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Nestor Antonio Lagos Wilson

Full Professor

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

SANTIAGO, Chile

Biochemistry; Physiology; Toxicology; BIOLOGY MARINE; BIOTECHNOLOGY;

Bioquímica, UNIVERSIDAD DE CHILE. Chile, 1987

Profesor Titular Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1976 - At present

Full Professor Full Time

Universidad de Chile

Santiago, Chile

1976 - At present

Son Muchas, No las anoto. ¡¡¡¡Disculpas!!!!


In vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats del Campo, Miguel; Lagos, Néstor; Lara, Hernán Article SCOPUS Journal of Endocrinology (2020)
Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages Montero, M. Cecilia; del Campo, Miguel; Bono, M.; Simon, M. Valeska; Guerrero, Julia; Lagos, Néstor Article Marine Drugs (2020)
Evaluation of Neosaxitoxin as a local anesthetic during piglet castration: A potential alternative for Lidocaine Valenzuela, Carolina; Torres, Cristian; Munoz, Vanina; Carlos Simbaina, Juan; Sanchez, Andrella; Bustamante, Tamara; Sepulveda, Joaquin M.; Piron, Robin; Del Campo, Miguel; Lagos, Nestor Article ISI SCOPUS TOXICON (2019)
Evaluation of Neosaxitoxin as a local anesthetic during piglet castration=> A potential alternative for Lidocaine. Valenzuela, Carolina; Torres, Cristian; Muñoz, Vanina; Simbaina, Juan Carlos; Sánchez, Andrella; Bustamante, Tamara; Sepúlveda, Joaquín M; Piron, Robin; Del Campo, Miguel; Lagos, Néstor Article Toxicon => official journal of the International Society on Toxinology (2019)
Phycobilisome isolation and C-phycocyanin purification from the cyanobacterium Aphanizomenon gracile Piron, R.; Bustamante, T.; Barriga, A.; Lagos, N. Article ISI SCOPUS PHOTOSYNTHETICA (2019)
Long-lasting, reversible and non-neurotoxic inactivation of hippocampus activity induced by neosaxitoxin Galindo, J.; Contreras, M.; Maldonado, P.; Torrealba, F.; Lagos, N.; Valdes, J. L. Article JOURNAL OF NEUROSCIENCE METHODS (2018)
Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model Riquelme, G; Sepulveda, JM; Al Ghumgham, Z; del Campo, M; Montero, C; Lagos, N Article TOXICON (2018)
Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells=> Negative health consequences. Del Campo, Miguel; Zhong, Ta-Ying; Tampe, Ricardo; García, Lorena; Lagos, Néstor Article Toxicon => official journal of the International Society on Toxinology (2017)
Gonyautoxins: First evidence in pain management in total knee arthroplasty Hinzpeter J.; Barrientos, C.; Zamorano Á.; Martínez A; Palet M.; Wulf R.; Barahona, M; Sepúlveda J.M.; Guerra, M; Bustamante, T.; del Campo, M; Tapia, E; Lagos, N. Article ISI SCOPUS TOXICON (2016)
First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome Manriquez, V.; Caperan, DC; Guzman, R; Naser M.; Iglesia, V; Lagos, N. Article ISI SCOPUS International Urogynecology Journal (2015)
Seasonal variability of Dinophysis spp. and Protoceratium reticulatum associated to lipophilic shellfish toxins in a strongly stratified Chilean fjord Alves-de-Souza, C; Varela D.; Contreras C.; de La Iglesia, P; Fernández P.; Hipp, B; Hernandez C.; Riobó P; Reguera, B; Franco JM; Diogene, J; Garcia C.; Lagos, N. Article ISI DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY (2014)
Determination of the variability of both hydrophilic and lipophilic toxins in endemic wild bivalves and carnivorous gastropods from the Southern part of Chile Zamorano, R; Marin M, Cabrera; F, Figueroa D; Contreras C, Barriga A.; Lagos N., Garcia C Article FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2013)
Okadaic Acid Toxin at Sublethal Dose Produced Cell Proliferation in Gastric and Colon Epithelial Cell Lines del Campo, M; Toledo, H; Lagos, N. Article ISI SCOPUS MARINE DRUGS (2013)
Exhaled Breath Condensate Analysis after Long Distance Races Araneda, O. F.; Guevara A.J.; Contreras C.; Lagos, N.; Berral F.J. Article ISI SCOPUS International Journal of Sports Medicine (2012)
FIRST REPORT OF DIARRHEIC SHELLFISH TOXINS IN MOLLUSKS FROM BUENOS AIRES PROVINCE (ARGENTINA) ASSOCIATED WITH DINOPHYSIS SPP.: EVIDENCE OF OKADAIC ACID, DINOPHYSISTOXIN-1 AND THEIR ACYL-DERIVATIVES Sar, EA; Sunesen, I; Goya, AB; Lavigne, AS; Tapia, E; Garcia C.; Lagos, N. Article ISI BOLETIN DE LA SOCIEDAD ARGENTINA DE BOTANICA (2012)
First report of diarrheic shellfish toxins in mollusks from buenos aires province (argentina) associated with dinophysis spp.: Evidence of okadaic acid, dinophysistoxin-1 and their acylderivatives Sar E.A.; Sunesen, I; Goya A.B.; Lavigne A.S.; Tapia, E; Garcia C.; Lagos, N. Article SCOPUS Boletin de la Sociedad Argentina de Botanica (2012)
Lipophilic toxin profiles detected in farmed and benthic mussels populations from the most relevant production zones in Southern Chile Garcia C.; Rodriguez-Unda, N; Contreras C.; Barriga, A.; Lagos, N. Article ISI SCOPUS Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment (2012)
Highly Toxic Microcystis aeruginosa Strain, Isolated from So Paulo-Brazil, Produce Hepatotoxins and Paralytic Shellfish Poison Neurotoxins Sant'Anna, CL; de Carvalho, LR; Fiore, MF; Silva-Stenico, ME; Lorenzi, AS; Rios, FR; Konno K.; Garcia C.; Lagos, N. Article ISI SCOPUS Neurotoxicity Research (2011)
Highly toxic microcystis aeruginosa strain, isolated from São Paulo-Brazil, produce hepatotoxins and paralytic shellfish poison neurotoxins Sant'Anna C.L.; De Carvalho L.R.; Rios F.R.; Fiore M.F.; Silva-Stenico M.E.; Lorenzi A.S.; Konno K.; Garcia C.; Lagos, N. Article NEUROTOXICITY RESEARCH (2011)
Route of metabolization and detoxication of paralytic shellfish toxins in humans Garcia C.; Barriga, A.; Diaz, JC; Lagos, M; Lagos, N. Article ISI SCOPUS Toxicon (2010)
Evidence of in vitro glucuronidation and enzymatic transformation of paralytic shellfish toxins by healthy human liver microsomes fraction Garcia C.; Rodriguez-Navarro, A; Diaz, JC; Torres R.; Lagos, N. Article ISI SCOPUS TOXICON (2009)
Local infiltration of gonyautoxin is safe and effective in treatment of chronic tension-type headache Lattes, K; Venegas P.; Lagos, N.; Lagos, M; Pedraza, L; Rodriguez-Navarro, AJ; Garcia C. Article ISI SCOPUS NEUROLOGICAL RESEARCH (2009)
Potentiation of Local Anesthetic Activity of Neosaxitoxin with Bupivacaine or Epinephrine: Development of a Long-Acting Pain Blocker Rodriguez-Navarro, AJ; Lagos, M; Figueroa C.; Garcia C.; Recabal P.; Silva P.; Iglesias V.; Lagos, N. Article ISI SCOPUS NEUROTOXICITY RESEARCH (2009)
Effects of the toxic dinoflagellate Gymnodinium catenatum on uptake and fate of paralytic shellfish poisons in the Pacific giant lions-paw scallop Nodipecten subnodosus Estrada, NA; Lagos, N.; Garcia C.; Maeda-Martinez, AN; Ascencio, F Article ISI SCOPUS MARINE BIOLOGY (2007)
GTX 2/3 epimers permeate the intestine through a paracellular pathway Torres R.; Pizarro, L; Garcia C.; Lagos, N.; Csendes, A Article SCOPUS JOURNAL OF TOXICOLOGICAL SCIENCES (2007)
Neosaxitoxin as a local anesthetic Rodriguez-Navarro, AJ; Lagos, N.; Lagos, M; Braghetto, I; Csendes, A; Hamilton, J.; Figueroa C.; Truan, D; Garcia C.; Rojas A.; Iglesias V.; Brunet L.; Alvarez, F. Article ISI SCOPUS ANESTHESIOLOGY (2007)
Treatment of chronic anal fissure by gonyautoxin Garrido, R; Lagos, N.; Lagos, M; Rodriguez-Navarro, AJ; Garcia C.; Truan, D; Henríquez Á. Article ISI SCOPUS COLORECTAL DISEASE (2007)
High amount of dinophysistoxin-3 in Mytilus chilensis collected in Seno de Reloncaví, Chile, during massive human intoxication associated with outbreak of Vibrio parahaemolyticus Garcia C.; Schonstedt V.; Santelices J.P.; Lagos, N. Article JOURNAL OF TOXICOLOGICAL SCIENCES (2006)
Gonyautoxin: New treatment for healing acute and chronic anal fissures Garrido, R; Lagos, N.; Lattes, K; Abedrapo M.; Bocic, G; Cuneo A.; Chiong, H; Jensen, C; Azolas, R; Henríquez Á.; Garcia C. Article ISI SCOPUS DISEASES OF THE COLON RECTUM (2005)
Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine Garcia C.; Lagos, M; Truan, D; Lattes, K; Vejar, O; Chamorro, B; Iglesias V.; Andrinolo, D; Lagos, N. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2005)
Lung oxidative stress as related to exercise and altitude. Lipid peroxidation evidence in exhaled breath condensate: a possible predictor of acute mountain sickness Araneda, OF; Garcia C.; Lagos, N.; Quiroga G; Cajigal J.; Salazar, MP; Behn, C Article ISI SCOPUS EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2005)
Metabolic transformation of dinophysistoxin-3 into dinophysistoxin-1 causes human intoxication by consumption of O-acyl-derivatives dinophysistoxins contaminated shellfish Garcia C.; Truan, D; Lagos, M; Santelices J.P.; Lagos, N.; Díaz J.C. Article SCOPUS JOURNAL OF TOXICOLOGICAL SCIENCES (2005)
First evidence of Dinophysistoxin-1 ester and carcinogenic polycyclic aromatic hydrocarbons in smoked bivalves collected in the Patagonia fjords Garcia C.; González V.; Cornejo, C.; Palma-Fleming, H; Lagos, N. Article ISI SCOPUS TOXICON (2004)
Paralytic shellfish poisoning: post-mortem analysis of tissue and body fluid samples from human victims in the Patagonia fjords Garcia C.; Bravo, MD; Lagos, M; Lagos, N. Article ISI SCOPUS TOXICON (2004)
Permeability of human jejunal segments to gonyautoxins measured by the Ussing chamber technique Mardones P.; Andrinolo, D; Csendes, A; Lagos, N. Article ISI TOXICON (2004)
Simultaneous presence of Paralytic and Diarrheic Shellfish Poisoning toxins in Mytilus chilensis samples collected in the Chiloe Island, Austral Chilean fjords Garcia C.; Mardones P.; Sfeir, A; Lagos, N. Article BIOLOGICAL RESEARCH (2004)
The effect of temperature on growth and production of paralytic shellfish poisoning toxins by the cyanobacterium Cylindrospermopsis raciborskii C10 Castro, D.; Vera, D.; Lagos, N.; Garcia C.; Vásquez M Article ISI SCOPUS TOXICON (2004)
The Gonyautoxin 2/3 epimers reduces anal tone when injected in the anal sphincter of healthy adults Garrido, R; Lagos, N.; Lattes, K; Garcia C.; Azolas, R; Bocic, G; Cuneo A.; Chiong, H; Jensen, C; Henríquez Á.; Fernandez, C. Article ISI SCIELO BIOLOGICAL RESEARCH (2004)
The gonyautoxin 2/3 epimers reduces anal tone when injected in the anal sphincter of healty adults Garrido, R; Azolas, R; Bocic, G; Cuneo A.; Chiong, H; Jensen, C; Henríquez Á.; Lagos, N.; Lattes, K; Garcia C.; Fernandez, C. Article SCOPUS BIOLOGICAL RESEARCH (2004)
Quantitation of diarrhetic shellfish poisoning toxins in Chilean Mussel using pyrenyldiazomethane as fluorescent labeling reagent Garcia C.; Pereira, P; Valle, L; Lagos, N. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2003)
Dynamics of intracellular calcium induced by lactate and glucose in rat pachytene spermatocytes and round spermatids Reyes JG.; Herrera, E; Lobos, L; Salas K; Lagos, N.; jorquera ra; Labarca P.; Benos, DJ Article ISI REPRODUCTION (2002)
Toxicokinetics and toxicodynamics of gonyautoxins after an oral toxin dose in cats Andrinolo, D; Iglesias V.; Garcia C.; Lagos, N. Article ISI SCOPUS TOXICON (2002)
Toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii (Cyanophyceae) isolated from Tabocas reservoir in Caruaru, Brazil, including demonstration of a new saxitoxin analogue Molica, R; Onodera, H; Garcia C.; Rivas, M; Andrinolo, D; Nascimento, S; Meguro, H; Oshima, Y; Azevedo, S.; Lagos, N. Article ISI PHYCOLOGIA (2002)
Transport of the organic cations gonyautoxin 2/3 epimers, a paralytic shellfish poison toxin, through the human and rat intestinal epitheliums Andrinolo, D; Gomes, P; Fraga S.; Soares-da-Silva, P; Lagos, N. Article ISI SCOPUS TOXICON (2002)
First report of diarrhetic shellfish toxins in magellanic fjords, southern Chile Uribe, JC; Garcia C.; Rivas, M; Lagos, N. Article ISI JOURNAL OF SHELLFISH RESEARCH (2001)
Temperature dependence of intracellular Ca2+ homeostasis in rat meiotic and postmeiotic spermatogenic cells Herrera, E; Salas K; Lagos, N.; Benos, DJ; Reyes JG. Article ISI SCOPUS REPRODUCTION (2001)
Biochemical characterization and inhibitory effects of dinophysistoxin-1, okadaic acid and microcystine 1-r on protein phosphatase 2a purified from the mussel Mytilus chilensis Rivas, M; Garcia C.; Liberona J.L.; Lagos, N. Article SCOPUS BIOLOGICAL RESEARCH (2000)
Biochemical characterization and inhibitory effects of dinophysistoxin-1, okadaic acid and microcystine l-r on protein phosphatase 2a purified from the mussel Mytilus chilensis. Rivas, M; Garcia C.; LIBERONA, JL; Lagos, N. Article ISI SCIELO BIOLOGICAL RESEARCH (2000)
Effect of casein-derived peptides on D-xylose absorption assessed by H-2 breath test in normal volunteers Defilippi C.; Madrid, AM; Salas K; Michea, L.; Lagos, N. Article ISI SCOPUS DIGESTIVE DISEASES AND SCIENCES (2000)
Energy metabolism and its linkage to intracellular Ca2+ and pH regulation in rat spermatogenic cells Herrera, E; Salas K; Lagos, N.; Benos, DJ; Reyes JG. Article ISI SCOPUS BIOLOGY OF THE CELL (2000)
Paralytic shellfish toxins in the freshwater cyanobacterium Aphanizomenon flos-aquae, isolated from Montargil reservoir, Portugal Pereira, P; Onodera, H; Andrinolo, D; Franca, S; Araujo, F; Lagos, N.; Oshima, Y Article ISI SCOPUS TOXICON (2000)
Paralytic shellfish toxins in mussels and Alexandrium tamarense at Valdes Peninsula, Chubut, Patagonia, Argentina: Kinetics of a natural depuration Andrinolo, D; Lagos, N.; Santinelli N.; Otano S.; Sastre V. Article JOURNAL OF SHELLFISH RESEARCH (1999)
The first evidence of paralytic shellfish toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii, isolated from Brazil Lagos, N.; Andrinolo, D; Onodera, H; Oshima, Y; Zagatto P.A.; Azevedo S.M.F.Q. Article TOXICON (1999)
Toxic effects, pharmacokinetics and clearance of saxitoxin, a component of paralytic shellfish poison (PSP), in cats Andrinolo, D; Lagos, N.; Michea L.F. Article TOXICON (1999)
Accumulation of paralytic shellfish poisoning toxins in the bivalve Aulacomya ater and two carnivorous gastropods concholepas concholepas and Argobuccinum ranelliformes during an Alexandrium catenella bloom in Southern Chile Compagnon D.; Ruiz-Tagle, N; Lagos, N.; Lembeye, G; Marcos N. Article JOURNAL OF SHELLFISH RESEARCH (1998)
Microalgal blooms: A global issue with negative impact in Chile Lagos, N. Article BIOLOGICAL RESEARCH (1998)


Absorption of paralyzing toxins from the dinoflagellate Gymnodinium catenatum in giant lions-paw scallop Nodipecten subnodosus Estrada A.; Ascencio, F; Contreras, RG; Cereijido, M; Shoshani, L; Torres R.; Lagos, N. Abstract ISI JOURNAL OF SHELLFISH RESEARCH (2007)


Life and interaction of hydrobiological organisms (Mytilus Sp.) with harmful algal blooms: Composition, distribution and metabolism of hydrophilic and hydrophobic toxins in the Austral Pacific Region Garcia C.; Lagos, N. BookWhole SCOPUS Materials Science and Technology Conference and Exhibition 2014, MS and T 2014 (2013)


Intrasphincteric neosaxitoxin injection: Evidence of lower esophageal sphincter relaxation in achalasia Rodriguez-Navaro, AJ; Lagos, N.; Lagos, M; Braghetto, I; Csendes, A; Hamilton, J.; Berger, Z; Wiedmaier G.; Henríquez Á. Letter ISI AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)


APLICACION DE TECNOLOGIAS PARA LA DETOXIFICACION DE MOLUSCOS CONTAMINADOS CON MAREA ROJA EN LAS REGIONES XI Y XII. Nestor Lagos Proyecto (0)
Detección y Cuantificación de DINOFISISTOXINA-3, una nueva toxina componente del Veneno Diarreico de Molusco (VDM) en mariscos del sur de Chile: Relación con intoxicaciones masivas asociadas al consumo de mariscos cocidos y síndrome diarreico. Nestor Lagos Proyecto (0)
Diarrheic Shellfish Toxins: biochemical and toxicological mechanism as tumor promoters Nestor Lagos Proyecto (0)
Investigación y Desarrollo de un proceso de producción industrial de toxinas marinas para uso farmacológico en patologías humanas. Nestor Lagos Proyecto (0)
PARTICIPACION DE LIPIDOS Y PROTEINAS INTRINSECAS DE MEMBRANA EN LA COMUNICACION INTERCELULAR EN EL CRISTALINO. Nestor Lagos Proyecto (0)
PRODUCCION DE ESTANDARES CERTIFICADOS PARA LA DETECCION Y CUANTIFICACION DE LAS TOXINAS PRESENTES EN EL VENENO DIARREICO DE MARISCO (VDM): PURIFICACION A PARTIR DE MARISCO CONTAMINADO. Nestor Lagos Proyecto (0)
PRODUCCION DE ESTANDARES CERTIFICADOS PARA LA DETECCION Y CUANTIFICACION DE VENENO PARALIZANTE DE MARISCO (VPM): PURIFICACION A PARTIR DE MARISCOS ALTAMENTE CONTAMINADOS. Nestor Lagos Proyecto (0)
Produccion y transformacion de toxinas bloqueadoras de canales de sodio por bacterias marinas aisladas desde moluscos bivalvos contaminados con veneno paralizante de molusco (Marea Roja) Nestor Lagos Proyecto (0)
Production of antisera which would have protection actions against paralytic shellfish poisoning toxins. Nestor Lagos Proyecto (0)
REGULACION DE LA COMUNICACION INTERCELULAR EN EL CRISTALINO. Nestor Lagos Proyecto (0)