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Maria Rosa Bono Merino

Profesor titular

UNIVERSIDAD DE CHILE

Santiago, Chile

Inmunologia; Biologia de la celula dendritica; Polarizacion de la respuesta inmune; Homing linfocitario; Histocompatibilidad y trasplante; Lupus; Autoinmunidad

Physical Chemistry, Université Paris XI. Francia, 1977
Quimico, UNIVERSIDAD DE CHILE. Chile, 1974

Profesor titular Full Time

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

1991 - At present

CR1 Full Time

C.N.R.S.

Paris, Francia

1983 - 1991
Posdoc Full Time

D.G.R.S.T.

Paris, Francia

1978 - 1980
Research Associate Full Time

Harvard University

Boston, Estados Unidos

1981 - 1983

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Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group Acevedo, Monica L.; Portillo, Hugo; Bono, Maria Rosa; Vargas, Leonardo; Simon, Valeska; ; Vial, Cecilia; Cortes, Lina Jimena; Valdes, Daniel Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Phenotypic and functional alterations of peritoneal macrophages in lupus-prone mice Tejon, G, Valdivieso, N., Flores-Santibañez, F., Barra-Valdebenito, V., Martinez, V., Rosemblatt, M., Sauma, D., Bono, MR. Article MOLECULAR BIOLOGY REPORTS (2022)
Serological study of CoronaVac vaccine and booster doses in Chile: immunogenicity and persistence of anti-SARS-CoV-2 spike antibodies Article BMC MEDICINE (2022)
A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds Obaid, Miguel Luis; Camacho, Juan Pablo; Brenet, Marianne; Corrales-Orovio, Rocio; Carvajal, Felipe; Martorell, Ximena; Werner, Consuelo; Simon, Valeska; Varas, Juan; Calderon, Wilfredo; et al. Article ISI FRONTIERS IN MEDICINE (2021)
CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity Farias, Paula; Vargas, Leonardo; Simon, Valeska; Cardenas, Cesar; Rosemblatt, Mario; Bono, Maria Rosa; Sauma, Daniela Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Dysregulated Immune Responses in COVID-19 Patients Correlating With Disease Severity and Invasive Oxygen Requirements Vargas, Leonardo; Simon, Valeska; Tobar, Eduardo; Maturana, Pablo; Naves, Rodrigo; Lopez, Mercedes; Osorio, Fabiola Article ISI FRONTIERS IN IMMUNOLOGY (2021)
The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity Castaneda, Justine; Hidalgo, Yessia; Sauma, Daniela; Rosemblatt, Mario; Bono, Maria Rosa Article ISI FRONTIERS IN IMMUNOLOGY (2021)
Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages Guerrero, Julia Article ISI Marine Drugs (2020)
P2X7 Receptor at the Crossroads of T Cell Fate Rivas-Yanez, Elizabeth; Parra-Tello, Brian; Briceno, Pedro; Rosemblatt, Mario; Sauma, Daniela Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Pathogen-induced tissue-resident memory T(H)17 (T(RM)17) cells amplify autoimmune kidney disease Krebs, Christian F.; Reimers, Daniel; Zhao, Yu; Paust, Hans-Joachim; Bartsch, Patricia; Hellmig, Malte; Kilian, Christoph; Borchers, Alina; Enk, Leon U. B.; Zinke, Michael; et al. Article ISI SCIENCE IMMUNOLOGY (2020)
Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice Hidalgo, Yessia; Jose Fuenzalidal, Maria; Martinez, Victor; Rosemblatt, Mario; Sauma, Daniela Article ISI FRONTIERS IN IMMUNOLOGY (2020)
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation Chovar O.; FalcÃ³n P.; Bono M.R. Article ISI SCOPUS JOURNAL OF NEUROINFLAMMATION (2019)
The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells Jose Saez, Juan; Diaz, Jheimmy; Pablo Bozo, Juan; Rosa Bono, Maria Article ISI SCOPUS JOURNAL OF CELL BIOLOGY (2019)
In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo Cuadra, Bárbara; Rosemblatt, Mariana V.; Cruz, Pablo; Cárdenas, J. César; LLadser, Alvaro; Rosemblatt, Mario; Sauma, Daniela Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response Sauma, Daniela; Hidalgo, Yessia; Rosemblatt, Mario Article ISI SCOPUS IMMUNOLOGIC RESEARCH (2017)
Purinergic Signaling as a Regulator of Th17 Cell Plasticity Fernández, Dominique; Flores-Santibáñez, Felipe; Neira, Jocelyn; Osorio-Barrios, Francisco; Tejón, Gabriela; Nuñez, Sarah; Fuenzalida, Maria Jose; Quintana, Francisco J.; Chamaillard, Mathias Article ISI PLOS ONE (2016)
Retinoic Acid as a Modulator of T Cell Immunity Article ISI SCOPUS NUTRIENTS (2016)
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs Doñas, Cristian; Carrasco, Macarena; Tejón, Gabriela; Osorio-Barrios, Francisco; Manríquez, Valeria Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2016)
The human thymus perivascular space is a functional niche for viral-specific plasma cells Moore, Carolina; Hidalgo, Yessia Article ISI SCIENCE IMMUNOLOGY (2016)
Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration Chavez, MN; Schenck, TL; Hopfner, U; Centeno-Cerdas, C; Somlai-Schweiger, I; Schwarz, C.; Machens, HG; Heikenwalder, M; Nickelsen J.; Egana, JT Article ISI SCOPUS BIOMATERIALS (2016)
Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance Ruiz, Paulina; Maldonado, Paula; Hidalgo, Yessia; Sauma, Daniela; Rosemblatt, Mario; Bono, Maria Rosa Article ISI SCOPUS Frontiers in immunology (2015)
Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection Moore, C; Tejon, G.; Fuentes C.; Hidalgo, Y; Bono M.R.; Maldonado P.; Fernandez, R.; Wood K.J.; Fierro J.A.; Rosemblatt, M.; et al. Article ISI SCOPUS EUROPEAN JOURNAL OF IMMUNOLOGY (2015)
CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression Bono, Mara Rosa; Fernndez, Dominique; Flores-Santibez, Felipe; Rosemblatt, Mario; Sauma, Daniela Article ISI SCOPUS FEBS Letters (2015)
CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells Flores-Santibez, Felipe; Fernndez, Dominique; Meza, Daniel; Tejn, Gabriela; Vargas, Leonardo; Varela-Nallar, Lorena; Arredondo, Sebastin; Rosemblatt, Mario; Bono, Mara Rosa; Sauma, Daniela Article ISI SCOPUS Immunology (2015)
Pro-Inflammatory Cytokines in Nasopharyngeal Aspirate From Hospitalized Children With Respiratory Syncytial Virus Infection With or Without Rhinovirus Bronchiolitis, and Use of the Cytokines as Predictors of Illness Severity Diaz PV; Valdivia G.; Zepeda, G; Rivas, M; Uasapud, P; Pinto, RA; Guerrero, J Article ISI SCOPUS Medicine (United States) (2015)
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation Tejn, Gabriela; Manrquez, Valeria; De Calisto, Jaime; Flores-Santibez, Felipe; Hidalgo, Yessia; Crisstomo, Natalia; Fernndez, Dominique; Sauma, Daniela; Mora, J. Rodrigo; Bono, Mara R.; et al. Article ISI SCOPUS BioMed Research International (2015)
Functional analysis reveals angiogenic potential of human mesenchymal stem cells from Wharton's jelly in dermal regeneration Edwards, SS; Zavala, G; Prieto CP; Elliott M.; Martínez, S.; Egana, JT; Palma, V Article ISI SCOPUS ANGIOGENESIS (2014)
Ca2+-Activated Cl- Channels of the ClCa Family Express in the Cilia of a Subset of Rat Olfactory Sensory Neurons Gonzalez-Silva, C; Vera, J; Gonzalez-Billault, C; Baxter, B; Hansen A.; Lòpez, R; Gibson, EA; Restrepo, D.; Bacigalupo, J Article ISI SCOPUS PLOS ONE (2013)
Dendritic and stromal cells from the spleen of lupic mice present phenotypic and functional abnormalities GLEISNER, MA; Reyes, P; Alfaro, J; Solanes P; Simon, V; Crisostomo, N; Sauma D.; Rosemblatt, M. Article ISI SCOPUS Molecular Immunology (2013)
Epithelial control of the human pDC response to extracellular bacteria Michea, P; Vargas, P.; Donnadieu, MH; Rosemblatt, M.; Dumenil, G; Soumelis, V Article ISI SCOPUS European Journal of Immunology (2013)
Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis Diaz PV; Pinto, RA; Mamani, R Article ISI REVISTA MEDICA DE CHILE (2013)
T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour Nunez, S; Saez, JJ; Fernández, D.; Flores-Santibanez, F; Alvarez, K; Tejon, G.; Ruiz, P; Maldonado P.; Hidalgo, Y; Manriquez, V.; et al. Article ISI SCOPUS Immunology (2013)
Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells Donas, C; Fritz, M.; Manriquez, V.; Tejon, G.; Loyola, A.; Rosemblatt, M. Article ISI SCOPUS Clinical and Developmental Immunology (2013)
Increased Expression of the Glucocorticoid Receptor beta in Infants With RSV Bronchiolitis Mamani, R; Uasapud P.A.; Bono M.R.; Gaggero A.A.; Guerrero, J; Goecke, A Article ISI SCOPUS Pediatrics (2012)
Notch Signalling Regulates Cytokine Production by CD8+and CD4+T Cells Sauma D.; Ramirez A.; Alvarez, K; Rosemblatt, M.; Bono M.R. Article ISI SCOPUS Scandinavian Journal of Immunology (2012)
Delivery of Alloantigens via Apoptotic Cells Generates Dendritic Cells With an immature Tolerogenic Phenotype GLEISNER, MA; Rosemblatt, M. Article ISI SCOPUS Transplantation Proceedings (2011)
Differential Regulation of Notch Ligands in Dendritic Cells upon Interaction with T Helper Cells Sauma D.; Espejo P.; Ramirez A.; Fierro, A.; Rosemblatt, M. Article ISI SCOPUS Scandinavian Journal of Immunology (2011)
MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells Villablanca, EJ; Wang, S; De Calisto, J.; Gomes, DCO; Kane, MA; Napoli, JL; Blaner, WS; Kagechika H.; Blomhoff, R; Rosemblatt, M.; et al. Article ISI SCOPUS Gastroenterology (2011)
Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation Moore, C; Fuentes C.; Sauma D.; Morales J.; Rosemblatt, M. Article ISI SCOPUS Transplantation Proceedings (2011)
T-cell homing to the gut mucosa: General concepts and methodological considerations De Calisto, J.; Villablanca, E. J.; Wang, S; Bono M.R.; Rosemblatt, M.; Mora, J. R. Article SCOPUS Methods in Molecular Biology (2011)
Cyclosporin A-treated Dendritic Cells may affect the outcome of organ transplantation by decreasing CD4(+)CD25(+) regulatory T cell proliferation Pino-Lagos, K; Michea, P; Sauma D.; Alba, A; Morales J.; Fierro, A.; Rosemblatt, M. Article ISI SCIELO BIOLOGICAL RESEARCH (2010)
Dendritic Cells and B Cells Cooperate in the Generation of CD4(+)CD25(+)FOXP3(+) Allogeneic T Cells Moore, C; Sauma D.; Morales J.; Rosemblatt, M. Article ISI SCOPUS Transplantation Proceedings (2010)
Development of Murine Lupus Involves the Combined Genetic Contribution of the SLAM and Fc gamma R Intervals within the Nba2 Autoimmune Susceptibility Locus Jorgensen Tn; Alfaro, J; Enriquez HL; Jiang C.; Loo WM; Atencio S; Bupp, MRG; Mailloux CM; Metzger T; Flannery, S; et al. Article ISI SCOPUS Journal of Immunology (2010)
Gap Junctions at the Dendritic Cell-T Cell Interface Are Key Elements for Antigen-Dependent T Cell Activation Elgueta R.; Shoji, KF; De Calisto, J.; Rosemblatt, M. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2009)
Transforming Growth Factor-beta and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells With Intestinal Homing Receptors Moore, C; Sauma D.; Morales J.; Rosemblatt, M. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2009)
Alemtuzumab Induction in Kidney Transplantation: Clinical Results and Impact on T-Regulatory Cells Morales J.; Fierro, A.; Iniguez, R; Zehnder C.; Rosemblatt, M.; Calabran, L; Herzog C.; Benavente D.; Aguilo, J; Pefaur, J; et al. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2008)
Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells Elgueta R.; Sepulveda, FE; Vilches, F.; Vargas L.; Mora, JR; Rosemblatt, M. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2008)
Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain Faure-Andre, G; Vargas, P.; Yuseff, MI; Heuze, M; Díaz, J; Lankar D.; Steri, V; Manry, J; Hugues, S; Vascotto, F; et al. Article ISI SCOPUS SCIENCE (2008)
Generation of dendritic cells with regulatory properties Ureta G.; Osorio, F; Morales J.; Rosemblatt, M. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2007)
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione Montecinos, V.; Guzman P.; Barra V; Villagrán M.; Munoz-Montesino, C; Sotomayor, K; Escobar, E; Godoy A.; Mardones L.; Sotomayor P.; et al. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens Vargas, P.; Cortes C.; Vargas L.; Rosemblatt, M. Article ISI SCOPUS IMMUNOBIOLOGY (2006)
Lymphoid B cells induce NF-kappa B activation in high endothelial cells from human tonsils Naves R.; Reyes, LI; Rosemblatt, M.; Jacobelli, S.; González A Article ISI SCOPUS INTERNATIONAL IMMUNOLOGY (2006)
T helper 1/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol Pinto, RA; Arredondo, SM; Diaz PV Article ISI SCOPUS PEDIATRICS (2006)
Functional consequences of immune cell adhesión to endotelial cells M. Rosemblatt and M.R. Bono Article CURRENT PHARMACEUTICAL DESIGN (2004)
Interleukin-4 selectively inhibits interleukin-2 secretion by lipopolysaccharide-activated dendritic cells Sauma D.; Michea, P; Lennon-Dumenil, AM; Fierro, A.; Morales J.; Rosemblatt, M. Article ISI SCOPUS SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2004)
Cyclosporine preconditions dendritic cells during differentiation and reduces IL-2 and IL-12 production following activation: A potential tolerogenic effect Sauma D.; Fierro, A.; Mora, JR; Lennon-Dumenil, AM; Rosemblatt, M.; Morales J. Article ISI TRANSPLANTATION PROCEEDINGS (2003)
Dendritic cells and the mode of action of anticalcineurinic drugs: an integrating hypothesis Fierro, A.; Mora, JR; Morales J.; Buckel, E; Sauma D.; Rosemblatt, M. Article ISI SCOPUS NEPHROLOGY DIALYSIS TRANSPLANTATION (2003)
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells Mora, JR; Manjunath, N; Weninger W.; Cavanagh, LL; Rosemblatt, M.; von Andrian, UH Article ISI SCOPUS NATURE (2003)
Adhesion of B cell lines to endothelial cells from human lymphoid tissue modulates tyrosine phosphorylation and endothelial cell activation(1) Reyes, LI; Escobar P.; Rosemblatt, M. Article ISI JOURNAL OF IMMUNOLOGY (2002)
Isoforms of the class II transactivator protein Barbieri, G; Deffrennes, V; Prod'homme, T; Vedrenne, J; Baton, F; Cortes C.; Fischer A.; Lisowska-Grospierre, B; Charron, D; Alcaide-Loridan, C Article ISI SCOPUS INTERNATIONAL IMMUNOLOGY (2002)
Low-dose prednisone accounts for a transient reduction on CD4(+) and CD8(+) T cells in renal transplant patients under triple therapy Sauma D.; Mora, JR; Fierro, A.; Morales J.; Herzog C.; Buckel, E; Rosemblatt, M. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2002)
MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator Naves R.; Barbieri, G; Reyes L.; Puga, G; Salas, L; Deffrennes, V; Rosemblatt, M.; Fellous, M; Charron, D; Alcaide-Loridan, C Article ISI SCOPUS INTERNATIONAL IMMUNOLOGY (2002)
Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines Hetz C. ; Barros, LF; Lagos R. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
CD4 and CD8 cytokine-producing T cells are transiently reduced following cyclosporine intake: Maximal inhibition occurs at 2 hours coincidental with drug C-max Mora, JR; Rosemblatt, M.; Rodríguez, S.; Morales J.; Buckel, E; Fierro, A. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2001)
Expression of the human SRY protein during development in normal male gonadal and sex-reversed tissues Salas-Cortes, L; Jaubert, F; Fellous, M; Rosemblatt, M. Article ISI SCOPUS JOURNAL OF EXPERIMENTAL ZOOLOGY (2001)
Increased expression of c-rel, from the NF-kappa B/Rel family, in T cells from patients with systemic lupus erythematosus Burgos P.; Metz, C; Bull, P; Pincheira, R; Massardo, L; Errazuriz, C; Jacobelli, S.; González A Article ISI JOURNAL OF RHEUMATOLOGY (2000)
A flow cytometric procedure for the quantification of cell adhesion in complex mixtues of cells Bono, M.R., Reyes, L.I. and M. Rosemblatt Article ISI JOURNAL OF IMMUNOLOGICAL METHODS (1999)
Differential expression of the MHC class II isotype chains C. Alcaïde-Loridan, A.M. Lennon, M.R. Bono, R. Barbouche, K. Dellagi and M. Fellous Article ISI MICROBES AND INFECTION (1999)
The human SRY protein is present in embryonic and adult Sertoli cells and germ cells L. Salas Cortes, F. Jaubert, S. Barbaux, C. Nessmann, M.R. Bono, M. Fellous, K. McElreavey and M. Rosemblatt Article ISI INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (1999)
CIITA B-cell-specific promoter suppression in MHC class II-silenced cell hybrids Article ISI IMMUNOGENETICS (1998)
Outward currents in Drosophila larval neurons: dunce lacks a maintained outward current component down regulated by cyclic AMP R. Delgado. R. Davis, M.R. Bono, R. Latorre and P. Labarca Article ISI JOURNAL OF NEUROSCIENCE (1998)
Isolation of a B cell-specific promoter for the human class II trans-activator .- A. M. Lenon, C. Ottone, G. Rigaud, L.L. Deaven, J. Longmire, M. Fellous, R. Bono and C. Alcaide-Loridan. Article ISI IMMUNOGENETICS (1997)
Spleen-derived stromal cells. Adhesion molecules expression and lymphocyte adhesion to reticular cell A. Castro, M.R. Bono, V. Simon, L. Vargas and M. Rosemblatt Article ISI EUROPEAN JOURNAL OF CELL BIOLOGY (1997)
Lymphocyte adhesion to endothelium derived human lymphoid tissue .- A. Castro, M.R. Bono, V. Simon and M. Rosemblatt Article ISI EUROPEAN JOURNAL OF CELL BIOLOGY (1996)
The RAG cell line defines a new complementation group of MHC class II deficiency A. M. Lennon, C. Ottone, A. Peijninburg, Ch. Hamond-Benais, F. Colland,S. Gobin, M. P. van der Elsen, M. Fellous, R. Bono and C. Alcaide-Loridan Article ISI IMMUNOGENETICS (1996)
Yeast artificial chromosome transfer into mammalian cells and comparative study of their integrit S.J.P. Gobin, C. Alcaide-Loridan, M.R. Bono, C. Ottone, I. Chumakov, R. Rothstein and M. Fellous Article ISI GENES (1995)
Gene-dosage mapping of 30 DNA markers on chromosome 21 J.M. Delabar, Z. Chettouh, Z. Rahmani, D. Theophile, J.L. Blouin, R Bono, J. Kraus, J. Barton, D. Patterson and P.M. Sinet Article ISI GENOMICS (1992)
Human chromosome 16 encodes a factor involved in induction of class-II MHC antigens by interferon gamma M.R. Bono, C. Alcaide-Loridan, P. Couillin, B. Letouzé, M.C. Grisard, H. Jouin and M. Fellous Article ISI Proc. Natl. Acad. Sci. (USA) (1991)
The recombinant human interferon-g receptor is fully functional in a human x murine hybrid containing human chromosome 21 M.R. Bono, C. Alcaide-Loridan, B. Letouzé, H. Jouin, S. J. P. Gobin and M. Fellous Article ISI RESEARCH IN IMMUNOLOGY (1991)
Selection of mouse cells expressing an interferon-inducible hygromycin resistance : An approach for the cloning of the interferon-b receptor gene C. Alcaide-Loridan, M.R. Bono, P. Benech, B. Letouzé, J. Chebath and M. Fellous Article ISI METHODS IN MOLECULAR AND CELLULAR BIOLOGY (1990)
Blocking of human T lymphocyte activation by channel antagonists M.R. Bono., V. Simons and M. Rosemblatt Article ISI CELL BIOCHEMISTRY AND FUNCTION (1989)
Characterisation of the human IFN-g response using somatic cell hybrids of hematopoietic and non-hematopoietic origin M. R. Bono, P. Benech, C. Alcaide, P. Couillin, M.C. Grisard, H. Jouin, D. Fisher and M. Fellous. Article ISI SOMATIC CELL AND MOLECULAR GENETICS (1989)
Use of monoclonal antibody immunoaffinity columns to purify subsets of human HLA-DR antigens D.W. Andrews, M.R. Bono, J.F. Kaufman, P. Knudsen and J.L. Strominger Article ISI METHODS IN ENZYMOLOGY (1984)
NH2-terminal sequence of the a and b chains of human DC-1 antigen isolated from the JY cell line. Homology with murine I-A molecules M.R. Bono and J.L. Strominger Article ISI IMMUNOGENETICS (1983)
A homozygous human cell line contains three subsets of HLA-DR-Like antigens distinguishable by aminoacid sequencing D.W. Andrews, M.R. Bono and J.L. Strominger Article ISI BIOCHEMISTRY (1982)
cDNA clone for the heavy chain of the human B cell alloantigen DC-1: Strong sequence homology to the HLA-DR heavy chain C. Auffray, A.J. Korman, M. Roux-Dosseto, R. Bono and J.L. Strominger Article ISI Proc Natl Acad Sci USA (1982)
Direct evidence of homology between human DC-1 antigen and murine I-A molecules Article ISI NATURE (1982)
Characterisation of five human teratoma cell lines for their developmental properties and expression of embryonic and major histocompatibility locus associated antigens P. Avner, R. Bono, M. Fellous and R. Berger Article ISI JOURNAL OF IMMUNOGENETICS (1981)
Interferon enhances the amount of membrane bound b2-microglobulin and its release from human Burkitt cells M. Fellous, R. Bono, F. Hyafil and I. Gresser Article ISI EUROPEAN JOURNAL OF IMMUNOLOGY (1981)
Selective expression of blood group antigens on human teratocarcinoma cell lines R. Bono, J.P. Cartron, c; Mulet, P. Avner and M. Fellous Article ISI Blood Transf. and Immunohematol. (1981)
Clinical, cytological, histological, immunological and hormonal studies in a case of true hermaphroditism C. Roy, M. Roger, L. Boccon-Gibod, M. Fellous, R. Bono, J. Pasqualini and J.P. Harpey. Article ISI CLINICAL ENDOCRINOLOGY (1980)
Methods of detection of H-Y antigen R. Bono and M. Fellous Article ISI Pediat. Adolesc. Endocr (1980)
"Monoclonal antibodies against HLA-D, DRw antigens R. Bono, F. Hyafil, J. Kalil, V. Koblar, J. Wiels, E. Wolman, C.Mawas and M. Fellous Article ISI Transpl. Clin. Immunol. (1979)
Enhanced expression of HLA antigens and b2-microglobulin on interferon treated cells M. Fellous, M. Kamoun, I. Gresser and R. Bono Article ISI EUROPEAN JOURNAL OF IMMUNOLOGY (1979)
Electron in cold alcohols: a pulse radiolysis study in ethanol L. Gilles, M.R. Bono and M. Schmidt Article ISI CANADIAN JOURNAL OF CHEMISTRY (1977)
Transplant tolerance: New insights and strategies for long-term allograft acceptance. Ruiz, P; Maldonado, P; Hidalgo, Y; Gleisner, A; Sauma, D; Silva, C; Saez, JJ; Nuñez, S; Rosemblatt, M; Bono, MR. Article CLINICAL AND DEVELOPMENTAL IMMUNOLOGY

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Towards Autotrophic Tissue Engineering: Photosynthetic Biomaterials for Tissue Regeneration Rosas, MNC; Schenck, TL; Hopfner, U; Centeno, C; Machens, HG; Somlai-Schweiger, I; Heikenwalder, M; Schwarz, C.; Nickelsen J.; Egana, JT Abstract ISI TISSUE ENGINEERING PART A (2015)

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T cell homing to the gut mucosa: General concepts and methodological considerations .- J. De Calisto, E.J. Villablanca, S. Wang, M.R. Bono, M. Rosemblatt and J.R. Mora. BookReview (2012)

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Citoquinas R. Naves y M. R. Bono; I. Palomo, A. Ferreira, C. Sepúlveda, M. Rosemblatt y U. Vergara BookSection (2002)
La citometría de flujo: principios básicos y sus aplicaciones M.R. Bono y V. Simon; I. Palomo, A. Ferreira, C. Sepúlveda, M. Rosemblatt y U. Vergara BookSection (2002)

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Etude par radiolyse pulsée de la formation et de la réactivité de l'électron solvaté dans l'éthanol et le n-propanol à basses températures M.R. Bono Monograph (1977)


Not too much, not too little, just right: the unexpected role of adenosine in the antitumor immune response Sauma, Daniela; Bono, Maria Rosa Proyecto (2022)
Thymic involution in autoimmune diseases Bono, Maria Rosa; Sauma, Daniela Proyecto (2019)
CD73-mediated adenosine production in the control of CD8+ T cell differentiation. FONDECYT (1180385) Proyecto 2018-2021 Coinvestigador(a)
Papel de los macrófagos en el lupus eritematoso sistémico PFCHA (3160224) Proyecto 2016-2019 Inv. Patrocinante
B cell synapse in autoimmune diseases. PCI (C14S02) Proyecto 2015-2017 Inv. Responsable
Cell sorter BD FACSAria III FONDEQUIP (EQM140016) Proyecto 2014-2016 Inv. Responsable
Leukocyte trafficking as a determinant of autoimmunity FONDECYT (1140431) Proyecto 2014-2017 Inv. Responsable
Fortalecimiento de la docencia y la investigación en las áreas de Inmunología y Biotecnología=> Inmunología del cáncer PAI (791100009) Proyecto 2012-2014 Inv. Patrocinante
The tumor microenvironment favors the generation of immunosuppressive Th17 cells FONDECYT (11121478) Proyecto 2012-2015 Coinvestigador(a)
Utilización de células mesenquimáticas de cordón umbilical para activar la vascularización FONDEF (D09/147) Proyecto 2011-2014 Coinvestigador(a)
Desarrollo de un método inmunológico mejorado para el sexaje de semen de ganado vacuno FONDEF (D08/1162) Proyecto 2010-2012 Coinvestigador(a)
Reprograming of regulatory T cells in gut immunity FONDECYT (1100448) Proyecto 2010-2014 Coinvestigador(a)
Rol of dendritic cells in the development of lupus FONDECYT (1100557) Proyecto 2010-2014 Inv. Responsable
Modulación de la respuesta inmune contra Neisseria Meningitidis por células epiteliales humanas de la orofaringe PCI (2009-12) Proyecto 2009-2012 Inv. Responsable
Microambiente linfoide y polarización de la respuesta inmune FONDECYT (1060834) Proyecto 2006-2009 Inv. Responsable
Modulación del homing en el sistema inmune FONDECYT (4060253) Proyecto 2006-2009 Coinvestigador(a)
Las proteasas endosomales y la biología de las células dendríticas PCI (C03S01) Proyecto 2005-2007 Coinvestigador(a)
Mecanismos que regulan la expresión de receptores de homing en linfocitos T FONDECYT (1030074) Proyecto 2003-2005 Coinvestigador(a)
Papel funcional de las moléculas de histocompatibilidad de clase II inducidas por adhesión de los linfocitos B a células endoteliales FONDECYT (1030875) Proyecto 2003-2005 Inv. Responsable
Inducción de las moléculas de histocompatibilidad de clase II por la adhesión linfocitaria FONDECYT (8000011) Proyecto 2000-2002 Inv. Responsable
Regulación de la expresión de las moléculas de histocompatibilidad de clase- II. Alteraciones tumorales PCI (C99S02) Proyecto 2000-2002 Inv. Responsable
Regulación de los genes de clase II del complejo mayor de histocompatibilidad FONDECYT (1990569) Proyecto 1999-2001 Inv. Responsable
Microambiente linfoide y diferenciación linfocitaria FONDECYT (1980208) Proyecto 1998-2000 Coinvestigador(a)
Vías de inducción de moléculas implicadas en la respuesta inmune por citoquinas FONDECYT (1960876) Proyecto 1996-1998 Inv. Responsable
Interacciones que regulan el desarrollo linfocitario en órganos linfoides secundarios FONDECYT (1950686) Proyecto 1995-1997 Coinvestigador(a)

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Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance Ruiz, P; Maldonado P.; Hidalgo, Y; gleisner a; Sauma D.; Silva C.; Saez, JJ; Nunez, S; Rosemblatt, M.; Bono, AR Review ISI SCOPUS Clinical and Developmental Immunology (2013)
The essential role of chemokines in the selective regulation of lymphocyte homing Elgueta R.; Sauma D.; Pino, K; Osorio, F; Michea, P; Fierro, A.; Rosemblatt, M. Review ISI SCOPUS CYTOKINE & GROWTH FACTOR REVIEWS (2007)
Functional consequences of immune cell adhesion to endothelial cells Rosemblatt, M. Review ISI CURRENT PHARMACEUTICAL DESIGN (2004)

Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

107

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Rosalba Lagos

Professor

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

PATRICIO VARGAS

Profesor Titular

FISICA

USM

Valparaiso, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Monica Acevedo

Profesor Asistente

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE

Santiago, Chile

Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Roxana Pincheira

Full Professor

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

Christian Guzmán

Chief Engineer

Ingenieria Electrica

Sky-Walkers SpA

Litueche, Chile

Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

Gonzalo Valdivia

Division Head, Full Professor

Medical School

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Andrés Marcoleta

Profesor Asistente

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

Felipe Reyes

Assistant professor

Universidad de S

Santiago de Chile, Chile

Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

Flavio Salazar

Profesor Titular

Oncología Básico Clínica

Universidad de Chile

SANTIAGO, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

LINA CORTES

Investigadora Postdoctoral

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

Mario Rosemblatt

Executive Director

Fundacion Ciencia & Vida

Santiago, Chile

LILIAN REYES

Director de Escuela de Bioquímica

Universidad San Sebastián

Santiago, Chile

Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

Gabriela Tejon

Investigador Postdoctoral

Biología

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Jheimmy Diaz

Investigador Adjunto

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Miguel del Campo

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

Jose Egana

Profesor asociado

Instituto de Ingeniería Biológica y Médica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Paulina Ruiz

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

Sarah Nuñez

Académico Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

Felipe Carvajal

Investigador Postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Iván Flores

Post Doc

Progama de Inmunología

Universidad de Chile

Santiago, Chile

Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

Gonzalo Ureta

Investigador post doctoral

Fundación Ciencia y Vida

Santiago, Chile

Estefania Nova

Associate Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

Guillermo Zepeda

Profesor Asistente

Pediatría y Cirugía Infantil, Campus Norte

Universidad de Chile

Santiago, Chile

Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Andrés Ramirez

Flow Cytometry Facility Manager

Consorcio Regenero

Santiago, Chile

PAOLA UASAPUD

Jacqueline Péfaur

Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

Patricia Diaz

Mabel Rivas

Titular

Pediatria

Hospital

Santiago, Chile

Jocelyn Neira

Especialista Profesional

Universidad Andrés Bello

Santiago, Chile

Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

CATALINA PRIETO

Investigadora senior

Biología

Universidad de Chile

Santiago, Chile

Jaime De Calisto

Director Docente

Escuela de Biotecnología

Universidad Mayor

Santiago, Chile

Glauben Landskron

Academic Researcher

Escuela de Medicina

Universidad Finis Terrae

Santiago, Chile

veronica rojas

Enfermera de Investigación

Medicina Interna

Universidad de Chile

Santiago, Chile

Yessia Hidalgo

Researcher

Centro de Investigación e Innovación Biomédica

Corporación IMPACT

Santiago, Chile

Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

Juan Hormazabal

Investigador Postdoctoral

Facultad De Medicina

Universidad del Desarrollo

Santiago, Chile

Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

Rocío Corrales

Investigadora responsable

Symbiox

Santiago, Chile

Elizabeth Rivas

Academico

Medicina

Universidad de Atacama

Copiapo, Chile

Camila Fuentes

Investigador Postdoctoral

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Javier Campos

Gestor de Propiedad Intelectual

Universidad Tecnológica Metropolitana

Santiago, Chile

Maria Rosa Bono Merino

Líneas de Investigación

Educación

Physical Chemistry, Université Paris XI. Francia, 1977

Quimico, UNIVERSIDAD DE CHILE. Chile, 1974

Experiencia Académica

Profesor titular Full Time

Experiencia Profesional

CR1 Full Time

Posdoc Full Time

Research Associate Full Time

Article (96)

Abstract (1)

BookReview (1)

BookSection (2)

Monograph (1)

Proyecto (25)

CD73-mediated adenosine production in the control of CD8+ T cell differentiation.

Papel de los macrófagos en el lupus eritematoso sistémico

B cell synapse in autoimmune diseases.

Cell sorter BD FACSAria III

Leukocyte trafficking as a determinant of autoimmunity

Fortalecimiento de la docencia y la investigación en las áreas de Inmunología y Biotecnología=> Inmunología del cáncer

The tumor microenvironment favors the generation of immunosuppressive Th17 cells

Utilización de células mesenquimáticas de cordón umbilical para activar la vascularización

Desarrollo de un método inmunológico mejorado para el sexaje de semen de ganado vacuno

Reprograming of regulatory T cells in gut immunity

Rol of dendritic cells in the development of lupus

Modulación de la respuesta inmune contra Neisseria Meningitidis por células epiteliales humanas de la orofaringe

Microambiente linfoide y polarización de la respuesta inmune

Modulación del homing en el sistema inmune

Las proteasas endosomales y la biología de las células dendríticas

Mecanismos que regulan la expresión de receptores de homing en linfocitos T

Papel funcional de las moléculas de histocompatibilidad de clase II inducidas por adhesión de los linfocitos B a células endoteliales

Inducción de las moléculas de histocompatibilidad de clase II por la adhesión linfocitaria

Regulación de la expresión de las moléculas de histocompatibilidad de clase- II. Alteraciones tumorales

Regulación de los genes de clase II del complejo mayor de histocompatibilidad

Microambiente linfoide y diferenciación linfocitaria

Vías de inducción de moléculas implicadas en la respuesta inmune por citoquinas

Interacciones que regulan el desarrollo linfocitario en órganos linfoides secundarios

Review (3)