Man

Ángelo Sebastián Torres Arévalo

Postdoctorado/Profesor Adjunto

Universidad Austral de Chile

Valdivia, Chile

Líneas de Investigación


En los últimos años me he centrado en dos líneas de investigación en biomedicina, siendo estas: mecanismos de fibrosis renal durante la nefropatía diabética; y estudios de resistencia múltiple a drogas e invasión celular en el cáncer.

Educación

  •  Ciencias Veterinarias, UNIVERSIDAD DE CONCEPCION. Chile, 2010
  •  Ciencias Veterinarias, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2017

Experiencia Académica

  •   Docente adjunto Part Time

    UNIVERSIDAD SAN SEBASTIAN

    Ciencias para el cuidado de la salud

    Valdivia, Chile

    2017 - At present

  •   Profesor Adjunto Part Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Ciencias

    Valdivia, Chile

    2017 - At present

  •   Postdoctorado Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Ciencias

    Valdivia, Chile

    2018 - At present

Experiencia Profesional

  •   Docente Adjunto Part Time

    Universidad San Sebastián

    Valdivia, Chile

    2017 - At present

  •   Profesor Adjunto Part Time

    Universidad Austral de Chile

    Valdivia, Chile

    2017 - At present

  •   Postdoctorado Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2018 - At present

  •   Profesor de Biologia Part Time

    Preuniversitario CPECH

    Valdivia, Chile

    2012 - 2017

Premios y Distinciones

  •   Distinción por Mejor desempeño académico en pregrado

    UNIVERSIDAD DE CONCEPCION

    Chile, 2010

    Premio para estudios de postgrado en honor al Mejor desempeño académico en pregrado en la Facultad de Ciencias Veterinarias de la Universidad de Concepción, sede Chillán.

  •   Mejor Presentación Oral

    SOCIEDAD DE BIOQUIMICA DE CHILE

    Chile, 2015

    Mejor Presentación Oral en la XXXVIII Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, Puerto Varas, Chile 22 al 25 de septiembre, 2015 Presentación: Adenosine receptors control the migration and invasion capabilities of glioblastoma multiforme cells.


 

Article (14)

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A(2B) Adenosine Receptor

Torres, Angelo; Munoz, Katherin; Nahuelpan, Yessica; Saez, Angelo-Paolo R.; Mendoza, Pablo; Jara, Claudia; Cappelli, Claudio; Suarez, Raibel; Oyarzun, Carlos; Quezada, Claudia; San Martin, Rody

Article ISI
CELLS  (2020)

The TGF-β profibrotic cascade targets ecto-5′-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease

Cappelli, Claudio; Tellez, Analia; Jara, Claudia; Alarcón, Sebastián; Torres, Angelo; Mendoza, Pablo; Podestá, Loreto; Flores, Claudio; Quezada, Claudia; Oyarzún, Carlos; San Martín, Rody

Article
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease  (2020)

Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness

Niechi, I; Uribe-Ojeda, A; Erices, JI; Torres, A; Uribe, D; Rocha, JD; Silva, P; Richter, HG; San Martin, R; Quezada, C

Article ISI
CELLS  (2019)

Blockade of the Adenosine A(3) Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1 beta and IL-18 in Diabetic Rats

Garrido, W; Jara C.; Torres A.; Suarez R.; Cappelli C.; Oyarzún C.; Quezada C.; Martín R.S.

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2019)

Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A(3) Adenosine Receptor activation under hypoxia

Torres, Angelo; Ignacio Erices, Jose; Sanchez, Fabiola; Ehrenfeld, Pamela; Turchi, Laurent; Virolle, Thierry; Uribe, Daniel; Niechi, Ignacio; Spichiger, Carlos; Dellis Rocha, Jose; Ramirez, Marcos; Salazar-Onfray, Flavio; San Martin, Rody; Quezada, Claudia

Article ISI SCOPUS
CANCER LETTERS  (2019)

Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells

Guequén A.; Zamorano P.; Córdova F.; Koning T.; Torres A.; Ehrenfeld P.; Boric M.P.; Salazar-Onfray F.; Gavard J.; Durán W.N.; Quezada C.; Sarmiento J.; Sánchez F.A.

Article ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2019)

Current natural therapies in the treatment against glioblastoma

Ignacio Erices, Jose; Torres, Angelo; Niechi, Ignacio; Bernales, Isabel; Quezada, Claudia

Article ISI SCOPUS
PHYTOTHERAPY RESEARCH  (2018)

FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells.

Torres, Angelo; Arriagada, Valentina; Erices, Jose Ignacio; Toro, María de los Angeles; Rocha, Jose Dellis; Niechi, Ignacio; Carrasco, Cristian; Oyarzún, Carlos; Quezada, Claudia

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2018)

The Adenosine A(3) Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia

Rocha, R; Torres, A; Ojeda, K; Uribe, D; ROCHA, D.; Erices, J; Niechi, I; Ehrenfeld, P; San Martin, R; Quezada, C

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2018)

Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme

Monrás, Claudia; Martín, Rody; Muñoz, Sebastián; Niechi, Ignacio; Howden, Jake; Uribe, Daniel; Erices, José; Arévalo, Ángelo

Article ISI SCOPUS
Current Medicinal Chemistry  (2017)

Multidrug resistance in glioblastoma stem-like cells: Role of the hypoxic microenvironment and adenosine signaling

Uribe, Daniel; Torres, Ángelo; Rocha, José Dellis; Niechi, Ignacio; Oyarzún, Carlos; Sobrevia, Luis; San Martín, Rody; Quezada, Claudia

Article ISI SCOPUS
MOLECULAR ASPECTS OF MEDICINE  (2017)

Adenosine A(3) receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells

Torres, Angelo; Vargas, Yosselyn; Uribe, Daniel; Jaramillo, Catherine; Gleisner, Alejandra; Salazar-Onfray, Flavio; López, Mercedes N.; Melo, Rómulo; Oyarzún, Carlos; San Martín, Rody; Quezada, Claudia

Article ISI SCOPUS
ONCOTARGET  (2016)

Pro-apoptotic and anti-angiogenic properties of the alpha /beta-thujone fraction from Thuja occidentalis on glioblastoma cells

Torres A.; Vargas, Y; Uribe, D; Carrasco C.; Torres C.; Rocha, R; Oyarzún C.; San Martín R.; Quezada C.

Article ISI SCOPUS
JOURNAL OF NEURO-ONCOLOGY  (2016)

Combined use of platelet rich plasma and vitamin C positively affects differentiation in vitro to mesodermal lineage of adult adipose equine mesenchymal stem cells

Castro, FO; Torres A.; Cabezas J.; Rodriguez-Alvarez, LL

Article ISI
RESEARCH IN VETERINARY SCIENCE  (2014)

ConferencePoster (15)

Adenosine receptor antagonism prevents diabetes-induced podocyte retraction by regulating cytoskeletal remodelling

Mendoza, Pablo Alexis; Torres, Angelo; San Martin, Rody Enrique

ConferencePoster
 (2019)

Blockade of Adenosine A2B Receptor attenuates diabetic glomerulosclerosis by inhibiting Macrophage-Myofibroblast Transition.

Torres, Angelo; Rody San Martin

ConferencePoster
 (2019)

Blockage of Adenosine A 2B Receptor decreases infiltration and myofibroblastic-transition of Macrophage in Diabetic Glomerulosclerosis.

Torres, Angelo; San Martin, Rody

ConferencePoster
 (2018)

A2B and A3 Adenosine Receptors control the Glioblastoma Stem-like Cells differentiation to Vascular Endothelial Cells under hypoxia.

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2016)

Adenosine A3 Receptor Elicits Chemoresistance Mediated by the Multiple Resistance-associated Protein-1 in Human Glioblastoma Stem-like Cells.

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2016)

Adenosine axis regulates the Epithelial-Mesenchymal Transition and cell migration/invasion of Glioblastoma Stem-like Cells through the activation of Low-Affinity Adenosine Receptors under hypoxia.

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2016)

Adenosine Generated by Ectonucleotidases of Glioblastoma-Initiating Cells Controls the cell migration/invasion of Glioma cells through the activation of Low-Affinity Adenosine Receptors under Hypoxia

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2016)

Adenosine promotes chemoresistance by regulating MRP1 and MRP3 expression in normoxia and hypoxia conditions

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2016)

Fosfatasa Acida Prostática promueve la migración/ invasión en Gliomas Stem-Like Cells a través de la activación de sus receptores de adenosina de baja afinidad bajo condiciones de hipoxia

Torres, Angelo; Quezada, Claudia A.

ConferencePoster
 (2016)

Prostatic Acid Phosphatase promotes epithelial-mesenchymal transtion and cell migration in Glioblastoma stem-like cells through low affinity adenosine receptor activation under hypoxia

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2016)

Reversion of glioblastoma stem-like cells chemoresistance by adenosine A3 receptor blockage

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2015)

Study of tacrolimus on chemosensitization of the glioblastoma stem like cells

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2015)

The hypoxia inducible factor-axis controls the adenosine survival in glioblastoma multiforme

Torres, Angelo

ConferencePoster
 (2015)

. Blockade of adenosine signaling reverses chemoresistance and growth of glioblastoma.

Torres, Angelo; San Martin, Rody

ConferencePoster
 (2014)

Effect of hypoxia on MDR in glioblastoma stem-like cells

Torres, Angelo; Quezada, Claudia

ConferencePoster
 (2014)

Proyecto (5)

Rol del receptor de adenosina A2B en la capacidad de infiltración y diferenciación miofibroblástica de monocitos/macrófagos en la glomeruloesclerosis diabética

Torres, Angelo

Proyecto
 (2018)

Beca MECESUP AUS 1203- UACh

Torres, Angelo

Proyecto
 (2015)

Beca VIDCA- UACh

Torres, Ange

Proyecto
 (2015)

Beca Instituto Curie

Torres, Angelo

Proyecto
 (2014)

Role of A3 adenosine receptor as a mediator of the chemoresistant and invasive properties of glioblastoma stem-like cells

Torres, Angelo

Proyecto
 (2013)

Review (1)

Role of extracellular vesicles in glioma progression

Quezada, C; Torres, A; Niechi, I; Uribe, D; Contreras-Duarte, S; Toledo, F; San Martin, R; Gutierrez, J; Sobrevia, L

Review ISI SCOPUS
MOLECULAR ASPECTS OF MEDICINE  (2018)

35
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

6
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

5
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

5
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

5
José Rocha

Postdoctoral Researcher

Facultad de Veterinaria

Universidad San Sebastián

Puerto Montt, Chile

3
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

2
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2
Cristián Carrasco

Director

Anatomía Patológica

HOSPITAL BASE VALDIVIA

Valdivia, Chile

2
CLAUDIA JARA

Asistente de Investigación

Universidad Austral de Chile

valdivia, Chile

2
INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2
Claudio Cappelli

Technical Laboratory Manager

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

2
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Catherinne Jaramillo

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

1
Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Joel Cabezas

Ph.D. in Veterinary Sciences

Ciencia Animal

Universidad de Concepción

Chillan , Chile

1
Romulo Melo

Neurosurgeon

Department of Neurosurgery

Instituto de Neurocirugía Dr. Asenjo

Santiago, Chile

1
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Anita Guequen

Asistente de investigación

Biología

Centro Estudios Científicos (CECs)

Valdivia, Chile

1
Pamela Silva

Lab Manager

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Carlos Oyarzún

Profesor Adjunto Asociado

Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Yessica Nahuelpán

Asistente de Investigación

Instituto de bioquímica y microbiología

Universidad Austral de Chile

Valdivia, Chile

1
FIDEL CASTRO

DIRECTOR LABORATORIO

FACULTAD DE CIENCIAS VETERINARIAS

UNIVERSIDAD DE CONCEPCIÓN

Chillan, Chile