
Enrique Brandan Siques
Profesor Titular
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile
Molecular mechanisms that regulate skeletal muscle formation and how they are affected in skeletal muscular dystrophies.
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Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1985
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Biology, UNIVERSIDAD DE CHILE. Chile, 1979
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Research Assistant Full Time
VANDERBILT UNIVERSITY
Nashville, Estados Unidos
1979 - 1981
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PostDoctoral Fellow Full Time
SAINT LOUIS UNIVERSITY
Medicine
Saint Louis, Estados Unidos
1985 - 1986
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Postdoctoral fellow Full Time
University of Massachusetts
Medicine
Worcester, Estados Unidos
1986 - 1987
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Assistant Professor Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Ciencias Biologicas
Santiago, Chile
1988 - 1992
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Associate Professor Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Ciencias Biologicas
Santiago, Chile
1992 - 1998
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Full Professor Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Ciencias Biológicas
Chile
1989 - At present
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Full Professor Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Ciencias Biologicas
Santiago, Chile
1999 - At present
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Research Associate Full Time
Vanderbilt University
Nashville, Estados Unidos
1979 - 1981
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Visiting Assistant Research Professor Full Time
St. Louis University
Saint Louis, Estados Unidos
1986 - 1987
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Assistant Professor Full Time
University of Massachusetts
Worcester, Estados Unidos
1987 - 1988
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Profesor Asistente Full Time
P. Universidad Católica de Chile
Santiago, Chile
1988 - 1992
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Profesor Asociado Full Time
P. Universidad Católica de Chile
Santiago, Chile
1992 - 1998
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Profesor Titular Full Time
P. Universidad Católica de Chile
Santiago, Chile
1999 - At present
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Profesor/Investigador Full Time
Fundación Ciencia & VIda
Chile
2019 - At present
Student: Winston Andrade
Career: Biology. Faculty of Biological Sciences, P. Universidad Católica de Chile.
Title: Composition, characterization and expression of proteoglycans in the extracellular matrix of rat skeletal muscle.
Duration: 1990-1991.
Student: Alejandro Campos.
Career: Biochemistry, Universidad de Concepción.
Title: Hydrophobic proteoglycans present on the surface of the skeletal muscle.
Duration: Octubre 1991-1993.
Student: Rebeca Nuñez.
Career: Biochemistry, University of Santiago.
Title: Differential expression of extracellular matrix sulfated macromolecules, during differentiation of the glands of the chick embryo.
Duration: 1991-1992.
Dr. Cecilia Köenig as Co-adviser.
Student: Jorge Cáceres.
Career: Biochemistry, Universidad de Concepción.
Title: Alzheimer: Interaction between ?-amyloid protein and extracellular matrix.
Duration: 1993-1994.
Student: Luis Fuentealba.
Career: Biochemistry, Universidad de Concepción.
Title: Synthesis, expression and function of syndecan-3 during myogenesis.
Duration: 1998-1999.
Student: Karin Alvarez.
Career: Biochemistry, Universidad Austral de Chile.
Title: Proteoglycan synthesis and expression in patients with Duchenne Muscular Dystrophy.
Duration: 2000-2001
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Student: Rosario Calderón.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: Expression and function of heparan sulfate proteoglycans in hippocampal cells: involvement of TGF-???
Duration: 2002-2003.
Student: Rebeca Droguett.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: Two different mechanisms of regulation dependent signaling TGF-? during skeletal muscle differentiation.
Duration: 2003-2004.
Student: Jaime Gutierrez.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: Changes in proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to BMP-2.
Duration: 2004-2005.
Student: Pablo Cañón.
Career: Biochemistry.
Title: LPA participation and stability of the cytoskeleton in the induction of CTGF in muscle cells.
Duration: 2004-2005.
Student: Daniel Cabrera.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: CTGF effect on proteoglycan synthesis in fibroblasts dystrophic.
Duration: 2006-2007.
With Claudio Cabello-Verrugio as Co-adviser
Student: Paula Painemal.
Career: Chemistry and Pharmacy, Universidad de Chile.
Title: Expression control of AT-1 receptor (for angiotensin II) in skeletal muscle.
Duration: 2010-2011.
Student: Camilo Riquelme.
Career: Molecular Biotechnology Engineering, Universidad de Chile.
Title: Interaction myoblast-extracellular matrix mediated by extracelular matrix is required for the expression of CTGF / CCN2.
Duration: 2014-2015.
Student: Juan Pablo Espinoza.
Career: Biotechnology, Universidad Santo Tomás. Santiago.
Title: Effect of SOD1 expression on muscle cells and fibroblasts: role in ALS.
Duration: Enerro 2016-julio 2017.
Professional Training
Student: Francisca Ruiz.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: Isolation of myoblast clones transfected with syndecan-1.
Duration: 1996.
Graduate
Masters in Sciences.
Student: Francisco Melo.
Career: Master in Science, Biochemistry, P. Universidad Católica de Chile.
Title: Differential effect of extracellular matrix in the expression of early and late markers during differentiation of skeletal muscle cells.
Duration: 1993-1994.
Student: María José Villar.
Career: Master in Science, Biochemistry, P. Universidad Católica de Chile.
Title: Characterization of perlecan in myoblasts, association with the cell membrane and its role in cell adhesion processes.
Duration: 1995-1997.
Student: Soledad Cáceres.
Career: Master in Science, Biochemistry, P. Universidad Católica de Chile.
Title: Molecular and biochemical characterization of proteoglycans in mdx skeletal muscle of mice.
Duration: 1997-1999.
PhD Theses in Progress
Student: David Gonzalez.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Role-fibrotic factors and extracellular matrix components in the progression of amyotrophic lateral sclerosis (ALS).
Duration: 2015~2017.
Student: Osvaldo Contreras.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: TCF4 transcription factor and PDGF receptor alpha are key participants in the biology of skeletal muscle: role in myofibroblast differentiation and fibrogenic process triggered by TGF-?.
Duration: 2015~2017.
Student: Roger Valle.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Role of hipoxia in the expression of CTGF/CCN2 in pro-fibrotic cells.
Duration: 2016~2018.
Student: Javier Cerda
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Co-mentoring with Dr. Viviana Montecinos.
Title: Activación de la vía de señalización de VEGF-A en fibroblastos asociados a carcinoma y su papel en la agresividad tumoral en células cancerosas de próstata
Duration: 2017-2019
Student: Mauricio Castro
Career: Ph.D. in Medical Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Co-mentoring with Dr. Verónica Eisner.
Title: Rol de la fibrosis en la pérdida de la fusión mitocondrial del músculo esquelético en la distrofia muscular de Duchenne
Duration: 2017-2019
Completed PhD Theses
Student: Juan Larraín.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Heparan sulfate proteoglycans: Modulators of myogenesis.
Duration: 1995-1998.
Student: Juan Pablo Henríquez.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Identification and Function of Ligand for heparan sulfate proteoglycans During myogenesis.
Duration: 1997-2001.
Student: Cecilia Riquelme.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Modulation of skeletal muscle differentiation by decorina: Effect on TGF-? binding to its receptors.
Duration: 1997-2001.
Student: Hugo Olguín.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Modulation of embryonic myogenesis by proteoglycans.
Duration: 1998-2002.
Student: Nelson Osses.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Effect of extracellular matrix in determining the lineage of mesodermal cells Duration: 1998-2002.
Student: Juan Carlos Casar, M.D.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Participation of proteoglycans in skeletal muscle regeneration in mouse.
Duration: 1999-2003.
Student: Claudia Hurtado.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Biglycan: Participation in skeletal muscle differentiation, modulating the bioavailability of TGF-? and factors that regulate their expression.
Duration: 2002-2005.
Student: Claudio Cabello-Verrugio.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: TGF-? dependent signaling during myogenesis. Participation of decorin and LRP.
Duration: 2004-2007.
Student: Valeria Mezzano, M.D.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: CTGF involvement in skeletal muscle fibrosis.
Duration: 2004-2007.
Student: Cecilia Vial.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: CTGF involvement in skeletal muscle fibrosis during myogenesis and its modulation by proteoglycans.
Duration: 2005-2008.
Student: Rebeca Droguett.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Participation of TGF-? receptors during myogenesis.
Duration: 2006-2009.
Student: Jaime Gutierrez.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Regulation of FGF-2 signaling by Glypican-1 during muscle differentiation.
Duration: 2007-2009.
Student: Daniel Cabrera.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Role of NFkB in skeletal muscle fibrosis induced by exercise.
Duration: 2010-2012.
Student: María Gabriela Morales.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Biological Role of Connective Tissue Growth Factor (CTGF / CCN2) in Skeletal Muscle Fibrosis.
Duration: 2009-2012.
Student: María José Acuña.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Role of the renin-angiotensin system in skeletal muscle fibrosis.
Duration: 2010-2013.
With Pascal Vigey as Co-Adviser
Student: Gozalo Córdova.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile and Doctorat de Biologie Cellulaire et Moléculaire, Université Pierre et Marie Curie, Paris, France.
Title: Role of CTGF and TNF on fibrosis in muscular dystrophy.
Duration: 2011-2014.
Student: Héctor A. Ramirez.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Angiotensina (1-7) promueve la regeneración muscular aumentando la expresión de inos en monocitos pro inflamatorios y promoviendo la expansión de células satélites de forma no dependiente
Duration: 2014-2016.
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"Program Science in developing countries".
NATIONAL SCIENCE FOUNDATION
Estados Unidos, 1988
"Program Science in developing countries". Título: Proteoglycan Sulfotransferases.
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Howard Hughes International Research Scholar
Howard Hughes Medical Institute
Estados Unidos, 1997
- Howard Hughes International Research Scholar
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“Best Teacher”
FEUC
Chile, 1997
Federación Estudiantes (FEUC), P. Universidad Católica de Chile
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Presidential Chair in Sciences
Presidencia de la República
Chile, 1998
- Cátedra Presidencial en Ciencias (1998-2000)
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- Award for “Best Undergraduate Thesis” Mr. Luis Fuentealba. (Enrique Brandan, Advisor)
Fundación Chilena para la Biología Celular
Chile, 2000
Premio a “La mejor Tesis de Pregrado” Sr. Luis Fuentealba, (Enrique Brandan, Director)
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Award for “Best PhD Thesis”. Dr. Juan Larrain (Enrique Brandan, Director)
Fundación Chilena para la Biología Celular
Chile, 2000
Premio a “La mejor Tesis de Doctorado”. Sr. Juan Larraín, (Enrique Brandan, Director)
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Howard Hughes International Research Scholar
Howard Hughes Medical Institute
Estados Unidos, 2002
Howard Hughes International Research Scholar
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- Member of the Chilean Academy of Sciences
Academia Chilena de Ciencias
Chile, 2008
Miembro Correspondiente de la Academia Chilena de Ciencias
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Best Teacher
Federación Estudiantes (FEUC), P. Universidad Católica de Chile
Chile, 2007
“Mejor Profesor”
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Recognition Award for Excellence in Teaching, P. Universidad Católica de Chile.
Vice Rectoría Académica, P. Universidad Católica de Chile
Chile, 2007
Premio de Reconocimiento a la Excelencia Docente
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Recognition for serving the P. Universidad Católica de Chile for 25 years
P. Universidad Católica de Chile
Chile, 2013
Reconocimiento a los 25 años de servicio a la P. Universidad Católica de Chile
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Innovation Award. Copec-UC
Fundación Copec-UC
Chile, 2014
Innovation Award
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- Miembro Académico de la Academia de Ciencias de América Latina (ACAL)
Academia de Ciencias de América Latina (ACAL)
Venezuela, 2017
Miembro Académico de la Academia de Ciencias de América Latina (ACAL)
Analysis of Pathological Activities of CCN2/CTGF in Muscle Dystrophy |
Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion |

Enrique Brandan
Profesor Titular
Biología Celular y Molecular
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Daniel Cabrera
Investigador Adjunto
Gastroenterología
Pontificia Universidad Catolica de Chile
santiago, Chile

Jaime Gutierrez
Associate Professor and Researcher
Tecnología Médica
Universidad San Sebastián
Santiago, Chile

María Acuña
Directora de Investigación, académico e investigador
Universidad Bernardo O´Higgins
Santiago, Chile

Felipe Simon
Profesor Titular
Department of Biological Sciences
UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS
Santiago, Chile

Nelson Osses
Associated Professor
Institute of Chemistry
PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO
Valparaíso, Chile

Maria Vial
Associate Professor/Profesor Asociado
Instituto de Ciencias e Innovación de Medicina
UNIVERSIDAD DEL DESARROLLO
Santiago, Chile

Hugo Olguin
Profesor Asociado
Biología Celular y Molecular
Pontificia Universidad Católica de Chile
Santiago, Chile

Hugo Olguin
Profesor Asociado
Biología Celular y Molecular
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

MARCO ARRESE
FULL PROFESSOR
GASTROENTEROLOGY
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

David González
Investigador postdoctoral
Institut des Neurosciences de Montpellier (INM)
Montpellier, Francia

JUAN PABLO HENRIQUEZ
Associate Professor
Cell Biology
UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR
Concepción, Chile

ricardo fadic
Jefe de Division
Division de Neurociencias
DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Yaneisi Vazquez
Directora técnica de proyectos
Genética Molecular
Pontificia Universidad Católica de Chile
Santiago, Chile

JUAN VILLENA
FULL PROFESSOR
ANATOMY
FACULTA DE MEDICINA. UNIVERSIDAD DE VALPARAISO
VIÑA DEL MAR, Chile

Silvana Zanlungo
Full Professor
Gastroenterology
Pontificia Universidad Católica de Chile
Santiago, Chile

Alejandra Alvarez
Full professor
Cell and Molecular Biology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS
Santiago, Chile

Francisco Melo
Profesor Titular
Genetica Molecular y Microbiologia
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Juan Agustín Larraín
Profesor Titular
Biologia Celular y Molecular
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Attilio Rigotti
Full Professor
Nutrition, Diabetes and Metabolism
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA
Santiago, Chile

Pedro Cisternas
Investigador Asociado
Biología Celular
Pontificia Universidad Católica de Chile
Santiago, Chile

LUIS SOBREVIA
Professor
Division of Obstetrics and Gynaecology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
SANTIAGO, Chile

Maria Paz Marzolo
Profesor Titular
Departamento de Biología Celular y Molecular
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA
Santiago, Chile

Olga Panes
Technical Director/ Associated Research
Hematology-Oncology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Andrea Leiva
Profesor Asociado
Facultad de Ciencias de la Salud
Universidad San Sebastián
Santiago, Chile

Victor Cortes
Associate professor
Nutrition, Diabetes and Metabolism
Pontificia Universidad Católica de Chile
Santiago, Chile

Attilio Rigotti
Full Professor
Nutrition, Diabetes and Metabolism
Pontificia Universidad Católica de Chile
Santiago, Chile

Alicia Nogueras
Profesor Asociado Adjunto
Departamento de Biología Celular y Molecular
P. UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Brigitte van Zundert
Full Professor
UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS
Santiago, Chile

Felipe Court
Full Professor and Director
Center for Integrative Biology
Universidad Mayor
Huechuraba, Chile

Mirentxu Iruretagoyena
Jefe Seccion Inmunologia
Laboratorio Clinico
Clinica Alemana de Santiago
Santiago, Chile

Francisco Barrera
Profesor Asociado
Gastroenterología
Pontificia Universidad Católica de Chile
Santiago, Chile

Loreto Cuitiño
Investigador Asociado
Oftalmología
Hospital Clínico Universidad de Chile
229788866, Chile

Mario Chiong
Profesor
Departamento de Bioquímica y Biología Molecular
Universidad de Chile
Santiago, Chile

Juan Espinoza
Encargado de Cultivo Celular y Bioterio
Universidad Bernardo O'Higgins
Santiago, Chile

Jennifer Faúndez
Phd(c) del programa de Doctorado Biotecnología y Bioemprendimiento
Universidad San Sebastián
Santiago, Chile