Man

Miguel Ignacio del Campo Zaldívar

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

Líneas de Investigación


Bioquímica; Compuestos naturales; Toxicología

Educación

  •  Doctorado en Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2014
  •  Bioquímico , UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

  •   Alumno doctoral Full Time

    UNIVERSIDAD DE CHILE

    2011 - 2014

Experiencia Profesional

  •   Investigador Adjunto Proyecto Fondecyt 105-0150

    Biosonda S.A

    Chile

    2006 - 2009

  •   Investigador Adjunto Proyecto COPEC-PUCSC0014

    Fundación Ciencia y Tecnología para el Desarrollo

    Chile

    2008 - 2010

  •   Investigador Adjunto Proyecto Fondecyt 1110651

    Fundación Ciencia y Tecnología para el Desarrollo

    Chile

    2014 - 2014

  •   Investigador Adjunto Proyecto FONDECYT 151337

    Fundación Ciencia y Tecnología para el Desarrollo

    Chile

    2015 - At present

  •   Investigador Adjunto Proyecto INNOVA 13IDL2-18697

    Fundación Ciencia y Tecnología para el Desarrollo

    Chile

    2014 - At present


 

Article (24)

C-type lectin receptors MR and DC-SIGN are involved in recognition of hemocyanins, shaping their immunostimulatory effects on human dendritic cells

Villar, Javiera; Salazar, Michelle L.; Jimenez, Jose M.; Del Campo, Miguel; Manubens, Augusto; Gleisner, Maria Alejandra; Avalos, Ignacio; Salazar-Onfray, Flavio; Salazar, Fabian; Mitchell, Daniel A.; Alshahrani, Mohammad Y.; Martinez-Pomares, Luisa; Becker, Maria Ines

Article ISI
EUROPEAN JOURNAL OF IMMUNOLOGY  (2021)

Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary

Benitez, Agustin; Riquelme, Raul; del Campo, Miguel; Araya, Camila; Lara, Hernan E.

Article ISI
FRONTIERS IN ENDOCRINOLOGY  (2021)

In vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats

del Campo, Miguel; Lagos, Néstor; Lara, Hernán

Article SCOPUS
Journal of Endocrinology  (2020)

Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages

Montero, M. Cecilia; del Campo, Miguel; Bono, M.; Simon, M. Valeska; Guerrero, Julia; Lagos, Nestor

Article ISI
Marine Drugs  (2020)

Effect of Superior Ovarian Nerve and Plexus Nerve Sympathetic Denervation on Ovarian-Derived Infertility Provoked by Estradiol Exposure to Rats

del Campo, Miguel; Piquer, Beatriz; Witherington, Jason; Sridhar, Arun; Lara, Hernan E.

Article ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2019)

Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer.

Mora Román, Juan José; Del Campo, Miguel; Villar, Javiera; Paolini, Francesca; Curzio, Gianfranca; Venuti, Aldo; Jara, Lilian; Ferreira, Jorge; Murgas, Paola; Lladser, Alvaro; Manubens, Augusto; Becker, María Inés

Article
Journal of immunology research  (2019)

Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside

Palacios, M; Tampe, R; del Campo, M; Zhong, TY; Lopez, MN; Salazar-Onfray, F; Becker, MI

Article ISI SCOPUS
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY  (2018)

Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model

Riquelme, G; Sepulveda, JM; Al Ghumgham, Z; del Campo, M; Montero, C; Lagos, N

Article ISI SCOPUS
TOXICON  (2018)

Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model.

Riquelme, Gricel; Sepúlveda, Joaquín M; Al Ghumgham, Zaki; Del Campo, Miguel; Montero, Cecilia; Lagos, Nestor

Article
Toxicon => official journal of the International Society on Toxinology  (2018)

Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells=> Negative health consequences.

Del Campo, Miguel; Zhong, Ta-Ying; Tampe, Ricardo; García, Lorena; Lagos, Néstor

Article
Toxicon => official journal of the International Society on Toxinology  (2017)

Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells=> Negative health consequences.

Del Campo, Miguel; Zhong, Ta-Ying; Tampe, Ricardo; García, Lorena; Lagos, Néstor

Article
Toxicon => official journal of the International Society on Toxinology  (2017)

The oxygen-binding properties of hemocyanin from the mollusk Concholepas concholepas.

González, Andrea; Nova, Esteban; Del Campo, Miguel; Manubens, Augusto; De Ioannes, Alfredo; Ferreira, Jorge; Becker, María Inés

Article
Biochimica et biophysica acta. Proteins and proteomics  (2017)

Antibacterial effect of kaempferol and (-)-epicatechin on Helicobacter pylori

Escandón R.A.; del Campo, M; López-Solís R.; Obreque-Slier, E; Toledo, H

Article ISI SCOPUS
EUROPEAN FOOD RESEARCH AND TECHNOLOGY  (2016)

Determination of the toxic variability of lipophilic biotoxins in marine bivalve and gastropod tissues treated with an industrial canning process.

García, C; Oyaneder-Terrazas, J; Contreras, C=> Del Campo; M, Torres; R, Contreras

Article
Food Addit Contam Part A Chem Anal Control Expo Risk Assess.  (2016)

Determination of the toxic variability of lipophilic biotoxins in marine bivalve and gastropod tissues treated with an industrial canning process.

García, Carlos; Oyaneder-Terrazas, Javiera; Contreras, Cristóbal; Del Campo, Miguel; Torres, Rafael; Contreras, Héctor R

Article
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment  (2016)

Gonyautoxins: First evidence in pain management in total knee arthroplasty

Hinzpeter J.; Barrientos, C.; Zamorano Á.; Martínez A; Palet M.; Wulf R.; Barahona, M; Sepúlveda J.M.; Guerra, M; Bustamante, T.; del Campo, M; Tapia, E; Lagos, N.

Article ISI SCOPUS
TOXICON  (2016)

Hemocyanins Stimulate Innate Immunity by Inducing Different Temporal Patterns of Proinflammatory Cytokine Expression in Macrophages

Zhong T.-Y.; Arancibia S.; Born R.; Tampe, R; Villar, J; del Campo, M; Manubens, A; Becker, M.I

Article ISI SCOPUS
JOURNAL OF IMMUNOLOGY  (2016)

A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma

Arancibia S.; Espinoza, C.; Salazar F.; del Campo, M; Tampe, R; Zhong, TY; De Ioannes, P; Moltedo, B; Ferreira J.; Lavelle EC; Manubens, A; De Ioannes, AE; Becker, MI

Article ISI SCOPUS
PLOS ONE  (2014)

Okadaic Acid Toxin at Sublethal Dose Produced Cell Proliferation in Gastric and Colon Epithelial Cell Lines

del Campo, M; Toledo, H; Lagos, N.

Article ISI SCOPUS
MARINE DRUGS  (2013)

Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects

Arancibia S.; Del Campo M.; Nova E.; Salazar F.; Becker MI.

Article
European Journal of Immunology  (2012)

Hemocyanins as immunostimulants

del Campo, M; Arancibia S.; NOVA, E; Salazar F.; González A; Moltedo, B; De Ioannes, P; Ferreira J.; Manubens, A; Becker, MI

Article ISI
REVISTA MEDICA DE CHILE  (2011)

Hemocyanins as immunostimulants Hemocianinas, una herramienta inmunológica de la biomedicina actual

del Campo, M; Arancibia S.; NOVA, E; Salazar F.; González A; Moltedo, B; De Ioannes, P; Becker, M.I; Ferreira J.; Manubens, A

Article SCOPUS
Revista Medica de Chile  (2011)

Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism

Manubens, A; Salazar F.; Haussmann, D.; Figueroa J.; del Campo, M; Pinto, JM; Huaquin, L; Venegas A.; Becker, MI

Article ISI SCOPUS
Cell and Tissue Research  (2010)

Immunodominant role of CCHA subunit of Concholepas hemocyanin is associated with unique biochemical properties

Becker, MI; Fuentes, A.; del Campo, M; Manubens, A; NOVA, E; Oliva, H; Faunes F.; Valenzuela, MA.; Campos-Vallette, M; Aliaga A.; Ferreira J.; De Ioannes, AE; De Ioannes, P; Moltedo, B

Article ISI SCOPUS
INTERNATIONAL IMMUNOPHARMACOLOGY  (2009)

Abstract (4)

Novel hemocyanin from the Fissurella latimarginata exhibits an outstanding immunogenicity and non-specific immunomodulatory effects in a melanoma model

Becker, M; Arancibia S.; Cecilia, E; Salazar F.; del Campo, M; Born R.; Ferreira J.; Manubens, A; De Ioannes, A.

Abstract ISI
JOURNAL OF IMMUNOLOGY  (2012)

Exceptional Immunological and Anticancer Properties of a New Hemocyanin from Fissurella Latimarginata (FLH)

Arancibia S.; Espinoza, C.; del Campo, M; Salazar F.; Becker, MI

Abstract ISI
JOURNAL OF IMMUNOTHERAPY  (2010)

Antitumor Effect of Concholepas Concholepas Hemocyanin (CCH) Using B16-F10 Mouse Melanoma Cells as a Model

Atancibia, S; del Campo, M; De Ioannes, A.; Becker, MI

Abstract ISI
JOURNAL OF IMMUNOTHERAPY  (2009)

Biochemical and Immunomodulatory Properties From Concholepas Hemocyanin (CCH) and Their Isolated Subunits

Becker, MI; del Campo, M; Manubens, A; NOVA, E; Campos-Vallete, M; Ferreira J.; De Ioannes, P; Moltedo, B; De Joannes, AE

Abstract ISI
JOURNAL OF IMMUNOTHERAPY  (2008)

Proyecto (9)

AUTONOMIC NEURAL CONTROL OF OVARY FUNCTION. PARTICIPATION IN THE POLYCYSTIC OVARY DEVELOPMENT AND FERTILITY.

FONDECYT (1170291)

Proyecto
2017-2020
Coinvestigador(a)

Prototype development of an enzymatic inhibition assay of Protein Phosphatase 2A for detection and quantification of diarrhetic toxins in fresh and canned extracts shellfish

FONDEF (ID16I10145)

Proyecto
2017-2018
Coinvestigador(a)

Mollusk hemocyanins as immunomodulatory proteins with beneficial clinical outcomes=> Elucidating the role of C-type lectin receptors in these effects.

FONDECYT (151337)

Proyecto
2015-2019
Investigador(a)

Diarrheic shellfish toxins=> biochemical and toxicological mechanism as tumor promoters

FONDECYT (1130037)

Proyecto
2013-2014
Tesista

Identificación de péptidos antimicrobianos desde moluscos litorales chilenos y potencial uso biotecnológico

Proyecto Innova (13IDL2-18697)

Proyecto
2013-2016
Investigador(a)

DOCTORADO EN BIOQUIMICA

PFCHA (21100413)

Proyecto
2010-2014
Inv. Responsable

Immunological basis involved in the immunomodulatory effects of mollusk hemocyanins in the immune system of mammals

FONDECYT (1110651)

Proyecto
2010-2014
Personal técnico y/o de apoyo

ESTUDIO DE LA ESTRUCTURA DE LA HEMOCIANINA DE MOLUSCOS EN RELACION A SUS MECANISMOS DE INMUNOESTIMULACION EN MAMIFEROS.

FONDECYT (105-0150)

Proyecto
2006-2009
Investigador(a)

Desarrollo de productos inmunoestimulantes en base a hemocianinas de C. concholepas.

Proyecto COPEC-PUC (COPEC-PUCSC0014)

Proyecto
2006-2010
Investigador(a)

Review (1)

Hemocianinas, una herramienta inmunológica de la biomedicina actual

Del Campo, Miguel; Arancibia, Sergio; Nova, Esteban; Salazar, Fabián.; Gonzalez, Andrea; Moltedo, Bruno; De Ioannes, Pablo; Ferreira, Jorge; Manubens, Augusto; Becker, María Inés

Review SCIELO
REVISTA MEDICA DE CHILE  (2011)

21
Miguel del Campo

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

11
Augusto Manubens

Director

Tecnical Support

BIOSONDA S.A.

Santiago, Chile

11
María Becker

Scientific Director, President

Research and Development

FUNDACIÓN CIENCIA Y TECNOLOGÍA PARA EL DESARROLLLO

Santiago, Chile

7
Sergio Arancibia

Medical Science Liaison

Medical Affairs

Johnson & Johnson (Janssen Pharmaceutical)

Santiago, Chile

7
Fabian Salazar

Postdoctoral Research Fellow

Biosciences

MRC Centre for Medical Mycology, University of Exeter

Exeter, Reino Unido

6
Pablo De Ioannes

Associate research scientist

Structural Biology

NYU Medical Center

NEW YORK, Estados Unidos

3
Nestor Lagos

Full Professor

Fisiología y Biofísica

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

SANTIAGO, Chile

2
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Andrea González

Investigadora Asociada

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

Santiago, Chile

1
Hernan Lara

Profesor Titular

Bioquimica y Biologia Molecular

U DE CHILE, FAC CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Jaime Hinzpeter

Staff Departamento

Ortopedia y Traumatología

Hospital Clínico U. de Chile

Santiago, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Denise Haussmann

Profesora Titular

Departamento de Ciencias Básicas

Universidad Santo Tomás

Valdivia, Chile

1
Tamara Bustamante

Asistente de Investigación

Fisiología y Biofísica

Facultad de Medicina Universidad de Chile

Santiago, Chile

1
Matias Guerra

Investigador

Banco de recursos Genéticos Microbianos

INIA Quilamapu

Chillan, Chile

1
Eric Tapia

Académico

Tecnología Médica

Universidad de Chile

Santaigo, Chile

1
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

1
Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Fernando Faunes

Profesor Asistente

Universidad Andrés Bello

Viña del Mar, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Héctor Venegas

Profesor Titular asociado al Centro

Universidad Diego Portales

Santiago, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Michelle Salazar

Asistente de Investigación

Fundación Ciencia y Tecnología para el Desarrollo (FUCITED)

Santiago, Chile