
Andrew Frederick Geoffery Quest Minikus
Full Professor
FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE
Santiago, Chile
Caveolin-1 as a tumor suppressor and metastasis promoter/Helicobacter pylori in gastric cancer/inflammation-associated changes in Caveolin-1 function
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Biochemistry, ETH Zuerich. Suiza, 1988
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Prof. Titular Full Time
UNIVERSIDAD DE CHILE
Facultad de Medicina
Santiago, Chile
2005 - At present
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Full Professor Full Time
Facultad de Medicina, Universidad de Chile
Santiago, Chile
2005 - At present
Post-doctoral fellows
1) Mauricio Henríquez (2006-2009 : Universidad de Chile). Working on alternative forms of cell death induced by ceramides (FONDAP 15010006). Fondecyt post-doctoral fellow award Nr. 3050037 (2007-2009) to study role of P2X7 receptors and ATP in FasL-induced necrosis. Position as Assistant Professor at the ICBM, Universidad de Chile since January 2009.
2) Vicente Torres (2009-2013: Universidad de Chile). Short additional post-doctoral training period working on effects of caveolin-1 as a tumor suppressor (FONDAP 15010006). As of 2010 funded by Fondecyt Chile Project Nr. 79090021 (2010-2012) “Renovacion academica para el desarollo de la medicina molecular“ financial support to promote integration of young scientists (post-doctoral fellows) into academia. Position as Assistant Professor at the Faculty of Odontology, Universidad de Chile since March 2011.
3) Manuel Valenzuela (2009-2011: Universidad de Chile). Continuation of Ph.D. thesis project working on mechanisms underlying cell death induced by Helicobacter Pylori in gastric epithelial cells for over a year. Subsequently, post-doctoral position in the laboratory of Dr. Pedro Buc Calderon, Université Catholique de Louvain, Belgium.
4) Denisse Bravo (2009-2011: Universidad de Chile). Continuation from Manuel working on mechanisms underlying cell death induced by Helicobacter Pylori in gastric epithelial cells. Position as assistant professor at the Faculty of Odontology, Universidad de Chile since March 2011.
5) Jimena Castillo (2013-2015: Universidad de Chile). Continuation from Carlos Sanhueza and Maria Ines Diaz’s work evaluating CAveolin-1 translocation to ER in hypoxia, the regulation there of eNOS and the connection to HIF-1a inhibition.
6) Simon Guerrero (2013-2015: Universidad de Chile). Collaboration with Marcelo Kogan from the Fcultad de Odontologia, Universidad de Chile, evaluating the potential of gold nanoparticles to track melanoma metastasis in vivo.
7) 2015-2018 Fondecyt Chile Project for post-doctoral fellows Nr. 3160384 (to Jimena Bravo; host laboratory A. Quest) “Role of Helicobacter pylori gamma glutamyl transpeptidase in autophagy of human gastric cells and the progression of precancerous lesions to gastric cancer” (ranked Nr.1 in study section medicine G2/G3).
8) 2017-2020 Fondecyt Chile Project for post-doctoral fellows Nr. 3170141 (to Paula Diaz; host laboratory A. Quest) “The role of PKR-like ER kinase (PERK) in Helicobacter pylori induced gastric cell death and progression of precancerous lesions to gastric cancer” (ranked Nr.5 in study section medicine G2/G3).
9) 2018-2022 Fondecyt Chile Project for post-doctoral fellows Nr. 3180656 (to Lorena Orostica; host laboratory A. Quest) “Rol del ambiente inflamatorio en la expresión de CAV1 y la progresión del Cáncer de Vesícula Biliar” (ranked Nr.2 in study section medicine G1).
10) 2018-2022 Fondecyt Chile Project for post-doctoral fellows Nr. 3180783 (to Alejandra Sandoval; host laboratory A. Quest) “The role of the ” Angiotensin II type 2 receptor in the molecular pathogenesis of human gastric carcinoma (ranked Nr.1 in study section medicine G2/3).
11) 2019-2022 Fondecyt Chile Project for post-doctoral fellows Nr. 3190330 (to Layla Simon; host laboratory A. Quest) “Caveolina-1 induce cambios metabólicos en células de cáncer que favorecen la metástasis” (ranked Nr.11 in study section Biology 2).
12) 2022-2025 Fondecyt Chile Project for post-doctoral fellows Nr. 3220587 (to Karen Bolaños; host laboratory A. Quest) “Photothermal effect and Extracellular vesicles to control the targeted release of doxorubicin to tumor cells” (ranked Nr. 5 in study section Chemistry).
PhD thesis students (finished)
1. Diego Rodriguez (April 2009): “Caveolina-1 inhibe la proliferación y promueve muerte celular mediante la regulación negativa de ciclooxigenasa-2 y survivina” (AQ thesis director/LLeyton co-director).
2. Manuel Valenzuela (May 2009): “Estudio del papel de survivina y caveolina-1 en la apoptosis inducida por Helicobacter pylori en celulas gastricas” (AQ thesis director/HToledo co-director).
3. Jorge Gutierrez (June 2009): “Rol de PKCalfa en la regulación de la expresión de caveolina-1 en celulas de cancer de endometrio, mama y colon“ (AQ thesis director/SLavandero co-director)
4. Rodrigo Herrera-Molina (August 2009) “La interaccion molecular integrina aVb3/Thy-1 en el contacto celula-celula entre astrositos y neuronas participa en la inhibición del crecimiento de neuritas y la retraccion de procesos neuronales s traves de una via de señalización que involucra a src“(AQ thesis codirector/LL director).
5. Alejandra Valdivia (June 2010): “Transduccion de senales mediada por Thy-1 en astrocitos: Participación secuencial de la integrina avb3 y sindican-4 en la formación de adhesiones focales y fibras de estrés” (AQ thesis codirector/LL director).
6. Adam Aguirre (June 2011) : “FasL promueve muerte celular en celulas linfoides via liberacion de ATP y activacion de receptores P2X7” (AQ thesis director/Mauricio Henriquez co-director).
7) Lorena Lobos (June 2011) :”La E-cadherina potencia a Caveolina-1 como supresor de tumores y reduce su efecto promotor de metastasis” ” (AQ thesis director/Lisette Leyton co-director).
8) Paulina Ormazabal (December 2011) “Evaluacion de moleculas relacionadas con la via metabolica de la insulina en celulas endometriales y en endometrio de mujeres con syndrome de ovario poliquistico“ Ph.D. advisor Margarita Vega, AQ co-advisor.
9) Jaime Gonzalo Fernandez (Jan 2012) “Survivina promueve la actividad transcripcional de b-catenina favoreciendo de esta manera angiogenesis” (AQ thesis director, co-advisor Julio Tapia).
10) Lorena Aguilar (Nov. 2012) “La terapia experimental conjunta de Calreticulina de Trypanosoma Cruzi y la inmunizacion con Survivina inhibe el crecimiento in vivo de un melanoma experimental murino” (AQ and Arturo Ferreira thesis advisors).
11) Sergio Nunez (Dec 2012) “Caveolina-1 sensibiliza a las células Min6 a la muerte inducida por ácidos grasos libres” (AQ director).
12) Carlos Sanhueza (Sept. 2013) “Caveolina-1 reduce la transcripcion dependiente de HIF-1a en un mecanismo dependiente del oxido nitrico en celulas tumorales” (AQ thesis advisor/ LL co-advisor).
13) Milene Kong (Jan 2014). “Thy-1 induce la migración de los astrocitos activando vías de señalización que involucran a FAK, PI3K, Tiam1 y Rac1” (LL thesis advisor/ AQ co-advisor).
14) Ph. D. Advisor of Rina Ortiz (Oct 2010 – Jan 2015) Ph.D. in Farmacology (funded by CONICYT/FONDAP; Mecesup travel fellowship) “Caveolin-1 expression promotes migration of B16F10 mouse melanoma cells in vitro and metastasis in vivo in C56BL6 mice in manner that requires phosphorylation on tyrosine by src family kinases” Thesis co-advisor Lisette Leyton, ICBM, Universidad de Chile. Teaching position at the Universidad de Valparaiso.
15) Ph. D. Co-advisor of Alvaro Alvarez (Oct 2010 – Jan 2015) Ph.D. in Farmacology (funded by CONICYT/FONDAP; Mecesup travel fellowship) “Role of the receptor P2X7 in astrocyte responses triggered by Thy-1 in an inflammatory environment” Thesis advisor Lisette Leyton, ICBM, Universidad de Chile. Teaching position at private university.
16) Ph. D. Advisor of Jorge Diaz (Dec 2011 – Mayo 2015) Ph.D. in Biochemistry (funded by CONICYT/FONDAP; MECESUP travel fellowship) “Caveolin-1 enhanced migration of metastatic tumor cells requires phosphorylation on tyrosine-14 and activation of the Rab5/Tiam-1/Rac1 axis” Thesis co-advisor Vicente Torres, Facultad de Odontologia, Universidad de Chile.
17) Ph. D. Co-advisor of Cesar Oyarce (Mar 2013 – July 2015) Ph.D. in Biomedical Sciences (funded by CONICYT/FONDAP) “Caveolin-1 promotes dendritic cell maturation by inhibiting b-catenin/Tcf-Lef-dependent transcription” Thesis advisor Alvaro Lladser, Fundacion Ciencia y Vida.
18) Ph. D. Co-advisor of Horacio Maldonado (Oct 2011 – Sept 2015) Ph.D. in Biochemistry (funded by CONICYT/FONDAP; PhD travel fellowship) “Study of signaling mechanisms associated with retraction/inhibition of neurite outgrowth mediated by ?v?3/Thy-1 interaction in neuronal cells in culture” Thesis advisor Lisette Leyton, ICBM, Universidad de Chile.
19) Ph. D. Co-advisor of Roberto Bravo (Oct 2011 – Oct 2015) Ph.D. in Biochemistry (funded by CONICYT/FONDAP) “Compartmentalizacion of physical and metabolic coupling between ER and mitochondria in cancer cells” Thesis advisor Sergio Lavandero, ICBM, Universidad de Chile.
20) Ph. D. Advisor of Maria Ines Diaz (Aug 2008 – Dec 2015) Ph.D. in Biochemistry (funded by Mecesup/CONICYT/FONDAP fellowships; Mecesup/DID University of Chile travel fellowships; CONICYT apoyo de tesis fellowship) “Role of the unfolded protein response in tumor suppression by caveolin-1” Thesis co-advisor Claudio Hetz, ICBM, Universidad de Chile. Teaching position in private university.
21) Ph. D. Advisor of Natalia Diaz (Oct 2012 – July 2016) Ph.D. in Biochemistry (funded by CONICYT/FONDAP; proyecto REDES travel fellowship) “Inhibition of Caveolin-1 enhanced migration of metastatic tumor cells by E-cadherin involves suppression of phosphorylation on tyrosine-14 and the Rab5/Tiam-1/Rac1 axis” Thesis co-advisor Lisette Leyton, ICBM, Universidad de Chile.
22) Ph. D. Advisor of Jimena Canales (Oct 2012 – Oct 2016) Ph.D. in Farmacology (funded by CONICYT/FONDAP; xxxxx travel fellowship) “Helicobacter pylori induced iNOS expression and NO production enhances HIF-1?-dependent transcription transition to a more mobile cell phenotype” Thesis co-advisor Denisse Bravo, ICBM, Universidad de Chile.
23) Ph. D. Advisor of Yeniffer Avalos (Oct 2012 – Oct 2016) Ph.D. in Farmacology (funded by CONICYT/FONDAP; PhD travel fellowship) “Caveolin-1-enhanced autophagy via reduced iNOS signaling favors caveolin-1-mediated tumor suppression”
24) Ph.D. Co-advisor of Andrea Orellana (Mar 2014 – November 2016) PhD in Pharmacology (funded by CONICYT, fellowship from Ecuador/FONDAP) “Modulation of the expression of SLC5A8, a gene associated with gastrointestinal cancer, by the infection with Helicobacter pylori in symptomatic and asymptomatic children”. Prize for Best Oral Presentation at the 365 World Congress of Pediatric Infectious Diseases (WCPID), Brazil, 2015. Thesis advisor Miguel O’Ryan, ICBM, Universidad de Chile. Now Assistant professor at the Universidad de Guayaquil, Ecuador.
25) Ph. D. Advisor of Victor Diaz (Jan 2014 – Sept 2017) Ph.D. in Biochemistry (funded by CONICYT/ANILLO/FONDAP) “Development of nanoparticles based on Quantum Dots to stady CAV1-enhanced metastasis of B16F10 cells in vivo” Thesis co-advisor Jose Miguel Perez, Universidad Andres Bello.
26) Ph. D. Co-advisor of Francesca Burgos (April 2014 – Oct 2017) Ph.D. in Biochemistry (funded by CONICYT/FONDAP) “The astrocyte proteoglycan Syndecan-4 participates in the inhibition of neuronal process outgrowth induced by engagement of neuronal Thy-1 and astrocyte avb3 integrin” Thesis advisor Lisette Leyton, ICBM, Universidad de Chile. Oriana Joisseau Young Female Scientist Award 2013 for Excellence in Biochemistry. PEW award Latin American Fellows Program in the Biomedical Sciences 2018. Now post-doc at UCSF in the USA.
27) Ph.D. Advisor of America Campos (Dec 2014 – April 2018) Ph.D. in Biochemistry (funded by CONICYT/FONDAP) “The role of CAV1 in exosome formation and malignancy of breast cancer cells” Best Oral presentation award (2nd place) Chilean Cell Biology Society 2017. Thesis co-advisor Lorena Lobos, ICBM, Universidad de Chile, Fundacion Ciencias para la Vida, Universidad de Desarollo. Post-doc in the lab for one year. Then got Becas Chile fellowship to go to the University of Queensland, Brisbane, Australia.
28) Roger Yefi (August 2018) “Regulation of tumor progression in colon cancer by the proteins CK2 and Caveolin-1” (Thesis advisors Julio Tapia, AQ).
29) Ph.D. Advisor of Samuel Martinez (July 2015 – Sept. 2018) Ph.D. in Molecular Biotechnology (funded by FONDAP ACCDiS) “Study of the anti-metastatic potential of the AT2R as a target to block melanoma metastasis”. Thesis co-advisor Sergio Lavandero, Facultad de Quimicas Farmaceuticas, Universidad de Chile. Short post-doc with Lisette Leyton, now doing post-doc at The Albert Einstein Colleage, USA.
30) Ph.D. Co-Advisor of Maritza Garrido (April 2016 – April 2019) Ph.D. in Pharmacology (funded by CONICYT/FONDAP) “Role of survivin/COX2 in NGF-induced angiogenesis in ovarian cancer” Thesis advisor Carmen Romero, Hospital Clinico, Universidad de Chile. Now has faculty position in the Hospital Clinico, Universidad de Chile.
31) Ph.D. Co-Advisor of Maximilian Arce (July 2016 – June 2019) Ph.D. in Biological Sciences PUC (funded by CONICYT/FONDAP) “FXa promotes metastasis through endothelial cell activation” Thesis advisor Gareth Owen, Facultad de Ciencias Biologicas, PUC. Now doing post-doc in the Univerity of Uppsula, Sweden.
32) Ph.D. Co-Advisor of Pablo Lara (June 2015 – June 2020) Ph.D. in Pharmacology (funded by CONICYT/FONDAP) “Exosomes from metastatic B16F10 cells as vectors for specific targetting of gold nanoparticles and curcumin to lung tumors” Thesis advisor Marcelo Kogan, Facultad de Quimicas Farmaceuticas, Universidad de Chile. Now post-doc in Holland, University of Leiden.
33) Ph.D. Co-Advisor of Monica Villa (June 2015 – July 2020) Ph.D. in Pharmacology (funded by CONICYT) “Evaluation of the oxidized low-density lipoprotein receptor, LOX-1, as a new therapeutic target in cardiac fibrosis” Thesis advisor Lorena Garcia, Facultad de Quimicas Farmaceuticas, Universidad de Chile. Now teaching at private University.
34) Ph.D. advisor of Ricardo Huilcaman (Jan 2018 – November 2020). Ph. D. in Biomedical sciences (funded by CONICYT/FONDAP) “Caveolin-1 phosphorylation of tyrosine-14 modulates the biochemical properties of extracellular vesicles from metastatic melanoma cells to promote malignancy of less metastatic cells” Thesis co-advisor Lisette Leyton, ICBM, Faculty of Medicine, Universidad de Chile. Now doing post-doc in the lab.
35) Ph.D. advisor of Renato Burgos (Agosto 2018 – April 2021). Ph. D. in Farmacology (funded by PhD program/FONDAP/Fcyt) “Caveolin-1-containing exosomes from breast cancer cells increase migration/invasion via Cyr61 activation of the integrin avb3” Thesis co-advisor Lisette Leyton, ICBM, Faculty of Medicine, Universidad de Chile.
36) Ph.D. advisor of Maria Fernanda Gonzalez (Sept 2018 – Sept 2021). Ph. D. in Biochemistry (funded by CONICYT/FONDAP) “Extracellular vesicles from H. pylori-infected gastric cells promote inflammation and progression of gastric cancer” Thesis co-advisor Alejandro Corvalan, Faculty of Medicine, PUC.
37) Ph.D. Co-advisor of Cristopher Soto (Oct 2017 – May 2022) Ph.D. in Biochemistry (funded by CONICYT/FONDAP) “Study of the effects of Helicobacter pylori on the virulence of Porphyromonas gingivalis and their participation in the progression of periodontal disease” Thesis advisor Denisse Bravo, Faculty of Odontology, Universidad de Chile.
38) Ph.D. co-advisor of Magda Carolina Diaz (April 2020 – June 2022). Ph. D. in Biomedical Sciences (funded by CONICYT/FONDAP) “Role of Polycistin-1 in tubulogenesis and the distribution of type-L calcium channels between transverse tubules and the membrane fraction enriched in caveolas” Thesis advisor Zully Pedroso, Faculty of Medicine, University of Chile.
39) PhD thesis advisor of Daniela Herrera (June 2019-Mar 2024) PhD in Biomedical. Sciences (funded by CONICYT/FONDAP) “H. pylori infection induces E-cadherin internalization and degradation via Rab5 in gastric cancer” Co-advisor Vicente Torres.
PhD thesis students (in progress)
40 PhD thesis advisor of Sofia Sanheza (Oct 2021-Mar 2024) PhD in Biomedical. Sciences (funded by CONICYT/FONDAP) “Role of Caveolin-1 in extracelular vesicles from adipocytes in the polarization of macrophages and inflammation in breast cancer” Co-advisor Mariane Cifuentes.
42) PhD thesis co-advisor of Daniela Leon (Oct 2021-Mar 2024) PhD in Biochemistry (funded by CONICYT/FONDAP) “Exosomes isolated from B16F10 cells overexpressing Caveolin-1 which contain gold nanorods as tools for theranosis of metastatic nodules in the lung” Advisor Marcelo Kogan.
Masters thesis students (finished)
1) Masters thesis adviser of Claudia Duran (May 2007 – Sept 2009) Magister in Biomedical Sciences, Microbiology “Role of caveolae in the internalization of pathogenic E.coli strains”. Thesis co-advisor Roberto Vidal, ICBM, Universidad de Chile. Continued working with Roberto Vidal.
2) Master’s thesis Co-advisor of Astrid Schmied (Mar 2011 – Nov 2013) “Caracterizacion del tipo de murte cellular enn linfocitos de sujetos con historia de cancer de piel y probable enfermedades de alzheimer” Thesis advisor Dr. Maria Isabel Behrens.
3) Masters student co-advisor of Paulina Cerda (Dec 2014- April 2016). MSc in Clinical Biochemistry (funded by FONDAP) “On the inverse relationship between survivin and Reprimo in gastric cancer” Thesis advisor Alejandro Corvalan, PUC. Now PhD student with Lorena Garcia.
4) Co-adviser for Masters thesis of Sebastian Cruz (Oct 2015-March 2017). (funded by FONDAP). Role of CAV1 in the chemiotaxis of dendritic cells towards lymph nodes. Alvaro Lladser Advisor. Now doing PhD thesis in Australia.
5) Co-advisor for masters thesis of Sujey Palma (Mar 2016-Oct 2017). (funded by FONDAP) “Isolation of exosomes containing functionalized gold nanoparticles from B16F10 cells” Advisor Marcelo Kogan.
6) Advisor for masters thesis of Carla Jorquera (Dec. 2016-Nov. 2017). (funded by FONDAP) Induction of HIF-1a by the Helicobacter pylori urease virulence factor. Co-advisor Sergio Nunez-Wehinger. Now doing PhD thesis University of Leiden, Holland.
7) Co-advisor for masters thesis of Olinda Nuñez (Dec. 2016-Dec. 2018). (funded by CEMC) “MAPKs activadas median la susceptibilidad por Caveolina-1 a muerte celular inducida por palmitato en células MIN6” Advisor Sergio Nunez-Wehinger. Now returned to Honduras.
8) masters advisor of Antonio Hidalgo (Aug 2018 – Mar 2022). MSc in Biochemistry (funded by FONDAP) “Study of the anti-bacterial effect of Curcumin nanoemulsions and chitosan nanocapsules on Helicobacter pylori” Thesis co-advisor Felipe Oyarzun, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile.
9) Co-advisor for masters thesis of Damian Perez (Mar 2019-Jan 2022). (funded by FONDAP) “Functionalization of exosomes from B16F10 cells with folic acid-conjugated gold nanorods” Advisor Marcelo Kogan.
Undergraduate thesis students (finished)
1) Thesis co-advisor for Hery Urra (Jan 2007 – May 2009) “Rol de caveolina-1 en migracion cellular de celulas metastaticas de cancer de mama y astrocitos” (Universidad de Valparaiso, Chile)
2) Thesis advisor for Natalia Diaz (May 2008 – March 2010) “Regulacion de la re-expresion de caveolina-1 en celulas tumorales” (Universidad de Valparaiso, Chile)
3) Visiting student, Tania Yareli (August-September, 2009) from Universidad Autonoma de Sinaloa, Mexico.
4) Visiting student, Cristina Gomez (October-December, 2009) from Universidad de Medellín, Colombia
5) Visiting student Stefan Brueck (March-June, 2010) from the Institute of Biochemistry and Molecular Biology of the Medical School of the RWTH Aachen University, Germany.
6)Thesis advisor for Hernan Huerta (August 2010 – May2012) “Estudio del rol de la proteina PKC? en la re-expresion de Caveolin-1 inducida por el ester de forbol 4?-TPA” (Universidad de Santiago, Chile)
7) Adviser for Unidad de Investigacion of 2nd year pre-medical students Victor Vicencio and Ruben Valenzuela (May-Dec 2010) “Estudio de los mecanismos moleculares de angiogenesis y metastasis en celulas tumorales” (Universidad de Chile, Chile)
8) Adviser for Unidad de Investigacion of 2nd year pre-medical students Mackarenna Norambuena Guamparito and Constanza Segura Rios (May-Dec 2011) “Caveolina-1 reduce la actividad de HIF-1 inducida por hipoxia en
células de melanoma B16F10” (Universidad de Chile, Chile)
9) Adviser for Unidad de Investigacion of 2nd year pre-medical students Wendy Soruco Guamparito and Konnie Yanez (May-Dec 2012) “El rol de Survivina y ?-Catenina en proliferación celular, apoptosis y resistencia a drogas en células de Leucemia Linfoblástica” (Universidad de Chile, Chile).
10) Undergraduate thesis co-adviser for Samantha Gonzalez (May 2012- April 2013) “Rol de la proteina survivina en la inhibicion de la apoptosis por Porphyromonas gingivalis” (Universidad de Chile, Chile)
11) Adviser for Unidad de Investigacion of 2nd year pre-medical students Diego Urbina – Andrés Vargas (May-Dec 2013) “Rol de la proteína caveolina-1 en la migración e invasión de células metastásicas” (Universidad de Chile, Chile).
12) Adviser for one month summer research stage of Students in Biochemistry (Dec 2013 – Mar 2014) Ana Victoria Rojas, Eliseo Parra, Francisco Cornejo.
13) Adviser for Unidad de Investigacion of 2nd year pre-medical students Daniel Rendon, Esteban Romero, Jose Ruiz (May-Dec 2014) “Estudio del eje Caveolina-1/Rab5 en la migración e invasion de células metastásicas de melanoma murino” (Universidad de Chile, Chile). 1er lugar en la evaluacion del proyecto.
14) Adviser for Unidad de Investigacion of 2nd year pre-medical students Patricio Castillo y Claudia Victoriano (May-Dec 2015) “PROMOCIÓN DEL METABOLISMO GLICOLÍTICO POR HIF-1? EN CÉLULAS GÁSTRICAS INFECTADAS CON HELICOBACTER PYLORI” (Universidad de Chile, Chile).
15) Adviser for Unidad de Investigacion of 2nd year pre-medical students Francisca Faundez y Fernando Garcia (May-Dec 2015) “El efecto supresor de tumores de caveolina-1 se relaciona con la inhibicion de autofagia” (Universidad de Chile, Chile).
16) Undergraduate thesis co-adviser for Ana Victoria Rojas (June 2016- August 2018) “P. gingivalis O-antigen participates in the modulation of IL-8 and migration of gingival epithelial cells” (Universidad de Chile, Chile). Thesis advisor Denisse Bravo.
17) Undergraduate thesis co-adviser for Sujey Fernanda Palma Flores (June 2016- October 2017) “Isolation of exosomes containing functionalized gold nanoparticles from B16F10 cells” (Universidad de Chile, Chile). Thesis advisor Marcelo Kogan.
18) Adviser for Unidad de Investigacion of 2nd year pre-medical students Maria Fernanda Maldonado y Miki Soto (May-Dec 2016) “ESTUDIO DEL RECEPTOR AT2 COMO BLOQUEADOR DE LA MIGRACIÓN DEPENDIENTE DE CAVEOLINA-1 EN CÉLULAS TUMORALES DE CÁNCER DE MELANOMA” (Universidad de Chile, Chile).
19) Adviser for Unidad de Investigacion of 2nd year pre-medical students Camila Gajardo y Javiera Saavedra (May-Dec 2017) “ESTUDIO DE ROL DE CAVEOLINA-1 EN EL INGRESO DE EXOSOMAS EN LAS CELULAS DE CANCER DE MAMA” (Universidad de Chile, Chile).
20) Tutor for Revision Bibliografico of 1st year medical students Josefa Clotet Morales, Amanda Collingwood-Selby Lois, Pablo Chamorro, Eguzki Mena, Isidora Contador Baeza (November 2017) “Exosomas en Cancer” (Universidad de Chile Chile)
21) Adviser for Unidad de Investigacion of 2nd year pre-medical students Benjamin Gonzalez y Dario Varas (May-Dec 2018) “ESTUDIO DEL ROL DE LA PROTEINA PERK EN CELULAS GASTRICAS POSTERIOR A LA INFECCION POR HELICOBACTER PYLORI ASOCIADO A LA PROGRESION DE LESIONES PRECANCEROSAS EN CANCER GASTRICA” (Universidad de Chile, Chile).
22) Tutor for Revision Bibliografico of 1st year medical students Francisca Martinez, Josefina Oliva, Isidora Poblete, Catalina Mandiola, Carlos Reyes (December 2018) “Helicobacter pylori in gastric cancer” (Universidad de Chile, Chile).
23) Adviser for Unidad de Investigacion of 2nd year pre-medical students Alonso Cortez and Bastian Bello (May-Dec 2019) “Efecto de TNF- ? sobre la expresión de Caveolina-1 y E-cadherina y sobre la migración de células de Cáncer de Vesícula Biliar” (Universidad de Chile, Chile).
24) Tutor for Revision Bibliografico of 1st year medical students Nicolás Cholaky, Juan Pedro Espinoza, Bárbara Paredes, Fernanda Quiroz, Martín Vergara (January 2020) “Exosomes in metastasis” (Universidad de Chile, Chile).
25) Tutor for Revision Bibliografico of 1st year medical students Josefa Alborniz Gonzalez, Felipe Arratia Rojas, Cristobal Bravo Romero, Katherine Carreño Manriquez, Florencia Fernanda Herrera (January 2020) “Helicobacter pylori in gastric cancer” (Universidad de Chile, Chile).
26) Co-advisor for undergraduate thesis of Damian Perez (June 2019- Aug 2021) (funded by FONDAP) “Funcionalizacion de exosomas de células B16F10 con AuNPs-acido fólico” Advisor Marcelo Kogan (Universidad de Chile, Chile).
27) Adviser for Unidad de Investigacion of 2nd year pre-medical students Miguel Lopez and Kathia Ramirez (May 2020- January 2021) “Rol de ATIP1 y 3a en la progresion del cancer gastrico humano” (Universidad de Chile, Chile).
28) Adviser for Unidad de Investigacion of 2nd year pre-medical students Joaquin Barraza, Matias Villegas, Mario Mendez (May 2021- January 2022) “Rol de Vesículas Extracelulares producidas por células infectadas con Helicobacter pylori en el desarrollo de cáncer gástrico” (Universidad de Chile, Chile).
29) Tutor for Revision Bibliografico of 1st year medical students. Tutor: Idan Stutin; Integrantes: Constanza Almuna, Rodrigo Bravo, Antonia Riquelme, Andrés Salvatierra, Cristian Sánchez y Magdalena Schwerter (January 2022) “Helicobacter pylori in extra-gastric diseases” (Universidad de Chile, Chile).
30) Tutor for Revision Bibliografico of 1st year medical students Tutor: Sofía Aguillón; Integrantes: Navarrete, Tamara Cádiz Ñeguey, Montserrat González Bravo, Eduardo Guerra Parraguez, Savka Valdebenito Céspedes, Isidora Vásquez Ramírez (January 2022) “Exosomal Caveolin-1 in cancer metastasis” (Universidad de Chile, Chile).
31) Adviser for Unidad de Investigacion of 2nd year pre-medical students Tutor: Gabriela Figueroa; Intergrantes: Martina Herrera, Natalia Huidobro, Ivonne Maldonado. (May 2022- December 2022) “Rol de Helicobacter pylori en el desarrollo de cáncer gástrico” (Universidad de Chile, Chile).
32) Adviser for Unidad de Investigacion of 2nd year pre-medical students Constanza Castillo, Marcelo Böhme (May 2023- December 2023) “Rol de exosomas con Caveolina-1 derivadas de adipocitos en la reprogramacion del microambiente tumoral” (Universidad de Chile, Chile).
33) Pasantia de Investigacion estudiante de Bioquimica 3er año Catalina Urra Titulo: “Cultivo de líneas células de diferentes origenes” semestre primavera 2023.
34) Pasantia de Investigacion estudiante de Bioquimica 4to año Sebastian Diaz Titulo: “Rol del factor de virulencia Ureasa en vesículas extracelulares liberados por Helicobacter pylori en inducir reactividad de astrocitos” semestre primavera 2023.
35) Adviser for Unidad de Investigacion of 2nd year pre-medical students Benjamín Ortiz – Emilia Oviedo – María Paz Rosales (May 2024- December 2024) “Rol de vesiculas exracelulares derivadas de adipocitos en la vasculogenesis y angiogenesis tumoral” (Universidad de Chile, Chile).
Undergraduate thesis students (in progress)
1) Undergraduate thesis co-adviser for Safka Anais, Hernandez (May 2024- April 2025) “Rol de las OMVs de Helicobacter pylori en promover la virulencia de Porphyromonas gingivalis” (Universidad de Chile. Chile)
2) Undergraduate thesis adviser for KatherinVasquez (August 2024- December 2024) “Rol de las EVs de adipocitos en promover vasculogenesis/angiogenesis” (Universidad Catolica del Maule, Chile)
UNDERGRADUATE TEACHING
1) Curso de Fisiológica y Patológica Integrada de la Facultad de Química Farmacéutico: Bases Moleculares del Cáncer (Marzo 2009, 3 h- directa, 125 alumnos).
2) “Unidades de Investigación 2010” para estudiantes del 2ndo ano de la carrera de medicina.
3) Clase magistral para estudiantes del 1er ano de medicina “Bases celulares y moleculares del cáncer” (Nov. 2010, 2 horas directas, 125 alumnos)
4) “Unidades de Investigación 2010” para estudiantes del 2ndo ano de la carrera de medicina
5) “Unidades de Investigación 2011/2012” para estudiantes del 2ndo ano de la carrera de medicina
6) Bases Científicas de Medicina I: Capitulo Biología Celular y Molecular (Nov-Dec 2011/2012).
7) “Unidades de Investigación 2012” para estudiantes del 2ndo ano de la carrera de medicina
8) Curso de Bioquímica de la Facultad de Química Farmaceutica: Compartmentalizacion en transduccion de senales (May 2012, 2 horas directa, 20 alumnos).
9) Bases Científicas de Medicina I: Capitulo Biología Celular y Molecular (Nov-Dec 2012).
10) Bases Científicas de Medicina I: Capitulo Biología Celular y Molecular (Nov-Dec 2013).
11) Bases Científicas de Medicina I: Capitulo Biología Celular y Molecular (Oct 2014).
12) “Unidades de Investigación 2014” para estudiantes del 2ndo ano de la carrera de medicina
13) Clase magistral para estudiantes del 1er ano de medicina 2014 “Mecanismos de la señalización celular” (Oct 24, 2 horas directas, 25 alumnos)
14) “Unidades de Investigación 2015” para estudiantes del 2ndo ano de la carrera de medicina
15) Clase magistral para estudiantes del 1er ano de medicina 2015 “Mecanismos de la señalización celular” (Oct 30, 2 horas directas, 125 alumnos)
16) “Unidades de Investigación 2016” para estudiantes del 2ndo ano de la carrera de medicina
17) Clase magistral para estudiantes del 1er ano de medicina 2016 “Mecanismos de la señalización celular” (Nov 07, 2 horas directas, 125 alumnos)
18) “Unidades de Investigación 2017” para estudiantes del 2ndo ano de la carrera de medicina
19) Clase magistral para estudiantes del 1er ano de medicina 2017 “Mecanismos de la señalización celular” (Oct 06, 2 horas directas, 125 alumnos)
20) Revision bibliografica 1er medicina 2017 “Exosomas en Cancer”. Tutor Rosario Matte. Integ, Josefa Clotet Morales, Amanda Collingwood-Selby Lois, Pablo Chamorro, Eguzki Mena, Isidora Contador Baeza
21) “Unidades de Investigación 2018” para estudiantes del 2ndo ano de la carrera de medicina
22) Clase magistral para estudiantes del 1er ano de medicina 2018 “Mecanismos de la señalización celular” (Nov 09, 2 horas directas, 125 alumnos).
23) Revision bibliografica 1er ano medicina 2018 “Mecanismos de induccion de cancer gastrico por Helicobacter pylori”. Tutor Josefa Lopez. Integrantes, Francisca Martinez, Josefina Oliva, Isidora Poblete, Catalina Mandiola, Carlos Reyes.
24) “Unidades de Investigación 2019” para estudiantes del 2ndo ano de la carrera de medicina
25) Clase magistral para estudiantes del 1er ano de medicina 2019 “Mecanismos de la señalización celular” (Oct 07, 2x1.5 horas directas, 125 alumnos).
26) Revision bibliografica 1er ano medicina 2019 “Exosomas en Metastasis”. Tutor María de los Ángeles Gatica. Integrantes, Nicolás Cholaky, Juan Pedro Espinoza, Bárbara Paredes, Fernanda Quiroz, Martín Vergara.
27) “Unidades de Investigación 2020” para estudiantes del 2ndo ano de la carrera de medicina
28) Clase magistral para estudiantes del 1er ano de medicina 2020 “Mecanismos de la señalización celular” clase virtual en 3 capsulas de approx 30 min cada uno y una sesión de preguntas (Jan 2021, 2x1.5 horas directas, 125 alumnos)
29) “Unidades de Investigación 2021” para estudiantes del 2ndo ano de la carrera de medicina
30) Clase magistral para estudiantes del 1er ano de medicina 2021 “Mecanismos de la señalización celular” clase virtual en approx 120 min con una sesión de preguntas (Nov 2021, 2 horas directas, 125 alumnos).
31) Revision bibliografica 1er ano medicina 2021 “Rol de Caveolina-1 exosomal en promover metastasis”. Tutor Alexandra Gotschlich K. Integrantes, Constanza Almuna, Rodrigo Bravo, Antonia Riquelme, Andrés Salvatierra, Cristian Sánchez y Magdalena Schwerter
32) Revision bibliografica 1er ano medicina 2021 “Helicobacter pylori en enfermedades extragastricas”. Tutor Idan Sutin. Integrantes, Constanza Almuna, Rodrigo Bravo, Antonia Riquelme, Andrés Salvatierra, Cristian Sánchez y Magdalena Schwerter.
33) Clase magistral para estudiantes del 1er ano de medicina 2022 “Mecanismos de la señalización celular” clase virtual en approx 120 min (Oct 2022, 2 horas directas, 125 alumnos)
34) “Unidades de Investigación 2022” para estudiantes del 2ndo ano de la carrera de medicina. Estudiantes: Marthina Herrera, Natalia Huidobro, Ivonne Maldonado.
35) Revision bibliografica 1er ano medicina 2022 “Rol de Caveolina-1 exosomal en promover metastasis”. Tutor Sofia Orellana; Integrantes, Sofía Bonnell, Elisa Fuentes, Catalina González, Maite González y Pedro Urria
36) Revision bibliografica 1er ano medicina 2022 “Helicobacter pylori en enfermedades extragastricas”. Tutor Gabriela Figueroa; Integrantes, Isabel Arias, Nicole Burgos, Anahí Córdova, Alejandra Córdova
37) “Unidades de Investigación 2023” para estudiantes del 2ndo ano de la carrera de medicina. Estudiantes: Constanza Castillo, Marcelo Böhme.
38) Clase magistral para estudiantes del 1er ano de medicina 2023 “Mecanismos de la señalización celular” clase virtual en approx 120 min (Oct 2023, 2 horas directas, 125 alumnos)
39) Revision bibliografica 1er ano medicina 2023 “Rol de Caveolina-1 exosomal en promover metastasis”. Tutor Matias Oyarce; Integrantes, ………
40) Revision bibliografica 1er ano medicina 2023 “Helicobacter pylori en enfermedades extragastricas”. Tutor Ignacio Henriquez; Integrantes, ………
41) Pasantias de Investigacion 2023 para estudiantes de Bioquimica 3er año (Catalina Urra) y 4to año (Sebastian Diaz) semestre primavera.
42) Pasantias de Investigacion 2024 para estudiantes de Bioquimica 4to año (Catalina Urra) y 5to año (Sebastian Diaz) semestre primavera.
43) Pasantias de Investigacion 2024 para estudiantes de Bioquimica 4to año (Catalina Urra) y 5to año (Sebastian Diaz) semestre primavera
POST-GRADUATE LECTURE COURSES (Chile)
1) Co-organizer (together with Sergio Lavandero) of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (April - May, 2014) and “Signalling in Biomedicine” (June-July, 2014). Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer” ICBM, Facultad de Medicina, U. de Chile. These two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas as well as Ciencias. This course represents a contribution of the anillo group NEMESIS(CEMC) to post-graduate education in four faculties of the Universidad de Chile.
2) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell and Molecular Biology” (April - May, 2014). Coordinator of the section “Dynamics of Cytoplasm, Cytoskeleton, and cell migration”. Lecturer for the following topics; “Organization of the plasma membrane – microdomains - cell migration”. This course is taught to students primarily from the Facultad de Ciencias, Ciencias Químicas y Farmacéuticas, Farmacología and Medicine. This course represents a contribution of the anillo group NEMESIS(CEMC) to inter-faculty post-graduate education at the Universidad de Chile.
3) Lecturer in post-graduate course entitled “Advanced Molecular Pharmacology” organized by Guillermo Diaz (August 2014), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile. Topic: “Cancer”
4) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by Lisette Leyton (Oct-Nov 2014), at Facultad de Medicina, Universidad de Chile.
5) Lecturer and organizer of post-graduate course entitled “Reading and Discussing papers in English” organized by Lisette Leyton (Oct-Nov 2014), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
6) Lecturer and organizer of post-graduate course entitled “Reading and Discussing papers in English” organized by AnaMaria Avalos (Oct-Nov 2014), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
7) Co-organizer (together with Sergio Lavandero) of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (April - May, 2015) and “Signalling in Biomedicine” (June-July, 2014). Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer” ICBM, Facultad de Medicina, U. de Chile. These two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas as well as Ciencias. This course represents a contribution of the anillo group NEMESIS/CEMC and the FONDAP group ACCDiS/CEMC to post-graduate education in four faculties of the Universidad de Chile.
8) Lecturer in post-graduate course entitled “Topics in Biomedical Research” organized by Miguel Concha (May 2015), at Facultad de Medicina, Universidad de Chile. Topic: “Cell migration, invasion and metastasis”
9) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell and Molecular Biology” (Sept - Dec, 2015). Coordinator of the section “Dynamics of Cytoplasm, Cytoskeleton, and cell migration”. Lecturer for the following topics; “Organization of the plasma membrane – microdomains - cell migration”. This course is taught to students primarily from the Facultad de Ciencias, Ciencias Químicas y Farmacéuticas, Farmacología and Medicine. This course represents a contribution of the anillo group NEMESIS/CEMC and the FONDAP group ACCDiS/CEMC to inter-faculty post-graduate education at the Universidad de Chile.
10) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by Lisette Leyton (Oct-Nov 2015), at Facultad de Medicina, Universidad de Chile.
11) Lecturer and organizer of post-graduate course entitled “Reading and Discussing papers in English” organized by AnaMaria Avalos (Oct-Nov 2015), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
12) Co-organizer (together with Sergio Lavandero) of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (April - May, 2016) and “Signalling in Biomedicine” (June-July, 2016). Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer” ICBM, Facultad de Medicina, U. de Chile. These two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas. This course represents a contribution of the FONDAP group ACCDiS/CEMC to post-graduate education in four faculties of the Universidad de Chile.
13) Lecturer in post-graduate course entitled “Topics in Biomedical Research” organized by Miguel Concha (May 2016), at Facultad de Medicina, Universidad de Chile. Topic: “Cell migration, invasion and metastasis”
14) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell and Molecular Biology” (Sept - Dec, 2016). Coordinator of the section “Dynamics of Cytoplasm, Cytoskeleton, and cell migration”. Lecturer for the following topics; “Organization of the plasma membrane – microdomains - cell migration”. This course is taught to students primarily from the Facultad de Ciencias, Ciencias Químicas y Farmacéuticas, Farmacología and Medicine. This course represents a contribution of the FONDAP group ACCDiS/CEMC to inter-faculty post-graduate education at the Universidad de Chile.
15) Lecturer in post-graduate course entitled “Advanced Molecular Farmacology” organized by Guillermo Diaz (August 2016), at Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Topic: “signalling mechanisms in cancer, cell cycle, cell death”
16) Co-organizer (together with Alejandro Corvalan and Gareth Owen) of the first transversal course in Cancer in the framework of ACCDiS between the UC and PUC “Biomedical Oncology” (Sept. – Dec. 2016). Coordinator and lecturer for the following topics: “Molecular mechanimsms in cancer”, “Cell cycle”, “Cell death”
17) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by Lisette Leyton (Oct-Nov 2016), at Facultad de Medicina, Universidad de Chile.
18) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by AnaMaria Avalos (Oct-Nov 2016), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
19) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by Lisette Leyton/AnaMaria Avalos (Oct-Nov 2016), at Facultad de Medicina, Universidad de Chile.
20) Co-organizer (together with Sergio Lavandero) of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (April - May, 2017) and “Signalling in Biomedicine” (June-July, 2016). Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer” ICBM, Facultad de Medicina, U. de Chile. These two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas. This course represents a contribution of the FONDAP group ACCDiS/CEMC to post-graduate education in four faculties of the Universidad de Chile.
21) Lecturer in post-graduate course entitled “Advanced Molecular Farmacology” organized by Guillermo Diaz (August 2017), at Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Topic: “signalling mechanisms in cancer, cell cycle, cell death”. Tutor for three “tesillas” of students in the Farmacology PhD program (Renato Burgos, Carolina Schaefer, Karen Toledo).
22) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by AnaMaria Avalos (May and Nov 2017), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
23) Co-organizer (together with Alejandro Corvalan and Gareth Owen) of the first transversal course in Cancer in the framework of ACCDiS between the UC and PUC “Biomedical Oncology” (Sept. – Dec. 2017). Coordinator and lecturer for the following topics: “Molecular mechanimsms in cancer”, “Cell cycle”, “Cell death”
24) Co-organizer (together with Sergio Lavandero) of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (April - May, 2018) and “Signalling in Biomedicine” (June-July, 2018). Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer” ICBM, Facultad de Medicina, U. de Chile. These two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas. This course represents a contribution of the FONDAP group ACCDiS/CEMC to post-graduate education in four faculties of the Universidad de Chile.
25) Lecturer in post-graduate course entitled “Advanced Molecular Farmacology” organized by Juan Diego Maya (March-August 2018), at Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Topic: “Signalling mechanisms in cancer, cell cycle, cell death”. Tutor “tesillas” of students in the Farmacology PhD program (Pedro Jara). Tutor “Unidad” to learn basic lab skills (Sept 2018) for students in Farmacology (Pedro Novoa).
26) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by AnaMaria Avalos (May and Nov 2018), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
27) Lecturer in post-graduate course entitled “Listening and Oral Communication” and “Oral Communication and Discussing papers in English” organized by Lisette Leyton (June and Oct 2018), at Facultad de Medicine, Universidad de Chile.
28) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell and Molecular Biology” (Aug - Nov, 2018). Coordinator of the section “Cell Signalling”. Lecturer for the following topics; “Organization of the eukaryotic cell, GPCRs, RTKs, nRTKs and other signalling mechanisms, plasma membrane – microdomains”. This course is taught to students primarily from the Facultad de Ciencias Químicas y Farmacéuticas and Medicine. This course represents a contribution of the anillo group NEMESIS/CEMC and the FONDAP group ACCDiS/CEMC to inter-faculty post-graduate education at the Universidad de Chile.
29) Co-organizer (together with Alejandro Corvalan and Gareth Owen) of the first transversal course in Cancer in the framework of ACCDiS between the UC and PUC “Biomedical Oncology” (Sept. – Dec. 2018). Coordinator and lecturer for the following topics: “Molecular mechanimsms in cancer”, “Cell cycle”, “Cell death”
30) Organizer of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (March - May, 2019), Novel Concepts in Signalling (May-June 2019) Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer”, “Exosomes”, “Lipid rafts and Caveolae”. ICBM, Facultad de Medicina, U. de Chile. The two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas and Faculty of Medicine. This course represents a contribution of the FONDAP group ACCDiS/CEMC to post-graduate education in four faculties of the Universidad de Chile.
31) Lecturer in post-graduate course entitled “Advanced Molecular Pharmacology” organized by Juan Diego Maya (March-August 2019), at Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Topic: “Signalling mechanisms in cancer, cell cycle, cell death”.
32) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by AnaMaria Avalos (May and Nov 2019), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
33) Lecturer in post-graduate course entitled “Listening and Oral Communication” and “Oral Communication and Discussing papers in English” organized by Lisette Leyton (June and Nov 2019), at Facultad de Medicine, Universidad de Chile.
34) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell Biology” (Aug - Nov, 2019). Coordinator of the section “Cell Signalling”. Lecturer for the following topics; “Organization of the eukaryotic cell, GPCRs, RTKs, nRTKs and other signalling mechanisms, plasma membrane – microdomains”. This course is taught to students primarily from the Facultad de Ciencias Químicas y Farmacéuticas and Medicine. This course represents a contribution of the anillo group NEMESIS/CEMC and the FONDAP group ACCDiS/CEMC to inter-faculty post-graduate education at the Universidad de Chile.
35) Co-organizer (together with Alejandro Corvalan and Gareth Owen) of the first transversal course in Cancer in the framework of ACCDiS between the UC and PUC “Biomedical Oncology” (Sept. – Dec. 2019). Coordinator and lecturer for the following topics: “Molecular mechanisms in cancer”, “Cell cycle”, “Cell death”
36) Organizer post-graduate curse of the PhD program in Biomedical Sciences of the Universidad de Talca “Analysis and discussion in English of scientific articles in the area of Signal Transduction” (April – December 2019). Coordinator and Lecturer.
37) Organizer of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (March - May, 2020), Novel Concepts in Signalling (May-June 2020) Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer”, “Exosomes”, “Lipid rafts and Caveolae”. ICBM, Facultad de Medicina, U. de Chile. The two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas and Faculty of Medicine. This course represents a contribution of the FONDAP group ACCDiS/CEMC to post-graduate education in four faculties of the Universidad de Chile.
38) Lecturer in post-graduate course entitled “Advanced Molecular Pharmacology” organized by Jenny Fiedler (March-August 2020), at Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Topic: “Signalling mechanisms in cancer, cell cycle, cell death”.
39) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by AnaMaria Avalos (May and Nov 2020), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
40) Lecturer in post-graduate course entitled “Listening and Oral Communication” and “Oral Communication and Discussing papers in English” organized by Lisette Leyton (June and Nov 2020), at Facultad de Medicine, Universidad de Chile.
41) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell Biology” (Aug - Nov, 2020). Coordinator of the section “Cell Signalling”. Lecturer for the following topics; “Organization of the eukaryotic cell, GPCRs, RTKs, nRTKs and other signalling mechanisms, plasma membrane – microdomains”. This course is taught to students primarily from the Facultad de Ciencias Químicas y Farmacéuticas and Medicine. This course represents a contribution of the anillo group NEMESIS/CEMC and the FONDAP group ACCDiS/CEMC to inter-faculty post-graduate education at the Universidad de Chile.
42) Co-organizer (together with Alejandro Corvalan) of the first transversal course in Cancer in the framework of ACCDiS between the UC and PUC “Biomedical Oncology” (Sept. – Dec. 2020). Coordinator and lecturer for the following topics: “Molecular mechanisms in cancer”, “Cell cycle”, “Cell death”
43) Organizer of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (March - May, 2021), Novel Concepts in Signalling (May-June 2021) Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer”, “Exosomes”, “Lipid rafts and Caveolae”. ICBM, Facultad de Medicina, U. de Chile. The two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas and Faculty of Medicine. This course represents a contribution of the FONDAP group ACCDiS/CEMC to post-graduate education in four faculties of the Universidad de Chile.
44) Lecturer in post-graduate course entitled “Listening and Oral Communication” and “Oral Communication and Discussing papers in English” organized by Lisette Leyton (June and Nov 2021), at Facultad de Medicine, Universidad de Chile.
45) Lecturer in the post-graduate course for biochemists entitled: “Molecular basis of cell signaling” organized by Mauricio Baez and Sergio Lavandero. Topics: “Lipid second messengers”; “Post-translational protein modification by phosphorylation”; “Organization and Compartmentalization of molecules in signaling” March/April 2021
46) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell Biology” (Aug - Nov, 2021). Coordinator of the section “Cell Signalling”. Lecturer for the following topics; “Organization of the eukaryotic cell, GPCRs, RTKs, nRTKs and other signalling mechanisms, plasma membrane – microdomains”. This course is taught to students primarily from the Facultad de Ciencias Químicas y Farmacéuticas and Medicine. This course represents a contribution of CEMC and the FONDAP group ACCDiS to inter-faculty post-graduate education at the Universidad de Chile. Course cancelled due to lack of inscriptions.
47) Co-organizer (together with Alejandro Corvalan) of the first transversal course in Cancer in the framework of ACCDiS between the UC and PUC “Biomedical Oncology” (Sept. – Dec. 2021). Coordinator and lecturer for the following topics: “Molecular mechanisms in cancer”, “Cell cycle”, “Cell death” course cancelled due to lack of inscriptions.
48) Organizer of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (March - May, 2022), Novel Concepts in Signalling (May-June 2022) ICBM, Facultad de Medicina, U. de Chile. The course was cancelled due to the lack of inscriptions by students from the PhD program in Biomedical Sciences.
Instead several modules (kinases, phosphatases, proteases, lipid second messengers, compartmentalization ) were taught to students of the Facultad de Ciencias Químicas y Farmacéuticas in the PhD programs of Biochemistry and Pharmacology.
49) Lecturer in post-graduate course entitled “Listening and Oral Communication” and “Oral Communication and Discussing papers in English” organized by Lisette Leyton (June and Nov 2022), at Facultad de Medicine, Universidad de Chile.
50) Lecturer in the post-graduate course for biochemists entitled: “Molecular basis of cell signaling” organized by Mauricio Baez and Sergio Lavandero. Topics: “Lipid second messengers”; “Post-translational protein modification by phosphorylation”; “Organization and Compartmentalization of molecules in signaling” March/May 2022
51) Lecturer in the post-graduate course for pharmacologists entitled: “Advanced Molecular Pharmacology” organized by Jenny Fiedler. Topics: “Lipid second messengers”; “receptor and non-receptor tyrosine kinases”; “Phosphatases”; “Proteases” March/May 2022
52) Organizer post-graduate course of the PhD program in Biomedical Sciences of the Universidad de Talca “Analysis and discussion in English of scientific articles in the area of Signal Transduction” (April – December 2019). Lecturer.
53) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell Biology” (Aug - Nov, 2022). Coordinator of the section “Cell Signalling”. Lecturer for the following topics; “Organization of the eukaryotic cell, GPCRs, RTKs, nRTKs and other signalling mechanisms, plasma membrane – microdomains”. This course is taught to students primarily from the Facultad de Ciencias Químicas y Farmacéuticas and Medicine. This course represents a contribution of CEMC and the FONDAP group ACCDiS to inter-faculty post-graduate education at the Universidad de Chile. Course cancelled due to lack of inscriptions.
54) Lecturer in the post-graduate course for biochemists entitled: “Cell signaling in Biomedicine” organized by Mauricio Baez and Sergio Lavandero. Topics: “Cancer” September 2022.
55) Lecturer in the post-graduate course for pharmacologists entitled: “Advanced Molecular Pharmacology” organized by Jenny Fiedler. Topics: “Lipid second messengers”; “Phosphatases” April/May 2023.
56) Lecturer in post-graduate course entitled “Listening and Oral Communication” and “Oral Communication and Discussing papers in English” organized by Lisette Leyton (June and Oct 2023), at Facultad de Medicine, Universidad de Chile.
57 Organizer of post-graduate Course for Biomedical Sciences, “Basic Concepts in Cell Signalling” (March - May, 2023), Novel Concepts in Signalling (May-June 2023) ICBM, Facultad de Medicina, U. de Chile.
58) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell Biology” (Sept - Dec, 2023). Coordinator of the section “Cell Signalling”. Lecturer for the following topics; “Organization of the eukaryotic cell, GPCRs, RTKs, nRTKs and other signalling mechanisms, plasma membrane – microdomains”.
59) Lecturer in the post-graduate course for biochemists entitled: “Molecular Basis of Cell signaling” organized by Mauricio Baez and Sergio Lavandero. Topics: “Post-translational protein modifications, Lipid Second Messengers, Compartmentalization” September 2024.
60) Lecturer in the post-graduate course for pharmacologists entitled: “Advanced Molecular Pharmacology” organized by Jenny Fiedler. Topics: “Lipid second messengers”; “Phosphatases” April/May 2024.
61) Lecturer in post-graduate course entitled “Listening and Oral Communication” and “Oral Communication and Discussing papers in English” organized by Lisette Leyton (June and Oct 2023), at Facultad de Medicine, Universidad de Chile.
62) Organizer of and lecturer in post-graduate Course for Biomedical Sciences, “Basic Concepts in Cell Signalling” (March - May, 2024), Novel Concepts in Signalling (May-July 2024) ICBM, Facultad de Medicina, U. de Chile.
63) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell Biology” (Sept - Dec, 2024). Coordinator of the section “Cell Signalling”. Lecturer for the following topics; “Organization of the eukaryotic cell, GPCRs, RTKs, nRTKs and other signalling mechanisms, plasma membrane – microdomains”.
64) Lecturer in the post-graduate course for biochemists entitled: “Cell signaling in Biomedicine” organized by Mauricio Baez and Sergio Lavandero. Topics: “Cancer” September 2024.
CONGRESS PARTICIPATION 2019-2024
1) Maritza P. Garrido, Manuel Valenzuela, Christopher Vallejos, Renato Salvatierra, Andrea Hernández, Margarita Vega, Andrew F.G. Quest and Carmen Romero. “Metformin induced decreases in NGF-induced cell proliferation of ovarian cancer cells are linked to reduced c-MYC and ?-catenin/TCF-Lef transcripcional activitiy and increased expression of oncosupressor micro-RNAs.” 23rd International Symposium on Molecular Medicine. Tawana Hotel, Bangkok, Thailand. March 28-30, 2019.
2) Burgos, R., Campos, A., Diaz-Valdivia, N., Varas-Godoy, M, Leyton L., Quest A. F. G. “Breast cancer exosomes with caveolin-1 increase cell migration / invasion of recipient cells possibly by a mechanism involving the adhesion protein Cyr61” First EMBO Workshop on Caveolae and Nanodomains: TRANSLATING STRUCTURAL PRINCIPLES AND DYNAMICS INTO FUNCTION" May 12-16th, 2019, Southern Brittany, France http://meetings.embo.org/event/19-caveolae
3) Oróstica, M.L, Romero, D., Bizama, C., García, P., Roa-Strauch, J.C., Quest A.F.G. “TNF?-induced Caveolin1 expression are associated with enhanced migration and invasion of gallbladder cancer cells” First EMBO Workshop on Caveolae and Nanodomains: TRANSLATING STRUCTURAL PRINCIPLES AND DYNAMICS INTO FUNCTION" May 12-16th, 2019, Southern Brittany, France http://meetings.embo.org/event/19-caveolae
4) Simón, L., Huilcamán, R., Oróstica, L., Sandoval, A., Quest, A.F.G. “Glycolysis inhibition by 2-deoxy-D-glucose reduces migration in cancer cells” XXXXII Reunión Anual de la Sociedad de Bioquímica y Biología Molecular de Chile. Centro de Convenciones Hotel Gavina Sans, Iquique, Chile (Oct 08-11th, 2019).
5) Sandoval-Bórquez, A., Martinez, S., Novoa, P., Carrasco-Avino, G., Corvalan, A., Lavandero, S., and Quest, A.F.G. “Reduced Angiotensin II Type 2 Receptor expression is associated with gastric cancer progression and receptor activation reduces gastric cancer cell migration” XXXXII Reunión Anual de la Sociedad de Bioquímica y Biología Molecular de Chile. Centro de Convenciones Hotel Gavina Sans, Iquique, Chile (Oct 08-11th, 2019).
6) González, M.F. and Quest, A.F.G. “Release of extracellular vesicles from gastric cells is enhanced by infection with Helicobacter pylori” XXXIII Reunión Anual de la Sociedad de Biología Celular de Chile. Centro de Convenciones Hotel Patagonico, Puerto Varas, Chile (November 26-30th, 2019).
7) Palacios, E., Quest, A.F.G., Valenzuela, M., Leyton, L. “Helicobacter pylori outer membrane vesicles induce astrocyte reactivity which prevents neurite outgrowth” XXXIII Reunión Anual de la Sociedad de Biología Celular de Chile. Centro de Convenciones Hotel Patagonico, Puerto Varas, Chile (November 26-30th, 2019).
8) Carrasco-Véliz, N., Palavecino, C., Garrido, M., Quest, A., and Valenzuela-Valderrama, M. “Translational regulation of the antiapoptotic protein Survivin by control elements in the 5’ untranslated region (5’UTR)” XXXIII Reunión Anual de la Sociedad de Biología Celular de Chile. Centro de Convenciones Hotel Patagonico, Puerto Varas, Chile (November 26-30th, 2019).
9) Diaz, J., Chamorro, A., Artigas, R., Corvalan, A., Quest, A.F.G., Leyton, L. “TNF-induced migration and ?3 integrin levels are regulated by the Rab endocytic pathway in reactive astrocytes” American Society for Cell Biology Annual Meeting, Washington DC, USA (December 07 - 11, 2019).
10) Sandoval-Bórquez, A., Martinez, S., Rodriguez, A., Wichman, I., Carrasco-Avino, G., Corvalan, A., Lavandero, S., and Quest, A.F.G. “Reduced Angiotensin II Type 2 Receptor expression is associated with gastric cancer progression and receptor activation reduces gastric cancer cell migration and invasion” Digestive Disease week, 2-5 May 2020, Chicago, USA
11) Soto, C., Pacheco, M., Yañez, L., Salinas, D., Hoare, A., Quest, A., Bravo, D. “Helicobacter pylori and Porphyromonas gingivalis interaction enhance cell migration” International Association for Dental Research IADR, Chilean Division, Annual Meeting 30-31 July, virtual meeting. https://www.iadrchile.cl/xxxii-reunion-anual-2020/. Award: best post-graduate student presentation.
12) Campos, A., Burgos, R., Huilcaman, R., Gonzalez, M.F., Diaz, J., Varas, M., LobosGonzalez, L., Leyton, L., Quest, A.F.G. “Caveolin1containing extracellular vesicles transport adhesion proteins which promote the development of malignant traits in recipient cells” 45th FEBS Virtual Congress 3-8th July, 2021.
13) Diaz, J., Chamorro, A., Perez, R.D., Artigas, R., Corvalan, A., Quest, A.F.G., Leyton, L. TNF-induced migration and ?3 integrin levels are regulated by the Rab endocytic pathway in reactive astrocytes. 45th FEBS Virtual Congress 3-8th July, 2021.
14) Simón, L., Quest, A.F.G. Glycolytic restriction induced by 2-deoxy-D-glucose reduces Caveolin-1-enhanced metastasis of cancer cells via downregulation of Akt signaling. “2021 Colloquium series in Cell Biology: Young Investigators” Sociedad de Biologia Celular de Chile, 29 November – 1st December. Virtual conference.
15) Palacios, E., Lobos-González, L., Guerrero, S., Quest, A.F.G., Leyton, L., and Valenzuela, M. Helicobacter pylori outer membrane vesicles induce astrocyte reactivity and cause neuronal damage through NF?B activation in a murine model. “2021 Colloquium series in Cell Biology: Young Investigators” Sociedad de Biologia Celular de Chile, 29 November – 1st December. Virtual conference
16) Sandoval-Bórquez, A., Martinez, S., Rodriguez, A., Wichman, I., Carrasco-Avino, G., Corvalan, A., Lavandero, S., and Quest, A.F.G. Reduced Angiotensin II Type 2 Receptor Expression Is Associated with Gastric Cancer Progression and enhanced Gastric Cancer Cell Migration/Invasion. ASBMB annual meeting, 2-5 April 2022, Philadelphia, USA.
Published as: Sandoval-Borquez AM, Wichman I, Carrasco-Avino G, Corvalan A, Lavandero S, Quest AFG. Reduced Angiotensin II Type 2 Receptor Expression Is Associated with Gastric Cancer Progression and Enhanced Gastric Cancer Cell Migration/Invasion. FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R5188. PMID: 35560882.
17) Bravo, D., Soto, C., Pacheco, M., Yañez, L., Salinas, D., Hoare, A., Quest, A.F.G. “Helicobacter pylori and Porphyromonas gingivalis Interaction Enhance P. gingivalis virulence and Cell Migration” American Society of Microbiology, ASM Microbe, June 09-13, 2022, Washington DC, USA.
18) Lobos-González, L., Oróstica, L., Díaz-Valdivia N., Rojas, V.M., Campos, A., Farfán N, Silva V, Maldonado, H., Leyton, L.*, Quest A.F.G.* “Exposure to the pro-inflammatory prostaglandin E2 disrupts E-cadherin/Caveolin-1-mediated tumor suppression to favor Caveolin-1 enhanced migration, invasion and metastasis of melanoma cells” 46th FEBS Congress, 09-14 July, 2022, Lisabon, Portugal.
19) Leyton, L. “Neuron-Astrocyte communication: Astroyctic b3 integrin controls life and death decisions in neurons”. 46th FEBS Congress, 09-14 July, 2022, Lisabon, Portugal.
20) González, M.F., Burgos-Ravanal, R., Shao, B., Heinecke, J., Valenzuela-Valderrama, M., Leyton, L., Corvalán, A., and Quest, A.F.G. “Extracellular vesicles from gastric epithelial cells infected with Helicobacter pylori contain hypoxia-induced factor-1a target genes and promote changes in recipient cells associated with malignancy.” Keystone meeting: Interconnection between the Gut, Brain and Microbiome for Metabolic Disease. Beaver Run Resort, Breckenridge, Colorado, USA. October 7-10, 2022.
21) Palacios, E., Lobos-Gonzalez, L., Guerrero, S., Kogan, M.J., Quest, A.F.G., Leyton, L., Valenzuela-Valderrama, M. “Helicobacter pylori outer membrane vesicles alter astrocyte and neuronal function in vitro and in vivo” Keystone meeting: Interconnection between the Gut, Brain and Microbiome for Metabolic Disease. Beaver Run Resort, Breckenridge, Colorado, USA. October 7-10, 2022.
22) Sanhueza, S., Cifuentes, M., Quest, A.F.G. “Extracellular vesicles from adipose cells promote in vitro vascular network formation by endothelial cells.” XXXIV Reunion anual Sociedad de Biologia Celular de Chile, 12 – 16th December, 2022. Puerto Varas, Chile.
23) Peña-Oyarzún, D., Flores, T., Torres, V.A., Quest, A.F.G., Reyes, M. “Inhibition of Wnt signaling prevents oral carcinogenesis” XXXIV Reunion anual Sociedad de Biologia Celular de Chile, 12 – 16th December 2022. Puerto Varas, Chile.
24) Herrera, D., Torres, V., Quest, A.F.G. “Helicobacter pylori activates the HIF-1?/ALS2/Rab5 signaling pathway to induce ?-catenin translocation to the nucleus in gastric cells” XXXIV Reunion anual Sociedad de Biologia Celular de Chile, 12 – 16th December 2022. Puerto Varas, Chile.
25) Palacios, E., Fernanda González, M., Lobos-González, L., Guerrero, S., Kogan, M.J., Shao, B., Heinecke, J., Quest, A.F.G., Leyton, L., and Valenzuela-Valderrama, M. “Helicobacter pylori outer membrane vesicles alter astrocyte and neuronal function by activating NF?B and the release of IFN-g from astrocytes” XXXIV Reunion anual Sociedad de Biologia Celular de Chile, 12 – 16th December 2022. Puerto Varas, Chile.
26) Santoro, P., Sandoval-Borquez, A., Olivares, W., Torres, K., Quest, A., F.G., Corvalan, A.H. Characterization of miR-597-5p and its competing endogenous network (KCNQ1OT1/miR-597-5p/RUNX1) in Gastric Cancer. XXXIV Reunion anual Sociedad de Biologia Celular de Chile, 12 – 16th December 2022. Puerto Varas, Chile.
27) Simón, L., Arazo, M., Andrades, G.R., Caro, A., González-Morelo, Quest, A.F.G., Pérez-Correa, R., Mariotti Celis, M.S “Phlorotannin-containing extracts from Chilean brown algae (Durvillae incurvata) inhibit melanoma cell migration.” The First International Conference on Antioxidants: Sources, Methods, Health Benefits and Industrial Applications. 10–12 May 2023, Barcelona, Spain.
28) Simon, L, Contreras, P., Diaz-Valdivia, N., Leyton, L., Quest, A.F.G. “Glycolytic restriction reduces Caveolin-1-enhanced metastasis via the downregulation of Akt signaling” 47th FEBS Congress, 08-12 July, 2023, Tours, France.
29) Palacios, E., Lobos-Gonzalez, L., Guerrero, S., Kogan, M.J., Shao, B., Heinecke, J., Quest, A.F.G., Leyton, L., Valenzuela-Valderrama, M.” Nanoscale outer membrane vesicles from Helicobacter pylori alter astrocyte functionality inducing neuronal degeneration” 47th FEBS Congress, 08-12 July, 2023, Tours, France.
30) Oyarzun-Ampuero, F., Alvarez-Acevedo, G., Valenzuela, C., Kogan, M.J., Quest, A., Cifuentes, F.F., Torres, C.G. “Tumor recurrance after application of a single dose of a curcumin nanoemulsion in dogs with incompletely resected tumors: A pilot study” WSAWA World Congress, 27-29th September 2023, Lisbon, Portugal.
31) Quest, A.F.G., Valenzuela, M., Leyton, L. “Local gastric and systemic effects of Helicobacter pylori” Reunion annual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 03-06 Octubre, 2023, La Serena, Chile.
32) Herrera, D., Tapia, H., Bravo, D., Quest, A.F.G., Torres, V.A. “HIF1?/Rab5/?-catenin: a novel signaling axis triggered by Helicobacter pylori in gastric cancer cells” Reunion annual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 03-06 Octubre, 2023, La Serena, Chile.
33) Sanhueza, S., Huilcamán, R., Albornoz, J., Shao, B., Heinecke, J., Cifuentes, M., Leyton, L., Quest, A.F.G “Extracellular vesicles from Caveolin-1-expressing B16F10 melanoma cells enhance in vitro vascular network formation by endothelial cells” Reunion annual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 03-06 Octubre, 2023, La Serena, Chile.
34) González, M.F., Kogan, M., Corvalán, A., Quest, A.F.G. and Leyton, L. “Extracellular vesicles isolated from the serum of patients with Helicobacter pylori contain circulating Hp-OMVs” Reunion annual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 03-06 Octubre, 2023, La Serena, Chile.
35) Simón, L., Rivera Andrades, G., Arazo-Rusindo, M., Guerrero, S., Oyarzún-Ampuero, F., Mariotti-Celis, M.S., Quest, A.F.G. “Phlorotannin-containing extracts from Chilean brown seaweeds and curcumin inhibit glycolysis and reduce the metastatic potential of cancer cells” Reunion annual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 03-06 Octubre, 2023, La Serena, Chile.
36) Olivares, W., Santoro, P., Carvajal, F., Riquelme, A., Quest, A.F.G and Corvalan, A. “Competing endogenous RNA networks in gastric cancer” Reunion annual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 03-06 Octubre, 2023, La Serena, Chile.
37) Carvajal, F., Olivares, W., Quest, A.F.G and Corvalan, A. “Competing endogenous RNA networks of KCNQ1OT in gastric cancer pathogenesis” Semana Panamericana de Enfermedades Digestivas (SPED), 08-11 Octubre, 2023, Santiago de Chile, Chile.
38) Bolaños, K., Leon, D., Araya, E., Quest, A.F.G, Kogan, M.”Melanoma cell-derived exosomes with inclusion of gold nanorods for potential photothermal therapy in metastatic cancer” VII Reunion Nacional de Nanotecnologia 12-15 November 2023, Pucon, Chile.
39) Carvajal, F.J., Olivares, W., Santoro, P., Quest, A., Corvalan, A. DYSREGULATION OF KCNQ1OT1 AND ITS COMPETING ENDOGENOUS RNA (CERNA) NETWORK AFTER H. PYLORI INFECTION: ROLE IN GASTRIC CANCER PATHOGENESIS. Digestive Disease Week (20 May 2024, San Diego, CA, USA.
40) Carrasco-Veliz, N., Garrido, M.P., Palavecino, A.M., Brito, R., Quest, A.F.G., Palacios, E., Villena, J., and Valenzuela-Valderrama, M. “The cap-independent translation of the Survivin 5’ untranslated region (5’UTR) and viral IRES sequences is inhibited by H. pylori infection in gastric cells”
37th Workshop of the European Helicobacter and Microbiota Study Group, Sept. 12-14, 2024 Porto Portugal. https://ehmsgworkshop.wixsite.com/ehmsg2023
41) Sanhueza, S., Campos, A., Burgos, R., Peña, D., Shao, B., Heinecke, J., Cifuentes, M., Leyton, L., Quest, A.F.G. “Extracellular vesicles from Caveolin-1-containing MDA-MB-231 breast cancer cells enhance endothelial cell tube formation” Reunion anual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 30 Sept-04 Octubre, 2024, La Serena, Chile.
42) Guzmán-Nawrath, K., Prodan, E., Chimento, A., Matiacich, E., Herrera, S., Quest, A.F.G., Cristina, C., Lobos-González, L. “MicroRNAs recovered from biobank samples as biomarker candidates in cancer research” Reunion anual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 30 Sept-04 Octubre, 2024, La Serena, Chile.
43) González C, M.F., Quest, A.F.G., and Leyton, L. “Outer membrane vesicles from Helicobacter pylori (Hp) promote NF?B activation mediated by TLR2 in astrocytes” Reunion annual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 30 Sept-04 Octubre, 2024, La Serena, Chile.
44) Quest, A.F.G. “Nanoformulations of curcumin and their applications in cancer prevention and treatment” Reunion annual de la Sociedad de Bioquimica y Biologia Molecular de Chile, 30 Sept-04 Octubre, 2024, La Serena, Chile.
ORAL PRESENTATIONS AT NATIONAL/INTERNTIONAL MEETINGS AND WORKSHOPS
1) Talk: “Caveolin-1 in tumor suppression and metastasis” Summer School, Faculty of Medicine, University of Chile, Santiago 15 January, 2019
2) Talk: “How inflammation subverts tumor suppressors” Summer Course in Cancer Research, Univeristy of Talca, Talca 16 January, 2019
3) Talk: “The GPI-anchored protein Thy-1 promotes wound healing upon injury to the skin by enhancing angiogenesis” GRIVAS meeting, University of BioBio, Chillan, April 4-6, 2019
4) Talk: “Exosomes containing Caveolin-1 propagate metastatic disease” Summer Course in Cancer Research, Univeristy of Talca, Talca 13/14 January, 2020
5) Talk:”Cross-talk between oral and stomach microbes” Summer Course in Dental Research, Univeristy of Talca, Talca 18/19 January, 2022
6) Talk: “About oncogenes and tumor suppressors – or – How good friends turn into bad villans? XII seminario en ciencias biomedicas, Universidad de Antiochia, Medellin, Colombia 2-4 Marzo, 2022
7) Talk: :”Inflammation in Cancer” Summer Course on Inflammation, Univeristy of Talca, Talca 19/20 January, 2023
8) Talk: “Local gastric and systemic effects of Helicobacter pylori” in Symposium on “Different angles to gastric cancer and related prevalent diseases” XLVI Annual Meeting of the Chilean Socienty for Biochemistry and Molecular Biology, La Serena 03-06 Oct, 2023.
9) Talk: “On the role of Caveolin-1- containing cancer cell derived extracellular vesicles in inflammation and metastasis” Symposium on Inflammation and Cancer. Facultad de Ciencias, UACH, Valdivia 2024, January 17-18th.
10) Talk: “The obesity connection to cancer” Summer Course on Obesity, Univeristy of Talca, Talca 22/23 January, 2024
11) Talk: “Unraveling molecular mechanisms underlying the development of prevalent cancers in Chile” Plenary Speaker: Annual meeting of the Maule Region Medical Society July 2024.
12) Talk: "Pharmacological applications of anoformulations using exosomes" and “Systemic nanoscale vesicles from Helicobacter pylori alter astrocyte functionality inducing neurodegeneration” 4th International School of Neurobiology Mendoza 2024 « From Molecules to Systems : Modern Neurobiology at a Glance » Aug. 26th-Sept 07th, 2024 Mendoza, Argentina.
OUTREACH – Press articles
2019
Estudiante de ACCDiS gana premio de mejor poster en la reunion de la Socieded de Microcirculacion y Vasculaturea en Holanda Abril 2019
https://www.accdis.cl/doctorante-accdis-gana-premio-a-mejor-poster-en-conferencia-en-holanda/
Nanoemulsion con Curcumina, producto que se generó en base de nuestros estudios publicados en la revista Nanoscale en 2018 entra al mercado y se puede comprar por internet www.nanofix.cl
Noticia en el Portal Bio Bio sobre Nano emulsión con Curcumina
Noticia en pagina web de la empresa Matchetune donde AQ es parte del board of directors – ver www.matchetune.cl
Noticia en el LUN 26 de Junio sobre la falta de Vitamina D en la población Chilena
http://www.lun.com/Pages/PrintPage.aspx?PrintParam=%27https://images.lun.com/luncontents/NewsPaperPages/2019/jun/26/LUCPR32LU2606_800.swf%27
2020
Webinar sobre producto nuevo de Matchetune llamado “Nanofit” para reducir inflamacion en deportistas.
Webinar sobre producto nuevo de Matchetune llamado “Nanovet” para reducir inflamacion y cancer en perros.
Artículos en el espacio "Science and community" en la página web del SBCCH, donde socios/as y miembros de la Sociedad científica están aportando con la difusión de sus trabajos. Un nuevos aporte en Noviembre han sido publicados por el Laboratorios de nuestro socios Andrew Quest y ha sido difundido en el siguientes enlace:
https://sbcch.cl/2020/11/21/un-posible-nuevo-mecanismo-de-inhibicion-de-la-metastasis-a-traves-de-la-proteina-ptpn14/
2020
Artículos en el espacio "Science and community" en la página web del SBCCH, donde socios/as y miembros de la Sociedad científica están aportando con la difusión de sus trabajos. Un nuevos aporte en Noviembre han sido publicados por el Laboratorios de nuestro socios Andrew Quest y ha sido difundido en el siguientes enlace:
https://sbcch.cl/2020/11/21/funciona-la-revision-por-pares-para-las-publicaciones-sobre-covid-19/
Este último aporte se trata de un artículo de opinión en un tema muy contingente (revisión de pares en el contexto de COVID-19) y que fue desarrollado en el marco de un curso de inglés para estudiantes de postgrado.
además:
https://sbcch.cl/2020/11/21/un-posible-nuevo-mecanismo-de-inhibicion-de-la-metastasis-a-traves-de-la-proteina-ptpn14/
“Un posible nuevo mecanismo de inhibicion de la metastasis a traves de la proteina PTPN14”
2021
El Mostrador, martes 18 de mayo 2021: “Celulas que cicatrizan heridas aceleran la metastasis en cancer” https://www.elmostrador.cl/cultura/2021/05/18/celulas-que-cicatrizan-heridas-aceleran-la-metastasis-en-cancer/
2022
Entreviasta TVN Abril 2022 en relacion a publicacion en Nature describiendo nuevo tratamento cancer de mama con un anticuerpo chimerico contra receptor de EGF y marcador de stem cells….
link con entrevista al Dr. Andrew Quest en noticiero central de TVN, sobre creación de anticuerpo que frena avance del cáncer. https://www.youtube.com/watch?v=oYkIZSvGihc&t=7s
Entrevista publicada en El Mercurio 19 de Mayo 2022: sobre “Crema desarrollada en Temuco mata el cáncer de piel más común”
2023
Cubertura del Summer school Talca 19/20 de enero 2023 organizado por Rodrigo Moore y Andrew Quest.
LA PRENSA
Ciencia de vanguardia se da cita en la UTalca. Se refiere Rodrigo Moore, director del Doctorado en Ciencias Biomédicas.
https://www.litoralpress.cl/paginaconsultas/Servicios_NClipSitio/Get_Imagen_Nota.aspx?LPKey=4CYMQXXGJFRFX53XCJJDKEW32S7ABIBGEBJGXKB6OSYISPT3N5VNEHOHAG4DQC2I6ITH47RLBUCAC
MEDIABANCO.COM
Expertos expusieron sobre los problemas de salud que se gatillan por una inflamación crónica. Se refiere Rodrigo Moore, director del Doctorado en Ciencias Biomédicas.
https://www.mediabanco.com/expertos-expusieron-sobre-los-problemas-de-salud-que-se-gatillan-por-una-inflamacion-cronica/
G5NOTICIAS.CL
Expertos expusieron sobre los problemas de salud que se gatillan por una inflamación crónica. Se refiere Rodrigo Moore, director del Doctorado en Ciencias Biomédicas.
https://g5noticias.cl/2023/01/21/expertos-expusieron-sobre-los-problemas-de-salud-que-se-gatillan-por-una-inflamacion-cronica/
The following entry in Encyclopedia has been updated:Entry ID: 41993
Category: Cell Biology
Title: Adipocyte–Macrophage Relationship in Cancer
Authors: Layla, Sofía, Mariana, Andrew F. G.
Created Date: 8 March 2023
Revised Author: Layla Simón
https://encyclopedia.pub/entry/41993
Research Features
Author: Andrew Quest
Caveolin-1: a double-edged sword in the fight against cancer metastasis.
The individual webpage for your feature is also now live:
https://researchfeatures.com/caveolin-1-double-edged-sword-fight-cancer-metastasis/
The whole digital publication of the issue containing your article is now live on our website:
https://researchfeatures.com/publications/research-features-magazine-146/
News ES EURO
Siete de cada diez chilenos deberían hacerse una endoscopia para prevenir el cáncer gástrico
https://news.eseuro.com/noticias/2328125.html
News Portal Red Salud
Siete de cada diez chilenos deberían hacerse una endoscopia para prevenir el cáncer gástrico
https://www.portalredsalud.cl/2023/10/04/siete-de-cada-diez-chilenos-deberia-hacerse-una-endoscopia-para-prevenir-cancer-gastrico/#:~:text=Siete%20de%20cada%20diez%20chilenos%20deber%C3%ADa%20hacerse%20una%20endoscop%C3%ADa%20para%20prevenir%20c%C3%A1ncer%20g%C3%A1strico,-Por&text=%2DExamen%20permitir%C3%ADa%20detectar%20bacteria%20que,de%20riesgo%20del%20c%C3%A1ncer%20g%C3%A1strico.
News NorteVision
Siete de cada diez chilenos deberían hacerse una endoscopia para prevenir el cáncer gástrico
https://nortevision.cl/2023/10/03/siete-de-cada-diez-chilenos-deberia-hacerse-una-endoscopia-para-prevenir-cancer-gastrico/
-La Región de Coquimbo:
abajo link y archivo de artículo que gestionamos en diario La Región de Coquimbo, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico. La publicación es muy buena, a página completa.
https://updatecomunicaciones.cl/update/noticia/231355
El Mostrador
Siete de cada diez chilenos deberían hacerse una endoscopia para prevenir el cáncer gástrico
https://www.elmostrador.cl/agenda-pais/vida-en-linea/2023/10/05/siete-de-cada-diez-chilenos-deberia-hacerse-una-endoscopia-para-prevenir-cancer-gastrico/
Uchile notiicas
70% de la poblacion estaria infectada con bacteria causante de cancer
https://uchile.cl/noticias/209795/70-de-la-poblacion-estaria-infectada-con-bacteria-causante-de-cancer#:~:text=su%20detección%20oportuna-,70%25%20de%20la%20población%20chilena%20estar%C3%ADa%20infectada%20con%20bacteria%20que,de%20riesgo%20de%20cáncer%20gástrico&text=Helicobacter%20Pylori%20(H.%20pylori),al%20año%20en%20nuestro%20pa%C3%
-Radio ADN online:
abajo link de artículo que gestionamos en radio ADN online, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico.
https://www.adnradio.cl/salud/2023/10/12/cerca-del-70-de-la-poblacion-chilena-estaria-infectada-con-bacteria-que-seria-el-factor-de-mayor-riesgo-de-cancer-gastrico.html#:~:text=Ahora%2C%20especialistas%20indican%20que%20aproximadamente,de%20riesgo%20de%20cáncer%20gástrico.
-Cienciaysalud:
abajo link de artículo que gestionamos en sitio Cienciaysalud, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico.
https://cienciaysalud.cl/2023/10/13/hasta-un-70-de-la-poblacion-chilena-estaria-infectada-con-bacteria-que-puede-provocar-cancer-gastrico/
-La Tercera online:
abajo link de artículo que gestionamos en La Tercera online, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico.
https://updatecomunicaciones.cl/update/noticia/231659
https://www.latercera.com/que-pasa/noticia/7-de-cada-10-chilenos-deberian-hacerse-una-endoscopia-para-detectar-el-mayor-factor-de-riesgo-del-cancer-gastrico/EJWEZOI5CNC4NIUY7ETX5XQZM4/
-TVN:
abajo link de entrevista a Dr. Andrew Quest que gestionamos en 24 Horas AM de TVN, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico.
https://www.youtube.com/watch?v=ndGdUNK6ZgA
-Eldinamo:
abajo link de artículo que gestionamos en Eldinamo, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico.
https://www.eldinamo.cl/pais/2023/10/15/h-pylori-la-bacteria-que-tiene-el-70-de-los-chilenos-y-que-influye-en-el-cancer-gastrico/
-T13:
abajo link de entrevista a Dr. Andrew Quest que gestionamos en T13 Central,
producto de la divulgación en diversos medios que estamos realizando de
nuestra crónica sobre importancia de endoscopía para prevenir cáncer
gástrico. Muy buena emisión en horario prime y siendo el Dr. Quest el único
experto entrevistado.
https://www.youtube.com/watch?v=6NfGeczTGro
Estimado Andrew, a continuación va reporte de publicaciones y emisiones para el día de hoy 17/10/2023:
-Radio Cooperativa:
abajo link de entrevista a Dr. Andrew Quest que gestionamos en radio Cooperativa, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico. Excelente emisión con más de 18 minutos al aire.
https://www.youtube.com/watch?v=ryI6bzfJPsg
-Radio TXS Plus:
abajo link de entrevista a Dr. Andrew Quest que gestionamos en Radio TXS Plus, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico. Excelente duración con más de 19 minutos.
https://www.youtube.com/watch?v=eEPrvnlFbHQ&t=3s
-Radio Duna:
abajo link de entrevista a Dr. Andrew Quest que gestionamos en Radio Duna, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico. Excelente duración con casi 19 minutos.
https://www.youtube.com/watch?v=tR6s6_ufrO4
-Radio Duna online:
abajo link de entrevista a Dr. Andrew Quest que gestionamos en Radio Duna online, producto de la divulgación en diversos medios que estamos realizando de nuestra crónica sobre importancia de endoscopía para prevenir cáncer gástrico.
https://www.duna.cl/programa/aire-fresco/2023/10/24/andrew-quest-y-bacteria-que-constituye-el-mayor-factor-de-riesgo-del-cancer-gastrico-en-chile-se-tendria-que-hacer-15-a-2-millones-de-endoscopias-al-ano-el-pais-no-tiene-la-capacidad-de-hacer/
2024
Radio cooperativa: www.cooperativa.cl
En Chile, el 70% de la población tiene una bacteria que causa el cáncer gástrico024
https://cooperativa.cl/noticias/pais/salud/en-chile-el-70-de-la-poblacion-tiene-una-bacteria-que-causa-el-cancer/2024-02-03/083143.html
La Tercera: www.latercera.com
Helicobacter Pylori: la infección que puede causar estragos en los estómagos
https://www.latercera.com/practico/noticia/helicobacter-pylori-la-infeccion-que-puede-causar-estragos-en-los-estomagos/F3ARKFUZVJG4ZOJWA7K66S5ZDA/#:~:text=%E2%80%9CLa%20presencia%20del%20Helicobacter%20pylori,c%C3%A1ncer%20g%C3%A1strico%E2%80%9D%2C%20puntualiza%20Calder%C3%B3n.
G5Noticias: www.g5noticias.cl
No hay conciencia en la población sobre el mayor riesgo de cáncer debido a la obesidad
https://g5noticias.cl/2024/01/25/no-hay-conciencia-en-la-poblacion-sobre-el-mayor-riesgo-de-cancer-debido-a-la-obesidad/
Porta prensa de salud: www.portalprensasalud.clAndrew Quest, académico de la Universidad de Chile: “No hay conciencia en la población sobre el mayor riesgo de cáncer debido a la obesidad”
https://portalprensasalud.cl/2024/01/23/andrew-quest-academico-de-la-universidad-de-chile-no-hay-conciencia-en-la-poblacion-sobre-el-mayor-riesgo-de-cancer-debido-a-la-obesidad/
TV 24 horas: La mañana informativa (Lorena Lobos como vocera para CEMC)
https://www.youtube.com/watch?v=9CeraZuqCE-cEw
Radio Duna: Aire Fresco (Lorena Lobos como vocera para CEMC)
Riesgo de cáncer debido a la obesidad-Radio Duna-Dra. Lorena Lobos-CEMC
https://www.youtube.com/watch?v=8C4rADK7pis
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Niemeyer Lecture
Sociedad Espanola de Bioquimica y Biologia Molecular
España, 2014
Niemeyer Conference - "Caveolin-1, a pleiotropic molecular switch in cancer progression" SEBBM (Sociedad Espanola de Bioquimica y Bioloiaa Molecular) 9-12 Sept. 2014, Granada, Spain.
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Editorial board member
Current Molecular Medicine
Estados Unidos, 2014
Just recently appointed as editorial board member. Still not mentioned in web of the journal.
Caveolin-1 in Melanoma Progression |
Meet our associate editor |
Signaling in cell death, survival, proliferation and degeneration |
Is there a link between dementia and cancer? |
Cellular Signaling |
Caveolina-1 induce cambios metabólicos en células de cáncer que favorecen la metástasis |
Advanced Center for Chronic Diseases (ACCDiS) |
Rol del ambiente inflamatorio en la expresión de CAV1 y la progresión del Cáncer de Vesícula Biliar |
The role of the ” Angiotensin II type 2 receptor in the molecular pathogenesis of human gastric carcinoma |
Phosphatases and exosomes in caveolin-1-mediated metastasis |
The role of PKR-like ER kinase (PERK) in Helicobacter pylori induced gastric cell death and progression of precancerous lesions to gastric cancer |
Role of helicobacter pylori gamma-glutamyl transpeptidase in autophagy of human gastriccells and the progression of precancerous lesions to gastric cancer |
THE THY-1 RECEPTORS αVβ3 INTEGRIN AND SYNDECAN-4 ON ASTROCYTES CONTROL MITOCHONDRIAL LOCATION AS WELL AS ATP RELEASE AND THEREBY CONTRIBUTE TO THE NEUROTOXIC EFFECTS OF REACTIVE ASTROCYTES. |
Advanced Center for Chronic Diseases (ACCDiS) |
CAVEOLIN-1-DEPENDENT MIGRATION AND METASTASIS OF CANCER CELLS REQUIRES TYR14 PHOSPHORYLATION, SEQUESTRATION OF P85A AND ACTIVATION OF THE RAB5-RAC1 PATHWAY, WHICH ARE INHIBITED BY EXPRESSION OF E-CADHERIN |
ESTUDIO DE LOS CAMBIOS EN LA LOCALIZACION INTRACELULAR DE CAVEOLINA-1 DURANTE LA HIPOXIA Y SU RELACION CON LA INHIBICION DE LA SINTASA DE OXIDO NITRICO ENDOTELIAL (eNOS) Y EL FACTOR INDUCIDO POR HIPOXIA, HIF-1a. |
TRÁFICO DE NANOPARTÍCULAS DENTRO DE CÉLULAS METASTÁSICAS, UN ACERCAMIENTO AL MARCAJE CELULAR PARA SU POSTERIOR SEGUIMIENTO IN VIVO |
Metabolic Stress Signaling in Cancer, Cardiovascular Diseases and Diabetes |
PRO-INFLAMMATORY STIMULI INCREASE ALPHAVBETA3 INTEGRIN EXPRESSION IN ASTROCYTES, WHICH UPON ENGAGEMENT OF NEURONAL THY-1 TRIGGERS BIDIRECTIONAL-SIGNALING EVENTS REQUIRED FOR ASTROCYTE MIGRATION AND AXONAL RETRACTION. |
SUPPRESSION OF TUMOR GROWTH BY CAVEOLIN-1 INVOLVES INHIBITION OF THE UNFOLDED PROTEIN RESPONSE |
ASOCIACION INVERSA ENTRE CANCER Y ENFERMEDAD DE ALZHEIMER=> UN POSIBLE MECANISMO BIOLOGICO COMUN. |
ASOCIACION INVERSA ENTRE CANCER Y ENFERMEDAD DE ALZHEIMER=> UN POSIBLE MECANISMO BIOLOGICO COMUN. |
ROL AUTOCRINO DE ATP COMO FORMA ALTERNATIVA DE MUERTE CELULAR=> PARTICIPACION DE P2X7 DETERMINA NECROSIS INDUCIDA POR FAS-L EN LINFOCITOS NEOPLASICOS. |
EL SUPRESOR DE TUMORES CAVEOLINA-1 INTERACTUA CON LA CICLOOXIGENASA-2 E INHIBE SU ACTIVIDAD CATALITICA, PROMOVIENDO LA APOPTOSIS EN CELULAS DE CANCER DE COLON. |
CENTER FOR MOLECULAR STUDIES OF THE CELL |
ELUCIDATION OF MECHANISMS UNDERLYING CAVEOLIN-1 TUMOR SUPPRESSOR ACTIVITY IN HUMAN COLON CARCINOMA CELLS AND PROTEIN KINASE C-DEPENDENT PATHWAYS CONTROLLING CAVEOLIN-1 EXPRESSION. |
PROTEIN KINASE C ISOFORMS IN THE CONTROL OF CELL GROWTH=> ROLE OF LIPID SECOND MESSENGERS AND COMPARTMENTALIZATION OF PKC ISOFORMS. |

Andrew Quest
Full Professor
Biologia Celular y Molecular
FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE
Santiago, Chile

Lisette Leyton
Full Professor
Cell and Molecular Biology
FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE
Santiago, Chile

SERGIO LAVANDERO
Director
Advanced Center for Chronic Diseases (ACCDiS)
UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS
Santiago, Chile

Vicente Torres
Associate Professor
Institute for Research in Dental Sciences
FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE
Santiago, Chile

Marcelo Kogan
Academico
Quimica Farmacologica y Toxicologica
UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS
Santiago, Chile

Lorena Lobos
Principal Investigator-Associate Proffesor
Facultad of Medicine - Clinic Alemana
Universidad Del Desarrollo
santiago, Chile

Roberto Bravo
Assistant Professor
Institute of Nutrition and Food Technology (INTA), Universidad de Chile
Santiago, Chile

ALEJANDRO CORVALAN
Principal Investigator
Hematology and Oncology
Pontificia Universidad Catolica de Chile
Santiago, Chile
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Mariana Cifuentes
Professor
Instituto de Nutricion y Tecnologia de los Alimentos
INTA UNIVERSIDAD DE CHILE
Santiago, Chile

Mario Chiong
Profesor
Departamento de Bioquímica y Biología Molecular
Universidad de Chile
Santiago, Chile

Rodrigo Troncoso
Associate Professor
Instituto de Nutrición y Tecnología de los Alimentos
Santiago, Chile

Paula Díaz
Coordinadora de Investigación y Postgrado
Facultad de Salud
Universidad Santo Tomás
Santiago, Chile

Natalia Diaz
Postdoctoral Fellow
Biofísica y Bioingeniería
Universidad de Barcelona
Barcelona , España

Simon Guerrero
Investigador
Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK
Universidad SEK
Santiago, Chile

Layla Simón
Académica Investigadora
Facultad de Medicina
Universidad Finis Terrae
Providencia, Chile

Rodrigo Herrera
Group Leader (staff member)
Combinatorial NeuroImaging Core Facility
Leibniz Institute for Neurobiology
Magdeburg, Alemania

Maritza Garrido
Bioquímico
Obstetricia y Ginecología
Hospital Clínico Universidad de Chile
Santiago, Chile

LORENA AGUILAR
Assistant Professor
Animal Pathology
Faculty of Veterinary Medicine and Livestock Sciences, University of Chile
Santiago, Chile

Paola Llanos
Profesor Asistente
Instituto de Investigacion en Ciencias Biomédicas
FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE
Santiago, Chile

María Díaz
Part time Professor
Ciencias Quimicas y Biologicas
Universidad Bernado O´higgins
Santiago , Chile

Daniel Peña
Investigador postdoctoral
Departamento de Fisiología
Pontificia Universidad Católica de Chile
Santiago, Chile

Patricio Silva
Investigador Principal FONDEF
Departamento de Biología Celular y Molecular
Universidad de Chile
Santiago, Chile

Sonja Buvinic
Associate Professor
Institute for Research in Dental Sciences
Universidad de Chile
Santiago, Chile

Maria Behrens
Profesor Titular
Neurología y Neurocirugía, y de Neurociencia
Hospital Clínico Universidad de Chile
Santiago, Chile

Alfredo Criollo
Associated Professor
Research Institute in Dental Sciences
Facultad de Odontología, Universidad de Chile
Santiago, Chile

Valentina Parra
Profesora Asistente / Assistant Professor
Departamento de Bioquímica y Biología Molecular
UNIVERSIDAD DE CHILE
Santiago, Chile

Claudio Hetz
Deputy Director
INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE
SANTIAGO, Chile

Sergio Wehinger
Académico Asociado
Bioquímica Clínica e Inmunohematología
UNIVERSIDAD DE TALCA
Talca, Chile

María Barrera
Profesor Asistente
Odontología
Universidad San Sebastián, Facultad de Odontología
Santiago, Chile

Fabian Tempio
Asistente de Investigación
Instituto de Ciencias Biomédicas
Universidad de Chile
Santiago, Chile

Paz Robert
Prof. Titular
Ciencia de los Alimentos y Tecnología Química
UNIVERSIDAD DE CHILE
Santiago, Chile

Felipe Oyarzún
Profesor Asociado
Ciencias y Tecnología Farmacéuticas
UNIVERSIDAD DE CHILE
Santiago, Chile

Rodrigo Pacheco
Associate Investigator; Head of the Laboratory of Neuroimmunology
Fundación Ciencia para la Vida
Santiago, Chile

Fanny Guzman
Investigador Senior
Núcleo de Biotecnología Curauma
Pontificia Universidad Católica de Valparaiso
Valparaiso, Chile

Alexis Kalergis
Full Professor
Microbiología
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS
Santiago, Chile

fresia ferreccio
Full Professor, Director PhD Epidemiolgy Program
Public Health
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.
Santiago, Chile

CLAUDIA BAMBS
PROFESORA ASOCIADA
SALUD PÚBLICA
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Daniela Rojas
Tecnólogo Médico
Patología y Medicina Preventiva
Universidad de Concepción
Chillán, Chile

Claudia Saez
Associate Professor
Hematology-Oncology
Pontificia Universidad Católica de Chile
Santiago, Chile

Raúl Lagos
Research associate
Department of Pharmacology
University of Cambridge
Cambridge, Reino Unido

Mercedes López
Profesora Asociada
Instituto de Ciencias Biomédicas
Universidad de chile
Santiago, Chile

Paulina Ormazábal
Docente investigador
Facultad de Ciencias para el cuidado de la Salud
Universidad San Sebastián
Santiago, Chile

Ethel Velásquez
Directora (t) Centro de Investigaciones Nucleares para Aplicaciones en Salud y Biomedicina
Comisión Chilena de Energía Nuclear
Santiago, Chile

Maria Ocaranza
Full Professor
Cardiovascular Diseases Division
Pontificia Universidad Catolica de Chile
Santiago, Chile

Vinicius Ramos Henriques
Associate Professor
Advanced Center for Chronic Diseases - ACCDiS
Univesidad de Chile
Santiago, Chile

Zully Pedrozo
Associated Professor
Physiology and Biophysical
Universidad de Chile
SANTIAGO DE CHILE, Chile

Eugenia Morselli
Profesor Asociado de Planta Ordinaria
Fisiología
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago de Chile, Chile

Javier Morales
Profesor Asociado
Departamento de Ciencias y Tecnología Farmacéuticas
Universidad de Chile
Santiago, Chile

Jorge Cancino
Associate Professor
Centro de Biología Celular y Biomedicina
Universidad San Sebastián
Santiago, Chile

SOLEDAD BOLLO
PROFESOR TITULAR
QUIMICA FARMACOLÓGICA Y TOXICOLÓGICA
UNIVERSIDAD DE CHILE
SANTIAGO, Chile

Mauricio Henriquez
Profesor asistente
PROGRAMA DE FISIOLOGÍA Y BIOFíSICA
Universidad de Chile / Facultad de Medicina
Santiago, Chile

Clara Quiroga
Profesor Asistente Adjunto
División de Enfermedades Cardiovasculares
Pontificia Universidad Católica de Chile
Santiago, Chile

Pablo Sepúlveda
Cardiólogo Intervencionista
División de Enfermedades Cardiovasculares
Pontificia Universidad Católica de Chile
Santiago, Chile

JORGE JALIL
FULL PROFESSOR
ENFS CARDIOVASCULARES
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA
Santiago, Chile

JOSE GALGANI
ASSOCIATE PROFESSOR
NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

César Osorio
Associate Professor
Kinesiología
Universidad Metropolitana de Ciencias de la Educación
Santiago, Chile

Mariana Sinning
Medico Staff
Neurología Psiquiatria y Oncología
Clinica Alemana Santiago
Santiago, Chile

Genaro Barrientos
Profesor Asistente
Fisiologia y Biofisica, ICBM
UNIVERSIDAD DE CHILE
Santiago, Chile

Maria Poblete
Profesor Auxiliar
Anatomia, Histologia y Patologia
Universidad Austral de Chile
Valdivia, Chile

INGRID EHRENFELD
FULL PROFESSOR
ANATOMIA; HISTOLOGIA & PATOLOGIA
UNIVERSIDAD AUSTRAL DE CHILE
VALDIVIA, Chile

Ignacio Wichmann
Assitant Professor
Obstetrics
Pontificia Universidad Católica de Chile
Santiago, Chile

JULIO TAPIA
Full Professor
Program of Cellular and Molecular Biology
UNIVERSIDAD DE CHILE
SANTIAGO, Chile

Valeria Garrido
Investigador Postdoctoral
Advanced Center for Chronic Disease
Universidad de Chile
Santiago, Chile

Rafael Burgos
FULL PROFESSOR
PHARMACOLOGY AND MORPHOPHYSIOLOGY
UNIVERSIDAD AUSTRAL DE CHILE
VALDIVIA, Chile

Margarita Montoya
Profesor Asociado
Biología
UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA
Santiago, Chile

Felipe Simon
Profesor Titular
Department of Biological Sciences
UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS
Santiago, Chile

Katherine Marcelain
Profesora Asociada
Oncología Básico Clínica
UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA
Santiago, Chile

Ricardo Armisen
Associate Professor
Centro de Genética y Genómica
Universidad del Desarrollo
Santiago, Chile

Francisca Sepúlveda
PhD(c)
Instituto de Ciencias e Innovación en Medicina
Universidad del Desarrollo
Santiago, Chile

Luisa Herrera
Profesor Asociado
Incstituto de Ciencias Biomédicas, Programa de Genética Humana
UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA-ICBM
Santiago, Chile

Soledad Henriquez
Profesor Asistente
INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE
Santiago, Chile

Hugo Verdejo
Profesor Asociado
División de Enferemedades Cardiovasculares
Pontificia Universidad Católica de Chile
Santiago, Chile

Juan Carlos Quintana
Médico nuclear
Radiología
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile