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Mariana Victoria Casas Atala

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Muscle Plasticity, Frequency decoding in skeletal muscle, Excitation Transcription Coupling, Muscle diseases, Sarcopenia

Cellular and Molecular Biology, UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI. Francia, 2006

Instructor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

2006 - 2010
Assistant Professor Full Time

Medicine

Santiago, Chile

2010 - At present

Instructor Full Time

Universidad de Chile, Facultad de Medicina

Santiago, Chile

2006 - 2010
Assistant Professor Full Time

Universidad de Chile

Santiago, Chile

2010 - At present

Profesional title of Medical technology thesis direction:
1. Reinaldo Figueroa. (July 2008).
2. Carlos Tapia. (July 2009).

Profesional title of Biochemistry, thesis direction:
Villalobos, Verónica: "REGENERACIÓN MUSCULAR POR INYECCIÓN LOCAL DE CÉLULAS MESENQUIMALES HUMANAS ESFEROIDES 3D (AT-hMSCs-3D) EN UN MODELO MURINO DE LESIÓN MUSCULAR SEVERA", 2019

UNIVERSIDAD DE CHILE, Magíster/Master/DEA:
1. Francisco Ignacio Jaque Fernández: "Participación de Panexina-1 en la regulación del funcionamiento de Cav1.1", 2016
2. Esteban Quezada, "“PAPEL DEL IP3R EN LOS CAMBIOS DE LA EXPRESIÓN DEL COMPLEJO MCU INDUCIDA POR ESTÍMULO ELÉCTRICO EN MÚSCULO ESQUELÉTICO ADULTO”", 2018

PhD thesis direction
1.Gonzalo Jorquera , PhD in Biomedical Sciences (September 2014)
2.Cristián Campos, PhD in Biomedical Sciences (January 2019)

International Travel Award

Biophysical Society

Estados Unidos, 2009

Support young scientists in attending the Annual Meeting of the Biophysical Society


Evaluating the essential role of RONS in vivo in exercised human muscle. Jaimovich, E; Casas, M Article Acta physiologica (Oxford, England) (2018)
Lactate administration activates the ERK1/2, mTORC1, and AMPK pathways differentially according to skeletal muscle type in mouse Cerda-Kohler, H; Henriquez-Olguin, C; Casas, M; Jensen, TE; Llanos, P; Jaimovich, E Article PHYSIOLOGICAL REPORTS (2018)
Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice del Campo, Andrea; Contreras-Hernández, Ignacio; Castro-Sepúlveda, Mauricio; Campos, Cristian A.; Figueroa, Reinaldo; Tevy, María Florencia; Eisner, Verónica; Casas, Mariana; Jaimovich, Enrique Article ISI SCOPUS AGING-US (2018)
Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle Arias-Calderón M.; Almarza G.; Díaz-Vegas A.; Contreras-Ferrat, A; Valladares, D; Casas M.; Toledo, H; Jaimovich E.; Buvinic, S. Article ISI SCOPUS SKELETAL MUSCLE (2016)
ROS Production via P2Y(1)-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells Diaz-Vegas, A; Campos CA; Contreras-Ferrat, A; Casas M.; Buvinic, S.; Jaimovich E.; Espinosa, A. Article ISI SCOPUS PLOS ONE (2015)
Exercise Sensitizes Skeletal Muscle to Extracellular ATP for IL-6 Expression in Mice Fernandez-Verdejo, R; Casas M.; Galgani, J; Jaimovich E.; Buvinic, S. Article ISI SCOPUS INTERNATIONAL JOURNAL OF SPORTS MEDICINE (2014)
Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion Mizgier M.L.; Casas M.; Contreras-Ferrat, A; Llanos P.; Galgani, J. E. Article ISI SCOPUS OBESITY REVIEWS (2014)
Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity Jorquera, G; Altamirano F.; Contreras-Ferrat, A; Almarza G.; Buvinic, S.; Jacquemond, V; Jaimovich E.; Casas M. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2013)
Electrical Stimuli Are Anti-Apoptotic in Skeletal Muscle via Extracellular ATP. Alteration of This Signal in Mdx Mice Is a Likely Cause of Dystrophy Valladares, D; Almarza G.; Contreras, A; Pavez, M.; Buvinic, S.; Jaimovich E.; Casas M. Article ISI SCOPUS PLOS ONE (2013)
Nifedipine Treatment Reduces Resting Calcium Concentration, Oxidative and Apoptotic Gene Expression, and Improves Muscle Function in Dystrophic mdx Mice Altamirano F.; Valladares, D; Henriquez-Olguin, C; Casas M.; Lopez, JR; Allen, PD; Jaimovich E. Article ISI SCOPUS PLOS ONE (2013)
PI3-kinase is involved in plasticity of adult myofibers acting as a nodal step that originates divergent pathways for gene expression Jorquera, G; Altamirano F.; Buvinic, S.; Contreras-Ferrat, A; Jaimovich E.; Casas M. Article FASEB JOURNAL (2013)
Measurement of calcium release due to inositol trisphosphate receptors in skeletal muscle Casas M.; Altamirano F.; Jaimovich E. Article SCOPUS Methods in Molecular Biology (2012)
IP 3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers Casas M.; Figueroa, R.; Jorquera, G; Escobar M.; Jaimovich E.; Molgó J. Article JOURNAL OF GENERAL PHYSIOLOGY (2010)
IP3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers Casas M.; Figueroa, R.; Jorquera, G; Escobar M.; Molgó J.; Jaimovich E. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2010)
ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle Buvinic, S.; Almarza G.; Bustamante, M; Casas M.; Lopez, J.; Riquelme M.; Sáez JC; Huidobro-Toro, JP; Jaimovich E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)


Cav1.1 controls ATP release to elicit gene expression in adult muscle fibers Jorquera, G; Valladares, D; Pietri-Rouxel, F; Allard, B; Jacquemond, V; Jaimovich E.; Casas M. Abstract ISI FASEB JOURNAL (2014)
Extracellular ATP as a relevant mediator between skeletal muscle depolarizaition and interleukin-6 expression: from cell culture to whole animal adaptations Buvinic, S.; Bustamante, M; Fernandez-Verdejo, R; Casas M.; Vasquez, J; Jaimovich E. Abstract ISI FASEB JOURNAL (2014)
Muscle slow to fast fiber plasticity is triggered by low frequency stimulation, membrane depolarization and ATP Casas M.; Llanos P.; Jorquera, G; Jaimovich E. Abstract ISI FASEB JOURNAL (2014)
Nifedipine Treatment Improves Muscle Function in Mdx Mice Altamirano F.; Valladares, D; Henriquez-Olguin, C; Casas M.; Lopez, JR; Allen, PD; Jaimovich E. Abstract ISI BIOPHYSICAL JOURNAL (2014)
Atp-Induced Membrane Depolarization Relates to Skeletal Muscle Fibers Plasticity Casas M.; Llanos P.; Jorquera, G; Hidalgo J.; Buvinic, S.; Jaimovich E. Abstract BIOPHYSICAL JOURNAL (2013)
Cav1.1 Controls ATP Release in Adult Muscle Fibers Jorquera, G; Pietri-Rouxel, F; Allard, B; Jacquemond, V; Gentil, C; Jaimovich E.; Casas M. Abstract BIOPHYSICAL JOURNAL (2013)
A molecular mechanism for frequency dependent skeletal muscle fiber plasticity Jaimovich E.; Jorquera, G; Buvinic, S.; Casas M. Abstract ISI FASEB JOURNAL (2012)
Cav1.1 Acts as a Voltage Sensor for Two Separate Processes in Skeletal Muscle with Different Voltage Dependence Casas M.; Jaimovich E. Abstract ISI BIOPHYSICAL JOURNAL (2011)
Muscle Plasticity Is Regulated by a Process Involving ATP Release and Inositol Trisphosphate Production in Skeletal Myofibers Jorquera, G; Almarza G.; Buvinic, S.; Jaimovich E.; Casas M. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2011)
TOWARDS A MOLECULAR MECHANISM FOR CALCIUM-DEPENDENT EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE Jaimovich E.; Buvinic, S.; Casas M.; Figueroa, R.; Garcia, I Abstract JOURNAL OF PHYSIOLOGICAL SCIENCES (2009)
Slow calcium signals induced by electrostimulation in adult skeletal muscle fibers. Casas M.; Jaimovich E. Abstract BIOPHYSICAL JOURNAL (2007)


Intracellular calcium modulation of gene expression Casas M.; Jaimovich E. BookWhole SCOPUS Food and Nutritional Components in Focus (2016)


Nueva Terapia Farmacológica para el tratamiento de sarcopenia y distrofias musculares=> Prueba de concepto FONDECYT (ID16I10101) Proyecto 2017-2018 Director(a)
EXCITATION-METABOLISM COUPLING IN SKELETAL MUSCLE; BASIC MECHANISMS AND THEIR ALTERATION IN OBESITY AND AGING FONDECYT (1151293) Proyecto 2015-2019 Coinvestigador(a)
UNVEILING MOLECULAR BASIS FOR MUSCLE REMODELING AND MUSCLE-BONE CROSSTALK AT THE MASTICATORY APPARATUS=> EXTRACELLULAR ATP AS A SIGNALING MOLECULE. FONDECYT (1151353) Proyecto 2015-2019 Coinvestigador(a)
Purinergic signaling in the adult muscle fiber=> functional crosstalk with the inositol phosphate pathway ECOS-CONICYT (C13B01) Proyecto 2014-2017 Coinvestigador(a)
Assessment of peripheral glucose utilization as a determinant factor of glucose-stimulated insulin secretion in humans FONDECYT (1130217) Proyecto 2013-2017 Coinvestigador(a)
A new role for Cav1.1 as a frequency decoder for signals related to skeletal muscle plasticity VID Universidad de Chile (VID U-Inicia 2011) Proyecto 2012-2013 Inv. Principal
Señalización por estrés metabólico en cáncer, enfermedades cardiovasculares y diabetes PIA (ACT 1111) Proyecto 2012-2015 Coinvestigador(a)
SIGNAUX CALCIQUES VOLTAGEDEPENDANTS GENERES PAR LE RECEPTEUR A L'INOSITOL TRISPHOSPHATE DANS LA FIBRE MUSCULAIRE ADULTE DE MAMMIFERE CNRS-Conicyt (EDC25448) Proyecto 2012-2013 Coinvestigador(a)
Membrane potential dependence of IP3-elicited calcium signals triggered by DHPR in adult muscle fibers CNRS-Conicyt (EDC24748) Proyecto 2011-2012 Coinvestigador(a)
A NEW ROLE FOR DYSTROPHIN IN EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE FONDECYT (1110467) Proyecto 2011-2014 Coinvestigador(a)


ATP Signaling in Skeletal Muscle: From Fiber Plasticity to Regulation of Metabolism Casas M.; Buvinic, S.; Jaimovich E. Review ISI SCOPUS EXERCISE AND SPORT SCIENCES REVIEWS (2014)