our lab is interested in the mechanisms that regulated cellular metabolism and bioenergetic’s, with special emphasis in the functional relation between the endoplasmic reticulum and mitochondria in the context of cancer and aging

.2017-2018 Postdoctoral advisor: Felix Urra, FONDECYT postdoctoral grant #3170813. “Mitochondrial glutamine metabolism in metastasis of breast cancer cells: a selective dependence that offers new anti-cancer strategies” Current position, Assistant Professor at University of Chile, Chile.

2014-2017 Postdoctoral advisor: Carla Basualto, FONDECYT postdoctoral grant #3150623. “Role of dysfunctional mitochondria in the muscle weakness and atrophy observed in Dermatomyositis and Polymyositis” Current position, Assistant Professor at Aysen University, Chile.

2013-2016 Postdoctoral advisor: Fabian Jana, FONDECYT postdoctoral grant #3140458. “Defining the role of mitochondrial electron transport chain complex I on the modulation of Ca2+ homeostasis: effects on cancer cell metabolism”.
Current position, Assistant Professor at Aysen University, Chile.

2017-present PhD advisor; Marioly Muller, “Role of IP3R-mediated exacerbated Ca2+ signaling in neurodegeneration and mitochondrial dysfunction in early onset of Familial Alzheimer disease”.

2017-present PhD advisor: Galdo Bustos, “Mitochondrial Ca2+ uptake of is essential to maintain mitochondrial metabolism and sustain breast cancer cell migration and invasion.

2016-present PhD advisor: Ulises Ahumada, “Endoplasmic reticulum – mitochondria coupling as regulator of cellular senescence”

2013-2016 PhD advisor: Felix Urra, “Metabolic remodeling in breast cancer: mitochondrial bioenergetics as target for the design of anti-metastatic drugs”.

2015-present Master advisor: Felipe Munoz. “Synthesis of 5,8-dihydroxi-4,4-dimetilnaftalen-1(4H)- ona-alquil TPP+ derivate; potential mitochondrial antioxidant with effects on cancer markers dependent of oxidative stress.

2014-2016 Master advisor: Melany Rios. “alpha-ketoglutarate dehydrogenase as a key regulator of metabolism in cancer cells” (University of Chile, Chile).

2015-2016 Undergraduate advisor: Santiago Sepulveda, “Mutant presenilin 1 (M146L) alter mitochondrial Ca2+ homeostasis in a model of familiar Alzheimer disease (FAD) (University of Chile, Chile).

2015-2016 Undergraduate advisor: Pablo Cruz, “Long term treatment with metformin induce changes in the cell cycle in leukemia cells. (University of Chile, Chile).

2015-2016 Undergraduate advisor: Daniela Gonzalez, “knockdown of nad-isocitrate dehydrogenase in mcf7 cells; comparative effect with InsP3R inhibition. (University of Chile, Chile).
2013-2015 Undergraduate advisor: Mery Ann Hidalgo, “Determination of autophagy levels in biopsies of patients with dysferlinophaty disease”. (University of Chile, Chile).

2014-2015 Undergraduate advisor: Natalia Smith. “Inhibition of inositol 1,4,5-trisphosphate receptor-mediated calcium release leads to decreased migration in different tumor cell lines. (University of Chile, Chile).

2013-2015 Undergraduate advisor: Sebastian Merino, “Role of MCU and MCUR1 in cancer bioenergetics” (University of Chile, Chile).

2013-2015 Undergraduate advisor: Carlos Valdes, “Modulation of cellular metabolism by InsP3R inhibition: role of sirtuin 1”. (Catholic University of Valparaiso, Chile).

2012-2013 Undergraduate advisor: Galdo Bustos “Determining the mechanism that drives cell death in the absence of InsP3R activity, by measuring apoptosis, autophagy and necrosis”. (University of Chile, Chile).

2012-2013 Undergraduate advisor: Camila Godoy “Melformin induces cell death specifically in breast tumor derived cell lines”. (University of Chile, Chile).