Man

Susana de las Mercedes Contreras Duarte

Assistant Professor

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Metabolismo lipídico; Antioxidantes sobre el metabolismo del colesterol y aterosclerosis; diabetes gestacional, dislipidemias , obesidad, postparto y embarazo, leche materna, glándula mamaria. Descendencia

Educación

  •  Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2016
  •  Licenciado en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

Experiencia Académica

  •   PhD student (ANID) Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    2012 - 2016

  •   Postdoctor (ANID) Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    2018 - 2021

  •   Assistant Professor Full Time

    Universidad San Sebastián

    Health Care Sciences

    Santiago, Chile

    2021 - At present

Experiencia Profesional

  •   Research assistant Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2010 - 2011

  •   Research assistant Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2008 - 2009

  •   Research assistant Other

    Universidad de Chile

    Santiago, Chile

    2009 - 2009

  •   Postdoctor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2017 - 2017

Premios y Distinciones

  •   Extension PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2016

    6 month extension PhD funding

  •   PhD Fellowship 2012-2016

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Funding for the development of the Medical Science PhD program

  •   Internship PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2015

    Funding to develop one goal of the PhD thesis abroad (Austria)

  •   Congresses and short courses abroad PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Attendance to Lyon, to the European Atherosclerosis Society congress


 

Article (26)

Small extracellular vesicles from pregnant women with maternal supraphysiological hypercholesterolemia impair endothelial cell function in vitro

Valdivia, Pascuala; Zapata, David; CERDA, ALVARO

Article ISI
VASCULAR PHARMACOLOGY  (2023)

High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies



Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2021)

Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia

Kallol S.; Pastén V.; Albrecht C.

Article ISI SCOPUS
Scientific Reports  (2020)

Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function



Article ISI SCOPUS
NUTRIENTS  (2020)

Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage

Labra, Valeria C.; Velarde, Victoria; Orellana, Juan A.

Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2020)

Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice

Chen, P.; Uribe, S.; Kopp, S.; Kern, S.; Marsche, G.; Busso, D.; Wadsack, C.; Rigotti A.

Article ISI SCIELO SCOPUS
BIOLOGICAL RESEARCH  (2018)

Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function

Labra, Valeria C.; Santibañez, Cristian A.; Gajardo-Gómez, Rosario; Avendaño, Beatriz C.; Díaz, Esteban F.; Montero, Trinidad D.; Velarde, Victoria; Orellana, Juan A.

Article ISI SCOPUS
FRONTIERS IN IMMUNOLOGY  (2018)

Foetoplacental epigenetic changes associated with maternal metabolic dysfunction

Kerr, Bredford; Leiva, Andrea; Toledo, Fernando; Stolzenbach, Francisca; Silva, Luis; Sobrevia, Luis

Article ISI SCOPUS
PLACENTA  (2018)

Foetoplacental epigenetic changes associated with maternal metabolic dysfunction.

Kerr, Bredford; Leiva, Andrea; Farías, Marcelo; Contreras-Duarte, Susana; Toledo, Fernando; Stolzenbach, Francisca; Silva, Luis; Sobrevia, Luis

Article
Placenta  (2018)

High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation

Birner-Gruenberger, Ruth; Wadsack, Christian; Rigotti, Attilio

Article ISI SCOPUS
JOURNAL OF TRANSLATIONAL MEDICINE  (2018)

Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature

Fuenzalida, B

Article ISI SCOPUS
Scientific Reports  (2018)

Role of extracellular vesicles in glioma progression.

Quezada, Claudia; Torres, Ángelo; Niechi, Ignacio; Uribe, Daniel; Contreras-Duarte, Susana; Toledo, Fernando; San Martín, Rody; Gutiérrez, Jaime; Sobrevia, Luis

Article
Molecular aspects of medicine  (2018)

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

Cantin, C.

Article ISI SCOPUS
MOLECULAR ASPECTS OF MEDICINE  (2017)

Adenosine receptors=> Modulators of lipid availability that are controlled by lipid levels

Leiva, Andrea; Guzmán-Gutiérrez, Enrique; Contreras-Duarte, Susana; Fuenzalida, Bárbara; Cantin, Claudette; Carvajal, Lorena; Salsoso, Rocío; Gutiérrez, Jaime; Pardo, Fabián; Sobrevia, Luis.

Article
MOLECULAR ASPECTS OF MEDICINE  (2017)

Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice

Contreras-Duarte, Susana; Amigo, Ludwig; Sepúlveda, Esteban; Quiñones, Verónica; Vinci, Maria Cristina

Article ISI SCOPUS
PloS one  (2017)

Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice.

Leiva, Andrea; Contreras-Duarte, Susana; Amigo, Ludwig; Sepúlveda, Esteban; Boric, Mauricio; Quiñones, Verónica; Busso, Dolores; Rigotti, Attilio

Article
PloS one  (2017)

Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin



Article ISI SCOPUS
ATHEROSCLEROSIS  (2017)

[ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS].

Awad, Fernanda; Contreras-Duarte, Susana; Molina, Patricia; Quiñones, Verónica; Serrano, Valentina; Abbott, Eduardo; Maiz, Alberto; Busso, Dolores; Rigotti, Attilio

Article
Nutricion hospitalaria  (2015)

[Protective role of high density lipoproteins in sepsis=> basic issues and clinical implications].

Contreras-Duarte, Susana; Varas, Pablo; Awad, Fernanda; Busso, Dolores; Rigotti, Attilio

Article
Revista chilena de infectologia => organo oficial de la Sociedad Chilena de Infectologia  (2014)

Papel protector de las lipoproteínas de alta densidad en sepsis: aspectos básicos e implicancias clínicas

Susana Contreras Duarte; Pablo Varas; Fernanda Awad; Dolores Busso; Attilio Rigotti

Article SCIELO SCOPUS
Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología  (2014)

Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI

Santander NG, Contreras-Duarte S, Awad MF, Lizama C, Passalacqua I, Rigotti A, Busso D

Article
Hum Mol Genet.  (2013)

Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI.

Santander, Nicolás Guillermo; Contreras-Duarte, Susana; Awad, María Fernanda; Lizama, Carlos; Passalacqua, Isabella; Rigotti, Attilio; Busso, Dolores

Article
Human molecular genetics  (2013)

Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels.

Orellana, Juan A; Sáez, Pablo J; Cortés-Campos, Christian; Elizondo, Roberto J; Shoji, Kenji F; Contreras-Duarte, Susana; Figueroa, Vania; Velarde, Victoria; Jiang, Jean X; Nualart, Francisco; Sáez, Juan C; García, María A

Article
Glia  (2012)

Glucose Increases Intracellular Free Ca2+ in Tanycytes via ATP Released Through Connexin 43 Hemichannels

Juan A. Orellana, Pablo J. Sáez, Christian Cortés Campos, Roberto J. Elizondo, Kenji F. Shoji, Susana Contreras-Duarte, Vania Figueroa, Victoria Velarde, Jean X. Jiang, Francisco Nualart, Juan C. Sáez, María A. García

Article
Glia  (2012)

Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions

Orellana JA, Figueroa XF, Sánchez HA, Contreras-Duarte S, Velarde V, Sáez JC

Article
CNS Neurol Disord Drug Targets  (2011)

Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones

Leiva, Andrea; Varas, Pablo; Amigo, Ludwig; Contreras Duarte Susana; Maiz, Alberto; Rigotti, Attilio

Article SCIELO
REVISTA CHILENA DE CARDIOLOGIA  (2010)

Proyecto (15)

Role of endocannabinoids and cannabinoid receptors in mammary gland adipocytes as determinants of inflammatory biomarkers in the breast milk of obesity models”

Susana Contreras

Proyecto
 (2025)

Characterization of cardiometabolic risk in women with hypercholesterolemia during pregnancy, postpartum and their infants: Search for biomarkers of cardiometabolic risk in breast milk.

Susana Contreras

Proyecto
 (2023)

Instalación académica para desarrollar una línea de investigación centrada en el impacto de patologías de la madre sobre la composición de la leche materna y sus efectos sobre la salud del lactante: efecto de la hipercolesterolemia materna durante el postparto.

Susana Contreras

Proyecto
 (2021)

Effects of maternal supraphysiological dyslipidemia in pregnancies with gestational diabetes mellitus: impact from the fetoplacental vascular function to the lipoprotein function in the neonatal circulation.

Susana Contreras

Proyecto
 (2018)

Enhanced Platelet Tissue Factor-Dependent Procoagulant Activity in Hypercholesterolemia and in Pregnacy Dyslipidemia=> Inhibition by Statins, HDL-cholesterol and Tissue Factor Pathway Inhibitor

FONDECYT (1181681)

Proyecto
2018-2021
Coinvestigador(a)

Involvement of PCSK9 in human maternal supraphysiological hypercholesterolemia. Effects on placental cholesterol traffic and functionality of neonatal lipoproteins

FONDECYT (1150344)

Proyecto
2015-2019
Postdoctorado

SR-BI-dependent functionality of high density lipoproteins=> mechanisms, regulation, pathogenic implications and therapeutic applications

FONDECYT (1150399)

Proyecto
2015-2016
Tesista

Efecto de un concentrado natural de berries chilenas sobre la funcionalidad de las lipoproteínas de alta densidad en un modelo de enfermedad isquémica coronaria en ratón

Pontificia Universidad Católica de Chile, Facultad de Medicina, Departamento de Nutrición, Diabétes y Metabolismo (NUT14-06)

Proyecto
2014-2015
Coinvestigador(a)

Effect of antioxidants on the composition and function of high density lipoprotein in coronary heart disease model mouse.

Pontificia Universidad Católica de Chile, Facultad de Medicina (PMD- 02 /14)

Proyecto
2014-2015
Inv. Responsable

Relevance of the HDL receptor SR-BI and HDL functionality in cholesterol metabolism and atherosclerosis=> Physiological, pathophysiological and pharmacological implications

FONDECYT (1110712)

Proyecto
2011-2014
Tesista

Mecanismos de arterioesclerosis en la insuficiencia renal crónica=> Regulación de los transportadores de fosfato y transdiferenciación del músculo liso por aldosterona y leptina

FONDECYT (1090223)

Proyecto
2009-2012
Personal técnico y/o de apoyo

Interacción Plaqueta-Endotelio en la patogenia de la aterosclerosis=> estudio comparativo en dos modelos de daño vascular acelerado.

Pontificia Universidad Católica de Chile (VRAID-PUC)

Proyecto
2008-2009
Tesista

Perfeccionamiento de moléculas inhibidoras de hemicanales para su uso anti-inflamatorio en enfermedades humanas

FONDEF (D07I1086)

Proyecto
2008-2013
Personal técnico y/o de apoyo

Metabolismo hepático del colesterol HDL mediado por el receptor SR-BI=> Aspectos básicos, mecanismos de regulación e implicancias fisiopatológicas y farmacológicas.

FONDECYT (1070634)

Proyecto
2007-2010
Personal técnico y/o de apoyo

Papel y regulación de los canales formados por conexina 43 astroglial en la disfunción y muerte celular en tejido cerebral in vitro inducida por isquemia-reperfusión en alta glucosa

FONDECYT (1070591)

Proyecto
2007-2010
Personal técnico y/o de apoyo

Review (3)

The Impact of Maternal Chronic Inflammatory Conditions on Breast Milk Composition: Possible Influence on Offspring Metabolic Programming

Arenas, Gabriela; Barrera, Maria Jose; Contreras-Duarte, Susana

Review ISI
NUTRIENTS  (2025)

Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation



Review ISI
CURRENT VASCULAR PHARMACOLOGY  (2019)

Role of extracellular vesicles in glioma progression

Niechi, I; Uribe, D.

Review ISI SCOPUS
MOLECULAR ASPECTS OF MEDICINE  (2018)

1
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

1
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
MONICA ACEVEDO

Titular Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

3
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

5
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

2
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

9
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

2
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

5
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

4
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

22
Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

1
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Bastian Sobrevia

Médico en etapa de Destinación y Formación

Servicio de Salud del Reloncaví

Puerto Montt, Chile

1
Trinidad Montero

postdoctorate

Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Nicolás Santander

Assistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
Mario Subiabre

1
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

7
Claudette Cantin

Profesor Asistente

Universidad San Sebastián

Puerto Montt, Chile

4
Lorena Carvajal

1
Esteban Díaz

Research Assistant

Department of Biology

Universidad de Santiago de Chile

Santiago, Chile