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HELMUTH ALBERTO SANCHEZ RIQUELME

INVESTIGADOR ADJUNTO

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

Líneas de Investigación


FISIOLOGIA; NEUROCIENCIAS; BIOFISICA

Educación

  •  DOCTORADO en CIENCIAS BIOLOGICAS, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  LICENCIATURA en CS.BIOLOGICAS, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

Experiencia Académica

  •   INVESTIGADOR ASOCIADO Full Time

    ALBERT EINSTEIN COLLEGE OF MEDICINE

    AECOM, School of Medicine

    Nueva York, Estados Unidos

    2015 - 2016

Experiencia Profesional

  •   POSTDOCTORADO Full Time

    ALBERT EINSTEIN COLLEGE OF MEDICINE

    Nueva York, Estados Unidos

    2008 - 2015

Formación de Capital Humano


Experience in the following techniques:
Cell culture management ( Contreras et al. 2002, Sanchez et al., 2009, Sanchez et al., 2010, Abbott et al., 2023, Waisblutt et al., 2023).
Electrophysiology, TVEC and single whole-cell records (Sanchez et al., 2009, Sanchez et al., 2010, Rubinos et al., 2012, Sanchez et al., 2013, 2014, 2016).
Immunotransference (Contreras et al, 2002, Sanchez et al., 2009, 2013)
Immunofluorescence (Eugenin et al., 2007, Sanchez et al., 2009, Sanchez and Verselis, 2014)


Difusión y Transferencia


https://cinv.uv.cl/members/helmuth-sanchez/

10.51445/sja.auditio.vol6.2022.0082



 

Article (21)

Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti
MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity
Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity
An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy
Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling
Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels
Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss
Altered Inhibition of Cx26 Hemichannels by pH and Zn2+ in the A40V Mutation Associated with Keratitis-Ichthyosis-Deafness Syndrome
The D50N mutation and syndromic deafness: Altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions
Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels
Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions
Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization
Differentially altered Ca(2+) regulation and Ca(2+) permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome
Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells
Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro
Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

Proyecto (1)

IDENTIFICATION OF CONGENITAL DEAFNESS MUTATIONS IN CHILE

Review (1)

Redox-mediated regulation of connexin proteins; focus on nitric oxide
20
HELMUTH SANCHEZ

INVESTIGADOR ADJUNTO

Laboratorio de Conexinas y Panexinas

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

9
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

4
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Carolina Flores

Investigador Postdoctoral

Neurociencias

Universidad de Valparaíso

Valparaíso, Chile

2
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

2
Ricardo Ceriani

Profesor adjunto

Farmacia

Universidad Valparaíso

Valparaíso, Chile

1
Hernan Gonzalez Diaz

Associate Professor

Cirugía Oncológica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
DONALD BROWN

PROFESOR TITULAR

FACULTAD DE CIENCIAS

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Loreto Véliz

Profesor Asistente Adjunto

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Oliver Schmachtenberg

Investigador titular

Instituto de Biología

Universidad de Valparaíso, CINV

Valparaíso, Chile

1
ISAAC GARCÍA

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

1
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Vania Figueroa

Directora InES Género y CTGénero, Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

1
Caroline Weinstein

profesor titular

Facultad de Farmacia

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile