
Bruno Nervi Nattero
Associated Professor
Pontificia Universidad Catolica de Chile
Santiago, Chile
1. Cancer interaction with the microenvironment 2. Acute myeloid leukemia progression and resistance to treatment modulated by the bone marrow stroma 2. Gallbladder cancer progression and resistance to treatment modulated by the tumor stroma
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Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1996
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Internal Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998
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Sub-specialty Hematology and Oncology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
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Sub-specialty Hematology - Oncology, WASHINGTON UNIVERSITY SCHOOL OF MEDICINE. Estados Unidos, 2006
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Assistant Professor Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Faculty of Medicine
Santiago, Chile
2009 - 2015
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Chief UC Medical Oncology Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Faculty of Medicine
Santiago, Chile
2011 - 2015
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Instructor in Medicine Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Faculty of Medicine
Santiago, Chile
2002 - 2008
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Associated Professor Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Faculty of Medicine
Santiago, Chile
2015 - At present
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Chief Medical Oncology Programme Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Faculty of Medicine
Santiago, Chile
2009 - At present
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Chief Hematology-Oncology Department Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Medicine
Santiago, Chile
2022 - At present
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Instructor of Medicine Full Time
Pontificia Universidad Catolica de Chile
Santiago, Chile
2002 - 2009
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Associated Professor Full Time
Pontificia Universidad Catolica de Chile
Santiago, Chile
2015 - At present
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Assistant Professor Full Time
Pontificia Universidad Catolica
Santiago, Chile
2009 - 2015
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Medical Director of the UC Cancer Center Full Time
Red de Salud UC-CHRISTUS
Santiago, Chile
2017 - 2021
Undergraduate and postgraduate students:
1. Francisco Barriga, Biochemistry, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Thesis: "The Interaction with bone marrow stroma protects leukemia cells from therapy-induced apoptosis", 2009.
2. Maria del Pilar Swett, Biochemistry, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Thesis: "The bone marrow stroma cells protects acute myeloid leukemia cells from Cytarabine induced apoptosis by modulation of human equilibrative nucleoside transporter", 2013-2014.
3. Antonella Rosati, MSc Biologia Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Thesis: "La transición mesenquimal es uno de los mecanismos de resistencia a la quimioterapia de leucemia mieloide aguda conferidos por el estroma", 2015-2016.
4. Macarena Tobar Tobar, Biochemistry, Facultad de Química y Biología, Universidad de Santiago. Thesis: "Bone marrow stroma cells confer resistance to acute myeloid leukemia cellls through the activation of tyrosine kinase and mTOR interacellular signaling", 2019-2020.
Biochemistry and Biology students:
1. Francisco Leisewitz, Universidad Andres Bello, 2010
2. Victoria Gidi, Pontificia Universidad Católica de Chile, 2011
3. Alejandra Guzmán, Pontificia Universidad Católica de Chile, 2012
4. María Ignacia García Vargas, Facultad de Ciencias Biológicas, Universidad Católica de Chile, 2019-2020.
Public Health Activities:
1. President of the Chilesincancer Foundation (www.chilesincancer.cl) (2015 to present).
Our mission is to generate the best conditions of infrastructure, human capital and management for the care of patients with cancer in Chile, and our purpose is that all Chileans have timely and quality cancer care.
2. President of the Advisory Council in matters of cancer (2018-2021).
This council incorporated experts from scientific societies, universities and foundations dedicated to cancer, to collaborate with
the Ministry of Health in the drafting and implementation of the National Cancer Plan 2018-2028.
3. Cancer Advisor to the Ministry of Health (2020-2021).
The objective was to collaborate for the implementation of the Cancer Law that was enacted by October 2020, favoring the participation of
civil society. Tha Cancer Law was promoted by former senator Carolina Goic, who currently has an academic appointment at the Universidad Católica de Chile, and Dr. Nervi played an active and
participative role from the University to contribute to the approval of the Law.
4. President of the National Cancer Commission (2021 to present).
The comission has 11 representatives of civil society that include 5 of the 19 presidents of scientific societies, 3 representatives of the 29 medical schools, and 3 representatives of the 40 patient groups and foundations. The mission of this commission is to advise the Ministry of Health in the implementation of the national cancer plan. It
will also support the management of competitive contests for training, research, prevention or care projects for cancer patients, who will apply for the cancer law fund.
Poster Presentations:
1. "The bone marrow stroma as a novel prognostic factor for patients with acute myeloid leukaemia". Patricia Macanas-Pirard, Richard Broekhuizen, Sergio Vargas-Salas, Romina Coronado, Carolina Bizama, Sabrina Muñiz-Muñoz, Oslando Padilla, Viviana Montecinos, Juan Carlos Roa and Bruno Nervi. . The virtual congress on controversies in leukemias. #21. Euroleuk2020.
2. The bone marrow stroma capacity to confer resistance to leukemia cells from Ara-C treatment as a prognostic factor for overall survival in AML. Patricia Macanas-Pirard, Sergio Vargas-Salas, Richard Broekhuizen, Romina Coronado, Carolina Bizama, Sabrina Muñiz-Muñoz, Vivianne Torres, Viviana Montecinos, Daniel Ernst, Francisco Melo, Juan Carlos Roa, Bruno Nervi. J Clin Oncol 37, 2019 (abstr e18500). DOI: 10.1200/JCO.2019.37.15_suppl.e18500. ASCO anual meeting.
3. “Nuevas estrategias para el tratamiento del cáncer de vesícula biliar mediante la modulación de la interacción entre microambiente y cáncer” Nervi Bruno, Macanás Patricia, Broekhuizen Richard, Swett Pilar, Ramírez Pablo, Leisewitz Andrea. Viña del Mar, Chile, 2012.
2. “Bone marrow stoma secretes a soluble factor that protects leukemia cells from cytarabine induced apoptosis by blocking ent activity” Patricia Macanás, PhD, Andrea Leisewitz, PhD, Richard Broekhuizen, Victoria Chomali, Francisco Leisewitz, Pablo Ramirez, MD, Kelly Cautivo, Alexis Kalergis, PhD, John F DiPersio, MD PhD and Bruno Nervi. Honolulu, Hawai, USA, 2011.
3. “Impacto del tipo de donante en los resultados de trasplante alogenico de precursores hematopoyéticos en niños con neoplasias hematológicas” Rojas N, Wietstruck MA, Zúñiga P, Silva A, Nervi B, Barriga F. XVII Congreso Chileno de Hematología, Coquimbo, Chile, 2010.
4. “Resistance to AraC involves ERK signaling pathway and hENT1 activity down regulation in leukemic cells”. Richard A.J.F. Broekhuizen, Patricia Macanas, Andrea V. Leisewitz, Bruno Nervi. Congreso Anual de la Sociedad Chilena de Biología, Pucón, Chile, 2010.
5. “Células estromales de la medula ósea secretan un factor soluble que protege a células leucémicas de muerte inducida por quimioterapia” Leisewitz F.J., Macanas P., Besa P., Riquelme E., Kalergis A., Leisewitz A.V. y Nervi B. Congreso Anual de la Sociedad Chilena de Biología, Pucón, Chile, 2009.
6. “The interaction between leukemia and bone marrow stroma protects the tumor cells from chemotherapy- and radiotherapy-induced apoptosis”. Francisco Barriga, Erick Riquelme, Patricia Macanás, Pelayo Besa, Richard Broekhuizen, John F DiPersio, Alexis Kalergis and Bruno Nervi. Bone Marrow Transplantation Tandem Meeting, Tampa, USA, 2009.
Undergraduate teaching
1. Responsible for the Oncology chapter, Fisiopathology course, Faculty of Medicine, Medicine third year students.
2. Responsible for the Oncology chapter, Fisiopathology course, Faculty of Medicine, Odontology third year students.
3. Lectures in the Faculty of Biological Sciences and Medicine: "Leukemia", "The interaction between cancer cells and their stroma", "Stem cell transplantation", "
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Best Scientific Award
Congreso Chileno de Cancerologia
Chile, 2012
Best Scientific Award for the best presented project at the Congreso Chileno de Cancerologia 2012.
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Junior Clinical Excellence Award
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Chile, 2011
I received a recognition Award for my clinical achievements at my Institution, the Pontificia Universidad Catolica de Chile, Faculty of Medicine.
The bone marrow stroma capacity to confer resistance to leukemia cells from Ara-C treatment as a prognostic factor for overall survival in AML. |
The bone marrow stroma as a novel prognostic factor for patients with acute myeloid leukaemia. |
Método ex vivo pronóstico y predictivo de respuesta de un cáncer al tratamiento con un agente antitumoral |
"Desarrollo de un test multigénico para pronóstico de LMA interrogando al estroma tumoral" |
"The modulation of the leukemia-stroma interaction as a new strategy to improve outcomes in acute myeloid leukemia" |
"Desarrollo de un test pronóstico para LMA interrogando por primera vez al estroma tumoral" |
Desarrollo de un test predictivo de respuesta para leucemia mieloide aguda basado en la resistencia a quimioterapia conferida por el estroma de la médula ósea |
The bone marrow stroma from acute myeloid leukemia patients secretes cytokines that protect leukemia cells from cytarabine induced apoptosis by modulation of human equilibrative nucleoside transporter-1 |
BM stroma from AML secretes cytokines that protect leukemia from cytarabine by modulation of hENT1 |
Plataforma de estudios preclinicos de xenotransplantes de tejidos metastasicos humanos para la evaluación de sensibilidad a drogas anticancerigenas. |
The Bone Marrow Stromal Cells protect Acute Myeloid Leukemia from Cytarabine induced Apoptosis by the Activation of a Tyrosine Kinase Receptor |
Instituto Milenio en Inmunología e Inmunoterapia |
The Bone Marrow Stromal Cells protect Acute Myeloid Leukemia from Cytarabine induced Apoptosis by the Activation of a Tyrosine Kinase Receptor |
Role of MCP-1/CCR2 Axis in the Survival and Progression of Acute Myeloid Leukemia |
Preferential mobilization of leukemia precursors from the bone marrow into peripheral blood by the CXCR4 inhibitor AMD3100 in a mouse model |
The interaction between leukemia and bone marrow stroma protects the tumor cells from drug induced apoptosis |
A Phase I/II Study of MOZOBIL with Mitoxantrone, Etoposide and Cytarabine (AMD3100+MEC) in Relapsed or Refractory AML |
La interacción entre leucemia y estroma de la médula ósea protege a las células tumorales de la apoptosis mediada por drogas |

Bruno Nervi
Associated Professor
Hematology - Oncology
Pontificia Universidad Catolica de Chile
Santiago, Chile

Marcelo Garrido
Director
CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Helga Weber
Investigador
Vicerrectoría de Investigación y Post Grado
Universidad de la Frontera
Temuco, Chile

Verónica Jara
enfermera coordinadora
hematologia y oncologia
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
santiago, Chile

Carolina Bizama
Assistant professor
Department of Pathology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Patricia García
Profesor Asistente
ANATOMIA PATOLOGICA
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
SANTIAGO, Chile

PAMELA LEAL
Profesor Asociado
Departamento de Ciencias Agronómicas y Recursos Naturales
UNIVERSIDAD DE LA FRONTERA
Temuco, Chile

Patricia Macanas
Profesor Asistente Adjunto
Hematology Oncology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
223543432, Chile

Marcela Ferres
Head of Department
Pediatric Infectious Diseases and Immunology
Pontificia Universidad Católica de Chile
Santiago, Chile

Cesar Sanchez
Profesor asistente
Hematologia-oncologia
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
santiago, Chile

Francisco Acevedo
Medico Oncologo
Hemato Oncologia
Pontificia Universidad Católica de Chile
Santiago, Chile

Daniel Ernst
Profesor Asistente
Hematología y Oncología
Pontificia Universidad Católica de Chile
Santiago, Chile

Ismael Riquelme
Académico - Investigador
Ciencias de la Salud
UNIVERSIDAD AUTÓNOMA DE CHILE
Temuco, Chile

Francisco Aguayo
Profesor Asociado
Programa de Virología, Instituto de Ciencias Biomédicas (ICBM)
Universidad de Chile
Santiago, Chile

MAURICIO SARMIENTO
PROFESOR ASISTENTE
HEMATOLOGIA
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Miguel Cordova
Estudiando de Doctorado
Departamento de Posgrado
Universidad de Chile
Santiago, Chile

MARCO ARRESE
FULL PROFESSOR
GASTROENTEROLOGY
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Alexis Kalergis
Full Professor
Microbiología
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS
Santiago, Chile

Raquel Aguilera
PROFESOR ASISTENTE
INMUNOLOGÍA CLÍNICA Y REUMATOLOGÍA
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
SANTIAGO, Chile

Ignacio Retamal
Assistant Professor
Centro de Oncología de Precisión
Universidad Mayor de Chile
Santiago, Chile

Ricardo Armisen
Associate Professor
Centro de Genética y Genómica
Universidad del Desarrollo
Santiago, Chile

ERICK RIQUELME
ASSISTANT PROFESSOR
ENFERMEDADES RESPIRATORIAS
Pontificia Universidad Católica de Chile
SANTIAGO, Chile

Fabian Tempio
Asistente de Investigación
Instituto de Ciencias Biomédicas
Universidad de Chile
Santiago, Chile

FERNANDO CROVARI
Jefe Departamento
Cirugía Digestiva
Pontificia Universidad Católica de Chile
Santiago, Chile

fresia ferreccio
Full Professor, Director PhD Epidemiolgy Program
Public Health
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.
Santiago, Chile

Pablo Muñoz
Profesor Asociado
Hematología-Oncología
Pontificia Universidad Católica de Chile
Santiago, Chile

ALEJANDRO CORVALAN
Principal Investigator
Hematology and Oncology
Pontificia Universidad Catolica de Chile
Santiago, Chile

Carolina Ruiz
Medico Jefe UPC
Unidad de Paciente Crítico
Complejo Asistencial Sotero del Rio
Santiago, Chile

Gabriel Bastias
Profesor Asociado
Facultad de Medicina
Pontificia Universidad Católica de Chile
Santiago, Chile

Arnoldo Riquelme
Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)
Gastroenterología
Pontificia Universidad Católica de Chile
Santiago, Chile

Andrés Tittarelli
Profesor Asociado
Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)
Universidad Tecnológica Metropolitana
Santiago, Chile

jose valbuena
Associate Professor
Anatomic Pathology
PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA
santiago, Chile

Felipe Bellolio
Cirujano coloproctólogo, Profesor Asistente
Cirugía Digestiva
Pontificia Universidad Católica de Chile
Santiago, Chile

Sergio Vargas
Investigador
Hematología-Oncología
Pontificia Universidad Católica de Chile
Santiago, Chile

Diego Catalán
Associate Professor
Programa Disciplinario de Inmunología
Universidad de Chile
Santiago, Chile

Mercedes López
Profesora Asociada
Instituto de Ciencias Biomédicas
Universidad de chile
Santiago, Chile

Helena Poggi
Coordinadora de Investiagción
División de Pediatría
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Viviana Montecinos
Assistant Professor
Hematology Oncology
Pontificia Universidad Catolica de Chile
Santiago, Chile

Ana Guzman
MÉDICO JEFE LABORATORIO
LABORATORIO CLÍNICO
PONTIFICIA UNIVERSIDAD CATÓLICA
SANTAIGO, Chile

Lorena Salazar
Profesora Asistente
Instituto de Ciencias Biomédicas
Universidad Autónoma de Chile
Lampa, Chile

Arnoldo Riquelme
Profesor titular
Gastroenterología
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA
Santiago, Chile

Claudia Duran-Aniotz
Profesor Asociado
Escuela de Psicología
Universidad Adolfo Ibánez
Santiago, Chile

EVA BUSTAMANTE
JEFE DE COORDINACION CIENTIFICA
INVESTIGACION Y DOCENCIA
FUNDACION ARTURO LOPEZ PEREZ
Santiago, Chile