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Xavier Horacio Figueroa Foessel

Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Control Mechanisms of vasomotor tone, Intercellular communication in the wall of resistance arteries and arterioles, Regulation of nitric oxide signaling Regulation of blood flow distribution Control of arterial blood pressure

Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Research Associate Full Time

University of Virginia

Charlottesville, Estados Unidos

2001 - 2006

Research Associate Full Time

University of Virginia

Charlottesville, Estados Unidos

2001 - 2006

Undergraduate students:
Pablo S. Gaete. Los canales de K+ activados por calcio son esenciales para la producción de NO inducida por Acetilcolina (Calcium-activated K+ channels are essential for the acetylcholine-induced NO production). Student of Biology at School of Biological Sciences, Pontificia Universidad Católica de Chile, 2007.

Felipe Ortiz. Los canales de Na+ dependientes de voltaje participan en el mecanismo vasodilatador endotelial activado por acetilcolina (Voltage-dependent Na+ channels participate in the endothelial cell vasodilator mechanism activated by acetylcholine). Student of Biology at School of Biological Sciences, Pontificia Universidad Católica de Chile, 2007.

Mauricio A. Lillo. Participación de los canales formados por conexinas en la transmisión intercelular del óxido nítrico en la pared vascular (Participation of connexin-foormed channels in the intercellular transmission of nitric oxide in the vascular wall). Student of Biochemistry at School of Biological Sciences, Pontificia Universidad Católica de Chile, 2011.

Manuel Muñoz. Regulación del acoplamiento neurovascular por óxido nítrico (Regulation of neurovascular coupling by nitric oxide). Student of Biology at School of Biological Sciences, Pontificia Universidad Católica de Chile, 2013.

Ph.D Students:
Pablo S. Gaete. Disfunción microvascular inducida por la liberación de CGRP desde las aferencias sensoriales primarias (Microvascular dysfunction induced by CGRP release from primary sensory nerves). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. Finished 2014.

Mauricio A. Lillo. Mecanismos de activación y coordinación longitudinal de las respuestas vasodilatadoras dependientes del endotelio en arterias de resistencia (Mechanisms of activation and longitudinal coordination of endothelium-dependent vasodilator responses in resistance arteries). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. Finished 2017.
Thesis Work recognized as: “Award for excellence in Ph.D. Thesis Work 2017” in the area of “Biology and Health Sciences”, School of Doctoral Programs, Pontificia Universidad Católica de Chile.

Mariela Puebla. Control del acoplamiento neurovascular a través de la regulación de los hemicanales de conexinas o panexinas por la producción de óxido nítrico en los astrocitos (Neurovascular coupling control through connexin or pannexin regulation by nitric oxide production in astrocytes). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. Finished 2018.

Pía Burboa. Mecanismos de activación de la entrada de calcio en la respuesta de hiperpermeabilidad en vénulas postcapilares (Mechanisms of Ca2+ influx activation in the response to hyperpermeability in postcapillary venules). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. Finished 2020.

Victor Lazo. Mecanismos que participan en el desarrollo de la disfunción endotelial asociada a estrés oxidativo (Mechanisms that participate in the development of the endotelial dysfunction associated to oxidative stress). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. In progress.

Manuel Francisco Muñoz Camus. Mecanismos glutamatérgicos de control y coordinación del tono vasomotor en arterias de resistencia cerebrales y periféricas (Glutamatergic mechanisms of control and coordination of vasomotor tone in cerebral and peripheric resistance arteries). Ph.D. Program in Physiological Science, P. Universidad Católica de Chile. Finished 2020.

Hilda Espinoza. Mecanismos de activación y coordinación de las señales de Ca2+ involucradas en la migración de las células endoteliales (Activation and coordination mechanisms of the Ca2+ signals involved in endothelial cell migration). Ph.D. Program in Physiological Science, P. Universidad Católica de Chile. Finished 2020.

Ph.D. Program Scholarship

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1996

Scholarship provides by the P. Universidad Catolica de Chile for Tuition and maintenance to stay in the Ph.D. program
Best Scientific Publication 1997 Award

Santiago’s Medical Association

Chile, 1997

Award from the Santiago’s Medical Association to the Best Scientific Publication of the year 1997
Ph.D. Scholarship

CONICYT

Chile, 1997

Ph.D. Scholarship for Tuition and maintenance
Merck Sharp & Dohme Young Investigator Award

2001 Merck Sharp & Dohme at the XIV Scientific

Chile, 2001

Merck Sharp & Dohme Young Investigator Award at the XIV Scientific Meeting of The Inter-American Society of Hypertension, Santiago, Chile
Hsueh-Hwa Wang Cardiovascular Section Travel Award

APS Cardiovascular Section

Estados Unidos, 2004

Hsueh-Hwa Wang Cardiovascular Section Travel Award sponsored by the APS Cardiovascular Section at the Experimental Biology Meeting, Washington
Best Scientific Work

SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS

Chile, 2011

Best scientific work at XXVI Reunión Anual Sociedad Chilena de Ciencias Fisiológicas.
Mejor trabajo Científico International Gap Junction Conference

International Gap Junction Conference

Chile, 2014

Mejor trabajo en formato Poster del International Gap Junction Conference 2014
Mejor trabajo científico de la XXVI Reunión Anual de la Sociedad Chilena de Ciencias Fisiológicas

SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS

Chile, 2011

Mejor trabajo científico de la XXVI Reunión Anual de la Sociedad Chilena de Ciencias Fisiológicas


Editorial: Cell Communication in Vascular Biology Boric, Mauricio P.; Duran, Walter N.; Figueroa, Xavier F. Article ISI FRONTIERS IN PHYSIOLOGY (2021)
Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation Lillo, Mauricio A.; Gaete, Pablo S.; Puebla, Mariela; Burboa, Pia C.; Poblete, Ines; Figueroa, Xavier F. Article ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
Design, characterization and quantum chemical computations of a novel series of pyrazoles derivatives with potential anti-proinflammatory response Burboa-Schettino, Pía; Bustos, Carlos; Molins, Elies; Figueroa, Xavier F; Llanquinao, Jesus; Zarate, Ximena; Vallejos, Gabriel; Diaz-Uribe, Carlos; Vallejo, William; Schott, Eduardo Article WOS Core Collection ISI ARABIAN JOURNAL OF CHEMISTRY (2020)
Function of P2X4 Receptors Is Directly Modulated by a 1:1 Stoichiometric Interaction With 5-HT(3)A Receptors Soto, Paola; Gaete Pablo, S.; Fuentes, Christian; Lozano, Benjamin; Naulin Pamela, A.; Figueroa Xavier, F.; Barrera Nelson, Patricio Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2020)
CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells Gaete P.S.; Lillo M.A.; Puebla M.; Poblete I.; Figueroa X.F. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries Lillo, MA; Gaete, PS; Puebla M.; Ardiles, NM; Poblete, I; Becerra, A; Simon, F; Figueroa, XF Article ISI SCOPUS FASEB JOURNAL (2018)
Pannexin channel and connexin hemichannel expression in vascular function and inflammation Begandt, Daniela; Good, Miranda E; Keller, Alex S.; DeLalio, Leon J.; Rowley, Carol; Isakson, Brant E.; Figueroa, Xavier F. Article ISI SCOPUS BMC CELL BIOLOGY (2017)
Coordinated Endothelial Nitric Oxide Synthase Activation by Translocation and Phosphorylation Determines Flow-Induced Nitric Oxide Production in Resistance Vessels Figueroa, XF; Gonzalez, DR; Puebla M.; Acevedo, JP; Rojas-Libano, D; Duran, WN; Boric, MP Article ISI SCOPUS Journal of Vascular Research (2013)
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy Cea, LA; Cisterna, BA; Puebla, C; Frank, M; Figueroa, XF; Cardozo C.; Willecke K.; Latorre R.; Sáez JC Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2013)
Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels. Figueroa, Xavier F; Lillo, Mauricio A; Gaete, Pablo S; Riquelme, Manuel A; Sáez, Juan C Article Neuropharmacology (2013)
Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells Echeverria, C.; Montorfano I.; Sarmiento D.; Becerra, A; Nunez-Villena, F; Figueroa, XF; Cabello-Verrugio, C; Elorza, AA; Riedel C.; Simon F. Article ISI SCOPUS Journal of Cellular and Molecular Medicine (2013)
Ca2+-activated K+ channels of small and intermediate conductance control eNOS activation through NAD(P)H oxidase Gaete P.S.; Lillo M.A.; Ardiles N.M.; Perez F.R.; Figueroa X.F. Article ISI SCOPUS Free Radical Biology and Medicine (2012)
Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions Orellana, JA; Figueroa, XF; Sanchez HA; Contreras-Duarte, S; Velarde, V; Sáez JC Article ISI SCOPUS CNS and Neurological Disorders - Drug Targets (2011)
NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors Figueroa, XF; Poblete, I; Fernandez, R.; Pedemonte, C; Cortés V.; Huidobro-Toro, JP Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction Figueroa, XF; Duling, BR Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone? Figueroa, XF; Chen, CC; Campbell, KP; Damon, DN; Day, KH; Ramos S.; Duling, BR Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
HISTAMINE REDUCES GAP JUNCTIONAL COMMUNICATION OF HUMAN TONSIL HIGH ENDOTHELIAL CELLS IN CULTURE Saez, Juan; Rosemblatt, Mario; Martinez, Agustin; Garces, Gladys; Figueroa, Xavier; Boric, Mauricio; Alviña, Karina Article MICROVASCULAR RESEARCH (2004)
Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo. Figueroa, Xavier F; Paul, David L; Simon, Alexander M; Goodenough, Daniel A; Day, Kathy H; Damon, David N; Duling, Brian R Article Circulation research (2003)
ACH-INDUCED ENDOTHELIAL NO SYNTHASE TRANSLOCATION, NO RELEASE AND VASODILATATION IN THE HAMSTER MICROCIRCULATION IN VIVO Figueroa, Xavier; Gonzalez, Daniel; Martinez, Agustin; Duran, Walter; Boric, Mauricio Article JOURNAL OF PHYSIOLOGY-LONDON (2002)
Clonidine-induced nitric oxide-dependent vasorelaxation mediated by endothelial alpha(2)-adrenoceptor activation Figueroa, XF; Poblete MI; Boric, MP; Mendizabal, VE; Adler-Graschinsky, E; Huidobro-Toro, JP Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2001)
In vivo assessment of microvascular nitric oxide production and its relation with blood flow Figueroa, XF; Martínez AD; Gonzalez, DR; Jara, PI; Ayala, S; Boric, MP Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)
Stimulation of NO production and of eNOS phosphorylation in the microcirculation in vivo Duran, WN; Seyama, A; Yoshimura, K; Gonzalez, DR; Jara, PI; Figueroa, XF; Boric, MP Article ISI MICROVASCULAR RESEARCH (2000)
Kinin B2 receptors mediate blockade of atrial natriuretic peptide natriuresis induced by glucose or feeding in fasted rats. Croxatto, H R; Figueroa, X F; Roblero, J; Boric, M P Article Hypertension (1999)
Rise in endothelium-derived NO after stimulation of rat perivascular sympathetic mesenteric nerves. Boric, M P; Figueroa, X F; Donoso, M V; Paredes, A; Poblete, I; Huidobro-Toro, J P Article The American journal of physiology (1999)
Croxatto's fifty-year pursuit: from pepsanurin to the discovery of a new kininogen-derived peptide (PU-D1). Boric, M P; Figueroa, X F; Albertini, R; Roblero, J S Article Biological research (1998)
Determination of nitric oxide production in the hamster cheek pouch microcirculation in vivo Boric M.P.; Figueroa X. Article FASEB JOURNAL (1998)
La glucosa en conjunto con péptidos derivados de cininógenos podrían actuar desde el aparato digestivo como bloqueadores de la acción diurética-natriurética del ANP. Croxatto H.R.; Figueroa X.; Boric M.P.; Roblero J.; Silva R. ; Albertini R Article Revista Medica de Chile (1998)
A peptide released by pepsin from kininogen domain 1 is a potent blocker of ANP-mediated diuresis-natriuresis in the rat. Croxatto H.R.; Silva R.; Figueroa X.; Albertini R.; Roblero J.S.; Boric M.P. Article Hypertension (1997)
A fragment of human kininogen containing bradykinin blunts the diuretic effect of atrial natriuretic Peptide Croxatto H.R.; Figueroa X.; Roblero J.S.; Albertini R.; Silva R.; Boric M.P. Article Proc. Soc. Exp. Biol. Med. (1996)


Connexin- and Pannexin-Mediated Vascular Signaling in Diabetes Puebla Mariela, and Figueroa Xavier F.; iConcept BookSection (2013)
Control and coordination of vasomotor tone in the microcirculation Lillo Mauricio A., Pérez Francisco R., Puebla Mariela, Gaete Pablo S. and Figueroa Xavier F.; Gaze David C. BookSection (2012)


Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone? - Reply Figueroa, XF; Duling, BR Letter ISI AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)


Combining force spectroscopy and cellular omics reveals the molecular mechanism of crosstalking interaction between plasma membrane P2X4 and 5-HT3a receptors Barrera, Nelson P.; Figueroa, Xavier F. Proyecto (2021)
PARACRINE EFFECT OF THE ENDOTHELIUM ON PROSTATE CANCER CELLS AND ITS ROLE DURING TUMOR PROGRESSION FONDECYT (1161115) Proyecto 2016-2019 Coinvestigador(a)
CONTROL AND COORDINATION OF MICROVASCULAR VASOMOTOR TONE BY NITRIC OXIDE-DEPENDENT REGULATION OF CONNEXIN- AND PANNEXIN-FORMED GAP JUNCTION CHANNELS OR HEMICHANNELS FONDECYT (1150530) Proyecto 2015-2019 Inv. Responsable
ROLE AND REGULATION OF HEMICHANNELS IN FUNCTIONAL RESPONSES OF INACTIVE, ACTIVE AND ACUTELY CACHEXIC ADULT SKELETAL MUSCLES. FONDECYT (1111033) Proyecto 2011-2015 Coinvestigador(a)
COORDINATION OF MICROVASCULAR FUNCTION BY LONG DISTANCE ENDOTHELIAL CELL SIGNALING BASED ON CONNEXIN-MEDIATED COMMUNICATION AND VOLTAGE-DEPENDENT VASODILATOR MECHANISMS FONDECYT (1100850) Proyecto 2010-2014 Inv. Responsable
Pro-inflammatory conditions increase the permeability of the cell membrane through pathways that offer new therapeutic targets for human diseases CONICYT (Anillos ACT-71) Proyecto 2010-2013 Inv. Principal
MECANISMOS DE DISFUNCION ENDOTELIAL EN HIPERTENSION. RELACION FUNCIONAL ENTRE LA EXPRESION DEL CANAL DE SODIO EPITELIAL (ENAC) Y LA LOCALIZACION SUBCELULAR DE LA OXIDO NITRICO SINTASA ENDOTELIAL (ENOS). FONDECYT (1090757) Proyecto 2009-2012 Coinvestigador(a)
Mecanismos endoteliales dependientes de voltaje para la propagación regenerativa de las respuestas vasodilatadoras Vice-rectoría de Investigación, Pontificia Universidad Católica de Chile (Proyecto Límite 15/2009) Proyecto 2009-2010 Inv. Responsable
Participación de las arginasas en la disfunción endotelial característica de la hipertensión arterial Vice-rectoría de Investigación, Pontificia Universidad Católica de Chile (BM-14) Proyecto 2007-2008 Inv. Principal
MECANISMOS DE SEÑALIZACION CELULAR PARA LA PROPAGACION DE LAS RESPUESTAS VASODILATADORAS. FONDECYT (11060289) Proyecto 2006-2008 Inv. Responsable
Signaling and Transmission pathways for Conducted Vasodilation American Heart Association (AHA2003) Proyecto 2003-2005 Inv. Responsable
PRODUCCION DE OXIDO NITRICO EN VASOS DE RESISTENCIA=> MECANISMOS DE TRANSDUCCION Y REGULACION CELULAR FONDECYT (2990079) Proyecto 1999-2001 Inv. Responsable


Connexins and Pannexins in Vascular Function and Disease Molica, F; Figueroa, XF; Kwak, BR; Isakson, BE; Gibbins, JM Review ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca2+ signaling Munoz, MF; Puebla M.; Figueroa, XF Review ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
Functional Role of Connexins and Pannexins in the Interaction Between Vascular and Nervous System Gaete, Pablo S., Lillo, Mauricio A., Figueroa, Xavier F. Review ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2014)
Gap Junctions in the Control of Vascular Function Figueroa, XF; Duling, BR Review ISI ANTIOXIDANTS & REDOX SIGNALING (2009)
Vascular gap junctions in hypertension Figueroa, XF; Isakson, BE; Duling, BR Review ISI HYPERTENSION (2006)