesterase and beta-amyloid interactions Inestrosa, NC Abstract ISI JOURNAL OF NEUROCHEMISTRY (2001)
Amyloid-beta-peptide-acetylcholinesterase complexes and Alzheimer's disease Inestrosa, NC; De Ferrari, GV; Muñoz FJ.; Reyes, AE Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)


In memoriam - Dr. Joaquin Luco Valenzuela - 1913-2002 Inestrosa, NC BiographicalItem ISI BIOLOGICAL RESEARCH (2003)


Comprehensive overview of Alzheimer’s disease neurodegeneration, from amyloid-beta to neuroinflammatory modulation Zolezzi, Juan M.; Inestrosa, Nibaldo C.; Aranda-Abreu, Gonzalo BookSection (2017)
PSD-95 (Postsynaptic Density Protein-95) Vallejo, Daniela; Inestrosa, Nibaldo C.; Choi, Sangdun BookSection (2017)
Inhibitory effects of β-amyloid aggregates on synaptic transmission in hippocampal neurons. Aguayo, Luis G; Parodi, Jorge; Sepúlveda, Fernando J.; Roa, Jorge; Opazo, Carlos; Bernhardi, RV; Inestrosa, NC BookSection (2008)
Zn 2+ -protein interactions in normal brain physiology and neuropathology. Opazo, Carlos; Castro, Patricio; Waldron, J; Parodi, Jorge; Fuentealaba, Jorge; Aguayo, Luis; Bernhardi, RV; Inestrosa, NC BookSection (2008)


New discoveries on the hyperforin derivative, tetrahydrohyperforin: Closer to an Alzheimer'S disease treatment? Montecinos-Oliva, C; Tapia-Rojas, C; Burgos, P.V.; Inestrosa, N. C. BookWhole SCOPUS Hypericum: Botanical Sources, Medical Properties and Health Effects (2015)
Monitoring mitochondrial membranes permeability in live neurons and mitochondrial swelling through electron microscopy analysis Arrázola M.S.; Inestrosa, N. C. BookWhole SCOPUS Neuronal Cell Death: Methods and Protocols (2014)
Role of Alzheimer's ?-Amyloid on Wnt signaling Inestrosa, N. C.; Grabowski C.; Arrazola M; Varela-Nallar L.; Toledo E.M. BookWhole SCOPUS Protein Misfolding Disorders: A Trip into the ER (2009)
Las incomunicaciones del Alzheimer Inestrosa, Nibaldo C. BookWhole (2007)
Alzheimer’s Disease; Acetylcholinesterase Interaction with Alzheimer Amyloid β Inestrosa, Nibaldo C; Sagal Juan Paulo; Colombres Marcela; Harris, Robin; Farenholz Falk BookWhole (2005)


EL APORTE DE LUCO A LA NEUROCIENCIA CHILENA Nibaldo C. Inestrosa ComunicacionBreve SCIELO BIOLOGICAL RESEARCH (2003)


Deletion of the gene encoding for the enzyme Methionine sulphoxide reductase A increases the toxicity of A beta (1-42) in an in vivo model. Minniti A; Inestrosa, N; Aldunate, R ConferencePaper ISI NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2009 (2009)
Effects of copper on A beta-induced pathological features in Caenorhabditis elegans. Minniti A; Rebolledo, D; Inestrosa, N ConferencePaper ISI NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2009 (2009)
Expression of Wnt receptors, frizzled, in rat neuronal cells Chacón MA; Columbres, M; Inestrosa, NC ConferencePaper ISI ADVANCES IN ALZHEIMER'S AND PARKINSON'S DISEASE: INSIGHTS, PROGRESS, AND PERSPECTIVES (2008)
Acetylcholinesterase-amyloid-?-peptide interaction: Effect of Congo Red and the role of the Wnt pathway Inestrosa, N. C.; Alvarez A.; Dinamarca M.C.; PÃ©rez-Acle T.; Colombres M. ConferencePaper SCOPUS CURRENT ALZHEIMER RESEARCH (2005)
Modulation of intracellular amyloid-beta-peptide aggregation by copper in Caenorhabditis elegans Minniti A; Grez, P; Opazo C.; Volitakis I.; Cherny R.; Masters C.; Bush, A; Inestrosa, N ConferencePaper ISI New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005 (2005)
Peroxisomal proliferation prevents beta-amyloid neurodegeneration Santos MJ; Quintanilla, RA; Godoy JA; Toro, A.; Inestrosa, NC ConferencePaper ISI New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005 (2005)
Molecular interactions of acetylcholinesterase with senile plaques Inestrosa, N. C.; Alarcon, R ConferencePaper ISI JOURNAL OF PHYSIOLOGY-PARIS (1998)


Activation of Wnt signaling by Andrographolide reduces the neuropathology presented in a model of sporadic Alzheimer´s Disease Lindsay, C; Inestrosa, NC ConferencePoster (2016)
ANDROGRAPHOLIDE RECOVERS COGNITIVE IMPAIRMENT IN A NATuRAL MODEL OF ALzHEIMER’S DISEASE (OCTODON DEGUS) Rivera, D; Lindsay, C; Bozinovic, F; Inestrosa, NC ConferencePoster (2016)
ANDROGRAPHOLIDE RESTORE COGNITIVE PERFORMANCE IN AGED OCTODON DEGUS Rivera, D; Bozinovic, F; Inestrosa, NC ConferencePoster (2016)
Role of Wnt-5a on GluN2B expression Ramos-Fernandez, E; Inestrosa, Nibaldo C. ConferencePoster (2016)
The non canonical ligand Wnt5a decreases mitochondrial motility and fusion in neuronal cells Silva-Álvarez, C; Eisner, V; Cisternas, P; Inestrosa, NC ConferencePoster (2016)
Wnt signaling effects on differentiation and development of neural progenitor cells derived from adult hippocampu Arredondo, S; Jensen-Flores, J; Guerrero, F; Inestrosa, NC; Varela-Nallar, L ConferencePoster (2016)
WNT SIGNALING INHIBITION CORRELATES WITH AN INCREASE IN ALzHEIMER ́S NEuROPATHOLOGY IN A NATURAL MODEL (OCTODON DEGUS) Lindsay, C; Rivera, D; Bozinovic, F; Inestrosa, NC ConferencePoster (2016)
The diterpenes Ferruginol, Jatrophone and Junicedric acid as neuroprotective agents against Aβ oligomers-induced damage Lindsay, CB; Theoduloz, C; Schmeda-Hirschmann, G; INESTROSA, NC ConferencePoster (2015)
The induction of hypothyroidism in early stagestriggers a decrease in the cognitive performance and hippocampus plasticity Salazar, P; Cisternas, P; Silva-Álvarez, C; Codoceo, JF; Inestrosa, NC ConferencePoster (2015)
The non canonical Wnt signaling modulates nitochondrial fusion in hippocampal neurons Silva-Alvarez, C; Eisner, V.; Inestrosa, NC ConferencePoster (2015)
The Wnt signaling pathways modulates mitochondrial fusion in hippocampal neurons Silva-Álvarez, C; Eisner, V; Inestrosa, NC ConferencePoster (2015)
WNT SIGNALING PREVENTS MITOCHONDRIAL MEMBRANE PERMEABILITY INDUCED BY AMYLOID-BETA OLIGOMERS, THROUGH THE PERMEABILITY TRANSITION PORE INHIBITION IN HIPPOCAMPAL NEURONS Arrázola, MS; Inestrosa, NC ConferencePoster (2015)
Wnt-3a metformin and rapamycin activity in the ampk-mTOR pathway in hippocampal neurons Ríos, JA; Inestrosa, NC ConferencePoster (2015)
Exo70 drives synaptogenesis and modulates dendrite morphology in dissociated hippocampal neurons Lira, M; Cruz, Y; García, J; Leal-Ortiz, S; Torres, V; Inestrosa, NC ConferencePoster (2014)
Frizzled- 1 receptor regulates neurogenesis in the hippocampus of adult mouse Mardones, M; Bustamante, D; Andaur, G; Varas-Godoy, M; Inestrosa, NC ConferencePoster (2014)
Impact of the Wnt non-canonical signaling pathway on AMPA receptors synaptic enrichment Montecinos-Oliva, C; Hafner, AS; Choquet, D; Inestrosa, NC ConferencePoster (2014)
Inhibition of canonical Wnt Signaling induces an increase in the Aβ levels and cognitive impairment in both wild-type and J20 mice model of Alzheimer disease Tapia-Rojas, C; Inestrosa, NC ConferencePoster (2014)
Metabolic syndrome induces a specific cognitive failure and alteration in hippocampus activity Cisternas, P; Lambert. C; Vio, C; Inestrosa, NC ConferencePoster (2014)
Mitochondrial structure alterations in Alzheimer's Arrázola, MS; Inestrosa, NC ConferencePoster (2014)
Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons Quintanilla, R; Godoy, J; von Bernhardi, R; Inestrosa, NC; Johnson, G ConferencePoster (2014)
The activation of the Wnt signaling modulates the function and mitochondrial dynamics in hippocampal neurons Silva-Álvarez, C; Inestrosa, NC ConferencePoster (2014)
THE GPCR RECEPTOR FRIZZLED-9 REGULATES DENDRITIC SPINE FORMATION GENERATED BY WNT-5A THROUGH G ALPHA O ACTIVATION Ramirez, VT; Ramos-Fernandez, E; Inestrosa, NC ConferencePoster (2014)
Transcriptional inhibitions of canonical Wnt signaling generate changes in the synapsis structure Ureta, R; Tapia-Rojas, C; INESTROSA, NC ConferencePoster (2014)
Wnt pathway modulates glucose metabolism in neurons: Role in Alzheimer`s disease Cisternas, P; Salazar, P; Vio, C; Inestrosa, NC ConferencePoster (2014)
Wnt-5a/Frizzled-9 regulates dendritic spine formation through Gαo and Gβγ stimulation Ramirez, VT; Ramos-Fernandez, E; Inestrosa, NC ConferencePoster (2014)
Wnt5a modulates mitochondrial distribution into synapses, regulating the dendritic spines morphology in hippocampal slices Arrázola, MS; Ordenes, D; Inestrosa, NC ConferencePoster (2014)
Wnt5a modulates mitochondrial dynamics through Drp1 activation in hippocampal neurons Silva-Álvarez, C; Inestrosa, NC ConferencePoster (2014)
Wnt5a modulates the postsynaptic density of dendritic spines and the distribution of mitochondria to the synapse in neurons from hippocampal slices Arrázola, MS; Ordenes, D; Inestrosa, NC ConferencePoster (2014)
Acute depletion of GSK-3 modulates lysosomal biogenesis leading to a reduction in amyloid precursor protein (APP) levels Barraza, R; Cavieres, V; Burgos, P; Inestrosa, NC ConferencePoster (2013)
Andrographolide activates the Wnt pathway and modulates the APP processing by direct inhibiton of GSK3β Tapia-Rojas, C; Mejías, C; Bustamante, H; Burgos, P; Inestrosa, NC ConferencePoster (2013)
Andrographolide increases cell proliferation and the generation of new neurons in the adult hippocampus Arredondo, S; Tapia-Rojas, C; Inestrosa, NC ConferencePoster (2013)
BDNF is expressed in a Wnt/β-catenin-dependent manner in hippocampal neurons and HT-22 cell line Mejías-Reyes, C; Inestrosa, NC ConferencePoster (2013)
Canonical Wnt/-catenin signaling stimulates the expression of fibrotic markers and triggers the disorganization of the primary cilium structure in MDCK cells Cisternas, P; Vio, C; Inestrosa, NC ConferencePoster (2013)
Chronic treatment of wild-type mice with high doses of methionine induces neurodegeneration Tapia-Rojas, C; Montecinos-Oliva, C; Lindsay, C; Hirsch, S; Inestrosa, NC ConferencePoster (2013)
Lithium induces changes in the neuronal activity and distribution of the Wnt pathway components Ureta, R; Oliva, C; Inestrosa, NC ConferencePoster (2013)
Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation Godoy, JA; Inestrosa, NC ConferencePoster (2013)
Non-canonical Wnt signaling increases AMPA receptor clusters in hippocampal neurons Montecinos-Oliva, C; Inestrosa, NC ConferencePoster (2013)
Octodon degu: brain evidence of the oxidative and metabolic stress age dependent related with Alzheimer-like pathology Rios, JA; Tapia-Rojas, C; Inestrosa, NC ConferencePoster (2013)
Regional distribution of Wnt components can explain differential effect of Lithium along ventro-dorsal entorhinal-hippocampal axis Oliva, C; Ureta, R; Inestrosa, NC ConferencePoster (2013)
Regulation of PSD-95 palmitoylation and APT-1 expression by Wnt signaling pathways in hippocampal neurons Codoceo, JF; Cao, T; Inestrosa, NC ConferencePoster (2013)
Role of canonical Wnt signaling in age-related neurodegeneration in the CNS of Octodon degu Carvajal, F; Ríos, JA; Tapia-Rojas, C; Retamales, R; Godoy, JA; Inestrosa, NC ConferencePoster (2013)
Role of Gαi/0 activation in Wnt-5a non-canonical pathway and dendritic spine formation in hippocampal neurons Ramirez, VT; Inestrosa, NC ConferencePoster (2013)
Role of the Wnt receptor Frizzled-1 in adult hippocampal neurogenesis Andaur, G; Henríquez, J; Varas-Godoy, M; Inestrosa, NC ConferencePoster (2013)
Role of Wnt-5a and Aβ in the GluN2B expression Ramos-Fernandez, E; Muñoz, F; Inestrosa, NC ConferencePoster (2013)
Secreted Frizzled Related Protein-2 (sFRP2) is reduced during events of memory and learning, facilitating long-term depression (LTD) induction Serrano, F; Tapia-Rojas, C; Inestrosa, NC ConferencePoster (2013)
Time-dependent control of ROCK2 and SYNGAP1 by Wnt5a in hippocampal neurons Codoceo, JF; Inestrosa, NC ConferencePoster (2013)
Wn5a ligand activates the mitochondrial fission protein Drp1 in hippocampal neurons Ordenes, D; Inestrosa, NC ConferencePoster (2013)
Wnt-5a acts through G!i/0 to regulate dendritic spine formation in hippocampal neurons Ramirez, VT; Ordenes, D; Serrano, F; Inestrosa, NC ConferencePoster (2013)
Wnt/Ca2+ signaling pathway modulates mitochondrial dynamics in hippocampal neurons Silva-Álvarez, C; Ordenes, D; Godoy, JA; Arrázola, MS; Inestrosa, NC ConferencePoster (2013)
Wnt3a ligand prevents mitochondrial permeability transition pore opening induced by Aβ oligomers Arrázola, MS; Inestrosa, NC ConferencePoster (2013)
Wnt5a regulates expression of ROCK2 and SYNGAP1 through Mir-101b in rat hippocampal neurons Codoceo, JF; Inestrosa, NC ConferencePoster (2013)
Andrographolide activates the Wnt pathway and modulates the APP processing possibly by direct inhibition of GSK3β Tapia-Rojas, C; Bustamante, H; Burgos, P; Inestrosa, NC ConferencePoster (2012)
Angiotensin II induces fibrosis in kidney tubule-epithelial cells via Wnt/beta-catenin signaling pathway Cuevas, C; Gonzáles, A; Inestrosa, NC; Vio, C; Prieto, M ConferencePoster (2012)
Chronic hypoxia and tetrahydrohiperforin stimulates hippocampal neurogenesis in a mice model of Alzheimer’s disease Varela-Nallar, L; Abbott, AC; Rojas-Abalos, M; Moya, EA; Iturriaga, R; Inestrosa, NC ConferencePoster (2012)
Fine tuning of Wnt signaling pathways in spontaneous network activity in the entorhinal hippocampal loop Oliva, C; Inestrosa, NC ConferencePoster (2012)
Frizzled receptors in progenitor and immature neurons of the adult hippocampus Varela-Nallar, L; Calderon, C; Toledo, E; Inestrosa, NC ConferencePoster (2012)
PSD-95 suppresses dendritic arbor development in mature hippocampal neurons by occluding synaptic insertion of NR2B-NMDA receptors Campos, M; Bustos, F; Varela-Nallar, L; Gonzáles, D; Henríquez, B; Van Zunder, B; Inestrosa, NC ConferencePoster (2012)
Wnt pathways modulate the α-7 nA ChR activities in hippocampal neurons and protect neurons from Aβ oligomers Godoy, J; Ríos, JA; Serrano, F; Varas, R; Inestrosa, NC ConferencePoster (2012)
Wnt-5a modulates the balance of metaplasticity in hippocampal CA1 mice Serrano, F; Inestrosa, NC ConferencePoster (2012)
Wnt5a regulates microRNAs in hippocampal neurons Codoceo, JF; Inestrosa, NC ConferencePoster (2012)
“(Pro) renin receptor stimulates the expression of fibrotic genes in mouse collecting ducts cells via Wnt/β-catenin signaling, independently of Angiotensin II Cuevas, C; Gonzáles, A; Inestrosa, NC; Vio, C; Prieto, M ConferencePoster (2012)
Activation of Wnt Signaling Pathway Prevents AB Oligomers Neurotoxicity Inestrosa, NC; Varela-Nallar, L ConferencePoster (2011)
Angiotensin II Acts through the Wnt/b-catenin signalling pathway: implications for Fibrosis Cuevas, C; Inestrosa, NC; Vio, C ConferencePoster (2011)
Cellular and Neuronal Network Properties during Different Oscillatory Activities in a Model of Alzheimer’s Disease Oliva, C; Inestrosa, NC ConferencePoster (2011)
Copper treatment ameliorates neuromuscular synaptic defects in a Caenorhabditis elegans model of Inclusion Body Myositis Aldunate, R; Rebolledo, D; Minniti, A; Inestrosa, NC ConferencePoster (2011)
Disabled-2 modulates the Wnt signalling pathway and dendritic development in neurons Marzolo, MP; Scheu, J; Benítez, ML; Inestrosa, NC ConferencePoster (2011)
Enhance excitatory neurotransmission in hippocampal slices by anti-P autoantibodies from a patient systemic lupus Parodi, J; Carcamo, C; Bravo, M; Massardo, L; Jacobelli, S; Inestrosa, NC; Gonzáles, A ConferencePoster (2011)
Hypoxia induces the Wnt/βcatenin pathway and in a mice model of Alzheimer´s disease increases adult hippocampal neurogenesis Rojas-Abalos, M; Varela-Nallar, L; Iturriaga, R; Inestrosa, NC ConferencePoster (2011)
IDN5706, a semi-synthetic derivative of hyperforin, increases adult hippocampal neurogenesis and long‐term memory in mice Abbott, AC; Varela-Nallar, L; Inestrosa, NC ConferencePoster (2011)
Nicotine prevents synaptic impairment induced by Ab oligomers through alpha7-Nachr activation Vargas, JY; Arrázola, MS; Farías, GG; Inestrosa, NC ConferencePoster (2011)
Oxidative stress induces loss of GFP labeled neurons and delayed development to adulthood in an Unc-13 mutant Kohn, RE; Mcgee, E; Frymoyer, C; Hollenbach, R; Amuquandoh, K; Sido, A; Roth, E; McLeod, K; Kuhn, J; Konstanzer, D; Murphy-Stout, A; Nidadavolu, S; McLarnon, F; Werkmeister, R; Gurenlian, L; King, L; Minniti, A; Inestrosa, NC ConferencePoster (2011)
Peroxisome proliferators decrease synaptic plasticity failure and neurodegeneration APPswe/PSEN1 E9 mouse model of Alzheimer´s disease Serrano, F; Tapia-Rojas, C; Carvajal, FJ; Parodi, J; Santos, MJ; Inestrosa, NC ConferencePoster (2011)
Role of oxidative stress in the neuronal damage induced by Ab fibrils Tajes, M; Ragga, G; Ramos-Fernandez, E; Bosch, M; Palomer, E; Godoy, J; Belmar, S; Cerpa, W; Inestrosa, NC; Muñoz, FJ ConferencePoster (2011)
Study of cellular and neuronal network properties during different oscillatory activities in a model of Alzheimer-disease Oliva, C; Inestrosa, NC ConferencePoster (2011)
Tetrahydrohyperforin prevents cognitive failure in double transgenic mice model of Alzheimer´s disease with activation of TRPC6 channel as a possible mechanism Montecinos-Oliva, C; Serrano, F; Tapia-Rojas, C; Parodi, J; Inestrosa, NC ConferencePoster (2011)
Wasp-1 protects against Ab oligomers-induced synaptic impairments through Wnt signalling pathway activation Vargas, JY; Arrázola, MS; Fuenzalida, M; Inestrosa, NC ConferencePoster (2011)
Wnt signaling in neural development and synaptic function Varela-Nallar, L; Inestrosa, NC ConferencePoster (2011)
β amyloid dodecamers and hiperphosphorylated Tau correlates with synaptic and cognitive impairments in aged Octodon degus Ardiles, AO; Barrientos, S; Araya, J; Tapia-Rojas, C; Inestrosa, NC ConferencePoster (2011)


Special series on trending themes in Neurobiology in Biological Research Nibaldo C. Inestrosa; Manuel J. Santos Editorial ISI SCIELO BIOLOGICAL RESEARCH (2016)


Contributions by researchers of "Ciencia de Frontera" of the Chilean Academy of Sciences Gonzalez-Billault, C; Inestrosa, NC; Santos MJ EditorialMaterial ISI SCIELO BIOLOGICAL RESEARCH (2011)
Copper promotes the formation of short neurotic beta-amyloid fibrils Opazo C.; Vasquez, MC; Inestrosa, NC EditorialMaterial ISI BIOMETALS (2003)


Publisher Correction: Non-canonical function of IRE1? determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (Nature Cell Biology, (2019), 21, 6, (755-767), 10.1038/s41556-019-0329-y) Carreras-Sureda A.; JaÃ±a F.; Urra H.; Durand S.; Mortenson D.E.; Sagredo A; Bustos G.; Hazari Y.; Ramos-FernÃ¡ndez E.; Sassano M.L.; PihÃ¡n P.; van Vliet A.R.; GonzÃ¡lez-Quiroz M.; Torres A.K.; Tapia-Rojas C.; Kerkhofs M.; Vicente R.; Kaufman R.J.; Inestrosa N.C.; Gonzalez-Billault C.; Wiseman R.L.; Agostinis P.; Bultynck G.; Court F.A.; Kroemer G.; CÃ¡rdenas J.C.; Hetz C. Errata ISI SCOPUS Nature Cell Biology (2019)
Identification of Cerebral Metal Ion Imbalance in the Brain of Ageing Octodon degus(vol 9, 66, 2017) Braidy N.; Poljak A.; Marjo C.; Rutlidge H.; Rich A.; Jugder B.-E.; Jayasena T.; Inestrosa N.C.; Sachdev P.S. Errata ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2017)
beta-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats (vol 2015, 726012, 2015) Cuevas, CA; Tapia-Rojas, C; Cespedes, C; INESTROSA, NC; Vio, CP Errata ISI BIOMED RESEARCH INTERNATIONAL (2016)


Tetrahydrohyperforin (IDN5706) targets the endoplasmic reticulum for autophagy activation: potential mechanism for Alzheimers disease therapy González A; Cavieres V.A.; Inestrosa, N. C.; Burgos, P.V. Note ISI SCOPUS NEURAL REGENERATION RESEARCH (2016)


Beta-amyloid-directed multitarget compounds for the treatment of Alzheimer’s disease Muñoz, Diego; Inestrosa, Nibaldo C.; Viayna, Elisabet; Sola, Irene; Vásquez, Santiago Patent Approved (2016)
A three compound mixture improving cognitive capacity Inestrosa, Nibaldo C.; Serrano, Felipe Patent Patent pending
Andrographolide as an inhibitor of GSK-3beta for Alzheimer disease and to stimulate Neurogenesis Inestrosa, Nibaldo C.; Hankcke, Juan Patent Patent pending


WNT SIGNALING REGULATES DENDRITIC SPINES THROUGH THE ACTIVATION OF THE SMALL RHO GTPASES FAMILY FONDECYT (3170043) Proyecto 2017-2020 Inv. Patrocinante
MOLECULAR BASIS OF THE SYNAPTIC FUNCTION OF WNT5A=> DENDRITIC SPINES AND BEHAVIOR FONDECYT (1160724) Proyecto 2016-2019 Inv. Responsable
LOSS OF WHITE MATTER INTEGRITY AS AN EARLY BIOMARKER AND PATHOLOGICAL EVENT IN ALZHEIMERS DISEASE A NEUROIMAGING AND ANIMAL/CELLULAR MODEL STUDY FONDECYT (3150224) Proyecto 2014-2017 Inv. Patrocinante
POTENTIAL THERAPEUTIC EFFECT OF THE BIS(THIOSEMICARBAZONES)-COPPER COMPLEXES IN THE COPPER HOMEOSTASIS DYSREGULATION IN ALZHEIMER DISEASE=> UNDERSTANDING OF THEIR NEUROPROTECTION MECHANISM. FONDECYT (3150291) Proyecto 2014-2017 Inv. Patrocinante
POTENTIAL THERAPEUTIC EFFECT OF THE BIS(THIOSEMICARBAZONES)-COPPER COMPLEXES IN THE COPPER HOMEOSTASIS DYSREGULATION IN ALZHEIMER DISEASE=> UNDERSTANDING OF THEIR NEUROPROTECTION MECHANISM. FONDECYT (3150291) Proyecto 2014-2017 Inv. Patrocinante
STUDY OF THE RELATIONSHIP BETWEEN WNT SIGNALING AND GLUCOSE MEBOLISM IMPAIRMENT IN THE COGNITIVE FAILURE OF ALZHEIMERS DISEASE MODELS FONDECYT (3150475) Proyecto 2014-2016 Inv. Patrocinante
UPREGULATION OF GLUN2B SUBUNIT OF NMDA RECPTORS IN THE POR-OXIDANT OUTCOM IN ALZHEIMEÂ´S AND THE PUTATIVE PROTECTIVE ROLE OF WNT FONDECYT (3140355) Proyecto 2013-2016 Inv. Patrocinante
WNT SIGNALING EFFECTS ON SYNAPTIC STRUCTURE AND FUNCTION=> ITS ROLE IN NEUROPROTECTION AGAINST THE AMYLOID-BETA PEPTIDE FONDECYT (1120156) Proyecto 2012-2016 Inv. Responsable
DISCOVERY OF NEURONAL ROLES FOR GENES THAT CAUSE LETHALITY IN C.ELEGANS USING RNA INTERFERENCE. FONDECYT (3100099) Proyecto 2009-2012 Inv. Patrocinante
Center For Cell Regulation and Pathology FONDAP (PFB12/2007) Proyecto 2007-2016 Director(a)
MECANISMOS QUE REGULAN LA DIFERENCIACION TERMINAL DEL MUSCULO ESQUELETICO DURANTE EL DESARROLLO Y LA REGENERACION MUSCULAR. FONDECYT (1990151) Proyecto 1999-2002 Coinvestigador(a)
EL ESTRES OXIDATIVO EN EL ORIGEN Y DESARROLLO DE LA ENFERMEDAD DE ALZHEIMER FONDECYT (3980024) Proyecto 1998-2000 Inv. Patrocinante
REGULACION DE LA ESTRUCTURA DEL AXON POR AGENTES LOCALES FONDECYT (1980973) Proyecto 1998-2000 Coinvestigador(a)
LA GLIA EN LA GENERACION Y NEUROTOXICIDAD DE LOS AGREGADOS DE B-AMILOIDE EN LA ENFERMEDAD DE ALZHEIMER=> SU ESTUDIO Y DISENO DE UN POSIBLE INSTRUMENTO DIAGNOSTICO DE LA POBLACION SUSCEPTIBLE FONDECYT (1971132) Proyecto 1997-2000 Coinvestigador(a)
ROL DE LA ACETILCOLINESTERASA EN LA FORMACION DE FIBRAS DE AMILOIDE FONDECYT (1971240) Proyecto 1997-2000 Inv. Responsable
FUNCION DE LOS PROTEOGLICANES DE HEPARAN SULFATO DE SUPERFICIE, DURANTE LA MIOGENESIS FONDECYT (1960634) Proyecto 1996-1999 Coinvestigador(a)
INTERACCION ENTRE CELULA DE SCHWANN Y AXON=> REGULACION MUTUA POR PROTEASAS EXTRACELULARES. FONDECYT (1950999) Proyecto 1995-1998 Coinvestigador(a)
POSIBLE PAPEL DE LA ACETILCOLINESTERASA EN EL PROCESAMIENTO EXTRACELULAR DE LA PROTEINA PRECURSORA DEL AMILOIDE Y SU IMPORTANCIA EN LA ENFERMEDAD DE ALZHEIMER FONDECYT (1940694) Proyecto 1994-1997 Inv. Responsable
PAPEL DE LOS PROTEOGLICANES EN LA FORMACION DE LA PLACA NEURITICA, EL CRECIMIENTO NEURONAL Y EL EVENTUAL DIAGNOSTICO DE LA ENFERMEDAD DE ALZHEIMER. FONDECYT (1930565) Proyecto 1993-1996 Coinvestigador(a)
PROCESAMIENTO DE LA PROTEINA PRECURSORA DEL AMILOIDE=> PRODUCCION DEL PEPTIDO -BETA A4 EN LA ENFERMEDAD DE ALZHEIMER FONDECYT (3930010) Proyecto 1993-1995 Inv. Patrocinante
NEUROTROFISMO DE SUBSTANCIAS CON ACTIVIDAD ANTIPROTEASICA, INCLUYENDO LA PROTEINA PRECURSORA DE B-AMILOIDE DE LA ENFERMEDAD DE ALZHEIMER FONDECYT (1920660) Proyecto 1992-1995 Coinvestigador(a)
ENFERMEDADES DE ALZHEIMER=> MARCADORES SISTEMATICOS Y SU UTILIZACION EN EL DIAGNOSTICO FONDECYT (1910651) Proyecto 1991-1994 Inv. Responsable
BIOTECNOLOGIA DEL MANEJO DE LARVAS DE LOCO=> INDUCTORES DE ASENTAMIENTOS Y HORMONAS DE CRECIMIENTO. FONDECYT (9893502) Proyecto 1989-1992 Inv. Responsable
REGENERACION DEL NERVIO PERIFERICO=> ACELERACION POR FACTOR DE CRECIMIENTO. FONDECYT (1890493) Proyecto 1989-1992 Investigador(a)
MORFOGENISIS Y DIFERENCIACION CELULAR AL COMIENZO DEL DESARROLLO DE MAMIFEROS. FONDECYT (1881171) Proyecto 1988-1991 Coinvestigador(a)
SINTESIS Y EXPRESION DE RECEPTORES DE ANGIOTENSINA II CEREBRALES EN OOCITOS DE ENOPUS LAEVIS=> CLONAMIENTO Y SEGUNDOS MENSAJEROS. FONDECYT (1880437) Proyecto 1988-1990 Inv. Responsable
ASOCIACION DE LA ACETILCOLINESTERASA GLOBULAR A LA MEMBRANA NEURONAL Y SU EXPRESION EN OOCITOS DE XENOPUS LAEVIS. FONDECYT (1870706) Proyecto 1987-1988 Inv. Responsable
POTENTIAL THERAPEUTIC EFFECT OF THE BIS(THIOSEMICARBAZONES)-COPPER COMPLEXES IN THE COPPER HOMEOSTASIS DYSREGULATION IN ALZHEIMER DISEASE: UNDERSTANDING OF THEIR NEUROPROTECTION MECHANISM. Inestrosa, Nibaldo C. Proyecto Sponsor (0)


Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model Bastias-Candia, S; Zolezzi, JM; Inestrosa, NC Review ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimers disease Tapia-Rojas, C; Inestrosa, NC Review ISI SCOPUS NEURAL REGENERATION RESEARCH (2018)
Wnt Signaling in the Central Nervous System: New Insights in Health and Disease Oliva, CA; Montecinos-Oliva, C; Inestrosa, NC Review ISI SCOPUS WNT SIGNALING IN HEALTH AND DISEASE (2018)
Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer's disease Cisternas, P; INESTROSA, NC Review ISI NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)
Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer's Disease? Codocedo J.F.; Ríos J.A.; Godoy, J.A.; Inestrosa, N. C. Review ISI SCOPUS MOLECULAR NEUROBIOLOGY (2016)
Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior Codocedo JF; Inestrosa, NC Review ISI SCOPUS NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)
P2C-Type ATPases and Their Regulation Retamales-Ortega, R; Vio, CP; Inestrosa, NC Review ISI SCOPUS MOLECULAR NEUROBIOLOGY (2016)
Role of Wnt Signaling in Central Nervous System Injury Lambert, C.; Cisternas P.; Inestrosa, N. C. Review ISI SCOPUS MOLECULAR NEUROBIOLOGY (2016)
Accelerating Alzheimer's research through 'natural' animal models Braidy, N; Poljak A.; Jayasena T.; Mansour H.; Inestrosa, NC; Sachdev, PS Review ISI SCOPUS Current Opinion in Psychiatry (2015)
How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario Arrazola, MS; Silva-Alvarez, C; Inestrosa, NC Review ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-beta brain balance and the putative role of PPARs Zolezzi, JM; Bastias-Candia, S; Santos MJ; Inestrosa, NC Review ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2014)
Brain metabolite clearance: impact on Alzheimer's disease Zolezzi, JM; Inestrosa, NC Review ISI METABOLIC BRAIN DISEASE (2014)
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum Rios, JA; Cisternas P.; Arrese M.; Barja S.; Inestrosa, NC Review ISI SCOPUS PROGRESS IN NEUROBIOLOGY (2014)
Metal and complementary molecular bioimaging in Alzheimer's disease Braidy, N; Poljak A.; Marjo C.; Rutlidge H.; Rich A.; Jayasena T.; Inestrosa, NC; Sachdev P Review ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2014)
Signaling pathway cross talk in Alzheimer's disease Godoy JA; Rios, JA; Zolezzi, JM; Braidy, N; Inestrosa, NC Review ISI SCOPUS CELL COMMUNICATION AND SIGNALING (2014)
Wnt signaling in the nervous system and in Alzheimers disease Inestrosa, NC; Varela-Nallar, L Review ISI JOURNAL OF MOLECULAR CELL BIOLOGY (2014)
Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood-Brain Barrier Zolezzi, JM; Inestrosa, NC Review ISI SCOPUS Molecular Neurobiology (2013)
WNT signaling in neuronal maturation and synaptogenesis Rosso SB; Inestrosa, NC Review ISI SCOPUS Frontiers in Cellular Neuroscience (2013)
Wnt signaling in the regulation of adult hippocampal neurogenesis Varela-Nallar, L; Inestrosa, NC Review ISI SCOPUS Frontiers in Cellular Neuroscience (2013)
Wnt signaling: Role in LTP, neural networks and memory Oliva, CA; Vargas JY; Inestrosa, NC Review ISI SCOPUS Ageing Research Reviews (2013)
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies Oliva, CA; Vargas JY; Inestrosa, NC Review ISI SCOPUS Frontiers in Cellular Neuroscience (2013)
Postsynaptic receptors for arnyloid-beta oligomers as mediators of neuronal damage in Alzheimer's disease Dinamarca, MC; Rios, JA; Inestrosa, NC Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2012)
Recent rodent models for Alzheimer's disease: clinical implications and basic research Braidy, N; Muñoz P; Palacios, AG; Castellano-Gonzalez, G; Inestrosa, NC; Chung RS; Sachdev P; Guillemin GJ. Review ISI SCOPUS Journal of Neural Transmission (2012)
Wnt Signaling: Role in Alzheimer Disease and Schizophrenia Inestrosa, NC; Montecinos-Oliva, C; Fuenzalida, M Review ISI SCOPUS Journal of Neuroimmune Pharmacology (2012)
Interactions of AChE with A beta aggregates in Alzheimer's brain: therapeutic relevance of IDN 5706 Carvajal, FJ; Inestrosa, NC Review ISI FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease Varela-Nallar, L; Aranguiz FC; Abbott AC; Slater PG; Inestrosa, NC Review ISI SCOPUS Birth Defects Research Part C - Embryo Today: Reviews (2010)
Emerging roles of Wnts in the adult nervous system Inestrosa, NC; Arenas E. Review ISI SCOPUS Nature Reviews Neuroscience (2010)
Neurobiological effects of hyperforin and its potential in Alzheimer's disease therapy Griffith T.N.; Varela-Nallar L.; Dinamarca M.C.; Inestrosa, N. C. Review ISI SCOPUS Current Medicinal Chemistry (2010)
Wnt Signaling Modulates Pre- and Postsynaptic Maturation: Therapeutic Considerations Farias GG.; Godoy JA; Cerpa, W.; Varela-Nallar, L; Inestrosa, NC Review ISI SCOPUS Developmental Dynamics (2010)
Amyloid-cholinesterase interactions - Implications for Alzheimer's disease Inestrosa, NC; Dinamarca, MC; Alvarez A. Review ISI FEBS JOURNAL (2008)
Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle Rebolledo, DL; Minniti AN; Grez, PM; Fadic, R; Kohn R.; Inestrosa, NC Review ISI MOLECULAR NEUROBIOLOGY (2008)
Structure-function implications in Alzheimer's disease: Effect of a oligomers A beta central synapses Cerpa, W.; Dinamarca, MC; Inestrosa, NC Review ISI CURRENT ALZHEIMER RESEARCH (2008)
The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease Inestrosa, NC; Toledo EM Review ISI MOLECULAR NEURODEGENERATION (2008)
Wnt signaling in neuroprotection and stem cell differentiation Toledo EM; Colombres M.; Inestrosa, NC Review ISI PROGRESS IN NEUROBIOLOGY (2008)
Role of copper in prion diseases: Deleterious or beneficial? Varela-Nallar, L; González A; Inestrosa, NC Review ISI CURRENT PHARMACEUTICAL DESIGN (2006)
Acetylcholinesterase interaction with Alzheimer amyloid beta. Inestrosa, N. C.; Sagal J.P.; Colombres M. Review SCOPUS SUB-CELLULAR BIOCHEMISTRY (2005)
Copper brain homeostasis: Role of amyloid precursor protein and prion protein Inestrosa, NC; Cerpa, W.; Varela-Nallar, L Review ISI SCOPUS IUBMB LIFE (2005)
Is there a role for copper in neurodegenerative diseases? Cerpa, W.; Varela-Nallar, L; Minniti A.N.; Inestrosa, N. C.; Reyes A.E. Review SCOPUS MOLECULAR ASPECTS OF MEDICINE (2005)
Trolox and 17 beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway Quintanilla, RA; Muñoz FJ.; Metcalfe MJ; Hitschfeld, M; Olivares, G; Godoy JA; Inestrosa, NC Review ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds Colombres M.; Sagal, JP; Inestrosa, NC Review ISI CURRENT PHARMACEUTICAL DESIGN (2004)
Structure and function of amyloid in Alzheimer's disease Morgan C.; Colombres M.; Nunez, MT; Inestrosa, NC Review ISI PROGRESS IN NEUROBIOLOGY (2004)
The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease Miranda, S.; Opazo C.; Larrondo, LF; Muñoz FJ.; Ruiz, F; Leighton F.; Inestrosa, NC Review ISI PROGRESS IN NEUROBIOLOGY (2000)
Wnt signaling function in Alzheimer's disease De Ferrari, GV; Inestrosa, NC Review ISI BRAIN RESEARCH REVIEWS (2000)

497

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Godoy

Investigador

Centro de Oncologia dePrecision

Santiago, Chile

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

Alicia Nogueras

Profesor Asociado Adjunto

Departamento de Biología Celular y Molecular

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Marcelo Chacon

Postdoc

Neurology

UTHealth

Houston, Estados Unidos

Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

Rebeca Aldunate

Profesor Titular

Ciencias

UNIVERSIDAD SANTO TOMÁS

Santiago, Chile

Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Maria Barria

Investigador, Associate Professor

Universidad San Sebastián

Puerto Montt, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

JUVENAL RÍOS

Investigador

CR de Investigación y Desarrollo

Instituto Nacional del Cáncer (INCANCER)

Santiago, Chile

Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

Carolina Oliva

Investigadora y Coordinadora Áreas STEM

Vicerrectoría de Investigación y Doctorados

Universidad Autónoma de Chile

Santiago, Chile

Paulina Salazar

CTO

Desarrollo de productos y servicios biotecnológicos SpA

Valparaíso, Chile

DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

Rodrigo Assar

Adjoint Professor

Facultad de Medicina

Universidad de Chile

Santiago, Chile

Daniela Rivera

Associate Professor

Universidad Mayor de Chile

Santiago, Chile

Valerie Ramirez

Senior Associate Scientist

Inflammation Research

Amgen

Thousand Oaks, Estados Unidos

Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

Christian Hodar

ASSISTANT PROFESSOR

BIOINFORMATICS & GENEXPRESSION LAB - INTA

UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

Gonzalo Olivares

ASSISTANT PROFESSOR

NEUROCIENCIA

Universidad de Chile

SANTIAGO, Chile

Fabián Segovia

Associate professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

ricardo fadic

Jefe de Division

Division de Neurociencias

DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

Andreas Schüller

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

Karen Fuenzalida

Investigador responsable de la Unidad de investigación y desarrollo del Laboratorio de Enfermedades Metabólicas, área de laboratorio.

Instituto de Nutrición y Tecnología de Alimentos

Universidad de Chile

Santiago, Chile

Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Jose Garrido

Investigador asesor, part time

Universidad San Sebastián

Puerto Montt, Chile

Alejandro Roth

Profesor Asistente

DEPARTAMENTO DE BIOLOGÍA,

DEPARTAMENTO DE BIOLOGÍA, FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

Macarena Arrázola

Profesor Asistente

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

Ricardo Matute

Academic Faculty

Departamento de Química

Universidad Técnica Federico Santa María

Valparaíso, Chile

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Claudia Pissani

Veronica Cambiazo

Profesora titular

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

Servet Martinez

Full professor

Mathematical Engineering

Universidad de Chile

Santiago, Chile

Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Diego Mezzano

Director

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Felix Diaz

Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Sussy Bastías

Profesor Asociado

Universidad de Magallanes

Punta Arenas, Chile

lisbell estrada

Decana Facultad Ciencias de la Salud

Facultad de Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

Luis Larrondo

Associate Professor

Genetica Molecular y Microbiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

Sebastian Belmar

Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

Alejandro Maass

Main Researcher

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

David Andrade

Associate Professor

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

Felipe Bodaleo

Postdoctoral Researcher

Universidad de Chile

Santiago, Chile

Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudia Yefi

Assistant professor

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Fernando Cruzat

Profesor Asociado

Oceanografia

Universidad de Concepción

Concepción, Chile

romina cataldo

project manager

Direccion de Innovacion

Universidad de La Frontera

temuco, Chile

GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

Carla Trigo

postdoctorante

Quimica y Biologia

Universidad de santiago de chile

santiago, Chile

Gonzalo Cancino

Assistant Professor

Faculty of Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

Sandra Hirsch

planta

ECRAN

INTA, UNIVERSIDAD DE CHILE

Santiago, Chile

Daniel Bunout

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

Patricio Fuentes

Medico Neurologo

Medicina

Hospital Clínico Universidad de Chile

Santiago, Chile

Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

Lina Vargas

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Francisco Melo

Profesor Titular

Genetica Molecular y Microbiologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Pablo Achurra

Cirujano Digestivo/ Instructor Adjunto

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Muñoz

Profesor titular

Patología y Fisiología

UNIVERSIDAD DE VALPARAÍSO

Valparaiso, Chile

Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

Juan Agustín Larraín

Profesor Titular

Biologia Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

Ataulfo Martinez

Hector Bustos

Director

Capia

Universidad Santo Tomas

Puerto Montt, Chile

Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

Hugo Diaz

PhD

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Duxan Arancibia

Investigador Posdoctoral

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Hianara Bustamante

Profesora Auxiliar

Instituto de Microbiología Clínica

Universidad Austral de Chile

Valdivia, Chile

Oscar Lazo

Research Fellow

UK Dementia Research Institute and Department of Neuromuscular diseases

UCL Queen Square Institute of Neurology

London, Reino Unido

Katherin Pereyra

Instructor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Genevieve Merabachvili

Profesor Asistente

salud

Universidad Santo Tomás

Santiago, Chile

Aldo Villalon

Director Académico/Profesor Asistente

Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Joaquìn Araya

Profesor Asistente

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

Octavio Monasterio

Profesor Titular

Departamento de Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

Claudio Allard

PROFESOR ASISTENTE

Química y Biología

Universidad de Atacama

Copiapó, Chile

Paula Slater

Postdoctoral researcher

Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

ADRIAN GONZALEZ

Postdoc

Biologia celular

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

Macarena Rojas

Directora Ejecutiva

Centro de Gerociencia, Salud Mental y Metabolismo, GERO

Santiago, Chile

Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

Matias Campos

Jefe Negocios

Centro Tecnológico para la innovación alimentaria

Santiago, Chile

María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

Rocío Retamales

Consultora de análisis genómicos

Freelance

Dresden, Alemania

Matías Lira

Postdoc

Universidad San Sebastián

Santiago, Chile

Carolina Cabeza

Académica y Jefa de Centro de Investigación

Universidad Bernardo O'Higgins

Santiago , Chile

Patricio Ramos

academico

Instituto de ciencias biológicas

UNIVERSIDAD DE TALCA

Talca, Chile

Néstor Corro

Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

Gonzalo Cabrera

Academic

Cell and Molecular Biology

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Omar Ramírez

Postdoc

UNIVERSITAT HEIDELBERG

Heidelberg, Alemania

Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

Francisco Bozinovic

Full professor

Ecology

Pontifical Catholic University of Chile

Santiago, Chile

Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

David Weinstein

Daniela Barrera

PhD Student

Environ SPA

Santiago, Chile

MIGUEL PEREZ

Associate Professor

Pontificia Universidad Catolica de Valparaiso

VALPARAISO, Chile

Claudia Lucero

Asistente Investigación-Docente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Yañez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

IVAN NEIRA

Académico

Tecnología Médica

Universidad de Antofagasta

Antofagasta, Chile

Nibaldo Manuel Inestrosa Cantin

Líneas de Investigación

Educación

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1979

Biologist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1974

Experiencia Académica

Full Professor Full Time

Experiencia Profesional

Full Professor Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

PLOS ONE Article in the Top 10% Most Cited

Scopus-Elsevier Prize in Medical Science for ISI citations.

Top-3 cited paper FEBS Journal

Faculty of 1000-Medicine

Premio Nacional de Ciencias

Beca UNESCO Curso “Aspectos Químicos y Eléctricos de la Neurotransmisión”

Postdoctoral grant

Course grant

Premio en Ciencia y Tecnología “Manuel Noriega Morales”

BERNARDO HOUSSAY del Consejo Nacional de Investigación Científica de Argentina

CATEDRA PRESIDENCIAL DE CIENCIA

fellowship

CATEDRA PRESIDENCIAL DE CIENCIA

Academic Degree Professor Emerito

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