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ISAAC EDUARDO GARCÍA CARRILLO

Profesor Adjunto

Universidad de Valparaiso

Valparaiso, Chile

Ion channel biophysics, Channelopaties, Connexins, Pannexins, inflammation and Nociception, Electrophysiology

Biological Science, Neuroscience, UNIVERSIDAD DE VALPARAISO. Chile, 2014
Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 2008
Ciencias Naturales y Exactas, UNIVERSIDAD DE CHILE. Chile, 2003

Visiting Researcher Other

RUTGERS UNIVERSITY NEWARK

MEDICAL SCIENCE

Newark, Estados Unidos

2014 - 2015
PROFESOR ADJUNTO Full Time

UNIVERSIDAD DE VALPARAISO

FACULTAD DE ODONTOLOGIA

VALPARAISO, Chile

2018 - At present

Visiting Researcher Full Time

New Jersey Medical School, Rutgers University, Department of Pharmacology and Physiology

Newark, NJ, Chile

2014 - 2015


The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening Capuccino, JMV; Garcia, IE; Botello-Smith, WM; Harris, AL; Luo Y.; Contreras, JE Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2019)
The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels Garcia, Isaac E.; Contreras, Gustavo F.; Pupo, Amaury; Alvarez, Osvaldo; Latorre, Ramon; Martinez, Agustin D. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2018)
Calcium binding and voltage gating in Cx46 hemichannels Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Conexinopathies: a structural and functional glimpse García IE., Prado, P., Pupo A., Jara, O., Rojas, D., Mujica, P., Flores-Muñoz, C., Gonzalez, J., Soto, C., Pinto, B., Retamal, MA., Gonzalez, C., Martínez AD Article BMC CELL BIOLOGY (2016)
Characterization of a novel water pocket inside the human Cx26 hemichannel structure Araya-Secchi R., Perez-Acle T., Seung-gu Kang, Huynh T., Escalona Y., Garate JA., Martínez AD., García IE., Sáez JC., Zhou R Article Biophys. J. (2014)
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function Jara O., Acuña R., García IE., Maripillán J., Figueroa V., Sáez JC., Araya R., Lagos C., Perez- Acle T., Berthoud V., Beyer E., Martínez AD Article Mol Biol Cell (2012)


TOWARDS A MOLECULAR MECHANISM FOR CALCIUM-DEPENDENT EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE Jaimovich E.; Buvinic, S.; Casas M.; Figueroa, R.; García, I. Abstract JOURNAL OF PHYSIOLOGICAL SCIENCES (2009)
Altered IP3 receptors, IP3-dependent Ca2+transients and Ca2+-dependent gene expression in a Duchenne muscular dystrophy cell line Jaimovich E.; Juretic, N; García, I.; Hartley, R; Figueroa, R.; Riveros, N.; Molgó J. Abstract ISI FASEB JOURNAL (2008)


Methods to determine the formation of heteromeric hemichannels Agustín D. Martínez, Oscar Jara, Ricardo Ceriani, Paula Mujica, and Isaac E. García BookSection (2016)


ROLE OF CCL5/CCR5 AXIS IN THE AGGRESSIVENESS OF ORAL SQUAMOUS CELL CARCINOMA Proyecto (2019)
Papel de los hemicanales de conexinas en el crosstalk entre odontoblastos y fibras nerviosas en la respuesta al dolor inducida por agentes cariogenicos Proyecto (2018)
ROLE OF CONNEXIN HEMICHANNELS IN THE CROSSTALK BETWEEN ODONTOBLASTS AND DENTAL PRIMARY AFFERENTS IN CARIOGENIC CONDITIONS Proyecto (2018)
Molecular determinants of the interaction between the amino termini and the water pocket of Cx26 hemichannels during gating Garcia, Isaac E. Proyecto (2014)


Redox-mediated regulation of connexin proteins; focus on nitric oxide Review ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

1

Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

3

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1

Mariana Casas

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1

Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1

HELMUTH SANCHEZ

INVESTIGADOR ADJUNTO

Laboratorio de Conexinas y Panexinas

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

1

Karel Mena

Profesor Asociado

Ciencias Biológicas y Químicas

Universidad Católica de Temuco

Temuco, Chile

15

ISAAC GARCÍA

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

1

Ricardo Hartley

Investigador

Instituto de Investigación y Postgrado

Universidad Central de Chile

Santiago, Chile