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Fabiola Alejandra Sánchez Vásquez

Associate Profesor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Inflammation, endothelial cell biology, S-nitrosylation

Molecular and Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1996

Associate Profesor Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Chile

2014 - At present
Assistant Profesor Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Chile

2009 - 2014

Research Associate Other

University of Medicine and Dentistry of New Jersey

Estados Unidos

2007 - 2008

THESIS DIRECTION (Tutor):

Finished Under-graduate:
-Roshniben J. Rana. Functional significance of cytosol, plasma membrane and Golgi-targeted endothelial nitric oxide synthase in ECV-304 cells. Master in Sciences. Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey. 2009.

-Rodrigo Carrasco. Modifications mediated by nitric oxide in proteins from the adherens junction during the increase in microvascular permeability. UACh. Biochemist. 2011.

-Natalie Marín. Nitric oxide modifies ß-Catenin and VASP through S-nitrosation dependen ton te subcellular location of eNOS. UACh. Medical Technician. 2012.

-Anita Guequén A. ''Rol del óxido nítrico sobre permeabilidad microvascular mediada por interleuquina 8''. BIOQUÍMICA. Universidad Austral de Chile. 2013.

-Francisco Córdova. Modificaciones en ELAM-1 e ICAM-1 por agonistas proinflamatorios que estimulan la producción de Óxido Nítrico en el comienzo de la respuesta inflamatoria. UACh. Medical Technician.

-Lorena Rebolledo. ROL DE LA S-NITROSILACIÓN DE VE-CADERINA EN EL CONTEXTO DE LA PERMEABILIDAD MICROVASCULAR ASOCIADA A CÁNCER DE MAMA” UACh. Medical Technician.

-Nicolás Nahuel. Mechanisms of regulation of VE-cadherin by S-nitrosylation. UACh. Medical Technician. 2018

-Tania Koning. Rol de la s-nitrosilación de VCAM-1 sobre la adhesión de leucocitos inducido por IL-8 y medio condicionado de células de cáncer de mama MDA-MB- 231.UACh. Biochemist. 2018

Finished Gaduate:
-Alejandra Aguilar. Mechanisms of regulation of ICAM-1 involved eNOS activation at the onset of the inflammatory response. Doctorate Program in Veterinary Sciences. 2019

In course Graduate:
-Patricia Zamorano. Galectin-8 induces increase in endothelial permeability through eNOs-S-nitrosylation signalling.
- Tania Koning. VCAM-1 Y S-NITROSILACIÓN DE PROTEÍNAS EN LA METÁSTASIS PULMONAR DE CÁNCER DE MAMA EN UN MODELO MURINO

THESIS DIRECTION (Co-Tutor):

2013. Andrade Y. ''Efecto de la Activación del Receptor b1 de Cininas vía Transactivación del EGFR en la Fosforilación de MAPKs, JNK, p38, Akt y mTOR en Células de Cáncer de Mama''. TECNOLOGÍA MÉDICA. Universidad Austral de Chile.

In course:
Beatriz Teuber. El RB1 modula los niveles de expresión de UPA y COX-2 en células de cáncer de mama. Master in Phatology. UACh.

2018. Organización 3rd International Symposium Cancer and Inflammation: from cell biology to therapy. Universidad Austral de Chile, Campus Isla Teja, Valdivia, Chile.
2017. Organización Curso sobre cuidado y uso de roedores de laboratorio, Valdivia,
2015. Organización 2nd International Symposium on Cancer and Inflammation: from adherens junctions to disease. CHILE, Valdivia.
2013. Organización International Symposium: Cancer and Inflammation: From Adherens Junctions to Disease. Valdivia, Chile.

August Krogh Postdoctoral Fellow Award

The Microcirculatory Society

Estados Unidos, 2008

Award to Post-Doctoral work
Recognition Award for Meritorious Research by a Young Investigator

The American Physiological Society, Cardiovascular Section

Chile, 2007

Award to young investigators


Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation Arce, Maximiliano; Pinto, Mauricio P.; Galleguillos, Macarena; Munoz, Catalina; Lange, Soledad; RAMIREZ, CAROLINA; Erices, Rafaela; Gonzalez, Pamela; Velasquez, Ethel; Tempio, Fabian; Lopez, Mercedes N.; Salazar-Onfray, Flavio; Cautivo, Kelly; Kalergis, Alexis M; Cruz, Sebastian; LLadser, Alvaro; Lobos-Gonzalez, Lorena; Valenzuela, Guillermo; Olivares, Nixa; Saez, Claudia; Koning, Tania; Sanchez, Fabiola A.; Fuenzalida, Patricia; Godoy, Alejandro; Contreras Orellana, Pamela; Leyton, Lisette; Lugano, Roberta; Dimberg, Anna; Quest, Andrew F. G.; Owen, Gareth, I Article ISI SCOPUS CANCERS (2019)
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A(3) Adenosine Receptor activation under hypoxia Torres, Angelo; Ignacio Erices, Jose; Sanchez, Fabiola; Ehrenfeld, Pamela; Turchi, Laurent; Virolle, Thierry; Uribe, Daniel; Niechi, Ignacio; Spichiger, Carlos; Dellis Rocha, Jose; Ramirez, Marcos; Salazar-Onfray, Flavio; San Martin, Rody; Quezada, Claudia Article ISI SCOPUS CANCER LETTERS (2019)
Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly Zamorano P, Koning T, Oyanadel C, Mardones GA, Ehrenfeld P, Boric MP, González A, Soza A, Sánchez FA. Article ISI SCOPUS CARCINOGENESIS (2019)
Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells GuequÃ©n A.; Zamorano P.; CÃ³rdova F.; Koning T.; Torres A.; Ehrenfeld P.; Boric M.P.; Salazar-Onfray F.; Gavard J.; DurÃ¡n W.N.; Quezada C.; Sarmiento J.; SÃ¡nchez F.A. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)
S-nitrosylation and its role in breast cancer angiogenesis and metastasis. Ehrenfeld P, Cordova F, Duran WN, Sanchez FA. Article Nitric Oxide (2019)
Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms Korayem, Adam H.; Mujica, Patricio E.; Aramoto, Haruo; Durán, Ricardo G.; Nepali, Prerna R.; Kim, David D.; Harris, Andrew L.; Sánchez, Fabiola A.; Durán, Walter N. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)
S-nitrosylation of VASP at cysteine 64 mediates the inflammation-stimulated increase in microvascular permeability Zamorano, Patricia; Marín, Natalie; Córdova, Francisco; Aguilar, Alejandra; Meininger, Cynthia; Boric, Mauricio P.; Golenhofen, Nikola; Contreras, Jorge E.; Sarmiento, José; Durán, Walter N.; Sánchez, Fabiola A. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)
New Member of Endothelial Arsenal Against Inflammation Durán WN, Sánchez FA. Article Circ Res (2016)
S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability Guequen, A; Carrasco, R; Zamorano, P; Rebolledo, L; Burboa, P; Sarmiento, j; Boric, MP; Korayem, A; Duran, WN; Sanchez, FA Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)
S-nitrosation of proteins: An emergent regulatory mechanism in microvascular permeability and vascular function Sánchez, Fabiola A.; Ehrenfeld, Ingrid P.; Durán, Walter N. Article Tissue Barriers (2013)
S-Nitrosation of beta-Catenin and p120 Catenin A Novel Regulatory Mechanism in Endothelial Hyperpermeability Marin, N.; Zamorano P.; Carrasco, R.; Mujica, P.; Gonzalez F.G.; Quezada C.; Meininger, C. J.; Boric M.P.; Duran W.N.; Sanchez F.A. Article ISI SCOPUS Circulation Research (2012)
Functional Significance of Cytosolic Endothelial Nitric-oxide Synthase (eNOS) REGULATION OF HYPERPERMEABILITY Sanchez FA; Rana, R; Gonzalez, FG; Iwahashi, T; Duran, RG; Fulton, DJ; Beuve, AV; Kim, DD; Duran, WN Article ISI SCOPUS Journal of Biological Chemistry (2011)
Independent Regulation of Periarteriolar and Perivenular Nitric Oxide Mechanisms in the In Vivo Hamster Cheek Pouch Microvasculature Kim, DD; Kanetaka, T; Duran, RG; Sanchez FA; Bohlen, HG; Duran, WN Article ISI SCOPUS Microcirculation (2009)
Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability Sanchez FA; Rana, R; Kim, DD; Iwahashi, T; Zheng, RF; Lal, BK; Gordon, DM; Meininger, CJ; Duran, WN Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules Sanchez F.A.; Kim, D. D.; Duran, R. G.; Meininger, C. J.; Duran W.N. Article American Journal of Physiology-Heart and Circulatory Physiology (2008)
Endothelial nitric oxide synthase is a molecular vascular target for the Chinese herb Danshen in hypertension Kim, D. D.; Sanchez F.A.; Duran, R. G.; Kanetaka, T; Duran W.N. Article American Journal of Physiology-Heart and Circulatory Physiology (2007)
. Endothelial nitric oxide synthase-derived NO signals regulate microvascular permeability Durán WN, Hatakeyama T, Sánchez FA Article The Physiological Society ISSN 1476-7996 (Print) ISSN 2041-6512 (Online) Physiology News (2006)
Functional significance of differential eNOS translocation Sanchez FA; Savalia, NB; Duran, RG; Lal, BK; Boric, MP; Duran, WN Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)
Evaluation of the internalization process of the fish pathogen Renibacterium salmoninarum in cultured fish cells Gonzalez, M.; Sanchez, F; Concha M.I.; Figueroa J.; León G.; Montecinos M.I. Article JOURNAL OF FISH DISEASES (1999)


S-nitrosylation of beta-catenin and p-120 catenin: a novel regulatory mechanism in endothelial hyperpermeability. Zamorano P.; Marin, N.; Carrasco, R.; Boric, M.; Duran, WN; Sanchez FA Abstract ISI FASEB JOURNAL (2012)
Platelet activating factor (PAF) induces s-nitrosylation of signalling proteins in an endothelial cell line Gonzalez, FG; Sanchez FA; Velarde, V; Boric, MP; Duran, WN Abstract ISI FASEB JOURNAL (2010)
Inhibition of eNOS internalization dissociates PAF-induced Sanchez FA; Rana, R; Kim, DD; Iwahashi, T; Duran, WN Abstract ISI FASEB JOURNAL (2009)
Opioid receptor are apically segregated in transfected MDCK cells Sanchez FA; Soza, AM; González A Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2002)


Unveiling the functional role, signaling and biomarker utility of KLK4 and KLK12 in breast cancer Pamela Ehrenfeld; Fabiola Sánchez Proyecto (2020)
Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process Sánchez, Fabiola A. Proyecto (2017)
Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process FONDECYT (1130769) Proyecto 2013-2017 Inv. Responsable
eNOS-derived NO signaling mechanisms in the regulation of endothelial paracellular permeability FONDECYT (1100569) Proyecto 2010-2013 Inv. Responsable
eNOS-derived NO signaling mechanisms in the regulation of endothelial paracellular permeability Fabiola Sánchez Proyecto (0)
Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process. Fabiola Sánchez Proyecto (0)


S-nitrosylation and its role in breast cancer angiogenesis and metastasis Ehrenfeld P.; Cordova F.; Duran W.N.; Sanchez F.A. Review ISI SCOPUS Nitric Oxide (2019)
Nitric Oxide, S-Nitrosation, and Endothelial Permeability Duran, WN; Beuve, AV; Sanchez FA Review ISI SCOPUS IUBMB Life (2013)
The NO cascade, eNOS location, and microvascular permeability Duran, WN; Breslin, JW; Sanchez FA Review ISI SCOPUS Cardiovascular Research (2010)
MECHANISMS OF ACUPUNCTURE AND HERBAL MEDICINE IN HYPERTENSION Kimelman, David; Sanchez, Fabiola; Boric, Mauricio; Duran, Walter Review ASIAN BIOMEDICINE (2008)

Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

Anita Guequen

Asistente de investigación

Biología

Centro Estudios Científicos (CECs)

Valdivia, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Ethel Velásquez

Directora (t) Centro de Investigaciones Nucleares para Aplicaciones en Salud y Biomedicina

Comisión Chilena de Energía Nuclear

Santiago, Chile

Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

José Rocha

Postdoctoral Researcher

Facultad de Veterinaria

Universidad San Sebastián

Puerto Montt, Chile

GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

Fabiola Alejandra Sánchez Vásquez

Líneas de Investigación

Educación

Molecular and Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004

Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1996

Experiencia Académica

Associate Profesor Full Time

Assistant Profesor Full Time

Experiencia Profesional

Research Associate Other

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

August Krogh Postdoctoral Fellow Award

Recognition Award for Meritorious Research by a Young Investigator

Article (19)

Abstract (4)

Proyecto (6)

Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process

eNOS-derived NO signaling mechanisms in the regulation of endothelial paracellular permeability

Review (4)