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Marioly Anneliese Muller Sobarzo

Académico

Universidad de Chile

Santiago, Chile

I am interested in exploring the mitochondrial Ca2+ regulation relieving the importance of mitochondrial Ca2+ dyshomeostasis and consequent Ca2+ overload as an early hallmark event in the pathophysiological process of several diseases.

Doctora en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2021
Magister en Biología Celular, UNIVERSIDAD DE CHILE. Chile, 2009
Licenciada en Tecnología Médica, UNIVERSIDAD DE CHILE. Chile, 2000
Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 2000
Educación en Ciencias de la Salud, UNIVERSIDAD DE CHILE. Chile, 2003

Profesor ayudante Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2001 - 2005
Profesor instructor Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2005 - 2012
Profesor asistente Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2013 - At present
Subdirectora Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2018 - 2022
Subdirectora Académica Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2022 - At present

Asistente de investigación Part Time

Universidad de Chile

Santiago, Chile

2001 - 2006
Asistente de investigación Full Time

Universidad de Pennsylvania

Filadelfia, Estados Unidos

2006 - 2012


HERPUD1 governs tumor cell mitochondrial function via inositol 1,4,5-trisphosphate receptor-mediated calcium signaling Quiroga, Clara; Jimenez-Gallegos, Danica; Chiong, Mario Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2024)
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging Mueller, Marioly; Sanhueza, Mario; Court, Felipe A.; Cardenas, Cesar Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2018)
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria (vol 14, pg 2313, 2016) Cardenas, Cesar; McNeal, Andrew; Smith, Natalia; Molgo, Jordi; Diehl, J. Alan; Ridky, Todd W. Article ISI Cell Reports (2016)
MCUR1 (ccdc90a) is a regulator of the mitochondrial calcium uniporter 3. Vais, H., K. Mallilankaraman, Müller, M, Tanis, JE and Foskett, JK Article CELL METABOLISM (2015)
Genetic identification of a role of InsP3 receptor-mediated exaggerated Ca2+ signaling in Alzheimer’s disease pathogenesis 4. Shilling D, M. Müller, H. Takano, D-O. D. Mak, T. Abel, D. Coulter and J.K. Foskett JK Article JOURNAL OF NEUROSCIENCE (2014)
Suppression of InsP<sub>3</sub> Receptor-Mediated Ca<SUP>2+</SUP> Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis Shilling, Dustin; Takano, Hajime; Mak, Don-On Daniel; Abel, Ted; Coulter, Douglas A. Article ISI JOURNAL OF NEUROSCIENCE (2014)
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Mallilankaraman, Karthik; Cárdenas, César; Doonan, Patrick J; Chandramoorthy, Harish C; Irrinki, Krishna M; Golenár, Tünde; Csordás, György; Madireddi, Priyanka; Yang, Jun; Müller, Marioly; Miller, Russell; Kolesar, Jill E; Molgó, Jordi; Kaufman, Brett; Hajnóczky, György; Foskett, J Kevin; Madesh, Muniswamy Article Nature cell biology (2012)
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Mallilankaraman, Karthik; Doonan, Patrick; Cárdenas, César; Chandramoorthy, Harish C; Müller, Marioly; Miller, Russell; Hoffman, Nicholas E; Gandhirajan, Rajesh Kumar; Molgó, Jordi; Birnbaum, Morris J; Rothberg, Brad S; Mak, Don-On Daniel; Foskett, J Kevin; Madesh, Muniswamy Article Cell (2012)
Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling. Müller, Marioly; Cárdenas, César; Mei, Lijuan; Cheung, King-Ho; Foskett, J Kevin Article Proceedings of the National Academy of Sciences of the United States of America (2011)
Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling Article ANTIOXIDANTS AND REDOX SIGNALING (2011)
Enhanced ROS Generation Mediated by Alzheimer's Disease Presenilin Regulation of InsP<sub>3</sub>R Ca<SUP>2+</SUP> Signaling Article ISI ANTIOXIDANTS & REDOX SIGNALING (2011)
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cárdenas, César; Miller, Russell A; Smith, Ian; Bui, Thi; Molgó, Jordi; Müller, Marioly; Vais, Horia; Cheung, King-Ho; Yang, Jun; Parker, Ian; Thompson, Craig B; Birnbaum, Morris J; Hallows, Kenneth R; Foskett, J Kevin Article Cell (2010)
Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating Cheung, K., Shineman, D., Müller, M., Cárdenas, C., Mei, L., Yang, J., Tomita, T., Iwatsubo, T., Lee, V. M. Y., & Foskett, J. K Article NEURON (2008)
Mechanism of Ca2+ disruption in Alzheimer’s disease by presenilin regulation of InsP3 receptor channel gating 10. Cheung K.H., Shineman, D, Müller, M, Cárdenas, C, Mei, Tomita, L, Iwatsubo, T, Lee, V and Foskett, JK Article ISI NEURON (2008)
Mechanism of Ca<SUP>2+</SUP> disruption in Alzheimer's disease by presenilin regulation of InsP<sub>3</sub> receptor channel gating Shineman, Diana; Cardenas, Cesar; Mei, Lijuan; Tomita, Taisuke; Iwatsubo, Takeshi; Lee, Virginia M. -Y. Article ISI NEURON (2008)
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons Kemmerling U.; Muñoz P; Sánchez G; Klann, E; Hidalgo C. Article ISI SCOPUS CELL CALCIUM (2007)
Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes Espinosa, A.; Leiva A.; Pena, M.; Debandi A.; Hidalgo C.; Jaimovich E. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase C alpha Cardenas C; Jaimovich E.; Pérez, F; Buchuk, D; Quest, AFG Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Depolarization-induced slow calcium transients activate early genes in skeletal muscle cells Riveros, N.; RIOS, J.; Torres, F; Pineda J.; Lantadilla S.; Jaimovich E. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells Estrada, M; Espinosa, A.; Jaimovich E. Article ISI SCOPUS ENDOCRINOLOGY (2003)
IP3 receptor function and localization in myotubes: an unexplored Ca2+ signaling pathway in skeletal muscle 16. Powell, J., Carrasco, MA, Adams, DS, Drouet, B, Rios, J, Müller, M, Estrada, M and Jaimovich, E. Article ISI JOURNAL OF CELL SCIENCE


MITOCHONDRIA CA2 UPTAKE MEDIATED BY INSP3 RECEPTORS IS REQUIRED TO MAINTAIN CANCER CELL BIOENERGETICS. ITS INHIBITION RESULTS IN SELECTIVE CANCER CELL DEATH. FONDECYT (1120443) Proyecto 2012-2016 Coinvestigador(a)


Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies Muller, Marioly; Verdugo, Carlos Review ISI FRONTIERS IN IMMUNOLOGY (2024)
Targeting VCAM-1: a therapeutic opportunity for vascular damage Riquelme, Jaime A.; Muller, Marioly; Garrido, Luis; Chiong, Mario Review ISI EXPERT OPINION ON THERAPEUTIC TARGETS (2023)