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Claudio Alejandro Cabello Verrugio

Full Professor

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

SKELETAL MUSCLE ATROPHY; AGING; FRAGILITY; RENIN ANGIOTENSIN SYSTEM; FISIOLOGIA MUSCULAR; FIBROSIS; TGF-beta FAMILY GROWTH FACTORS, SIGNALING AND REGULATION, CELL BIOLOGY.

Cell Biology, P. Universidad CAtolica de Chile. Chile, 2007
Biochemist, Universidad de Chile. Chile, 2001

Post doc Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

2007 - 2011
Associate Investigator Full Time

Universidad del Desarrollo

Facultad de Medicina

Santiago, Chile

2011 - 2012
Associate professor Full Time

Universidad Andres Bello

Ciencias Biologicas

Chile

2012 - 2018
Full Professor Full Time

Universidad Andres Bello

Life Sciences

Santiago, Chile

2018 - At present

Post Doc Part Time

Universidad Catolica de Chile

Santiago, Chile

2007 - 2011
Associate Investigator Full Time

Universidad del Desarrollo

Santiago, Chile

2011 - 2012
Associate professor Full Time

Universidad Andres Bello

Santiago, Chile

2012 - At present
Investigador Asociado

Universidad Católica de Chile

Santiago, Chile

2001 - 2002

Post-grado:

Co-dirección de Tesis de Doctorado Srta. Maria José Acuña, Programa de Doctorado en Ciencias Biológicas Mención Biología Celular y Molecular, P. Universidad Católica de Chile. Finalizada Enero 2013. "Papel del Sistema Renina Angiotensina en la fibrosis muscular esquelética"

Dirección de Tesis de Magister carrera de Ingeniería en Biotecnología (Facultad de Ciencias Biológicas, Universidad Andrés Bello). Sr. Franco Cisternas. Finalizada Marzo 2014.
"Efecto del eje Ang (1-7)/Mas-1 sobre la atrofia muscular esquelética: importancia de la señalización de AKT".

Dirección de Tesis de Magister carrera de Ingeniería en Biotecnología (Facultad de Ciencias Biológicas, Universidad Andrés Bello). Srta. Carla Meneses. Finalizada Abril 2014.
"Angiotensina 1-7, a través de su receptor Mas1, disminuye la apoptosis inducida por Angiotensina II en musculo esquelético"

Dirección de Tesis de Magister carrera de Ingeniería en Biotecnología (Facultad de Ciencias Biológicas, Universidad Andrés Bello). Sr. Javier Aravena Castro. Finalizada Marzo 2016.
"Regulación de la actividad biológica dependiente de miostatina por Angiotensina 1-7: implicancias en atrofia muscular esquelética"

Dirección de Tesis de Magister carrera de Bioquímica (Universidad Andrés Bello). Sr. Fabián Campos. Finalizada Marzo 2017. "Papel del receptor TGR-5 de ácidos biliares en la caquexia inducida por un modelo de enfermedad hepática crónica”.

Dirección de Tesis de Magister carrera de Ingeniería en Biotecnología (Facultad de Ciencias de la Vida, Universidad Andrés Bello). Sr. Francisco Gonzalez. En curso. "Los ácidos biliares producen atrofia muscular esquelética en forma dependiente de NF-kB”.

Dirección de Tesis de Magister carrera de Bioquímica (Facultad de Ciencias de la Vida, Universidad Andrés Bello). Sr. Luis Maldonado. En curso. "Rol de los ácidos biliares Cólico y Desoxicólico y se receptor TGR5 en la fibrosis muscular esquelética inducida por TGF-b”.

Dirección de Tesis de Doctorado Sr. Juan Carlos Rivera, Programa de Doctorado en Biociencias Moleculares, Universidad Andres Bello. Finalizada Enero 2019. "Regulación de la autofagia por Angiotensina (1-7) en un modelo de atrofia muscular esquelética inducida por lipopolisacárido"

Dirección de Tesis de Doctorado Srta. Johanna Abrigo Leon, Programa de Doctorado en Biociencias Moleculares, Universidad Andres Bello. En curso. “Efecto de los ácidos biliares a través de su receptor TGR5 sobre la atrofia muscular y función mitocondrial en el músculo esquelético en un modelo de enfermedad hepática crónica.”

Pre-grado:

Dirección de Memoria de Investigación carrera de Bioquímica (Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile). Srta. Paula Painemal. Finalizada Mayo 2011.
"Efecto de TGF-b sobre los niveles proteicos de los receptores AT-1 y AT-2 para Angiotensina II en células musculares esqueléticas y musculo esquelético"

Dirección de Memoria de Investigación carrera de Bioquímica (Facultad de Ciencias Químicas y Farmacéuticas, Universidad Católica de Valparaíso). Srta. Johanna Ábrigo. Finalizada Mayo 2014. "TGF-?1 aumenta la expresión de atrogina-1 y MuRF-1 mediante un mecanismo dependiente de especies reactivas de oxígeno inducidas por NADPH oxidasa en células musculares esqueléticas".

Dirección de Tesis de Pregrado carrera de Kinesiología (UMCE). Sr. Ignacio Barría Olmedo. Finalizada Diciembre 2015. "Asociación de los polimorfismos de ECA-2 1075A/G, 879OA/G y 16854G/C con la generación de fuerza muscular en adultos mayores sedentarios".

Dirección de Tesis de Pregrado carrera de Kinesiología (UMCE). Sr. Alejandro Contreras Sanchez. Finalizada Diciembre 2015. "Asociación de los polimorfismos de ECA-2 1075A/G, 879OA/G y 16854G/C con la generación de fuerza muscular en adultos mayores sedentarios".

Dirección de Tesis de Pregrado carrera de Ingeniería en Biotecnología (U de Chile). Sr. Sebastian Perez. Finalizada Enero 2017. "Efecto de Angiotensina (1-7) sobre la capacidad miogénica de células satélite adultas".

Dirección de Tesis de Pregrado carrera de Tecnología Médica (Universidad Pedro de Valdivia). Sr. Betzabé Irigoyen. Finalizada Enero 2017. "Papel de eje GH/IGF-1 en la debilidad muscular esquelética inducida por hígado graso no alcohólico”.

Dirección de Unidad de Investigación carrera de Tecnología Médica (Universidad Andrés Bello). Sr. Tabita Marín. Finalizada Agosto 2016. "Estudio de Apoptosis Mionuclear en un modelo de atrofia muscular esquelética inducida por enfermedad hepática crónica”.

Dirección de Unidad de Investigación carrera de Tecnología Médica (Universidad Andrés Bello). Sr. Estefany Olguin. Finalizada Agosto 2016. "Expresión de la Desubiquitinasa 19 (Usp19) en músculo esquelético atrófico inmovilizado”.

Charla Magistral Sesión Inaugural año Académico de Programas de Magíster Universidad Bernardo O´Higgins: “Más que una pasión: la importancia de hacer ciencia en Chile”. 2017

Clase Inaugural, Curso de Postgrado “Modelos Biológicos Utilizados en Biología y Fisiología Celular”. Programa de Apoyo Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, P. Universidad Católica de Chile y Programa de Doctorado Facultad de Ciencias de la Salud, Universidad de Antofagasta. Enero 2011.

Clase Magistral XII Jornada Estudiantil de Kinesiología UMCE 2011.

Asistencia Diálogos con el Conocimiento: “La Genética: del debate científico al debate social”. Facultad de Medicina, Universidad de Chile. 2011.

1 Charla Explora año 2015.
3 Charlas Explora año 2017.
Participación Tour de la Ciencia (Organizado Centro Estudiantes Bioquimica UNAB).
1 Entrevistas Portales Ciencia Mexicano 2017
1 Entrevista Radial Universidad de Chile 2016.
1 Charla Instituto Chileno-Frances (Colaboración Ecos Conicyt) 2017.


Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis Jimenez-Dinamarca, Ivanka; Prado, Yolanda; Tapia, Pablo; Gatica, Sebastian; Alt, Clemens; Lin, Charles P.; Reyes-Martinez, Cristian; Feijoo, Carmen G.; Aravena, Cristobal; Gonzalez-Canacer, Alejandra; Correa, Simon; Varela, Diego; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI SCIELO BIOLOGICAL RESEARCH (2023)
Effect of Dietary Supplements with omega-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats Prado, Yolanda; Echeverria, Cesar; Feijoo, Carmen G. G.; Riedel, Claudia A. A.; Cabello-Verrugio, Claudio; Santibanez, Juan F. F.; Simon, Felipe Article ISI ANTIOXIDANTS (2023)
NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration Cabezas, Felipe; Cabello-Verrugio, Claudio; Gonzalez, Natalia; Salas, Jeremy; Ramirez, Manuel J.; de la Vega, Eduardo; Olguin, Hugo C. Article ISI SCIELO BIOLOGICAL RESEARCH (2023)
Procoagulant phenotype induced by oxidized high-density lipoprotein associates with acute kidney injury and death Prado, Yolanda; Perez, Lorena; Eltit, Felipe; Echeverria, Cesar; Llancalahuen, Felipe M.; Tapia, Pablo; Gonzalez, Pablo A.; Kalergis, Alexis M.; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI THROMBOSIS RESEARCH (2023)
Sepsis-Induced Coagulopathy Phenotype Induced by Oxidized High-Density Lipoprotein Associated with Increased Mortality in Septic-Shock Patients Prado, Yolanda; Tapia, Pablo; Eltit, Felipe; Reyes-Martinez, Cristian; Feijoo, Carmen G.; Llancalahuen, Felipe M.; Riedel, Claudia A.; Cabello-Verrugio, Claudio; Stehberg, Jimmy; Simon, Felipe Article ISI ANTIOXIDANTS (2023)
The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions Salazar, Javier; Carmona, Thais; Zacconi, Flavia C.; Venegas-Yazigi, Diego; Cabello-Verrugio, Claudio; Choi, Won Il; Vilos, Cristian Article ISI PHARMACEUTICS (2023)
Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux Orozco-Aguilar, Josue; Tacchi, Franco; Aguirre, Francisco; Valero-Breton, Mayalen; Castro-Sepulveda, Mauricio; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI SCIELO BIOLOGICAL RESEARCH (2023)
Bile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fibers Abrigo, Johanna; Olguin, Hugo; Gutierrez, Danae; Tacchi, Franco; Arrese, Marco; Cabrera, Daniel; Valero-Breton, Mayalen; Elorza, Alvaro A.; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI ANTIOXIDANTS (2022)
Combined Administration of Andrographolide and Angiotensin- (1-7) Synergically Increases the Muscle Function and Strength in Aged Mice Abrigo, Johanna; Simon, Felipe; Cabrera, Daniel; Vilos, Cristian; Cabello-Verrugio, Claudio Article ISI CURRENT MOLECULAR MEDICINE (2022)
Intensive care unit-acquired weakness: A review from molecular mechanisms to its impact in COVID-2019 Gonzalez, Andrea; Abrigo, Johanna; Achiardi, Oscar; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (2022)
Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality Rojas, Macarena; Prado, Yolanda; Tapia, Pablo; Carreno, Leandro J.; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI ANTIOXIDANTS (2022)
Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor Abrigo, Johanna; Gonzalez, Francisco; Aguirre, Francisco; Tacchi, Franco; Gonzalez, Andrea; Paz Meza, Maria; Simon, Felipe; Cabrera, Daniel; Arrese, Marco; Karpen, Saul; Cabello-Verrugio, Claudio Article ISI JOURNAL OF CELLULAR PHYSIOLOGY (2021)
Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic review and meta-analysis Gonzalez, Andrea; Valero-Breton, Mayalen; Huerta-Salgado, Camila; Achiardi, Oscar; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (2021)
Redox-Dependent Effects in the Physiopathological Role of Bile Acids Orozco-Aguilar, Josue; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration Tacchi, Franco; Orozco-Aguilar, Josue; Gutierrez, Danae; Simon, Felipe; Salazar, Javier; Vilos, Cristian; Cabello-Verrugio, Claudio Article ISI NANOMEDICINE (2021)
The Critical Role of Oxidative Stress in Sarcopenic Obesity Gonzalez, Andrea; Simon, Felipe; Achiardi, Oscar; Vilos, Cristian; Cabrera, Daniel; Cabello-Verrugio, Claudio Article ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
Angiotensin (1-7) decreases myostatin-induced NF-kb signaling and skeletal muscle atrophy Aravena J.; Abrigo J.; Gonzalez F.; Aguirre F.; Gonzalez A.; Simon F.; Cabello-verrugio C. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle Rivera, Juan Carlos; Abrigo, Johanna; Tacchi, Franco; Simon, Felipe; Brandan, Enrique; Santos, Robson A.; Bader, Michael; Chiong, Mario; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease Abrigo, Johanna; Marin, Tabita; Aguirre, Francisco; Tacchi, Franco; Vilos, Cristian; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Cabello-Verrugio, Claudio Article ISI SCOPUS CURRENT MOLECULAR MEDICINE (2020)
Protective Effect of Angiotensin 1-7 on Sarcopenia Induced by Chronic Liver Disease in Mice Aguirre, Francisco; Abrigo, Johanna; Gonzalez, Francisco; Gonzalez, Andrea; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD) Gonzalez, Andrea; Huerta-Salgado, Camila; Orozco-Aguilar, Josue; Aguirre, Francisco; Tacchi, Franco; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)
Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5 Abrigo, Johanna; Campos, Fabian; Gonzalez, Francisco; Aguirre, Francisco; Gonzalez, Andrea; Huerta-Salgado, Camila; Conejeros, Sabrina; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Elorza, Alvaro A.; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle Gonzalez, Andrea; Orozco-Aguilar, Josue; Achiardi, Oscar; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
TRPM Channels in Human Diseases Jimenez, Ivanka; Prado, Yolanda; Marchant, Felipe; Otero, Carolina; Eltit, Felipe; Cabello-Verrugio, Claudio; Cerda, Oscar; Simon, Felipe Article ISI CELLS (2020)
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia Gatica S.; Villegas V.; Vallejos A.; Olivares P.; Aballai V.; Lagos-Meza F.; Echeverria C.; Cabello-Verrugio C.; Varela D.; Simon F. Article ISI SCOPUS LABORATORY INVESTIGATION (2020)
Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction Tapia, Pablo; Gatica, Sebastian; Cortés-Rivera, Cristian; Otero, Carolina; Becerra, Alvaro; Riedel, Claudia A; Cabello-Verrugio, Claudio; Kalergis, Alexis M; Simon, Felipe Article ISI SCOPUS CRITICAL CARE MEDICINE (2019)
Endothelial Cells Exhibit Two Waves of P-selectin Surface Aggregation Under Endotoxic and Oxidative Conditions Barrionuevo N.; Gatica S.; Olivares P.; Cabello-Verrugio C.; Simon F. Article ISI SCOPUS PROTEIN JOURNAL (2019)
Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival Vallejos A.; Olivares P.; Gatica S.; Villegas V.; Echeverria C.; Cabello-Verrugio C.; Simon F. Article ISI SCOPUS LABORATORY INVESTIGATION (2019)
Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: A New Target for Sepsis Gatica S.; Eltit F.; Santibanez J.F.; Varela D.; Cabello-Verrugio C.; Simon F. Article ISI SCOPUS CURRENT MOLECULAR MEDICINE (2019)
Mitochondrial Dysfunction in Skeletal Muscle Pathologies Abrigo, Johanna; Simon, Felipe; Cabrera, Daniel; Vilos, Cristian; Cabello-Verrugio, Claudio Article ISI SCOPUS CURRENT PROTEIN & PEPTIDE SCIENCE (2019)
OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-kappa B pathway on endothelial cells Perez, L; Vallejos A.; Echeverria, C; Varela, D; Cabello-Verrugio, C; Simon, F Article ISI SCOPUS LABORATORY INVESTIGATION (2019)
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability Perez, Viviana; Bermedo-Garcia, Francisca; Zelada, Diego; Court, Felipe A.; Angel Perez, Miguel; Fuenzalida, Marco; Abrigo, Johanna; Cabello-Verrugio, Claudio; Moya-Alvarado, Guillermo; Carlos Tapia, Juan; Valenzuela, Vicente; Hetz, Claudio; Bronfman, Francisca C.; Pablo Henriquez, Juan Article ISI SCOPUS ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis Haensgen, H; Albornoz, E; Opazo, MC; Bugueno, K; Fernandez, ELJ; Binzberger, R; Rivero-Castillo, T; Salas, LFV; Simon, F; Cabello-Verrugio, C; Elorza, AA; Kalergis, AM; Bueno, SM; Riedel, CA Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival Vallejos A.; Olivares, P; Varela, D; Echeverria, C; Cabello-Verrugio, C; Perez-Leighton, C; Simon, F Article ISI FRONTIERS IN PHYSIOLOGY (2018)
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia Abrigo, Johanna; ELorza, Alvaro A.; Riedel, Claudia A; Vilos, Cristian; Simon, Felipe; Cabrera, Daniel; Estrada, Lisbell; Cabello-Verrugio, Claudio Article ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Sarcopenia in a mice model of chronic liver disease: role of the ubiquitin-proteasome system and oxidative stress Campos, F; Abrigo, J; Aguirre, F; Garces, B.; Arrese, M; Karpen, S; Cabrera, D; Andia, ME; Simon, F; Cabello-Verrugio, C Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2018)
Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation Cabrera, D; Cabello-Verrugio, C; Solis, N; San Martin D.; Cofre, C; Pizarro, M; Arab, JP; Abrigo, J; Campos, F; Irigoyen, B; Carrasco-Avino, G; Bezares, K; Riquelme, V; Riquelme, A; Arrese, M; Barrera, F Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
TGF-beta requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy Cabello-Verrugio, Claudio; Riedel, Claudia; Abrigo, Johanna; Cabrera, Daniel; Simon, Felipe; Vilos, Cristian; Campos, Fabian Article BIOLOGICAL CHEMISTRY (2018)
Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis Cabrera D., Wree A., Povero D., Solís N., Hernandez A., Pizarro M., Moshage, H., Torres, J., Feldstein AE., Cabello-Verrugio C., Brandan E., Barrera F., Arab JP. and Arrese M. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-beta 1/ALK5/Smad pathway Becerra A., Rojas M.; Vallejos A., Villegas V.; Pérez L., Cabello-Verrugio C. Article LABORATORY INVESTIGATION (2017)
Endothelial-to-mesenchymal transition=> Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Pérez, Lorena; Muñoz-Durango, Natalia; Riedel, Claudia A; Echeverría, Cesar; Kalergis, Alexis M; Cabello-Verrugio, Claudio; Simon, Felipe Article Cytokine & growth factor reviews (2017)
Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2016. Cabello-Verrugio C.; Simon F.; Trollet, C; Santibañez, JF Article ISI Oxid Med Cell Longev. (2017)
Skeletal muscle wasting: new role of nonclassical renin-angiotensin system. Cabello-Verrugio, C; Rivera, JC; Garcia D. Article ISI Curr Opin Clin Nutr Metab Care. (2017)
Skeletal muscle wasting=> new role of nonclassical renin-angiotensin system Cabello-Verrugio, Claudio; Rivera, Juan C; Garcia, Dominga Article CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2017)
The complex of PAMAM-OH dendrimer with Angiotensin (1-7) prevented the disuse-induced skeletal muscle atrophy in mice Márquez-Miranda V.; Abrigo J.; Rivera J.C.; Araya-Durán I.; Aravena J.; Simon F.; Pacheco N.; González-Nilo F.D.; Cabello-Verrugio C. Article ISI SCOPUS INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. Morales MG, Abrigo J; Acuña MJ, Santos RA; Bader M, Brandan E; Simon F, Olguin H; Cabrera D, Cabello-Verrugio C. Article DISEASE MODELS AND MECHANISMS (2016)
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. Morales, María Gabriela; Abrigo, Johanna; Acuña, María José; Santos, Robson A; Bader, Michael; Brandan, Enrique; Simon, Felipe; Olguin, Hugo; Cabrera, Daniel; Cabello-Verrugio, Claudio Article Disease models & mechanisms (2016)
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy via the Mas receptor. Morales, MG; Abrigo, J; Acuña, MJ; Santos, RA; Bader, M; Brandan, E; Simon, F; Olguin, H; Cabrera, D; Cabello-Verrugio, C Article ISI Dis Model Mech (2016)
Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-beta) via Mas Receptor Activation Ábrigo J, Simon F; Cabrera D, Cabello-Verrugio C. Article CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)
Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation Abrigo, J; Simon, F; Cabrera, D; Cabello-Verrugio, C Article ISI Cell Physiol Biochem (2016)
Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Pérez L; Muñoz-Durango N; Riedel, CA; Echeverría C; Kalergis, AM; Cabello-Verrugio C.; Simon F. Article ISI Cytokine Growth Factor Rev (2016)
High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis Abrigo, J; Rivera, JC; Aravena, J; Cabrera, D; Simon, F; Ezquer, F; Ezquer, M; Cabello-Verrugio, C Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Transforming growth factor type beta (TGF- β) requires reactive oxygen species to induce skeletal muscle atrophy Abrigo, J; Rivera, JC; Simon, F; Cabrera, D; Cabello-Verrugio, C. Article ISI Cell Signal (2016)
Transforming growth factor type beta (TGF-?) requires reactive oxygen species to induce skeletal muscle atrophy Abrigo, J; Rivera J.C., Simon F.; Cabrera, D Article Cellular Signalling (2016)
Transforming growth factor type beta (TGF-Î²) requires reactive oxygen species to induce skeletal muscle atrophy. Abrigo, Johanna; Rivera, Juan Carlos; Simon, Felipe; Cabrera, Daniel; Cabello-Verrugio, Claudio Article Cellular signalling (2016)
Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism Cisternas, F.; Morales, MG; Meneses, C.; Simon F.; Brandan, E.; Abrigo, J; Vazquez, Y; Cabello-Verrugio, C Article ISI CLINICAL SCIENCE (2015)
Apocynin inhibits the upregulation of TGF-beta(1) expression and ROS production induced by TGF-beta in skeletal muscle cells Abrigo, J; Morales, MG; Simon F.; cabrera, D; Di CApua G; Cabello-Verrugio, C Article ISI SCOPUS Phytomedicine (2015)
Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism Morales, MG; Olguin, H; Di CApua G; Brandan, E.; Simon F.; Cabello-Verrugio, C Article ISI SCOPUS Clinical Science (2015)
Expression of the Mas receptor is upregulated in skeletal muscle wasting Morales, MG; Abrigo, J; Meneses, C; Cisternas, F; Simon, F; Cabello-Verrugio, C Article HISTOCHEMISTRY AND CELL BIOLOGY (2015)
Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway Echeverria, C.; Montorfano I.; Cabello-Verrugio, C; Armisen, R; Varela D.; Simon F. Article ISI SCOPUS Journal of Hypertension (2015)
The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice Meneses, C.; Morales M.; Abrigo, J; Simon F.; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
Transforming growth factor type-beta inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies Cofré C; Acuña MJ; Contreras O.; Morales, MG; Riquelme C.; Cabello-Verrugio, C; Brandan, E. Article ISI SCOPUS BioFactors (2015)
Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis Cabrera, Daniel; Gutiérrez, Jaime; Cabello-Verrugio, Claudio; Morales, Maria; Mezzano, Sergio; Fadic, Ricardo; Casar, Juan; Hancke, Juan L.; Brandan, Enrique Article ISI SCOPUS SKELETAL MUSCLE (2014)
Angiotensin 1-7 Decreases Skeletal Muscle Atrophy induced by Angiotensin II through Mas Receptor Dependent Mechanism Cisternas, Franco; Morales, Maria Gabriela; Meneses, Carla; Simon, Felipe; Brandan, Enrique; Abrigo, Johanna; Vazquez, Yaneisi; Cabello-Verrugio, Claudio Article ISI CLINICAL SCIENCE (2014)
Angiotensin 1-7/Mas-1 axis attenuates the expression and signaling of TGF-1 induced by Angiotensin II in mouse skeletal muscle Morales, Maria Gabriela; Abrigo, Johanna; Meneses, Carla; Simon, Felipe; Cisternas, Franco; Rivera, Juan Carlos; Vazquez, Yaneisi; Cabello-Verrugio, Claudio Article ISI CLINICAL SCIENCE (2014)
Endotoxin Induces Fibrosis in Vascular Endothelial Cells through a Mechanism Dependent on Transient Receptor Protein Melastatin 7 Activity Echeverría, Cesar; Montorfano, Ignacio; Hermosilla, Tamara; Armisén, Ricardo; Velásquez, Luis A.; Cabello-Verrugio, Claudio; Varela, Diego; Simon, Felipe; Li, Liwu Article ISI SCOPUS PLOS ONE (2014)
Endotoxin-Induced Endothelial Fibrosis Is Dependent on Expression of Transforming Growth Factors beta 1 and beta 2 Echeverría C1, Montorfano I2, Tapia P3, Riedel C4, Cabello-Verrugio C5, Simon F6. Article ISI SCOPUS INFECTION AND IMMUNITY (2014)
Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-kappa B pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity Sarmiento, Daniela; Montorfano, Ignacio; Cáceres, Mónica; Echeverría, Cesar; Fernandez, Ricardo; Cabello-Verrugio, Claudio; Cerda, Oscar; Tapia, Pablo; Simon, Felipe Article ISI SCOPUS INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)
Expression of the Mas receptor is upregulated in skeletal muscle wasting. Morales, Maria Gabriela; Abrigo, Johanna; Meneses, Carla; Cisternas, Franco; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI HISTOCHEMISTRY AND CELL BIOLOGY (2014)
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel Sarmiento, Daniela; Montorfano, Ignacio; Cerda, Oscar; Cáceres, Mónica; Becerra, Alvaro; Cabello-Verrugio, Claudio; ELorza, Alvaro A.; Riedel, Claudia; Tapia, Pablo; Velásquez, Luis A.; Varela, Diego; Simon, Felipe Article Microvascular Research (2014)
Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-beta 1 and TGF-beta 2-dependent pathway Montorfano, Ignacio; Becerra, Alvaro; Cerro, Roberto; Echeverría, Cesar; Sáez, Elizabeth; Morales, Maria Gabriela; Fernandez, Ricardo; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI SCOPUS LABORATORY INVESTIGATION (2014)
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling Acuña MJ; Pessina P; Olguin, H; cabrera, D; Vio, CP; Bader M.; Munoz-Canoves, P; Santos RA; Cabello-Verrugio, C; Brandan, E. Article ISI HUMAN MOLECULAR GENETICS (2014)
The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-beta 1 induced by AngII in mouse skeletal muscle Morales, MG; Abrigo, J; Meneses, C.; Simon F.; Cisternas, F.; Rivera, JC; Vazquez, Y; Cabello-Verrugio, C Article ISI SCOPUS CLINICAL SCIENCE (2014)
The angiotensin (1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice Meneses, Carla; Morales, Maria Gabriela; Abrigo, Johanna; Simon, Felipe; Brandan, Enrique; Cabello-Verrugio, Claudio Article ISI Pflügers Archiv - European Journal of Physiology (2014)
Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2) Morales, MG; cabrera, D; Cespedes, C; Vio, CP; Vazquez, Y; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS Cell and Tissue Research (2013)
Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells Echeverria, C.; Montorfano I.; Sarmiento D.; Becerra, A; Nunez-Villena, F; Figueroa, XF; Cabello-Verrugio, C; Elorza, AA; Riedel C.; Simon F. Article ISI SCOPUS Journal of Cellular and Molecular Medicine (2013)
Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy Morales, MG; Gutierrez J.; Cabello-Verrugio, C; cabrera, D; Lipson, KE; Goldschmeding, R; Brandan, E. Article ISI SCOPUS Human Molecular Genetics (2013)
Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle Painemal P; Acuña MJ; Riquelme C.; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS BioFactors (2013)
Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles Cabello-Verrugio, C; Morales M.G.; cabrera, D; Vio C.P.; Brandan, E. Article ISI SCOPUS Journal of Cellular and Molecular Medicine (2012)
Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells Morales M.G.; Vazquez, Y; Acuna M.J.; Rivera J.C.; Simon F.; Salas J.D.; Alvarez Ruf J; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS International Journal of Biochemistry and Cell Biology (2012)
The Internal Region Leucine-rich Repeat 6 of Decorin Interacts with Low Density Lipoprotein Receptor-related Protein-1, Modulates Transforming Growth Factor (TGF)-beta-dependent Signaling, and Inhibits TGF-beta-dependent Fibrotic Response in Skeletal Musc Cabello-Verrugio, C; Santander C.; Cofré C; Acuña MJ; Melo F.; Brandan, E. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type beta receptors and the JNK pathway Cabello-Verrugio, C; Córdova G.; Vial, C; Zuñiga LM; Brandan, E. Article ISI SCOPUS Cellular Signalling (2011)
CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy Morales, MG; Cabello-Verrugio, C; Santander C.; cabrera, D; Goldschmeding, R; Brandan, E. Article ISI SCOPUS Journal of Pathology (2011)
Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells Cabello-Verrugio, C; Acuña MJ; Morales, MG; Becerra, A; Simon F.; Brandan, E. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2011)
TGF-beta receptors, in a Smad-independent manner, are required for terminal skeletal muscle differentiation Droguett R; Cabello-Verrugio, C; Santander C.; Brandan, E. Article ISI SCOPUS Experimental Cell Research (2010)
Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation Vial, C; Zuñiga LM; Cabello-Verrugio, C; Canon, P.; Fadic, R; Brandan, E. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
A novel modulatory mechanism of transforming growth factor-ss signaling through decorin and LRP-1 Cabello-Verrugio, C; Brandan, E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation Droguett R; Cabello-Verrugio, C; Riquelme C.; Brandan, E. Article ISI SCOPUS MATRIX BIOLOGY (2006)
LDL receptor-related protein (LRP) is an endocytic receptor for decorin and participates in a novel regulatory mechanism of TGF beta signaling by decorin Cabello-Verrugio, C; Marzolo, MP; Brandan, E. Article FASEB JOURNAL (2006)
The low density lipoprotein receptor-related protein functions as an Endocytic receptor for decorin Brandan, E.; Retamal, C; Cabello-Verrugio, C; Marzolo, MP Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation Casar, JC; Cabello-Verrugio, C; Olguin, H; Aldunate, R; Inestrosa, NC; Brandan, E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2004)
Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation - Cloning of murine betaglycan gene promoter and its modulation by myoD, retinoic acid, and transforming growth factor-beta Lopez-Casillas, F; Riquelme C.; Perez-Kato, Y; Ponce-Castaneda, MV; Osses N.; Esparza-Lopez, J; Gonzalez-Nunez, G; Cabello-Verrugio, C; Mendoza V.; Troncoso, V; Brandan, E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1 Cabrera, D; Ruiz, A; Cabello-Verrugio, C; Brandan, E Article


NFkB inhibition by Andrographolide ameliorates inflammation and fibrogenesis through inflammasome substrate depletion in experimental Non-Alcoholic Steatohepatitis (NASH) cabrera, D; Wree, A; Povero, D; Solís N.; Pizarro M.; de Santiago, PR; Torres J.; Moshage, H; Cabello-Verrugio, C; Feldstein, AE; Brandan, E.; Arrese M. Abstract ISI HEPATOLOGY (2015)
Diet-induced nonalcoholic fatty liver disease is associated with sarcopenia and decreased serum insulin growth factor-1 Ruiz A.; cabrera, D; Quintero, P.; Pizarro M.; Solís N.; Torres J.; Cabello-Verrugio, C; Brandan, E.; Barrera F.; Arrese M. Abstract ISI HEPATOLOGY (2014)
Lipopolysaccharide-induced skeletal muscle atrophy is prevented by Angiotensin (1-7) via Mas receptor. Morales, MG; Olguin, HH; Brandan, E.; Simon F.; Cabello-Verrugio, C Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
Transforming growth factor type beta 1 (TGF-beta 1) induces skeletal muscle atrophy by a mechanism dependent of NADPH oxidase-induced reactive oxygen species. Abrigo, J; Morales, MG; Simon F.; Cabello-Verrugio, C Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
Vascular endothelial fibrosis induced by endotoxin: characteristics, mechanism and therapeutic perspectives Simon F.; Echeverria, C.; Montorfano I.; Becerra, A; Varela D.; Hermosilla T.; Cabello-Verrugio, C; Armisen, R Abstract ISI CARDIOVASCULAR RESEARCH (2014)


Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2018 Cabello-Verrugio, C; Vilos, C; Rodrigues-Diez, R; Estrada L. EditorialMaterial ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Role of transforming growth factor family of peptides in health and diseases Cabello-Verrugio C. EditorialMaterial ISI SCOPUS (2018)
Oxidative Stress in Disease and Aging: Mechanisms and Therapies Cabello-Verrugio, C; Ruiz-Ortega, M; Mosqueira, M; Simon F. EditorialMaterial ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)


Transforming growth factor type- inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies (vol 42, pg 111, 2015) Cofré C; Acuña MJ; Contreras O.; Morales, MG; Riquelme C.; Bader M.; Santos R.; Cabello-Verrugio, C; Brandan, E. Errata ISI SCOPUS BioFactors (2015)


Effect of Quillaic Acid in Sarcopenia induced by COPD patients-derived factors Cabello, Claudio Alejandro; PEÑAILILLO, LUIS Proyecto (2023)
Deciphering muscle-liver connections in MAFLD: experimental and clinical studies Cabello-Verrugio, Claudio; Simon, Felipe Proyecto (2020)
Participation of TRPC6 and TRPM7 ion channels in the adrenergic stimulation-induced coagulation Simon, Felipe; Cabello-Verrugio, Claudio Proyecto (2020)
RANTES, a new myokine that participates in sarcopenia induced by bile acids during chronic liver diseases Cabello, Claudio Alejandro; Simon, Felipe Proyecto (2020)
Role of Renin angiotensin system in myogenesis and muscle regeneration: new combined therapeutic strategies based in nanomedicine for muscular dystrophies Cabello-Verrugio, Claudio; Trollet, Capucine Proyecto (2017)
Role of Renin angiotensin system in myogenesis and muscle regeneration=> new combined therapeutic strategies based in nanomedicine for muscular dystrophies PCI (C16S02) Proyecto 2017-2019 Director(a)
Mechanisms involved in cachexia induced by chronic liver diseases Cabello-Verrugio, Claudio Proyecto (2016)
MECHANISMS INVOLVED IN THE CACHEXIA INDUCED BY CHRONIC LIVER DISEASES FONDECYT (1161646) Proyecto 2016-2020 Inv. Responsable
Participation of TRPM7 in the generation of endothelial dysfunction characteristics, enhanced inflammatory response, and multiple organ failure during endotoxemia Simon, Felipe; Cabello-Verrugio, Claudio Proyecto (2016)
PARTICIPATION OF TRPM7 IN THE GENERATION OF ENDOTHELIAL DYSFUNCTION CHARACTERISTICS, ENHANCED INFLAMMATORY RESPONSE, AND MULTIPLE ORGAN FAILURE DURING ENDOTOXEMIA. FONDECYT (1161288) Proyecto 2016-2020 Coinvestigador(a)
The vascular neural muscle unit in sepsis induced intensive care unit acquired-weakness Simon, F; Cabello-Verrugio, C; Elorza, A; Riedel, C Proyecto (2015)
The vascular neural muscle unit in sepsis induced intensive care unit acquired-weakness. Universidad Andres Bello (DI-741-15/N) Proyecto 2015-2018 Inv. Principal
"Effects of Angiotensin 1-7 in Cell Death by Apoptosis on Angiotensin II-induced Skeletal Muscle Atrophy". Cabello-Verrugio, C Proyecto (2013)
Angiotensina 1-7 modula la señalización dependiente del factor de crecimiento tipo insulínico 1 y el factor nuclear kappa B en un modelo de atrofia muscular esquelética inducido por lipopolisacárido Morales, Gabriela; Cabello-Verrugio, Claudio Proyecto (2013)
Anti-atrophic role of Angiotensin 1-7 on skeletal muscle Association-Francaise Contre Les Myopathies (AFM). (16670) Proyecto 2013-2015 Director(a)
Effects of Angiotensin 1-7 in Cell Death by Apoptosis on Angiotensin II-induced Skeletal Muscle Atrophy Universidad Andrés Bello Proyecto 2013-2014 Inv. Principal
Role of Angiotensin 1-7 on skeletal muscle wasting Cabello-Verrugio, Claudio Proyecto (2013)
ANGIOTENSINA 1-7 MODULA LA SEÑALIZACION DEPENDIENTE DEL FACTOR DE CRECIMIENTO TIPO INSULINICO 1 Y EL FACTOR NUCLEAR KAPPA B EN UN MODELO DE ATROFIA MUSCULAR ESQUELETICA INDUCIDO POR LIPOPOLISACARIDO FONDECYT (3130593) Proyecto 2012-2015 Inv. Patrocinante
Anti-atrophic role of Angiotensin 1-7 on skeletal muscle FONDECYT (1120380) Proyecto 2012-2016 Inv. Principal
Anti-atrophic role of Angiotensin 1-7 on skeletal muscle Cabello-Verrugio, Claudio Proyecto (2012)
Sepsis-induced endothelial fibrosis: Role of TRPM4 and TRPM7 ion channels as novel targets for prevention of endothelial fibrosis during sepsis Simon, Felipe; Cabello-Verrugio, Claudio Proyecto (2012)
SEPSIS-INDUCED ENDOTHELIAL FIBROSIS=> ROLE OF TRPM4 AND TRPM7 ION CHANNELS AS NOVEL TARGETS FOR PREVENTION OF ENDOTHELIAL FIBROSIS DURING SEPSIS FONDECYT (1121078) Proyecto 2012-2016 Coinvestigador(a)
“Anti-atrophic role of Angiotensin 1-7 on skeletal muscle”. Cabello-Verrugio, C; Simon, F Proyecto (2012)
Novel antifibrotic role of the ACE2/Angiotensin 1-7/Mas axis in skeletal muscular dystrophies Brandan, Enrique; Cabello-Verrugio, Claudio Proyecto (2011)
NOVEL ANTIFIBROTIC ROLE OF THE ACE2/ANGIOTENSIN 1-7/MAS AXIS IN SKELETAL MUSCULAR DYSTROPHIES FONDECYT (1110426) Proyecto 2011-2015 Coinvestigador(a)
CTGF=> the factor involved in fibrosis development in DMD Muscular Dystrophy Association MDA 89419 Proyecto 2008-2011 Coinvestigador(a)
Droga Botánica para el tratamiento de enfermedades crónicas asociadas a fibrosis de alta incidencia nacional y mundial FONDEF (D07I1051) Proyecto 2008-2011 Investigador(a)
Profibrotic effect of the renin-angiotensin system and connective tissue growth factor (CTGF) in dystrophic skeletal muscle FONDECYT (11080212) Proyecto 2008-2011 Inv. Principal
Mecanismos Reguladores de la Actividad Biológica de TGF-beta durante la diferenciación de células musculares esqueléticas FONDECYT (24050108) Proyecto 2005-2008 Inv. Principal


Endothelial dysfunction in pregnancy metabolic disorders Echeverria C.; Eltit F.; Santibanez J.F.; Gatica S.; Cabello-Verrugio C.; Simon F. Review SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2019)
The Emerging Roles of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 in Skeletal Muscle Redox Signaling and Metabolism HenrÃquez-OlguÃn C.; Boronat S.; Cabello-Verrugio C.; Jaimovich E.; Hidalgo E.; Jensen T.E. Review ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2019)
Central role of transforming growth factor type beta 1 in skeletal muscle dysfunctions: An update on therapeutic strategies Abrigo J.; Simon F.; Cabrera D.; CÃ³rdova G.; Trollet C.; Cabello-Verrugio C. Review ISI SCOPUS (2018)
Combined Therapies for Duchenne Muscular Dystrophy to Optimize Treatment Efficacy Cordova, G; Negroni, E; Cabello-Verrugio, C; Mouly, V; Trollet, C Review ISI SCOPUS FRONTIERS IN GENETICS (2018)
TGF-? and hepatocellular carcinoma: When a friend becomes an enemy Arrese M.; Hernandez A.; Astete L.; Estrada L.; Cabello-Verrugio C.; Cabrera D. Review ISI SCOPUS (2018)
Transforming growth factor-beta family: Advances in vascular function and signaling Gatica S.; Cabello-Verrugio C.; Simon F. Review ISI SCOPUS (2018)
Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle Cabello-Verrugio, C; Morales, MG; Rivera, JC; cabrera, D; Simon F. Review ISI SCOPUS Medicinal Research Reviews (2015)
Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans Simon F.; Varela D.; Cabello-Verrugio, C Review ISI SCOPUS Cellular Signalling (2013)
Angiotensin II: Role in skeletal muscle atrophy Cabello-Verrugio C.; CÃ³rdova G.; Salas J.D. Review ISI SCOPUS Current Protein and Peptide Science (2012)
Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy Brandan, E.; Cabello-Verrugio, C; Vial, C Review ISI MATRIX BIOLOGY (2008)

118

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Cristian Vilos

Académico Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

María Acuña

Directora de Investigación, académico e investigador

Universidad Bernardo O´Higgins

Santiago, Chile

Andrea González

Docente

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

Sebastián Gatica

Investigador Postdoctoral

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Yaneisi Vazquez

Directora técnica de proyectos

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

Alvaro Becerra

Profesor Asociado

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

ricardo fadic

Jefe de Division

Division de Neurociencias

DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

lisbell estrada

Decana Facultad Ciencias de la Salud

Facultad de Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

Tomás Rivero

Agente de Innovación

Comercial

Andes Pacific Technology Access

Santiago , Chile

Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Maria Opazo

Profesor Asociado

Universidad de Las Américas

Santiago, Chile

Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Alejandro Vallejos

Asistente de Investigación

Ciencias de la Vida

Laboratorio de Fisiopatología Integrativa

Santiago, Chile

Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

Viviana Pérez

Profesor Asistente

Fisiología

Universidad de Concepción

Concepcion, Chile

Sergio Mezzano

Catedratico

Medicina

Universidad Austral de Chile

Valdivia, Chile

Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Nicolas Pacheco

PROFESOR ADJUNTO

CIENCIAS BIOLOGICAS

Universidad Andrés Bello

Santiago centro, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Pablo Cañón

Académico Regular

Escuela de Agronomía

Universidad Mayor de Chile

Santiago, Chile

Diego Venegas

Full Professor

Quimica de los Materiales

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA, DEPARTAMENTO DE QUÍMICA DE LOS MATERIALES

Santiago, Chile

MIGUEL PEREZ

Associate Professor

Pontificia Universidad Catolica de Valparaiso

VALPARAISO, Chile

Rebeca Aldunate

Profesor Titular

Ciencias

UNIVERSIDAD SANTO TOMÁS

Santiago, Chile

Carlos Henríquez

Professor Asistente

Kinesiologia

Universidad Finis Terrae

Santiago, Chile

simon correa

Head of Computational Biology

Computational Biology

Protera

Santiago, Chile

Nelson Osses

Associated Professor

Institute of Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

Claudio Alejandro Cabello Verrugio

Líneas de Investigación

Educación

Cell Biology, P. Universidad CAtolica de Chile. Chile, 2007

Biochemist, Universidad de Chile. Chile, 2001

Experiencia Académica

Post doc Part Time

Associate Investigator Full Time

Associate professor Full Time

Full Professor Full Time

Experiencia Profesional

Post Doc Part Time

Associate Investigator Full Time

Associate professor Full Time

Investigador Asociado

Formación de Capital Humano

Difusión y Transferencia

Article (93)

Abstract (5)

EditorialMaterial (3)

Errata (1)

Proyecto (29)

Role of Renin angiotensin system in myogenesis and muscle regeneration=> new combined therapeutic strategies based in nanomedicine for muscular dystrophies

MECHANISMS INVOLVED IN THE CACHEXIA INDUCED BY CHRONIC LIVER DISEASES

PARTICIPATION OF TRPM7 IN THE GENERATION OF ENDOTHELIAL DYSFUNCTION CHARACTERISTICS, ENHANCED INFLAMMATORY RESPONSE, AND MULTIPLE ORGAN FAILURE DURING ENDOTOXEMIA.

The vascular neural muscle unit in sepsis induced intensive care unit acquired-weakness.

Anti-atrophic role of Angiotensin 1-7 on skeletal muscle

Effects of Angiotensin 1-7 in Cell Death by Apoptosis on Angiotensin II-induced Skeletal Muscle Atrophy

ANGIOTENSINA 1-7 MODULA LA SEÑALIZACION DEPENDIENTE DEL FACTOR DE CRECIMIENTO TIPO INSULINICO 1 Y EL FACTOR NUCLEAR KAPPA B EN UN MODELO DE ATROFIA MUSCULAR ESQUELETICA INDUCIDO POR LIPOPOLISACARIDO

Anti-atrophic role of Angiotensin 1-7 on skeletal muscle

SEPSIS-INDUCED ENDOTHELIAL FIBROSIS=> ROLE OF TRPM4 AND TRPM7 ION CHANNELS AS NOVEL TARGETS FOR PREVENTION OF ENDOTHELIAL FIBROSIS DURING SEPSIS

NOVEL ANTIFIBROTIC ROLE OF THE ACE2/ANGIOTENSIN 1-7/MAS AXIS IN SKELETAL MUSCULAR DYSTROPHIES

CTGF=> the factor involved in fibrosis development in DMD