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Andrea Alejandra Leiva Mendoza

Profesor Asociado

Universidad San Sebastián

Santiago, Chile

Maternal hypercholesterolemia in human pregnancy: effects on placental cholesterol transport and in maternal and offspring lipid metabolism, lipoprotein function and endothelial function.

Bioquimico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

Associate Resercher Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2012 - 2014
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

SANTIAGO, Chile

2014 - 2019
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Chile

2019 - 2020
Associate Professor Full Time

UNIVERSIDAD SAN SEBASTIAN

Medicina y Ciencia

SANTIAGO, Chile

2020 - 2023
POFESORA TITULAR Full Time

UNIVERSIDAD SAN SEBASTIAN

Medicina y Ciencia

SANTIAGO, Chile

2023 - At present

Biochemist, technical assistant Full Time

Pontificia Universidad Catolica de Chile

Chile

2004 - 2006
PhD Student Full Time

Pontificia Universidad Catolica de Chile

Chile

2006 - 2010
Post-doctor Full Time

Pontificia Universidad Catolica de Chile

Chile

2010 - 2012
Associated Researcher Full Time

Pontificia Universidad Catolica de Chile

SANTIAGO, Chile

2012 - 2014
Assistant Professor Full Time

Pontificia Universidad Catolica de Chile

SANTIAGO, Chile

2014 - 2019
Sub-director PhD Program in Medical Sciences Full Time

Pontificia Unversidad Católica de Chile

Santiago, Chile

2018 - At present
Visiting Professor. MSc in neurosciences and physiology Part Time

Universidad de Sevilla

Sevilla, España

2018 - At present
Evaluator of grants from the Group Medicine G1 del grupo Medicina G1 Other

Fondo Nacional de Ciencia y Tecnología (FONDECYT)

Santiago, Chile

2019 - At present
Profesor Asociado Full Time

Pontificia Universidad Catolica de Chile

SANTIAGO, Chile

2019 - 2020
Directora Doctorado en Enfermedades Crónicas Full Time

Universidad San Sebastian

Santiago, Chile

2023 - At present

- Postdoctorate (sponsor researcher):
(2018-2021) Effects of maternal supraphysiological dyslipidaemia in pregnancies with gestational diabetes mellitus: impact from the feto-placental vascular function to the lipoprotein function in the
neonatal circulation.

- Direction of PhD thesis:
PhD Program in Medical Sciences, Pontificia Universidad Catolica de Chile
(2017-2020) Effects of maternal supraphysiological hypercholesterolemia in the traffic of cholesterol in the human placenta.
(2018-2021) Characterization and effects of LDL and HDL from women with hypercholesterolemia during pregnancy in the maternal vasculature and in the communication between endothelial cells and
macrophages.

PhD Program in Biological Sciences, Pontificia Universidad Catolica de Chile
(2018-2021) Rol of oxidized LDL in the process of autophagy and in the invasion and vascular remodeling capacity of trophoblast cells from pregnancies with preeclampsia.

- Direction of Master thesis:
Master in Medical Sciences, Universidad de Valparaíso
(2015-2017) Rol of adenosine receptor A1 in the effect of insulin over the L-arginine transports in human umbilical vein endothelial cells from pregnancies with gestational diabetes mellitus

Master in Physiology and Neurosciences, Universidad de Sevilla, España
(2018-2019) Role of cholesterol and its derivates in the formation of soluble endoglin and the pathogenesis of preeclampsia
(2018-2019) Role of maternal dyslipidemia in the development of preeclampsia

- Direction of undergraduate thesis: Biochemist Universidad de Antofagasta (1: 2014-2016), Biochemist PUC (2: 2016-2018; 2018-2019)
- Director of research units: Medicine PUC (6), Biochemist PUC (3), Nursing PUC (1), PhD in Medical Sciences PUC (2), PhD in Biological Sciences PUC (1)

2011-2012 Explora (Club cientifico explorines para preescolares)
2012-2013 REDECs (Red de clubes científicos preescolares en 7 ciudades de Chile)
2013-2016 Club cientifico explorines para preescolares
2018 Taller de alimentación para parto saludable (San Felipe, Chile)

Award for the best student of the career of biochemist

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2004

.
Award to the best work in the annual meeting of the Sociedad Chilena de cardiología y cirugía cardiovascular.

SOCIEDAD CHILENA DE CARDIOLOGIA Y CIRUGIA CARDIOVASCULAR

Chile, 2006

.
Award for the best research work

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2016

Award for the best research work in the annual meeting of the obstetrics and gynecology division from the Pontifica Universidad Católica de Chile
IFPA Award for middle career researchers

International Federation of Placental Associations (IFPA)

Argentina, 2019

IFPA Award for middle career researchers in the are of placental biology


Association between maternal obesity, essential fatty acids and biomarkers of fetal liver function Ortiz, Macarena; Sanchez, Francisca; Alvarez, Daniela; Flores, Cristian; Salas-Perez, Francisca; Valenzuela, Rodrigo; Cantin, Claudette; Leiva, Andrea; Crisosto, Nicolas; Maliqueo, Manuel Article ISI PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2023)
Small extracellular vesicles from pregnant women with maternal supraphysiological hypercholesterolemia impair endothelial cell function in vitro Contreras-Duarte, Susana; Escalona-Rivano, Rodrigo; Cantin, Claudette; Valdivia, Pascuala; Zapata, David; Carvajal, Lorena; Brito, Roberto; Cerda, Alvaro; Illanes, Sebastian; Gutierrez, Jaime; Leiva, Andrea Article ISI VASCULAR PHARMACOLOGY (2023)
Aldosterone and renin concentrations were abnormally elevated in a cohort of normotensive pregnant women Pasten, Valentina; Tapia-Castillo, Alejandra; Fardella, Carlos E.; Leiva, Andrea; Carvajal, Cristian A. Article ISI ENDOCRINE (2022)
Epigenetic Changes as a Possible Mechanism Leading to Increased Fetal Cardiovascular Disease Risk in Pregnancies with Gestational Diabetes Mellitus and/or Maternal Hypercholesterolemia Espinoza, Cristian; Fuenzalida, Barbara; Leiva, Andrea Article ISI CURRENT VASCULAR PHARMACOLOGY (2022)
Human Placental Intracellular Cholesterol Transport: A Focus on Lysosomal and Mitochondrial Dysfunction and Oxidative Stress Yanez, Maria Jose; Leiva, Andrea Article ISI ANTIOXIDANTS (2022)
Increased Circulating Levels of PCSK9 and Pro-Atherogenic Lipoprotein Profile in Pregnant Women with Maternal Supraphysiological Hypercholesterolemia Cantin, Claudette; Jesus Garchitorena, Maria; Escalona, Rodrigo; Carvajal, Jorge A.; Illanes, Sebastian E.; Gutierrez, Jaime; Leiva, Andrea Article ISI ANTIOXIDANTS (2022)
Primary Human Trophoblasts Mimic the Preeclampsia Phenotype after Acute Hypoxia-Reoxygenation Insult Fuenzalida, Barbara; Kallol, Sampada; Zaugg, Jonas; Mueller, Martin; Mistry, Hiten D.; Gutierrez, Jaime; Leiva, Andrea; Albrecht, Christiane Article ISI CELLS (2022)
The LDL receptor: Traffic and function in trophoblast cells under normal and pathological conditions Aguilera-Olguin, Macarena; Leiva, Andrea Article ISI PLACENTA (2022)
Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells Carvajal, Lorena; Gutierrez, Jaime; Morselli, Eugenia; Leiva, Andrea Article ISI FRONTIERS IN ONCOLOGY (2021)
Effects of lipoproteins on endothelial cells and macrophages function and its possible implications on fetal adverse outcomes associated to maternal hypercholesterolemia during pregnancy Cantin, Claudette; Arenas, Gabriela; San Martin, Solange; Leiva, Andrea Article ISI PLACENTA (2021)
Increased Fetal Cardiovascular Disease Risk: Potential Synergy Between Gestational Diabetes Mellitus and Maternal Hypercholesterolemia Espinoza, Cristian; Fuenzalida, Barbara; Leiva, Andrea Article ISI CURRENT VASCULAR PHARMACOLOGY (2021)
The polarized localization of lipoprotein receptors and cholesterol transporters in the syncytiotrophoblast of the placenta is reproducible in a monolayer of primary human trophoblasts Fuenzalida, Barbara; Kallol, Sampada; Luthi, Michael; Albrecht, Christiane; Leiva, Andrea Article ISI PLACENTA (2021)
Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia Fuenzalida B.; Cantin C.; Kallol S.; Carvajal L.; PastÃ©n V.; Contreras-Duarte S.; Albrecht C.; Gutierrez J.; Leiva A. Article ISI SCOPUS SCIENTIFIC REPORTS (2020)
Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function Contreras-Duarte S.; Carvajal L.; Garchitorena M.J.; Subiabre M.; Fuenzalida B.; Cantin C.; FarÃas M.; Leiva A. Article ISI SCOPUS NUTRIENTS (2020)
High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus Gutierrez-Vega, Sebastian; Armella, Axel; Mennickent, Daniela; Loyola, Marco; Covarrubias, Ambart; Ortega-Contreras, Bernel; Escudero, Carlos; Gonzalez, Marcelo; Alcala, Martin; Ramos, Maria del Pilar; Viana, Marta; Castro, Erica; Leiva, Andrea; Guzman-Gutierrez, Enrique Article ISI PLOS ONE (2020)
Maternal hypercholesterolemia during pregnancy: Potential modulation of cholesterol transport through the human placenta and lipoprotein profile in maternal and neonatal circulation Cantin C.; Fuenzalida B.; Leiva A. Article ISI SCOPUS Placenta (2020)
Foetoplacental epigenetic changes associated with maternal metabolic dysfunction Kerr, Bredford; Leiva, Andrea; Farías, Marcelo; Contreras-Duarte, Susana; Toledo, Fernando; Stolzenbach, Francisca; Silva, Luis; Sobrevia, Luis Article ISI SCOPUS PLACENTA (2018)
Human umbilical vein endothelium-derived exosomes play a role in foetoplacental endothelial dysfunction in gestational diabetes mellitus Sáez, Tamara; Salsoso, Rocío; Leiva, Andrea; Toledo, Fernando; de Vos, Paul; Faas, Marijke; Sobrevia, Luis Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)
Maternal dyslipidaemia in pregnancy with gestational diabetes mellitus: Possible impact on foetoplacental vascular function and lipoproteins in the neonatal circulation Contreras-Duarte S.; Carvajal L.; Fuenzalida B.; Cantin C.; Sobrevia L.; Leiva A. Article SCOPUS Current Vascular Pharmacology (2018)
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature Fuenzalida, B; Sobrevia, B; Cantin, C; Carvajal, L; Salsoso, R; Gutierrez, J; Contreras-Duarte, S; Sobrevia, L; Leiva, A Article ISI SCOPUS SCIENTIFIC REPORTS (2018)
Adenosine and preeclampsia Salsoso, R. .; Farias, M.; Gutierrez, J.; Pardo, F.; Chiarello, D. I.; Toledo, F.; Leiva, A.; Mate, A.; Vazquez, C. M.; Sobrevia, L Article ISI SCOPUS MOLECULAR ASPECTS OF MEDICINE (2017)
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels Leiva, A.; Guzman-Gutierrez, E.; Contreras-Duarte, S.; Fuenzalida, B.; Cantin, C.; Carvajal, L.; Salsoso, R.; Gutierrez, J.; Pardo, F.; Sobrevia, L. Article ISI SCOPUS MOLECULAR ASPECTS OF MEDICINE (2017)
Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy Villalobos-Labra, Roberto; Silva, Luis; Subiabre, Mario; Araos, Joaquín; Salsoso, Rocío; Fuenzalida, Bárbara; Sáez, Tamara; Toledo, Fernando; González, Marcelo; Quezada, Claudia; Pardo, Fabián; Chiarello, Delia I.; Leiva, Andrea; Sobrevia, Luis Article ISI SCOPUS Journal of Diabetes Research (2017)
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes Jayabalan, Nanthini; Nair, Soumyalekshmi; Nuzhat, Zarin; Rice, Gregory E.; Zuñiga, Felipe A.; Sobrevia, Luis; Leiva, Andrea; Sanhueza, Carlos; Gutiérrez, Jaime Agustín; Lappas, Martha; Freeman, Dilys Jane; Salomon, Carlos Article ISI SCOPUS FRONTIERS IN ENDOCRINOLOGY (2017)
Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice Leiva, Andrea; Contreras-Duarte, Susana; Amigo, Ludwig; Sepúlveda, Esteban; Boric, Mauricio; Quiñones, Verónica; Busso, Dolores; Rigotti, Attilio; Vinci, Maria Cristina Article ISI SCOPUS PLOS ONE (2017)
Insulin/adenosine axis linked signalling Silva, Luis; Subiabre, Mario; Araos, Joaquín; Sáez, Tamara; Salsoso, Rocío; Pardo, Fabián; Leiva, Andrea; San Martín, Rody; Toledo, Fernando; Sobrevia, Luis Article ISI SCOPUS MOLECULAR ASPECTS OF MEDICINE (2017)
Intracellular acidification increases adenosine transport in human umbilical vein endothelial cells Celis, Natalia; Araos, Joaquín; Sanhueza, Carlos; Toledo, Fernando; Beltrán, Ana R.; Pardo, Fabián; Leiva, Andrea; Ramírez, Marco A.; Sobrevia, Luis Article ISI SCOPUS PLACENTA (2017)
Maternal insulin therapy does not restore foetoplacental endothelial dysfunction in gestational diabetes mellitus Subiabre, Mario; Silva, Luis; Villalobos-Labra, Roberto; Toledo, Fernando; Paublo, Mario; López, Marcia A.; Salsoso, Rocío; Pardo, Fabián; Leiva, Andrea; Sobrevia, Luis Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2017)
Molecular implications of adenosine in obesity Pardo, F.; Villalobos-Labra, R.; Chiarello, D. I.; Salsoso, R.; Toledo, F.; Gutierrez, J.; Leiva, A.; Sobrevia, L. Article ISI SCOPUS MOLECULAR ASPECTS OF MEDICINE (2017)
Preeclampsia associates with RECK-dependent decrease in human trophoblasts migration and invasion Gutiérrez, Jaime; Aedo, Alejandro; Mora, Jacob; Maldonado, Jorge; Salsoso, Rocío; Toledo, Fernando; Farías, Marcelo; Pardo, Fabián; Leiva, Andrea; Sobrevia, Luis Article ISI SCOPUS PLACENTA (2017)
Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer Sanhueza, C.; Araos, J.; Naranjo, L.; Toledo, F.; Beltran, A. R.; Ramirez, M. A.; Gutierrez, J.; Pardo, F.; Leiva, A.; Sobrevia, L Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)
A hypothesis for the role of RECK in angiogenesis Gutierrez J.; Droppelmann C.A.; Salsoso, R; Westermeier, F; Toledo, F.; Salomon, C; Sanhueza C.; Pardo F.; Leiva A.; Sobrevia L. Article SCOPUS Current Vascular Pharmacology (2016)
Are NHE1 and inducible nitric oxide synthase involved in human ovarian cancer? Sanhueza, Carlos; Araos, Joaqun; Naranjo, Luciano; Barros, Eric; Toledo, Lilian; Subiabre, Mario; Toledo, Fernando; Gutirrez, Jaime; Chiarello, Delia I; Pardo, Fabin; Leiva, Andrea; Sobrevia, Luis Article ISI SCOPUS PHARMACOLOGICAL RESEARCH (2016)
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus Sobrevia, Luis; Salsoso, Roco; Fuenzalida, Brbara; Barros, Eric; Toledo, Lilian; Silva, Luis; Pizarro, Carolina; Subiabre, Mario; Villalobos, Roberto; Araos, Joaqun; Toledo, Fernando; Gonzlez, Marcelo; Gutirrez, Jaime; Faras, Marcelo; Chiarello, Delia I; Pardo, Fabin; Leiva, Andrea Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2016)
Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus Westermeier, F; Sez, T.; Arroyo, P; Toledo, F.; Gutirrez, J.; Sanhueza C.; Pardo F.; Leiva A.; Sobrevia L. Article ISI SCOPUS DIABETES-METABOLISM RESEARCH AND REVIEWS (2016)
Insulin requires A(1) adenosine receptors expression to reverse gestational diabetes-increased L-arginine transport in human umbilical vein endothelium Guzman-Gutierrez, E; Armella A,; Toledo, F.; Pardo F.; Leiva A.; Sobrevia L. Article ISI SCOPUS PURINERGIC SIGNALLING (2016)
Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus Araos, Joaqun; Silva, Luis; Salsoso, Roco; Sez, Tamara; Barros, Eric; Toledo, Fernando; Gutirrez, Jaime; Pardo, Fabin; Leiva, Andrea; Sanhueza, Carlos; Sobrevia, Luis Article ISI SCOPUS PLACENTA (2016)
Modulation of intracellular ph in human ovarian cancer Sanhueza C.; Araos, J; Naranjo, L.; Villalobos, R; Westermeier, F; Salomon, C; Beltrán A.R.; Ramirez, M. A.; Gutierrez J.; Pardo F.; Leiva A.; Sobrevia L. Article SCOPUS Current Molecular Medicine (2016)
Nitric oxide and pH modulation in gynaecological cancer Sanhueza, C.; Araos, J.; Naranjo, L.; Barros, E.; Subiabre, M.; Toledo, F.; Gutierrez, J.; Chiarello, D. I.; Pardo, F.; Leiva, A.; Sobrevia, L. Article ISI SCOPUS JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)
Nitric oxide is a central common metabolite in vascular dysfunction associated with diseases of human pregnancy Leiva A.; Fuenzalida, B; Barros, E; Sobrevia, B; Salsoso, R; Sáez T.; Villalobos, R; Silva, L; Chiarello I.; Toledo, F.; Gutierrez J.; Sanhueza C.; Pardo F.; Sobrevia L. Article SCOPUS Current Vascular Pharmacology (2016)
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia Leiva, Andrea; Fuenzalida, Brbara; Westermeier, Francisco; Toledo, Fernando; Salomn, Carlos; Gutirrez, Jaime; Sanhueza, Carlos; Pardo, Fabin; Sobrevia, Luis Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia Leiva, Andrea; Fuenzalida, Brbara; Salsoso, Roco; Barros, Eric; Toledo, Fernando; Gutirrez, Jaime; Pardo, Fabin; Sobrevia, Luis Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
Cross-sectional and longitudinal lipid determination studies in pregnant women reveal an association between increased maternal LDL cholesterol concentrations and reduced human umbilical vein relaxation Leiva A.; Salsoso, R; Sáez T.; Sanhueza C.; Pardo F.; Sobrevia L. Article ISI SCOPUS Placenta (2015)
Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T-84 Human Intestinal Epithelial Cells Beltran, AR; Carraro-Lacroix, LR; Bezerra, CNA; Cornejo M.; Norambuena, K; Toledo, F.; Araos, J; Pardo F.; Leiva A.; Sanhueza C.; Malnic, G; Sobrevia L.; Ramirez, MA Article ISI SCOPUS PLOS ONE (2015)
Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction Pardo F.; Silva, L; Sáez T.; Salsoso, R; Gutierrez J.; Sanhueza C.; Leiva A.; Sobrevia L. Article ISI SCOPUS International Journal of Obesity (2015)
Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium Westermeier, F; Salomon, C; Farias M.; Arroyo, P; Fuenzalida, B; Sáez T.; Salsoso, R; Sanhueza C.; Guzman-Gutierrez, E; Pardo F.; Leiva A.; Sobrevia L. Article ISI SCOPUS FASEB Journal (2015)
Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia Salsoso, R; Guzman-Gutierrez, E; Sáez T.; Bugueno, K; Ramirez, M. A.; Farias M.; Pardo F.; Leiva A.; Sanhueza C.; Mate, A; Vazquez, C.; Sobrevia L. Article ISI SCOPUS PLACENTA (2015)
Insulin Reverses D-Glucose-Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells Gonzalez, M.; Rojas, S.; Avila P.; Cabrera L.; Villalobos, R; Palma C.; Aguayo, C.; Peña E; Gallardo V.; Guzman-Gutierrez, E; Saaz, T; Salsoso, R; Sanhueza C.; Pardo F.; Leiva A.; Sobrevia L. Article ISI SCOPUS PLOS ONE (2015)
Reduced L-Carnitine Transport in Aortic Endothelial Cells from Spontaneously Hypertensive Rats Salsoso R, Guzmán-Gutiérrez E, Arroyo P, Salomón C, Zambrano S, Ruiz-Armenta MV, Blanca AJ, Pardo F, Leiva A, Mate A, Sobrevia L, Vázquez C. Article ISI SCOPUS PLOS ONE (2014)
Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction Role of Endothelial Nitric Oxide Synthase and Arginase II Leiva A.; de Medina, CD; Salsoso, R; Sáez T.; San Martin, S; Abarzua, F; Farias M.; Guzman-Gutierrez, E; Pardo F.; Sobrevia L. Article ISI SCOPUS ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy Calligaris, SD; Lecanda M; Solis, F; Ezquer, M; Gutierrez J.; Brandan, E.; Leiva A.; Sobrevia L.; Conget P. Article ISI SCOPUS PLOS ONE (2013)
Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy. Calligaris, Sebastián D; Lecanda, Manuel; Solis, Felipe; Ezquer, Marcelo; Gutiérrez, Jaime; Brandan, Enrique; Leiva, Andrea; Sobrevia, Luis; Conget, Paulette Article PloS one (2013)
Role of equilibrative adenosine transporters and adenosine receptors as modulators of the human placental endothelium in gestational diabetes mellitus Pardo E.; Arroyo, P; Salomon, C; Westermeier, E; Salsoso, R; Sáez T.; Guzman-Gutierrez, E; Leiva A.; Sobrevia L. Article ISI SCOPUS PLACENTA (2013)
Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin Salomon, C; Westermeier, F; Puebla, C; Arroyo, P; Guzman-Gutierrez, E; Pardo F.; Leiva A.; Casanello, P; Sobrevia L. Article ISI SCOPUS PLOS ONE (2012)
Insulin-Increased L-Arginine Transport Requires A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium Guzman-Gutierrez, E; Westermeier, F; Salomon, C; Gonzalez, M.; Pardo F.; Leiva A.; Sobrevia L. Article ISI SCOPUS PLOS ONE (2012)
New therapeutic approaches to treating hypertension in pregnancy. Mate, Alfonso; Vázquez, Carmen M; Leiva, Andrea; Sobrevía, Luis Article Drug discovery today (2012)
Potential Role of Sodium-Proton Exchangers in the Low Concentration Arsenic Trioxide-Increased Intracellular pH and Cell Proliferation Aravena, C; Beltrán A.R.; Cornejo M.; Torres V.; Diaz E.S.; Guzman-Gutierrez, E; Pardo F.; Leiva A.; Sobrevia L.; Ramirez, M. A. Article ISI SCOPUS PLOS ONE (2012)
Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice Amigo, L; Quiñones V.; Leiva A.; Busso, D.; Zanlungo S.; Nervi, F; Rigotti, A. Article ISI SCOPUS Liver International (2011)
Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy. Leiva, Andrea; Pardo, Fabián; Ramírez, Marco A; Farías, Marcelo; Casanello, Paola; Sobrevia, Luis Article Experimental diabetes research (2011)
Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes Guzman-Gutierrez, Enrique; Abarzua, Fernando; Belmar, Cristian; Nien, Jyh K.; Ramirez, Marco A.; Arroyo, Pablo; Salomon, Carlos; Westermeier, Francisco; Puebla, Carlos; Leiva, Andrea; Casanello, Paola; Sobrevia, Luis Article ISI CURRENT VASCULAR PHARMACOLOGY (2011)
Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium Westermeier, F; Salomon, C; Gonzalez, M.; Puebla, C; Guzman-Gutierrez, E; Cifuentes F.; Leiva A.; Casanello, P; Sobrevia L. Article ISI SCOPUS DIABETES (2011)
Insulin-Stimulated L-Arginine Transport Requires SLC7A1 Gene Expression and Is Associated With Human Umbilical Vein Relaxation Gonzalez, M.; Gallardo V.; Rodríguez N.; Salomon, C; Westermeier, F; Guzman-Gutierrez, E; Abarzua, F; Leiva A.; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2011)
Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism. Leiva, Andrea; Verdejo, Hugo; Benítez, María Luisa; Martínez, Alvaro; Busso, Dolores; Rigotti, Attilio Article Atherosclerosis (2011)
Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes Sobrevia L.; Salomon, C; Westermeier, F; Puebla, C; Cifuentes F.; Guzman-Gutierrez, E; Leiva A.; Casanello, P; Abarzua, F; Nien, J. K. Article ISI SCOPUS Placenta (2011)
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones Leiva, Andrea; Varas, Pablo; Amigo, Ludwig; Contreras-Duarte, Susana; Maiz, Alberto; Rigotti, Attilio Article Rev Chil Cardiol (2010)
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones Leiva, Andrea; Varas, Pablo; Amigo, Ludwig; Contreras Duarte Susana; Maiz, Alberto; Rigotti, Attilio Article SCIELO Revista chilena de cardiología (2010)
PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function Yesilaltay A.; Kocher O.; Pal, R; Leiva A.; Quiñones V.; Rigotti, A.; Krieger M. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)


ELEVETED MATERNAL LIPID LEVEL INCREASES CHOLESTEROL EFFLUX TO HDL IN HUMAN TROPHOBLAST BUT NOT IN PLACENTAL MICROVASCULAR ENDOTHELIAL CELLS Fuenzalida, B; Cantinl, C; Carvajal, L; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
ENDOPLASMIC RETICULUM STRESS IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS FROM PRE-GESTATIONAL MATERNAL OBESITY Villalobos-Labra, R; Salsoso, R; Subiabre, M; Silva, L; Farias-Jofre, M; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
EXCESSIVE GESTATIONAL WEIGHT GAIN REDUCES THE RESPONSE TO VASOACTIVE MOLECULES IN HUMAN FETOPLACENTAL MICROVESSELS Pardo, F; Aedo, A; Silva, L; Chiarello, DI; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
HIGH D-GLUCOSE-INCREASED NITRIC OXIDE GENERATION LEADS TO HIGHER DEIODINASE 3 MRNA LEVEL IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS Nunez-Hermosilla, J; Armella, A; Hernandez, M; Gallardo, D; Gutierrez, S; fernandez, P; Gallegos, J; Leiva, A; González, M; Escudero, C; Sobrevia, L; Guzman-Gutierrez, E Abstract ISI PLACENTA (2017)
HUMAN MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA INCREASES THE EFFLUX OF CHOLESTEROL FROM PLACENTAL TROPHOBLAST AND MICROVASCULAR ENDOTHELIAL CELLS Fuenzalida, B; Cantin, C; Carvajal, L; Contreras-Duarte, S; Pardo, F; Chiarello, DI; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
HUMAN MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA LEADS TO ENDOTHELIAL DYSFUNCTION OF THE PLACENTAL MICROVASCULATURE Fuenzalida, B; Sobrevia, B; Cantin, C; Carvajal, L; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
INCREASED MATERNAL LIPID LEVELS REDUCE THE PLACENTAL HDL AND LDL CHOLESTEROL UPTAKE IN HUMAN TROPHOBLAST Cantin, C; Carvajal, L; Fuenzalida, B; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
INSULIN RECOVERS ENDOTHELIAL DYSFUNCTION REQUIRING An ADENOSINE RECEPTOR ACTIVATION IN HUMAN UMBILICAL VEIN ENDOTHELIUM FROM LATE-ONSET PREECLAMPSIA Salsoso, R; Pardo, F; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
INSULIN THERAPY DOES NOT REVERSE GESTATIONAL DIABETES-ASSOCIATED FOETOPLACENTAL ENDOTHELIAL DYSFUNCTION Subiabre, M; Salsoso, R; Villalobos-Labra, R; Silva, L; Fuenzalida, B; López, M; Paublo, M; Pardo, F; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
INSULIN THERAPY FAILS TO REVERSE THE HUMAN FOETOPLACENTAL ENDOTHELIAL DYSFUNCTION IN GESTATIONAL DIABETES MELLITUS Subiabre, M; Salsoso, R; Villalobos-Labra, R; Silva, L; Fuenzalida, B; Araos, J; Lopez, A; Paulo, M; Pardo, F; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
INSULIN THERAPY RESTORES THE EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 EXPRESSION IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES MELLITUS Silva, L; Subiabre, M; Villalobos-Labra, R; Salsoso, R; Lopez, A; Paulo, M; Pardo, F; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
MATERNAL OBESITY ASSOCIATES WITH FOETOPLACENTAL VASCULAR DYSFUNCTION INVOLVING ENDOPLASMIC RETICULUM STRESS AND ALTERED INSULIN VASCULAR REACTIVITY Saavedra, A; Rojas, S; Haensgen, A; Cid, M; González, M; Farias, M; Villalobos-Labra, R; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
MATERNAL SUPRAPHYSIOLOGICAL DYSLIPIDEMIA IN PREGNANCY WORSE VASCULAR RESPONSE OF UMBILICAL VEIN RINGS FROM GESTATIONAL DIABETES MELLITUS Carvajal, L; Cantin, C; Fuenzalida, B; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
MODULATION OF THE PLACENTAL HDL AND LDL CHOLESTEROL UPTAKE BY THE MATERNAL LIPIDS LEVEL IN HUMAN TROPHOBLAST Cantin, C; Carvajal, L; Fuenzalida, B; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
NEONATAL HIGH-DENSITY LIPOPROTEIN FROM PREGNANCIES WITH MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA IMPAIRS NITRIC OXIDE SYNTHASE ACTIVITY IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS Contreras-Duarte, S; Fuenzalida, B; Cantin, C; Carvajal, L; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
NHE1 MODULATES INTRACELLULAR PH AND CELL PROLIFERATION IN HUMAN OVARIAN CANCER Araos, J; Naranjo, L; Sanhueza, C; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
PREVALENCE OF MATERNAL SUPRAPHYSIOLOGICAL DYSLIPIDEMIA IN A GROUP OF CHILEAN PREGNANT WOMEN WITH GESTATIONAL DIABETES MELLITUS Contreras-Duarte, S; Carvajal, L; Cantin, C; Fuenzalida, B; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
RECIC EXPRESSION IS INDUCED IN PLACENTAS FROM PREECLAMPSIA AND REDUCES MIGRATION, INVASION, AND ENDOVASCULAR REMODELLING OF FIRST TRIMESTER HUMAN TROPHOBLAST Gutierrez, JA; Mora, J; Salsoso, R; Leiva, A; Sobrevia, L Abstract ISI PLACENTA (2017)
SODIUM/PROTON EXCHANGER SUBTYPE 1 REGULATES INTRACELLULAR PH IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES MELLITUS Araos, J; Saavedra, A; Sanhueza, C; Leiva, A; Ramirez, MA; Sobrevia, L Abstract ISI PLACENTA (2017)
GESTATIONAL DIABETES AND FETO-PLACENTAL ENDOTHELIAL DYSFUNCTION: ROLE OF EXOSOMES FROM HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS ON L-ARGININE/NO SIGNALLING PATHWAY Saez, T; Salsoso, R; Sanhueza, C; Pardo, F; Leiva, A; Faas, M; Sobrevia, L Abstract ISI PLACENTA (2016)
INSULIN RECEPTOR A AND A(1) ADENOSINE RECEPTORS EXPRESSION ARE REQUIRED TO RESTORE HUMAN FETOPLACENTAL ENDOTHELIAL FUNCTION IN GESTATIONAL DIABETES MELLITUS Sáez T.; Salsoso, R; Silva, L; Sanhueza C.; Pardo F.; Leiva A.; Sobrevia L. Abstract ISI PLACENTA (2015)
INSULIN RESTORES L-ARGININE AND ADENOSINE TRANSPORT REQUIRING ADENOSINE RECEPTORS ESPRESSION IN HUMAN FETOPLACENTAL ENDOTHELIUM FROM GESTATIONAL DIABETES MELLITUS Sobrevia L.; Sáez T.; Salsoso, R; Silva, L; Villalobos, R; Araos, J; Naranjo, L.; Guzman-Gutierrez, E; Gutierrez J.; Sanhueza C.; Pardo F.; Leiva A. Abstract ISI PLACENTA (2015)
INSULIN-INCREASED ENDOTHELIAL L-ARGININE/NO SIGNALLING PATHWAY REQUIRES A(2B) ADENOSINE RECEPTORS ACTIVATION IN HUMAN UMBILICAL VEIN ENDOTHELIUM FROM LATE-ONSET PREECLAMPSIA Salsoso, R; Sáez T.; Sanhueza C.; Pardo F.; Leiva A.; Mate, A; Vazquez, CM; Sobrevia L. Abstract ISI PLACENTA (2015)
MATERNAL SUPRAPHYSIOLOGICAL HYPERCOLESTEROLEMIA LEADS TO ENDOTHELIAL DYSFUNCTION OF THE HUMAN FETOPLACENTAL MACRO AND MICROVASCULATURE Leiva A.; Salsoso, R; Sáez T.; Silva, L; Sanhueza C.; Pardo F.; Sobrevia L. Abstract ISI PLACENTA (2015)
OBESITY IN PREGNANCY ALTERS RECYCLING OF HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORT 1 (HENT1) IN HUMAN UMBILICAL VEIN ENDOTHELIUM FROM GESTATIONAL DIABETES Pardo F.; Silva, L; Sáez T.; Salsoso, R; Sanhueza C.; Leiva A.; Sobrevia L. Abstract ISI PLACENTA (2015)
Insulin requires normal expression of insulin receptor A and A(1) adenosine receptors activation to reverse the gestational diabetes-increased L-arginine transport in human umbilical vein endothelial cells Sáez T.; Guzman-Gutierrez, E; Salsoso, R; Pardo F.; Sanhueza C.; Leiva A.; Sobrevia L. Abstract ISI ANGIOGENESIS (2014)
MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA LEADS TO REDUCED NITRIC OXIDE SYNTHASE ACTIVITY ASSOCIATED WITH REDUCED LEVELS OF TETRAHYDROBIOPTERIN IN HUVEC Leiva A.; Fuenzalida, B; Sobrevia, B; Pardo F.; Sobrevia L. Abstract ISI ATHEROSCLEROSIS (2014)
INVOLVEMENT OF A(2A) ADENOSINE RECEPTORS IN INSULIN-INCREASED L-ARGININE TRANSPORT IN HUMAN UMBILICAL VEIN ENDOTHELIUM Guzman-Gutierrez, E; Salomon, C; Westermeier, F; Arroyo, P; Pardo F.; Leiva A.; Sobrevia L. Abstract ISI PLACENTA (2012)
SREBP-1C AND HCHOP-C/EBP alpha INVOLVEMENT IN INSULIN MODULATION OF HENT2 ACTIVITY IN HUMAN PLACENTA MICROVASCULAR ENDOTHELIUM FROM GESTATIONAL DIABETES Salomon, C; Westermeier, F; Guzman-Gutierrez, E; Arroyo, P; Pardo F.; Leiva A.; Casanello, P; Mitchell M.; Rice, G; Sobrevia L. Abstract ISI PLACENTA (2012)
Differential Expression of A and B Isoforms of Insulin Receptor Are Involved in the Insulin-Mediated Recovery of Gestational Diabetes to Normal Phenotype in Human Placental Microvascular Endothelium Salomon, C; Westermeier, F; Guzman, E; Leiva A.; Casanello, P; Luis S Abstract JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
INSULIN ACTIVATES EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2 INVOLVING INSULIN RECEPTOR A IN HUMAN PLACENTA MICROVASCULAR ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES Salomon, C; Westermeier, F; Guzman-Gutierrez, E; Leiva A.; Casanello, P; Sobrevia L. Abstract PLACENTA (2011)
INSULIN RECEPTOR A IS INVOLVED IN GESTATIONAL DIABETES-REDUCED ADENOSINE TRANSPORT VIA HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS Westermeier, F; Salomon, C; Guzman-Gutierrez, E; Puebla, C; Leiva A.; Casanello, P; Sobrevia L. Abstract PLACENTA (2011)
Insulin Reverses Gestational Diabetes-Increased L-Arginine Transport Via A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium Guzman-Gutierrez, E; Puebla, C; Salomon, C; Westermeier, F; Leiva A.; Casanello, P; Sobrevia L. Abstract JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
Maternal Supraphysiological Hypercholesterolemia Leads to Reduced Endothelium-Dependent Vasodilation of Umbilical Vein and Increased L-Arginine Transport in HUVEC Leiva A.; Guzman-Gutierrez, E; Abarzua, F; Casanello, P; Sobrevia L. Abstract JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
THE LACK OF THE HDL RECEPTOR SR-BI AFFECTS EMBRYO CHOLESTEROL CONTENT AND NEURAL TUBE CLOSURE IN MICE Santander N.; Leiva A.; Contreras S.; Rigotti, A.; Busso, D. Abstract PLACENTA (2011)


Oxidative stress in pregnancies complicated by diabetes Lappas, Martha; Leiva, Andrea; Pardo, Fabián; Sobrevia L.; Jawerbaum, Alicia; Lapas, M BookSection (2014)
Transplacental transport of calcium in health and disease Sobrevia, Luis; Saez, Tamara; Fuenzalida, Bárbara; Salsoso, Rocio; Jawerbaum, Alicia; Vazquez, Mary C; Arroyo, Pablo; Guzman-Gutierrez, Enrique; Pardo, Fabián; Leiva, Andrea; Uauy R.; Carmuega E.; Weil, R BookSection (2014)
Maternal Hypercholesterolemia in Gestational Diabetes and the Association with Placental Endothelial Dysfunction Leiva, Andrea; Diez de Medina, Camila; Guzman-Gutierres, Enrique; Pardo, Fabián; Sobrevia, Luis; Luis Sobrevia BookSection (2013)
The Adenosine–Insulin Signaling Axis in the Fetoplacental Endothelial Dysfunction in Gestational Diabetes Guzman-Gutierrez, Enrique; Arroyo, Pablo; Pardo, Fabián; Leiva, Andrea; Sobrevia L.; Sobrevia L. BookSection (2013)
Fetoplacental vascular pathophysiology in preeclampsia Sobrevia, Luis; Guzman-Gutierres, Enrique; Westermeier, Franciaco; Salomon, carlos; Arroyo, Pablo; Palacios, Esteban; Bugueño, Katherine; Santos Manuel; Diez de Medina, Camila; Gonzalez, Marcelo; Escudero, Carlos; Mate, Alfonso; Vazquez, Carmen; Pardo, Fabián; Leiva, Andrea BookSection (2012)
Maternal and fetal metabolic dysfunction in pregnancy diseases associated with vascular oxidative and nitrative stress Gonzalez, Marcelo; Muñoz, Ernesto; Puebla, C; Guzman-Gutierres, Enrique; Cifuentes, Fredi; Nien, Ji Kae; Abarzua, Fernando; Leiva A.; Cassanello, Paola; Sobrevia, Paola BookSection (2011)


Maternal Supraphysiological hypercholesterolemia: Extra Virgin Olive Oil as a nutritional intervention during pregnancy to reduce the impact of this maternal condition Andrea Leiva; Gutierrez, Jaime Proyecto (2023)
Characterization of "gestational diabesity" as a pregnancy metabolic condition causing micro and macrovascular fetoplacental endothelial dysfunction via mechanisms that are different to those described for gestational diabetes or maternal obesity. Sobrevia, Luis; Leiva, Andrea; Gutierrez, Jaime. Proyecto (2019)
Maternal supraphysiological hypercholesterolemia in human pregnancy: contribution of lipoproteins and exosomes to vascular dysfunction of the mother and offspring at birth and later in childhood. Leiva, Andrea; Gutierrez, Jaime.; Carvajal, Jorge; Martinez, Gonzalo; Sobrevia, Luis; Carvajal, Cristian; Farias, Marcelo Proyecto (2019)
Effects of maternal supraphysiological dyslipidaemia in pregnancies with gestational diabetes mellitus: impact from the feto-placental vascular function to the lipoprotein function in the neonatal circulation. Contreras-Duarte, Susana; Leiva, Andrea Proyecto (2018)
Effects of maternal supraphysiological dyslipidaemia in pregnancies with gestational diabetes mellitus=> impact from the feto-placental vascular function to the lipoprotein function in the neonatal circulation FONDECYT (3180442) Proyecto 2018-2021 Inv. Patrocinante
Enhanced Platelet Tissue Factor-Dependent Procoagulant Activity in Hypercholesterolemia and in Pregnancy Dyslipidemia: Inhibition by Statins, HDL-cholesterol and Tissue Factor Pathway Inhibitor Mezzano, Diego; Leiva, Andrea; Contreras-Duarte, Susana; Farias, Marcelo; Panes Olga Proyecto (2018)
Enhanced Platelet Tissue Factor-Dependent Procoagulant Activity in Hypercholesterolemia and in Pregnancy Dyslipidemia=> Inhibition by Statins, HDL-cholesterol and Tissue Factor Pathway Inhibitor. FONDECYT (1181681) Proyecto 2018-2022 Coinvestigador(a)
Role of RECK in preeclampsia development: as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling. Gutierrez, Jaime.; Leiva, Andrea; Farias, Marcelo; Sobrevia, Luis Proyecto (2018)
Role of RECK in preeclampsia development=> as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling FONDECYT (1180935) Proyecto 2018-2022 Coinvestigador(a)
INVOLVEMENT OF PCSK9 IN â€˜HUMAN MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIAâ€™. EFFECTS ON PLACENTAL CHOLESTEROL TRAFFIC AND FUNCTION OF NEONATAL LIPOPROTEINS. FONDECYT (1150344) Proyecto 2015-2019 Inv. Responsable
Involvement of PCSK9 in ‘human maternal supraphysiological hypercholesterolemia’. Effects on placental cholesterol traffic and functionality of neonatal lipoproteins. Leiva, Andrea; Sobrevia, Luis; Carvajal, Jorge Proyecto (2015)
ROLE OF INSULIN RECEPTORS AND ADENOSINE RECEPTORS IN PREVENTION OF FETOPLACENTAL ENDOTHELIAL DYSFUNCTION BY INSULIN IN WOMEN WITH GESTATIONAL DIABETES MELLITUS. FONDECYT (1150377) Proyecto 2015-2019 Coinvestigador(a)
International network for the study of feto-placental vascular dysfunction in diseases of pregnancy PCI (130102) Proyecto 2013-2014 Inv. Responsable
INTERNATIONAL NETWORKING BETWEEN RESEARCH CENTERS Leiva, Andrea; Faas Mirejka Proyecto (2013)
Effect of maternal supraphysiological hypercholesterolemia in pregnancy in the endothelial function and atherosclerosis of the human placenta vasculature Leiva, Andrea Proyecto (2011)
EFFECT OF MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA IN PREGNANCY IN THE ENDOTHELIAL FUNCTION AND ATHEROSCLEROSIS OF THE HUMAN PLACENTA VASCULATURE FONDECYT (11110059) Proyecto 2011-2014 Inv. Responsable
Characterization of the pathohysiological mechanisms, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy. PIA (ACT73) Proyecto 2010-2013 Postdoctorado
Metabolismo hepático del colesterol HDL mediado por el receptor SR-BI=> aspectos básicos, mecanismos de regulación e implicancias fisiopatológicas y farmacológicas. FONDECYT (1070634) Proyecto 2006-2010 Tesista


Insulin therapy and fetoplacental vascular function in gestational diabetes mellitus Sobrevia L.; Salsoso, R; Sáez T.; Sanhueza C.; Pardo F.; Leiva A. Review ISI SCOPUS Experimental Physiology (2015)
Is a low level of free thyroxine in the maternal circulation associated with altered endothelial function in gestational diabetes? Guzman-Gutierrez, E; Veas C.; Leiva A.; Escudero, c; Sobrevia L. Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2014)
Role of Insulin and Adenosine in the Human Placenta Microvascular and Macrovascular Endothelial Cell Dysfunction in Gestational Diabetes Mellitus Guzman-Gutierrez, E; Arroyo, P; Salsoso, R; Fuenzalida, B; Sáez T.; Leiva A.; Pardo F.; Sobrevia L. Review ISI SCOPUS Microcirculation (2014)
New therapeutic approaches to treating hypertension in pregnancy Mate, A; Vazquez C.M.; Leiva A.; Sobrevia L. Review ISI SCOPUS Drug Discovery Today (2012)
Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy Leiva A.; Pardo F.; Ramirez, MA; Farias M.; Casanello, P; Sobrevia L. Review ISI SCOPUS Experimental Diabetes Research (2011)
Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism Leiva A.; Verdejo H.; Benitez ML; Martínez A; Busso, D.; Rigotti, A. Review ISI SCOPUS Atherosclerosis (2011)

118

Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

Tamara Sáez

Postdoctoral fellow

Obstetrics and Gynecology

University of Alberta

Edmonton, Canada

Claudette Cantin

Profesor Asistente

Universidad San Sebastián

Puerto Montt, Chile

Francisco Westermeier

Universidad de Chile

Santiago, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

MARCO RAMIREZ

Associate Professor

Universidad de Antofagasta

Antofagasta, Chile

Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

Mario Subiabre

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

Delia Chiarello

Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

Roberto Villalobos

Académico

Facultad de Medicina

Universidad de Valparaíso

San Felipe, Chile

Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

Lorena Carvajal

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Fernando Abarzua

Assitant researcher

Universidad de La Frontera

Temuco, Chile

Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

Ana Beltrán

Profesor asociado

Educación

Universidad de Antofagasta

Antofagasta, Chile

Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

MARCELO CORNEJO

Académico

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

Sebastián Gutiérrez

Asistente de Investigación

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

Alvaro Martínez

Director Asociado de Propiedad Intelectual y Transferencia Tecnológica

FUNDACIÓN CIENCIA PARA LA VIDA (FCV)

Santiago, Chile

Emilce Diaz

Profesor Asociado

Biomédico

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Erica Castro

Investigadora

Obstetricia y Puericultura

Universidad de Atacama

Copiapó, Chile

Carmen Aravena

Acádemico

Universidad de Valparaíso

San Felipe, Chile

Maria Yañez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

Bastian Sobrevia

Médico en etapa de Destinación y Formación

Servicio de Salud del Reloncaví

Puerto Montt, Chile

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

natalia rodriguez

Encargada de Programa de Prevencion y Control VIH/Sida e ITS, Servicio de Salud Ñuble

Direccion de Atención Primaria

Servicio de Salud Ñuble

Chillán, Chile

Carlos Veas

BIOQIUMICO

MEDICINA

HOSPITAL REGIONAL GUILLERMO GRANT BENAVENTE

CONCEPCION, Chile

Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Andrea Alejandra Leiva Mendoza

Líneas de Investigación

Educación

Bioquimico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004

Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

Experiencia Académica

Associate Resercher Full Time

Assistant Professor Full Time

Associate Professor Full Time

Associate Professor Full Time

POFESORA TITULAR Full Time

Experiencia Profesional

Biochemist, technical assistant Full Time

PhD Student Full Time

Post-doctor Full Time

Associated Researcher Full Time

Assistant Professor Full Time

Sub-director PhD Program in Medical Sciences Full Time

Visiting Professor. MSc in neurosciences and physiology Part Time

Evaluator of grants from the Group Medicine G1 del grupo Medicina G1 Other

Profesor Asociado Full Time

Directora Doctorado en Enfermedades Crónicas Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Award for the best student of the career of biochemist

Award to the best work in the annual meeting of the Sociedad Chilena de cardiología y cirugía cardiovascular.

Award for the best research work

IFPA Award for middle career researchers

Article (67)

Abstract (35)

BookSection (6)

Proyecto (18)

Effects of maternal supraphysiological dyslipidaemia in pregnancies with gestational diabetes mellitus=> impact from the feto-placental vascular function to the lipoprotein function in the neonatal circulation

Enhanced Platelet Tissue Factor-Dependent Procoagulant Activity in Hypercholesterolemia and in Pregnancy Dyslipidemia=> Inhibition by Statins, HDL-cholesterol and Tissue Factor Pathway Inhibitor.

Role of RECK in preeclampsia development=> as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling