Man

Susana de las Mercedes Contreras Duarte

Assistant Professor

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Metabolismo lipídico; Antioxidantes sobre el metabolismo del colesterol y aterosclerosis; diabetes gestacional, dislipidemias , obesidad, postparto y embarazo, leche materna, glándula mamaria. Descendencia

Educación

  •  Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2016
  •  Licenciado en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

Experiencia Académica

  •   PhD student (ANID) Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    2012 - 2016

  •   Postdoctor (ANID) Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    2018 - 2021

  •   Assistant Professor Full Time

    Universidad San Sebastián

    Health Care Sciences

    Santiago, Chile

    2021 - At present

Experiencia Profesional

  •   Research assistant Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2010 - 2011

  •   Research assistant Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2008 - 2009

  •   Research assistant Other

    Universidad de Chile

    Santiago, Chile

    2009 - 2009

  •   Postdoctor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2017 - 2017

Premios y Distinciones

  •   Extension PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2016

    6 month extension PhD funding

  •   PhD Fellowship 2012-2016

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Funding for the development of the Medical Science PhD program

  •   Internship PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2015

    Funding to develop one goal of the PhD thesis abroad (Austria)

  •   Congresses and short courses abroad PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Attendance to Lyon, to the European Atherosclerosis Society congress


 

Article (15)

Small extracellular vesicles from pregnant women with maternal supraphysiological hypercholesterolemia impair endothelial cell function in vitro

Valdivia, Pascuala; Zapata, David; Cerda, Alvaro

Article ISI SCOPUS
Vascular Pharmacology  (2023)

High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies



Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2021)

Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia

Kallol S.; Pastén V.; Albrecht C.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2020)

Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function



Article ISI SCOPUS
NUTRIENTS  (2020)

Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage

Labra, Valeria C.; Velarde, Victoria; Orellana, Juan A.

Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2020)

Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice

Chen, P; Uribe, S; Kopp, S.; Kern, S; Marsche, G.; Busso, D; Wadsack, C.; Rigotti, A

Article ISI SCIELO SCOPUS
BIOLOGICAL RESEARCH  (2018)

Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function

Labra, Valeria C.; Santibañez, Cristian A.; Gajardo-Gómez, Rosario; Avendaño, Beatriz C.; Díaz, Esteban F.; Montero, Trinidad D.; Velarde, Victoria; Orellana, Juan A.

Article ISI SCOPUS
Frontiers in Immunology  (2018)

Foetoplacental epigenetic changes associated with maternal metabolic dysfunction

Kerr, Bredford; Leiva, Andrea; Toledo, Fernando; Stolzenbach, Francisca; Silva, Luis; Sobrevia, Luis

Article ISI SCOPUS
PLACENTA  (2018)

High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation

Birner-Gruenberger, Ruth; Wadsack, Christian; Rigotti, Attilio

Article ISI SCOPUS
JOURNAL OF TRANSLATIONAL MEDICINE  (2018)

Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature

Fuenzalida, B

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2018)

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

Cantin, C

Article ISI SCOPUS
MOLECULAR ASPECTS OF MEDICINE  (2017)

Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice

Contreras-Duarte, Susana; Amigo, Ludwig; Sepúlveda, Esteban; Quiñones, Verónica; Vinci, Maria Cristina

Article ISI SCOPUS
PLOS ONE  (2017)

Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin



Article ISI SCOPUS
ATHEROSCLEROSIS  (2017)

Papel protector de las lipoproteínas de alta densidad en sepsis: aspectos básicos e implicancias clínicas

Susana Contreras Duarte; Pablo Varas; Fernanda Awad; Dolores Busso; Attilio Rigotti

Article SCIELO SCOPUS
REVISTA CHILENA DE INFECTOLOGIA  (2014)

Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones

Leiva, Andrea; Varas, Pablo; Amigo, Ludwig; Contreras Duarte Susana; Maiz, Alberto; Rigotti, Attilio

Article SCIELO
REVISTA CHILENA DE CARDIOLOGIA  (2010)

Proyecto (4)

Role of endocannabinoids and cannabinoid receptors in mammary gland adipocytes as determinants of inflammatory biomarkers in the breast milk of obesity models”

Susana Contreras

Proyecto
 (2025)

Characterization of cardiometabolic risk in women with hypercholesterolemia during pregnancy, postpartum and their infants: Search for biomarkers of cardiometabolic risk in breast milk.

Susana Contreras

Proyecto
 (2023)

Instalación académica para desarrollar una línea de investigación centrada en el impacto de patologías de la madre sobre la composición de la leche materna y sus efectos sobre la salud del lactante: efecto de la hipercolesterolemia materna durante el postparto.

Susana Contreras

Proyecto
 (2021)

Effects of maternal supraphysiological dyslipidemia in pregnancies with gestational diabetes mellitus: impact from the fetoplacental vascular function to the lipoprotein function in the neonatal circulation.

Susana Contreras

Proyecto
 (2018)

Review (3)

The Impact of Maternal Chronic Inflammatory Conditions on Breast Milk Composition: Possible Influence on Offspring Metabolic Programming

Arenas, Gabriela; Barrera, Maria Jose; Contreras-Duarte, Susana

Review ISI SCOPUS
Nutrients  (2025)

Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation



Review ISI
CURRENT VASCULAR PHARMACOLOGY  (2019)

Role of extracellular vesicles in glioma progression

Niechi, I; Uribe, D

Review ISI SCOPUS
MOLECULAR ASPECTS OF MEDICINE  (2018)

1
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

1
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
MONICA ACEVEDO

Titular Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

3
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

5
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

2
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

9
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

2
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

5
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

4
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Enrique Guzman

Profesor Asociado

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

22
Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

1
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Bastian Sobrevia

Médico en etapa de Destinación y Formación

Servicio de Salud del Reloncaví

Puerto Montt, Chile

1
Trinidad Montero

postdoctorate

Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Nicolás Santander

Assistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
Mario Subiabre

1
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

7
Claudette Cantin

Profesor Asistente

Universidad San Sebastián

Puerto Montt, Chile

4
Lorena Carvajal

1
Esteban Díaz

Assistant Professor

Universidad Autónoma de Chile

Santiago, Chile