Role of Lactadherin sEVs/metastasis promoter (Fondecyt 1211223) (ID21I10210) ASncmtRNAs in breast cancer role of exosomes/ FONDECYT(11140204) PAI, (7812030019) Antisense Teraphy in CERVIX/FONDEF (D10E1090), ACDDIS Fondap 15130011

irector of Doctoral Thesis
2019 / current Doctorate Thesis Eduardo Duran, Doctorate in Sciences and Innovation in Medicine.

2014/2019 América Vanessa Campos, Student of the Biochemistry Doctorate at the Faculty of Chemical and Pharmaceutical Sciences of the University of Chile. He will develop his PhD thesis with Dr Andrew Quest under the shared direction.
Title: In vitro and in vivo study of the pro-metastatic role of CAV1 in exosomes originating from the metastatic breast cancer cell line
Profesor Guía de Unidad de Investigación de Doctorado

2014 América Vanessa Campos, Biochemistry Doctoral Student at the Faculty of Chemical and Pharmaceutical Sciences of the University of Chile, developed her second Research Unit, with the aim of obtaining preliminary data for her PhD thesis.
The main objective of my tutoring on this student was to standardize subcutaneous tumor formation curves of mammary tumor lines in immunosuppressed animals.

Master's Thesis Guide Professor

2016 / current Roció Bustos, Biotechnology Engineering degree, Andrés Bello University.
Exosomes secreted by MDA-MB-231 breast cancer cells post-interference of antisense non-coding mitochondrial RNAs (ASncmtRNA) decrease tumorigenic properties.

2013/2014 Valeria Silva, Biotechnology Engineering degree, Andrés Bello University,
Decreased tumorigenic properties in breast cancer by interfering with non-coding mitochondrial RNAs.
Profesor Guía de Práctica Profesional

2016 Francisca Guevara, Biotechnology Engineering degree, Andrés Bello University, In vivo PDXs Models of the Cervical Uterine, implants and therapies.

2015 Roció Bustos, Biotechnology Engineering degree, Andrés Bello University, study of the effect of exosomes on migratory properties of human breast cancer tumor cells.

2012 Valeria Silva, Biotechnology Engineering degree, Andrés Bello University, study of in vitro migration models in murine breast cancer.

Undergraduate Thesis Guide Professor

2005 "Fe +2 bisglycine chelate a new pharmacological formulation in the treatment of iron deficiency anemia in piglets and measurement of peroxidase activity".
Title thesis of the Veterinary Medicine Career.
School of Veterinary Medicine, Faculty of Agricultural Sciences, Universidad de Las Américas. Student: Christian Bavestrello L.

2004 "Detection of catalase enzyme activity in piglets after preventive treatment of iron deficiency anemia".
Title thesis of the Veterinary Medicine Career.
School of Veterinary Medicine, Faculty of Agricultural Sciences, Universidad de Las Américas. Student: Pamela Peña and Lillo

Presentaciones en Congresos Científicos

Lobos-González L, Bustos R, Campos A, Silva V, Carrasco M, Guevara F, Varas-Godoy M, Oliveira L, Burzio V, Burzio L
Exosomes from metastatic breast cancer cells post-interference of ncmtRNAs decreased metastasis in a model of carcinomatosis intraperitonneally
Reunión Anual Sociedad De Bioquímica y Biología Celular de Chile, Puerto Varas, 27-30 Septiembre de 2016

Campos A, Bustos R, Carrasco M, Guevara F, Varas M, Lobos González L*, Quest A.F.G.*
Caveolin-1 in exosomes from metastatic breast cancer cells enhances metastasis in a novel model of intraperitoneal carcinomatosis
*equal contributions
Reunión Anual Sociedad De Bioquímica y Biología Celular de Chile, Puerto Varas, 27-30 Septiembre de 2016

Bustos R, Campos A, Varas-Godoy M, Carrasco M, Guevara F, Villegas J, Burzio V, Burzio L, Lobos González L.
Exosomes released upon knockdown of the Antisense non-coding mitochondrial RNAs modulate tumorigenic properties of the human breast cancer cell line MDA-MB-231.
Reunión Anual Sociedad De Bioquímica y Biología Celular de Chile, Puerto Varas, 27-30 septiembre de 2016

Campos A, Bustos R, Díaz-Valdivia N, Carrasco M, Guevara F, Varas-Godoy M, Lobos-González L, Quest AFG
Caveolin-1 in extracellular vesicles from metastatic breast cancer cells promotes metastasis in a novel model of intraperitoneal carcinomatosis
ACDDis Cancer Spring Symposium, Olmue, 7-9 september 2016

Diaz-Valdivia N, Campos A, Contreras P, Lobos-González L, Perez V, Frei B, Leyton , Quest AFG.
E-cadherin-dependent recruitment of the non-receptor tyrosine phosphatase PTPN4 prevents cell migration invasión and metastasis induced by CAV1 phosphorylation on tyrosine 14.
ACDDis Cancer Spring Symposium, Olmue, 7-9 september 2016

Iva Polakovi?ová, Lorena Lobos-González, Nicolás Carrasco, Alejandra Sandoval-Bórquez,
Manuel Varas-Godoy, Alejandro Corvalán
EMBL Course and Poster presentation:
Role of Gastric Cancer Exosomes in the Pathogenesis of Gastric Carcinoma.
EMBL Advanced Training Centre, Heidelberg, Germany. 19-24 september 2016.
Extracellular Vesicles from Biology to Biomedical Applications
An international workshop with presentation and discusión of results.

Polakovicova I, Lobos-González L, Carrasco N, Sandoval Bórquez A, Corvalan A
Search for an in vivo mouse model to demonstrate the role of gastric
ACDDis Cancer Spring Symposium, Olmue, 7-9 september 2016

Arce M, Lange S, Erices R, Valenzuela R, Velasquez E, Oliva B,Ramirez C, Kalergis AM, Lobos L Quest AF, Owen GI
Coagulation Factor Xa increases cancer growth and metastasis
Reunión Anual Sociedad De Biología Celular de Chile, Puerto Varas, 25-29 octubre de 2015

V. Borgna, L. Lobos-González, J. Villegas, M Araya, V Silva, Teresa Socías, L. Burzio
Terapia Génica Contra Los RNA Mitocondriales No Codificantes Largos AS Como Una Nueva Contra el Cáncer Vesical
XXX\/II CONGRESO CHILENO DE UROLOGIA, Puerto Varas, 21-24 octubre 2015

Campos A, Bustos R, Lobos-González L, Quest A
Caveolin-1 expression in metastatic breast cancer cells promotes exosome formation
Reunión Anual Sociedad De Bioquímica y Biología Celular de Chile, Puerto Varas, 22-25 septiembre de 2015

Silva M, V. Silva, V. Socias, T. Villegas, J. Burzio, L. Lobos-González, L.
Interference of the Antisense Mitochondrial Non-coding RNA decreases tumorigenic properties in Human Breast Cancer cell lines.
XIII PABMB CONGRESS, Chile, Puerto Varas, 6-11 Noviembre 2014

Ávila, R., Farfán, N.,Villota, C., Dadlani, K., Lobos-Gonzales, L .,Socias, M.,Socias, T., Bustamante, E ., Burzio, L., Villegas, J.
Primary cultures of advanced cervical cancer as model for selective anti-sense therapy
XXXVII ANNUAL MEETING SOCIEDAD DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR DE CHILE Puerto Varas - Chile • September 30 - Octubre 04 • 2014

Borgna, V., Lobos-Gonzalez, L.,Avila, R.,Rivas, A.,Lopez, C .,Socias, T.,Burzio, L., Villegas, J.
Anti- sense therapy in genitourinary cancer: Non coding mitochondrial RNAs as target
XXXVII ANNUAL MEETING SOCIEDAD DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR DE CHILE Puerto Varas - Chile • September 30 - Octubre 04 • 2014

Ávila, R., Villota, C. Lobos-Gonzalez, L., Socias, T., Burzio, L., Villegas, J.
Safety and selectivity of anti-sense approach in cervical cancer: non coding mitochondrial RNAs as therapeutical targets
XXXVII ANNUAL MEETING SOCIEDAD DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR DE CHILE Puerto Varas - Chile • September 30 - Octubre 04 • 2014

Bendek, M., Lobos-González, L., Silva, V., Silva, V., Avila, M.,Villegas, J.,Burzio, L.,Landerer, E.
The use of anti-sense oligonucleotides as an effective, selective and safe therapy for bladder cancer in the mouse model C57BL/6-MB49.
XXXVII ANNUAL MEETING SOCIEDAD DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR DE CHILE Puerto Varas - Chile • September 30 - Octubre 04 • 2014