Man

Alejandra María Loreto Sandoval Bórquez

Associate Professor

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

Líneas de Investigación


Cellular and Molecular Pathology; Applied research in gastrointestinal tumors; Epigenetics, non-coding RNAs, microRNAs

Educación

  •  Medical Technology, UNIVERSIDAD DE LA FRONTERA. Chile, 2007
  •  Sciences mention Cell Biology and Applied Molecular Biology, UNIVERSIDAD DE LA FRONTERA. Chile, 2011
  •  Sciences mention Cell Biology and Applied Molecular Biology, UNIVERSIDAD DE LA FRONTERA. Chile, 2015
  •  Medical Technologist with mention in Clinical Laboratory, Hematology and Blood Bank, UNIVERSIDAD DE LA FRONTERA. Chile, 2008
  •  University education, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2025

Experiencia Académica

  •   Academic/Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Faculty of Sciences

    Valparaiso, Chile

    2023 - At present

Experiencia Profesional

  •   Invited teacher

    Universidad de Chile

    Chile

    2016 - 2016

  •   Invited teacher

    Pontificia Universidad Católica de Chile

    Chile

    2015 - 2015

  •   Invited teacher

    Universidad de La Frontera

    Chile

    2010 - 2010

  •   Laboratory Teaching Assistant

    Universidad de La Frontera

    Chile

    2010 - 2010

  •   Research Assistant

    Universidad de La Frontera

    Chile

    2006 - 2006

  •   Laboratory Teaching Assistant

    Universidad de La Frontera

    Chile

    2005 - 2005


 

Article (14)

Low Cortisone as a Novel Predictor of the Low-Renin Phenotype

Sandoval, Alejandra; Allende, Fidel; Solari, Sandra

Article ISI
JOURNAL OF THE ENDOCRINE SOCIETY  (2024)

Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development

Diaz, Paula; Herrera, Daniela

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2021)

Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease

Diaz, Paula

Article ISI
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY  (2021)

AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells

Martínez-Meza S.; Sandoval-Bórquez A.; Huilcaman, R.; Ocaranza, M.P.

Article ISI SCOPUS
CANCERS  (2019)

MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer

Polakovicova, I; Carrasco-Veliz, N; Bizama, C

Article ISI SCOPUS
Clinical Epigenetics  (2017)

Structural and functional identification of vasculogenic mimicry in vitro

Racordon, Dusan; Valdivia, Andres; Mingo, Gabriel; Erices, Rafaela; Aravena, Raúl; Santoro, Felice; Bravo, Maria Loreto; Ramirez, Carolina; Gonzalez, Pamela; Sandoval, Alejandra; González, Alfonso; Retamal, Carolina; Kogan, Marcelo; Kato, Sumie; Cuello Mauricio, Osorio; German, Nualart; Francisco, Alvarez; Pedro, Gago-Arias; Araceli, Fabri; Daniella, Espinoza; Ignacio, Sanchez ; Beatriz, Corvalán; Alejandro, Pinto; Mauricio, Owen GI

Article
Scientific Reports  (2017)

miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway

Riquelme, I.; Tapia O.; Leal P.; Sandoval A.; Varga, MG; Letelier P; Buchegger, K; Bizama, C; Peek, RM

Article ISI SCOPUS
CELLULAR ONCOLOGY  (2016)

The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines

Riquelme I.; Tapia O.; Espinoza J.A.; Leal P.; Buchegger K.; Sandoval A.; Bizama C.; Araya J.C.; Peek R.M.; Roa J.C.

Article
Pathology and Oncology Research  (2016)

Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers.

Sandoval-Bórquez, Alejandra; Saavedra, Kathleen; Carrasco-Avino, Gonzalo; Garcia-Bloj, Benjamin; Fry, Jacqueline; Wichmann, Ignacio; Corvalán, Alejandro H

Article
Disease markers  (2015)

Immunohistochemical Expression of Vascular Endothelial Growth Factor A in Advanced Gallbladder Carcinoma

Letelier P, Garcia P, Leal P, Ili C, Buchegger K, Riquelme I, Sandoval A, Tapia O, Roa JC

Article
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY  (2014)

The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance

Tapia O, Riquelme I, Leal P, Sandoval A, Aedo S, Weber H, Letelier P, Bellolio E, Villaseca M, Garcia P, Roa JC

Article
VIRCHOWS ARCHIV  (2014)

AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines

Leal, P; Garcia, P; Sandoval, A; Buchegger, K; Weber, H; Tapia, O; Roa J.C.

Article
ONCOTARGETS AND THERAPY  (2013)

Cellular FLICE-like Inhibitory Protein Long Form (c-FLIPL) Overexpression is Related to Cervical Cancer Progression

Ili, CG; Brebi, P; Tapia, O; Sandoval, A; Lopez J; Garcia, P; Leal, P; Sidransky, D; Guerrero-Preston, R; Roa JC

Article
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY  (2013)

Immunohistochemical Expression of Phospho-mTOR Is Associated With Poor Prognosis in Patients With Gallbladder Adenocarcinoma

Leal, P; Garcia, P; Sandoval, A; Letelier, P; Brebi, P; Ili, C; Alvarez, H; Tapia, O; Roa JC

Article
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE  (2013)

Abstract (3)

mTOR/P70S6K signaling pathway as a potential target for advanced gallbladder cancer therapy

Leal P.; Weber, H; Garcia, P.; Sandoval A.; Buchegger, K; Tapia O.; Nervi, B; Grez, M

Abstract ISI
JOURNAL OF CLINICAL ONCOLOGY  (2014)

Expression of vascular endothelial growth factor a (VEGF-A) in advanced gallbladder cancer

Letelier P; Buchegger, K; Ili C.; Garcia, P.; Brevi, P; Sandoval A.; Leal P.; Riquelme, I.

Abstract ISI
CANCER RESEARCH  (2013)

Level of miR-125B and miR-451 and Deregulated Expression of PI3K/AKT/mTOR Pathway in Gastric Cancer

Tapia O.; Riquelme, I.; Sandoval A.; Letelier P; Leal P.

Abstract ISI
LABORATORY INVESTIGATION  (2013)

BookSection (2)

MicroRNA-335-5p and Gastrointestinal Tumors

Santoro P. M., Sandoval-Bórquez A., Corvalan A.

BookSection
 (2020)

Epstein-Barr Virus–Associated Gastric Carcinoma: The Americas’ Perspective

Alarcon A, Figueroa U, Espinoza B, Sandoval A, Carrasco-Aviño G, Aguayo F, Corvalan A.

BookSection
 (2017)

ConferencePoster (25)

Reduced Angiotensin II Type 2 Receptor Expression Is Associated with Gastric Cancer Progression and Enhanced Gastric Cancer Cell Migration/Invasion

Sandoval-Borquez A., Martinez S., Wichman I., Carrasco-Avino G., Norero E., Corvalan, AH. Lavandero S., Quest A.F.G

ConferencePoster
 (2022)

miR-597-5p is associated with tumor invasion and metastasis in gastric cancer

Sandoval-Borquez A., Polakovicova I., Carrasco-Veliz N., Norero E., Corvalan, AH.

ConferencePoster
 (2019)

Reduced Angiotensin II Type 2 Receptor expression is associated with gastric cancer progression and receptor activation reduces gastric cancer cell migration.

Sandoval-Bórquez A., Martinez S., Novoa P., Carrasco-Avino G., Corvalan A., PRESENTACIONES A CONGRESOS NACIONALES (los más relevantes) Lavandero S., Quest A. F. G.

ConferencePoster
 (2019)

“microRNA-597-5p un nuevo gen supresor de tumores en cáncer gástrico.”.

Sandoval-Bórquez A., Polakovicova I., Carrasco-Véliz N., Norero E., Corvalán A. H.

ConferencePoster
 (2018)

Establishment of an in vitro model for the study of vasculogenic mimicry in ovarian and gastrointestinal cancer cells

Valdivia A, Racordon D., Aravena R., Mingo G., Sandoval A., Bravo ML., Cuello M., Kato S., Erices R., Ramirez C., Gonzalez P., Sanchez B., Corvalán A., Owen G

ConferencePoster
 (2017)

MicroRNA-335-5p is expressed in gastric cancer derived extracellular vesicles and modulates the invasiveness of gastric cancer cells.

Polakovi?ová I., Lobos L., Carrasco N., Varas-Godoy M., Sandoval-Bórquez A., Corvalán A.

ConferencePoster
 (2017)

Vasculogenic mimicry: an alternative model of tumor irrigation in ovarian cancer.

Mingo G., Valdivia A., Racordon D., Bravo ML., Sandoval A., González A., Retamal C., Cuello M., Nualart F., Sanchez B., Corvalán A., Owen G.

ConferencePoster
 (2017)

MicroRNA-335-5p is a potential suppressor of metastasis and invasion in non-Asian gastric cáncer.

Sandoval-Bórquez A., Polakovicova I., Riquelme I., Carrasco-Avino G., Carrasco N., Bizama C., Owen G., Roa J., Corvalán A.

ConferencePoster
 (2016)

Role of Gastric Cancer Exosomes in the Pathogenesis of Gastric Carcinoma

Polakovi?ová I., Lobos L., Carrasco N., Sandoval-Bórquez A., Varas-Godoy M., Corvalán A.

ConferencePoster
 (2016)

Vasculogenic Mimicry in Gastric Cancer.

Valdivia A., Sandoval A., Carrasco-Avino G., Racordon D., Rodríguez A., Olivares W., Corvalán A., Owen G.

ConferencePoster
 (2016)

Comparison of Zinc Finger and RNA-guided CRISPR-based Artificial Transcription Factors to reactivate the endogenous transcription of a dormant Tumor Suppressor Gene.

Garcia B., Moses C., SgroA., Sandoval A., Constantine J., Blancafort P.

ConferencePoster
 (2015)

miR-335-5p is a potential suppressor of metastasis and in gastric cancer.

Sandoval A., Riquelme I, Alarcón A., Olivares W., Polakovicova I., Roa JC., Corvalán A.

ConferencePoster
 (2015)

Deregulated expression of the PI3K/AKT/mTOR pathway in gastric cancer.

Riquelme I., Tapia T., Aedo S., Sandoval A., Leal P., Roa JC.

ConferencePoster
 (2013)

Downregulation of miR-335 in Gastric Cancer.

Sandoval A., I. Riquelme, JC Roa., Corvalan

ConferencePoster
 (2013)

miR-335 and miR-597 potential biomarkers of gastric cancer.

Sandoval A., Riquelme I., Olivares W., Saavedra K., Garcia B. 1 , Roa JC., Corvalan A.

ConferencePoster
 (2013)

mTOR/P70S6K signaling pathway as a potential target for Gallbladder cancer therapy.

Roa JC., Leal P., Weber H., Garcia P., Sandoval A., Buchegger K., Tapia and Grez M.

ConferencePoster
 (2013)

Role of the mir-335 and mir-597 in gastric carcinogenesis.

Sandoval A., Riquelme I., Olivares W., Garcia P., Saavedra K., Garcia B., Roa JC., Corvalán A.

ConferencePoster
 (2013)

Upregulation of mir-597 correlated with downregulated of RPRM in gastric cancer

Sandoval A., Riquelme I., Saavedra K., Garcia B., Roa JC., Corvalán A.

ConferencePoster
 (2013)

Upregulation of mir-597 correlated with downregulated of RPRM in gastric cancer.

Sandoval A., Riquelme I., Buchegger K., Olivares W., Saavedra K., Garcia B., Roa JC., Corvalán A.

ConferencePoster
 (2013)

Expression of deregulated PI3K/ AKT/ mTOR pathway in gastric cancer..

Tapia O., Riquelme I., Sandoval A., Aedo S., Leal P., Roa JC.

ConferencePoster
 (2012)

Integration of mRNA and miR profiles and unique patterns restricted identified in Breast & Colon cancer cell lines.

Garcia B., Sandoval A., Droguett R., Diaz J., Corvalan A.

ConferencePoster
 (2012)

Expression of Vascular Endothelial Growth Factor (VEGFA) in advanced gallbladder cancer.

Letelier P., Leal P., Sandoval A., Buchegger K., Tapia O. Roa JC.

ConferencePoster
 (2011)

“AKT / mTOR signaling Pathway in Gallbladder Cancer: an Immunohistochemical Case- Control Study".

Leal P., Garcia P., Sandoval A. , Brebi P., Ili C. , Lopez J., Letelier P., Tapia O., Roa JC.

ConferencePoster
 (2010)

Effect of trypsin inhibitors on training and acrosome reaction in canine sperm incubated in capacitating conditions.

Sandoval A., Deppe M., Risopatrón J., Damian A., Sanchez R.

ConferencePoster
 (2007)

Standardization and implementation of Tissue Microarrays (TMA) for gastric cancer histological techniques.

Sandoval A., Damian A., Roa I., Melo A., Roa JC.

ConferencePoster
 (2007)

Patent (1)

Non-invasive method for the early diagnosis of gastric cancer using as a biomarker the methylation levels in the DNA sequence of microRNA-335-5p promoter

Sandoval Borquez, Alejandra; Corvalán, Alejandro

Patent
 (2022)

Proyecto (7)

MTUS1 DNA Methylation as a Potential Diagnostic and Prognostic Biomarker in Breast, Gastric, and Colon Cancer

Sandoval-Borquez, Alejandra Maria

Proyecto
 (2024)

Ex Vivo Study of Extracellular Vesicles Derived from Obese Adult Subjects in Cell Lines.

Sandoval-Borquez, Alejandra Sandoval

Proyecto
 (2023)

Role of Angiotensin II Type 2 Receptor in the molecular pathogenesis of human gastric carcinoma

Sandoval-Borquez, Alejandra Maria

Proyecto
 (2018)

Advanced Center for Chronic Diseases (ACCDiS)

FONDAP (15130011)

Proyecto
2015-2017
Postdoctorado

ROLE OF REPRIMO, A P53-DEPENDENT G2 ARREST MEDIATOR CANDIDATE, IN THE PATHOGENESIS OF HUMAN GASTRIC CARCINOMA

FONDECYT (1111014)

Proyecto
2011-2015
Tesista

VALIDATION OF MTOR METABOLIC PATHWAY INACTIVATION FOR GALLBLADDER CANCER TARGETED THERAPY

FONDECYT (1090171)

Proyecto
2009-2012
Personal técnico y/o de apoyo

MARCADORES PRONOSTICOS EN MATRICES DE TEJIDOS TUMORALES DE PACIENTES CON CANCER DE LA VESICULA BILIAR EN ESTUDIOS POTENCIALMENTE CURABLES

FONDECYT (1060375)

Proyecto
2006-2008
Tesista

Review (3)

Adipose Tissue Dysfunction and the Role of Adipocyte-Derived Extracellular Vesicles in Obesity and Metabolic Syndrome

Sandoval-Borquez, Alejandra; Carrion, Pablo; Hernandez, Maria Paz; Perez, Jorge A.; Tapia-Castillo, Alejandra; Vecchiola, Andrea; Fardella, Carlos E.; Carvajal, Cristian A.

Review ISI
JOURNAL OF THE ENDOCRINE SOCIETY  (2024)

The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor

Vecchiola, Andrea; Uslar, Thomas; Friedrich, Isidora; Aguirre, Joaquín; Sandoval, Alejandra; Carvajal, Cristian A.; Tapia-Castillo, Alejandra; Martinez-Garcia, Alejandra; Fardella, Carlos E.

Review ISI
CARDIOVASCULAR ENDOCRINOLOGY & METABOLISM  (2024)

Role of microRNAs and Exosomes in Helicobacter pylori and Epstein-Barr Virus Associated Gastric Cancers

Jerez S.; Wichmann, IA; Corvalan, AH

Review ISI SCOPUS
FRONTIERS IN MICROBIOLOGY  (2018)

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

3
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sandra Solari

Profesor Clinico Asociado

Laboratorios Clinicos

Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carmen Ili

Academico Asociado

Scientific and technological Bioresource Nucleus (BIOREN)

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

2
PAMELA LEAL

Profesor Asociado

Departamento de Ciencias Agronómicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

3
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Pablo Letelier

Docente Planta Permanente (Instructor)

UNIVERSIDAD CATOLICA DE TEMUCO

temuco, Chile

1
Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

2
Kurt Buchegger

Investigador Postdoctoral

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

4
Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

1
Manuel Valenzuela

Académico Investigador

VRA

Universidad Central de Chile

santiago, Chile

2
Carolina Bizama

Assistant professor

Department of Pathology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Paula Díaz

Academic Researcher

UNIVERSIDAD MAYOR

Santiago, Chile

43
Alejandra Sandoval

Associate Professor

Faculty of Sciences

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Juan Araya

Pathologist

Anatomía Patológica

Hospital Dr. Hernan Henríquez Aravena

Temuco, Chile

1
Maria Ocaranza

Full Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Helga Weber

Investigador

Vicerrectoría de Investigación y Post Grado

Universidad de la Frontera

Temuco, Chile

3
ALEJANDRA TAPIA

Investigador

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ana Rojas

Asistente de Investigación

Universidad Autónoma de Chile

Santiago, Chile

1
Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

1
Ignacio Wichmann

Assitant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Huilcamán

Investigador

Universidad de Chile

Santiago, Chile

1
Daniela Herrera

1
Alejandra Martínez

Profesor Asistente

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile