Man

Mauricio Arturo Pinto Paganini

Investigador

STORM SPA

Santiago, Chile

Líneas de Investigación


Gastric cancer, ovarian cancer, breast cancer; targeted therapies in cancer, 3D models; epithelial-stroma interactions

Educación

  •  Ciclo basico en ciencias biologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
  •  Doctorado en Ciencias Biologicas Mencion Ciencias Fisiologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005
  •  Biologo especializacion bioprocesos, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998

Experiencia Académica

  •   Profesor asistente Full Time

    UNIVERSIDAD ANDRES BELLO

    2014 - 2016

Experiencia Profesional

  •   Investigador postdoctoral/ postdoctoral fellow

    Universidad de Colorado

    Estados Unidos

    2005 - 2010

  •   Instructor of Medicine (faculty)

    Universidad de Colorado

    Estados Unidos

    2010 - 2013

  •   Investigador Full Time

    STORM SPA

    Santiago, Chile

    2017 - At present


 

Article (30)

Complete Response to Immunotherapy Plus Chemotherapy After an Unusual Clinical Response to Afatinib and Stereotactic Radiosurgery in a Patient With Metastatic EGFR-Mutant Non-Small-Cell Lung Cancer

Pizarro G.; Pinto, M. P.; Muñoz-Medel M.; Cordova-Delgado M.; Bravo, M. L.; Nervi B.; Sánchez C.; Ibañez C.; Peña J.; Walbaum B.; Madrid J.; Briones J.; Koch E.; Valbuena J.; Gonzalez S.; Gejman R.; Acevedo F.; Mondaca S.; Garrido M.; Vines E.; Galindo H.

Article ISI SCOPUS
Clinical Lung Cancer  (2020)

Cost-minimization analysis of subcutaneous versus intravenous trastuzumab administration in Chilean patients with HER2-positive early breast cancer

Rojas L.; Muñiz S.; Medina L.; Peña J.; Acevedo F.; Pinto, M. P.; Sanchez C.

Article ISI SCOPUS
PLOS ONE  (2020)

Eribulin-induced radiation recall dermatitis: a case report and brief review of the literature

Tran, Wiliam T.; Ibanez, Carolina; Pinto, Mauricio P.; Sanchez, Cesar; Czarnota, Gregory J.; Merino, Tomas

Article WOS-ESCI
ECANCERMEDICALSCIENCE  (2020)

First-line endocrine therapy for advanced breast cancer. A real-world study at a Latin American university health institution

Walbaum, Benjamin; Acevedo, Francisco; Medina, Lidia; Bravo, M. Loreto; Merino, Tomas; Camus, Mauricio; Dominguez, Francisco; Mondaca, Sebastian; Galindo, Hector; Nervi, Bruno; Ibanez, Carolina; Madrid, Jorge; Pena, Jose; Koch, Erica; Garrido, Marcelo; Pinto, Mauricio P.; Sanchez, Cesar

Article ISI
CURRENT MEDICAL RESEARCH AND OPINION  (2020)

Mammography correlates to better survival rates in breast cancer patients: a 20-year experience in a University health institution

Maiz, Cristobal; Silva, Fernando; Dominguez, Francisco; Galindo, Hector; Camus, Mauricio; Leon, Augusto; Oddo, David; Villarroel, Alejandra; Razmilic, Dravna; Navarro, Maria Elena; Medina, Lidia; Merino, Tomas; Vines, Eugenio; Pena, Jose; Maldonado, Daniela; Pinto, Mauricio P.; Acevedo, Francisco; Sanchez, Cesar

Article WOS-ESCI
ECANCERMEDICALSCIENCE  (2020)

Biliary tract cancer prognostic and predictive genomics

Mondaca S.; Nervi B.; Pinto M.; Abou-Alfa G.K.

Article WOS-ESCI SCOPUS
Chinese Clinical Oncology  (2019)

Chilean Registry for Neuroendocrine Tumors: A Latin American Perspective

Pinto, MP; Medel, MM; Carrillo, D; Retamal, IN; Bravo, ML; Valenzuela, Y; Nervi, B; Sanchez, C; Galindo, H; Ibanez, C; Pena J.; Balmaceda, C; Madrid J.; Briones, J; Torres, J; Nilo, F.; Guarda, FJ; Quintana, JC; Orellana, P; Mondaca, S; Acevedo, F; Vicentini, D; Cordova-Delgado, M; Owen, GI; Garrido, M

Article ISI SCOPUS
HORMONES & CANCER  (2019)

Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation

Arce, Maximiliano; Pinto, Mauricio P.; Galleguillos, Macarena; Munoz, Catalina; Lange, Soledad; RAMIREZ, CAROLINA; Erices, Rafaela; Gonzalez, Pamela; Velasquez, Ethel; Tempio, Fabian; Lopez, Mercedes N.; Salazar-Onfray, Flavio; Cautivo, Kelly; Kalergis, Alexis M; Cruz, Sebastian; LLadser, Alvaro; Lobos-Gonzalez, Lorena; Valenzuela, Guillermo; Olivares, Nixa; Saez, Claudia; Koning, Tania; Sanchez, Fabiola A.; Fuenzalida, Patricia; Godoy, Alejandro; Contreras Orellana, Pamela; Leyton, Lisette; Lugano, Roberta; Dimberg, Anna; Quest, Andrew F. G.; Owen, Gareth, I

Article ISI SCOPUS
CANCERS  (2019)

Fact or Fiction, It Is Time for a Verdict on Vasculogenic Mimicry?

Valdivia A.; Mingo G.; Aldana V.; Pinto, M. P.; Ramirez M.; Retamal C.; Gonzalez A.; Nualart F.; Corvalan A.H.; Owen, G. I.

Article ISI SCOPUS
FRONTIERS IN ONCOLOGY  (2019)

High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study

Cordova-Delgado, Miguel; Pinto, Mauricio P.; Retamal, Ignacio N.; Munoz-Medel, Matias; Loreto Bravo, Maria; Fernandez, Maria F.; Cisternas, Betzabe; Mondaca, Sebastian; Sanchez, Cesar; Galindo, Hector; Nervi, Bruno; Ibanez, Carolina; Acevedo, Francisco; Madrid, Jorge; Pena, Jose; Koch, Erica; Jose Maturana, Maria; Romero, Diego; de la Jara, Nathaly; Torres, Javiera; Espinoza, Manuel; Balmaceda, Carlos; Liao, Yuwei; Li, Zhiguang; Freire, Matias; Garate-Calderon, Valentina; Caceres, Javier; Sepulveda-Hermosilla, Gonzalo; Lizana, Rodrigo; Ramos, Liliana; Artigas, Rocio; Norero, Enrique; Crovari, Fernando; Armisen, Ricardo; Corvalan, Alejandro H.; Owen, Gareth, I; Garrido, Marcelo

Article ISI SCOPUS
CANCERS  (2019)

Patient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer

Pinto, M. P.; Balmaceda C.; Bravo, M. L.; Kato S.; Villarroel A.; Owen, G. I.; Roa, J.C; Cuello, M. A.; Ibañez C.

Article ISI SCOPUS
Gynecologic Oncology  (2018)

The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat

Lux S.; Lobos N.; Lespay-Rebolledo C.; Salas-Huenuleo E.; Kogan M.J.; Flores C.; Pinto M.; Hernandez A.; Pelissier T.; Constandil L.

Article ISI SCOPUS
JOURNAL OF PHARMACY AND PHARMACOLOGY  (2018)

Structural and functional identification of vasculogenic mimicry in vitro

Racordon, Dusan; Valdivia, Andrés; Mingo, Gabriel; Erices, Rafaela; Aravena, Raúl; Santoro, Felice; Bravo, Maria Loreto; Ramirez, Carolina; Gonzalez, Pamela; sandoval, alejandra; González, Alfonso; Retamal, Claudio; Kogan, Marcelo J.; Kato, Sumie; Cuello, Mauricio A.; Osorio, German; Nualart, Francisco; Alvares, Pedro; Gago-Arias, Araceli; Fabri, Daniella; Espinoza, Ignacio; Sanchez, Beatriz; Corvalán, Alejandro H.; Pinto, Mauricio P.; Owen, Gareth I.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2017)

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells

Pinto, Mauricio; SOTOMAYOR, PAULA; Carrasco-Avino, Gonzalo; Corvalan, Alejandro; Owen, Gareth

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2016)

Behavioral characterization of a model of differential susceptibility to obesity induced by standard and personalized cafeteria diet feeding

Gac, L; Kanaly, V; Ramírez V.; Teske, JA; Pinto, MP; Perez-Leighton, CE

Article ISI SCOPUS
Physiology and Behavior  (2015)

Independent Anti-Angiogenic Capacities of Coagulation Factors X and Xa

Lange, S., Aranda, E., Gonzalez, I., Valenzuela, R., Pinto, M., Elliot, M., Alvarez, M., Henríquez, S., Velasquez, E.V., Orge, F., Oliva, B., Gonzalez., P., Villalón, M., Cautivo, K.M., Kalergis, A.M., Pereira, K., Mendoza, C., Sáez., Kato, S., Cuello, M.

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2014)

Luminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cells

Ogba, N; Manning, NG; Bliesner, BS; Ambler, SK; Haughian, JM; Pinto, MP; Jedlicka P.; Joensuu, K; Heikkila, P; Horwitz, KB

Article ISI
BREAST CANCER RESEARCH  (2014)

Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling

Pinto, MP; Dye, WW; Jacobsen BM; Horwitz, KB

Article ISI SCOPUS
BMC CANCER  (2014)

Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease

Knox, AJ; Scaling, AL; Pinto, MP; Bliesner, BS; Haughian, JM; Abdel-Hafiz, HA; Horwitz, KB

Article ISI SCOPUS
BREAST CANCER RESEARCH  (2014)

Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor

Bravo, M. L.; Pinto, M. P.; Gonzalez, I; Oliva, B.; Kato, S; Cuello, M. A.; Lange C.A.; Owen, G. I.

Article ISI SCOPUS
Endocrine  (2014)

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

Haughian, JM; Pinto, MP; Harrell, JC; Bliesner, BS; Joensuu, KM; Dye, WW; Sartorius, CA; Tan, AC; Heikkila, P; Perou, CM; Horwitz, KB

Article ISI
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  (2012)

Vascular Endothelial Growth Factor Secreted by Activated Stroma Enhances Angiogenesis and Hormone-Independent Growth of Estrogen Receptor-Positive Breast Cancer

Pinto, MP; Badtke, MM; Dudevoir, ML; Harrell, JC; Jacobsen BM; Horwitz, KB

Article ISI
CANCER RESEARCH  (2010)

Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75

Meneses, AM; Medina RA.; Kato, S; Pint M.; Jaque, MP; Lizama I; Garcia, MDLA; Nualart, F.; Owen, GI

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2008)

Estrogen insensitivity in a model of estrogen receptor-positive breast cancer lymph node metastasis

Harrell, Joshua Chuck; Dye, Wendy W.; Harvell, Djuana M. E.; Pinto, Mauricio; Jedlicka, Paul; Sartorius, Carol A.; Horwitz, Kathryn B.

Article ISI
CANCER RESEARCH  (2007)

In vivo and in vitro estrogenic and progestagenic actions of Tibolone

Sadarangani, A; Salgado, AN; Kato, S; Pinto, M; Carvajal, A; Monso, C; Owen, GI; Vigil, P

Article ISI
BIOLOGICAL RESEARCH  (2005)

Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1

Kato, S; Pinto, M; Carvajal A.; Espinoza, N; Monso, C; Sadarangani, A; Villalón M.; Brosens, JJ; White, JO; Richer, JK; Horwitz, KB; Owen, GI

Article ISI SCOPUS
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM  (2005)

Progesterone pre-treatment potentiates EGF pathway signaling in the breast cancer cell line ZR-75

Carvajal A.; Espinoza, N; Kato, S; Pinto, M; Sadarangani, A; Monso, C; Aranda, E; Villalón M.; Richer, JK; Horwitz, KB; Brosens, JJ; Owen, GI

Article ISI SCOPUS
BREAST CANCER RESEARCH AND TREATMENT  (2005)

Tissue factor is regulated by epidermal growth factor in normal and malignant human endometrial epithelial cells

Kato, S; Pinto, M; Carvajal A.; Espinoza, N; Monso, C; Bravo, L; Villalón M.; Cuello, M.; Quest, AF; Suenaga, A; Brosens, JJ; Owen, GI

Article ISI SCOPUS
THROMBOSIS AND HAEMOSTASIS  (2005)

Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells

Medina RA.; Meneses, AM; Vera, JC; Guzmán C; Nualart, F.; Rodriguez,F; Garcia, MD; Kato, S; Espinoza, N; Monso, C; Carvajal A.; Pinto, M; Owen, GI

Article ISI SCOPUS
JOURNAL OF ENDOCRINOLOGY  (2004)

Estrogen and progesterone up-regulate glucose transporter expression in ZR-75-1 human breast cancer cells

Medina RA.; Meneses, AM; Vera, JC; Guzmán C; Nualart, F.; Astuya A.; Garcia, MD; Kato, S; Carvajal A.; Pinto, M; Owen, GI

Article ISI SCOPUS
ENDOCRINOLOGY  (2003)

Proyecto (5)

Systematically evaluation of the mechanistic synergism between MAPK kinase inhibitor with clinically approved cytotoxic agents

FONDECYT (1161438)

Proyecto
2016-2019
Coinvestigador(a)

Modulation of the process of angiogenesis by Factor X

FONDECYT (1140970)

Proyecto
2014-2018
Personal técnico y/o de apoyo

Desarrollo de in kit diagnostico, o servicio, para predecir la respuesta y toxicidad de los tratamientos de quimioterapia en cada paciente

CORFO (#13IDL2-18608 Linea 2)

Proyecto
2013-2016
Personal técnico y/o de apoyo

Effect of statins in the maintenance, differentiation and drug sensitivity of cancer-initiating cells in ovarian cancer

FONDECYT (1120292)

Proyecto
2012-2016
Personal técnico y/o de apoyo

DEVELOPMENT OF AN ER-POSITIVE BREAST CANCER METASTASIS MODEL THROUGH STROMAL-EPITHELIAL INTERACTIONS

Susan G Komen Foundation (Race for the cure) (PDF0706748)

Proyecto
2007-2009
Inv. Principal

Review (3)

Angiogenesis inhibitors in early development for gastric cancer

Pinto M.P.; Owen G.I.; Retamal I.; Garrido M.

Review ISI SCOPUS
EXPERT OPINION ON INVESTIGATIONAL DRUGS  (2017)

Targeted brain delivery nanoparticles for malignant gliomas

Pinto M.P.; Arce M.; Yameen B.; Vilos C.

Review ISI SCOPUS
NANOMEDICINE  (2017)

2-Methoxyestradiol and Disorders of Female Reproductive Tissues

Pinto, MP; Medina RA.; Owen, GI

Review ISI SCOPUS
HORMONES & CANCER  (2014)

33
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

16
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

9
Andres Carvajal

Investigador

INIA

Osorno, Chile

6
Cesar Sanchez

Profesor asistente

Hematologia-oncologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

santiago, Chile

6
Francisco Acevedo

Medico Oncologo

Hemato Oncologia

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

4
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

3
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

3
Ana Meneses

Académico

Universidad Diego Portales

Santiago, Chile

3
Anil Sadarangani

Director de Innovacion

Innovacion

Universidad de Los Andes

santiago, Chile

3
Ignacio Retamal

Assistant Professor

Centro de Oncología de Precisión

Universidad Mayor de Chile

Santiago, Chile

3
Matías Muñoz

Research Assistant

Universidad Mayor de Chile

Santiago, Chile

2
Allisson Astuya

profesor asociado

Departamento de Oceanografia de la Universidad de Concepción

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
ALEJANDRO CORVALAN

Principal Investigator

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Erica Koch

Oncólogo Médico

Red de Salud UC Christus

Santiago, Chile

2
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

2
Ethel Velásquez

Directora (t) Centro de Investigaciones Nucleares para Aplicaciones en Salud y Biomedicina

Comisión Chilena de Energía Nuclear

Santiago, Chile

2
María Villarroel

Médico Anátomo-Patólogo

Anatomía Patológica

Red de Salud UC Christus / Pontificia Universidad Católica de Chile

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Edison Salas

Director de laboratorio de nanotecnología

Aintech

Santiago, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

1
María Maturana

Bioquimico

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

1
Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Ignacio Espinoza

Profesor Asociado

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Luis Constandil

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Cristian Vilos

Académico Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Gago

Profesor Asistente

Facultad de Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Rafaela Erices

Postdoctorante

Ginecología y Obstetricia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
mauricio cuello

1
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
FERNANDO CROVARI

Jefe Departamento

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Verónica Palma

Associate Professor

Biology

Universidad de Chile

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
jose valbuena

Associate Professor

Anatomic Pathology

PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

santiago, Chile

1
German Osorio

Especialista en Microscopia

Biologia Celular

Universidad de Concepción

Concepción, Chile

1
Isabel Lizama