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Hugo Cesar Olguin Marin

Profesor Asociado

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Muscle regeneration, satellite cells, adult stem cells, the ubiquitin-proteasome system, skeletal muscle growth, myogenesis

Educación

  •  Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002

Experiencia Académica

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Chile

    2009 - At present

Experiencia Profesional

  •   Profesor Asociado Full Time

    Pontificia Universidad Católica de Chile

    Chile

    2017 - At present

Formación de Capital Humano


DIRECCIÓN DE TESIS DE MAGISTER, PREGRADO O DE TÍTULOS PROFESIONALES (terminadas)
Sebastían Perez González
Efecto de Angiotensina 1-7 sobre la capacidad miogénica en Células Satélites adultas. Tutor, Dr. Claudio Cabello, UNAB; Co-tutor, Hugo Olguín (FCB-UC)
Ingeniería en Biotecnología Molecular, Universidad de Chile
Enero 19, 2017

Phamela Abarzúa
Evaluation of the effect of fiber morphology and the presence of decorin in the cellular response of myoblasts on polymer fiber scaffolds obtained by electrospinning. Tutor, Dra. Loreto Valenzuela (ING-UC); Co-tutor, Hugo Olguin (FCB-UC)
Magister Ingeniería, Pontificia Universidad Católica de Chile
Septiembre 20, 2016

Cristina Padilla
Biocompatibility studies of chitosan/poly(OTE) blends as a scaffold to maintain myoblast regeneration potential in vitro. Tutor, Dra. Loreto Valenzuela (ING-UC); Co-tutor, Hugo Olguin (FCB-UC)
Magister Ingeniería, Pontificia Universidad Católica de Chile
Junio 9, 2016

Natalia González
Fosforilación de Pax7 en progenitores musculares adultos. Tutor, Hugo Olguín.
Bioquímico, Pontificia Universidad Católica de Chile
Mayo 8, 2014

DIRECCIÓN DE TESIS DE DOCTORADO (terminadas)
Fabián Montecino
Rol de c-Abl en miogénesis y regeneración muscular. Tutor, Hugo Olguín; Cotutor, Alejandra Alvarez
Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Junio 12, 2020

Felipe Cabezas
Estudio del requerimiento de Nedd4-1 en la miogénesis de los progenitores musculares y la regeneración del músculo esquelético. Tutor, Hugo Olguín
Universidad y Grado Académico Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Fecha defensa/ obtención Diciembre 10, 2019

Eduardo de la Vega
Usp7 desubiquitinase regulates early differentiation of adult muscle progenitors. Tutor, Hugo Olguín.
Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Marzo 19, 2019

Francisco Bustos
Regulación de la estabilidad del factor de transcripción Pax7 mediada por Nedd4 y su papel en la función de progenitores musculares adultos. Tutor, Hugo Olguín.
Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Enero 21, 2015



 

Article (24)

USP7-dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors
Chitosan/poly-octanoic acid 2-thiophen-3-yl-ethyl ester blends as a scaffold to maintain myoblasts regeneration potential in vitro
Improving myoblast differentiation on electrospun poly(ε-caprolactone) scaffolds.
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas.
Ck2-Dependent Phosphorylation Is Required to Maintain Pax7 Protein Levels in Proliferating Muscle Progenitors.
Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis.
Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism
Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism.
NEDD4 Regulates PAX7 Levels Promoting Activation of the Differentiation Program in Skeletal Muscle Precursors.
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling
Marking the tempo for myogenesis: Pax7 and the regulation of muscle stem cell fate decisions.
PAX7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD.
Regulation of Pax7 protein levels by caspase-3 and proteasome activity in differentiating myoblasts.
Syndecan-3 and Notch cooperate in regulating adult myogenesis.
Reciprocal inhibition between Pax7 and MRFs modulates myogenic cell fate determination
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation
Increased Expression of Heparan Sulfate Proteoglycans in Skeletal Muscle Regeneration: Relevance of Syndecan-3
Pax-7 up-regulation inhibits myogenesis and cell cycle progression to promote satellite cell quiescence
Inhibition of myoblast migration, via decorin expression, is critical for normal skeletal muscle differentiation
Expression and localization of proteoglycans during limb myogenic activation
Expression and localization of proteoglycans during limb myogenic activation
Chitosan/ poly-octanoic acid 2-thiophen-3-yl-ethyl ester blends as a scaffold to maintain myoblasts regeneration potential in vitro

Abstract (1)

Decorin is required to maintain committed skeletal muscle cell population grouped allowing normal differentiation in vivo

Proyecto (11)

INTERPLAY BETWEEN UBIQUITIN LIGASE NEDD4 AND UBIQUITIN PROTEASE USP7 REGULATE MUSCLE STEM CELL FUNCTION.
Electrotherapeutics for Musculoskeletal Tissue Repair & Regeneration
Comportamiento mecanobiológico de células bajo la rotación controlada de nanocilindros magnéticos en su interior. Proyectos de Investigación Interdisciplinarios, CIEN-UC
PARTICIPATION OF MESENCHYMAL PROGENITORS IN THE INITIATION OF SKELETAL MUSCLE FIBROSIS=> EFFECT OF TGFBETA/CTGF/PDGF AND CO-FACTORS ON FIBROBLASTS’ ABILITY TO MODULATE MYOGENESIS
Anti-atrophic role of Angiotensin 1-7 on skeletal muscle
Post-translational control of transcription factor Pax7 and the gulation of muscle progenitor cell fate
Development of polymeric scaffold for muscle tissue engineering and repair.
Post-translational regulation of Pax7 function in myogenic progenitors
Regulation of Pax7 function through PKC and CaMKII dependent signaling
Pax7 role in satellite cell self-renewal
Mechanisms that activate skeletal muscle differentiation=> proteoglycans and the regulation of embryonic myogenesis
8
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

2
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

2
María Acuña

Directora de Investigación, académico e investigador

Universidad Bernardo O´Higgins

Santiago, Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Mauricio Isaacs

Full Professor

Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Loreto Valenzuela

Profesor Asociado

Ingeniería Química y Bioprocesos

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Flavia Zacconi

Associate Professor

Organic Chemistry

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Cristina Padilla

Administrador de laboratorio e Investigador

Centro de Investigaciones Biomedicas

Universidad de Los Andes

Santiago, Chile

1
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

1
Rebeca Aldunate

Profesor Titular

Ciencias

UNIVERSIDAD SANTO TOMÁS

Santiago, Chile

1
Fabian Montecino

Asistente de investigación

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Natasha Blanco

Coordinadora I+D+i

Enfermedades infecciosas e inmunología pediatrica

Pontificia Universidad Católica de Chile

Santiago, Chile