Man

Carlos Alberto Puebla Aracena

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Líneas de Investigación


1- Regulación de canales y hemicanales formados por conexinas o panexinas 2- Señalización celular inducida por ácidos grasos libres 3- Receptores asociados a proteína G (GPCR)

Educación

  •  Ciencias Biológicas con mención en Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
  •  Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Bioquímica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Ciencias de la Salud

    Santiago, Chile

    2016 - 2019

  •   Profesor Asistente Adjunto Part Time

    UNIVERSIDAD ANDRES BELLO

    Medicina

    Santiago, Chile

    2015 - 2016

  •   Profesor Asistente Full Time

    Universidad de O'Higgins

    Instituto de Ciencias de la Salud

    Rancagua, Chile

    2019 - At present

Experiencia Profesional

  •   Postdoctorado Full Time

    Universidad del Desarrollo

    Santiago, Chile

    2016 - 2016

  •   Postdoctorado Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2012 - 2015

  •   Postdoctorado Full Time

    Centro Interdisciplinario de Neurociencia de Valparaíso

    Santiago, Chile

    2011 - 2012

  •   Profesor Asistente Full Time

    Universidad Autónoma de Chile

    Santiago, Chile

    2016 - 2019

  •   Profesor Asistente Full Time

    Universidad de O'Higgins

    Rancagua, Chile

    2019 - At present


 

Article (21)

Pannexin 1-based channels activity as a novel regulator of multiple sclerosis progression



Article ISI SCOPUS
NEURAL REGENERATION RESEARCH  (2020)

De novo expression of functional connexins 43 and 45 hemichannels increases sarcolemmal permeability of skeletal myofibers during endotoxemia

Balboa, Elisa; Regueira, Tomas; Saez, Juan C

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2019)

Role of Connexin-Based Gap Junction Channels in Communication of Myelin Sheath in Schwann Cells

Cisterna, Bruno A.; Arroyo, Pablo

Article ISI SCOPUS
FRONTIERS IN CELLULAR NEUROSCIENCE  (2019)

Regulation of Connexin-Based Channels by Fatty Acids



Article ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2017)

Connexin hemichannels explain the ionic imbalance and lead to atrophy in denervated skeletal muscles

Vargas, An?bal A.; S?ez, Juan C.

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2016)

Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels

Vargas, An?bal A.; Escamilla, Rosalba; Regueira, Tom?s; S?ez, Juan C.

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2016)

Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis

Cea L.A.; Puebla, C; Escamilla, R; Frank M.; Martínez-Montero P.; Prior C.; Molano J.; Esteban-Rodríguez I.; Pascual, I.; Gallano, P; et al.

Article ISI SCOPUS
CELLULAR AND MOLECULAR LIFE SCIENCES  (2016)

Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40-and Akt-dependent mechanism

Puebla, C; Salas D.P.; Sáez, J.C.

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS  (2016)

Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells

Contador D.; Ezquer, F; Espinosa,M; Arango-Rodriguez, M; Puebla, C; Sobrevia, L; Conget P.

Article ISI SCOPUS
Experimental Biology and Medicine  (2015)

Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition

Salas, D; Puebla, C; Lampe, PD; Lavandero, S

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2015)

De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy

Cisterna, BA; Puebla, C; Frank M.; Figueroa, XF; Cardozo C.; Willecke K.; Latorre, R

Article ISI SCOPUS
Proceedings of the National Academy of Sciences of the United States of America  (2013)

Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin

Salomon, C; Westermeier, F; Puebla, C; Arroyo P.; Guzman-Gutierrez, E; Pardo, F; Leiva, A; Casanello, P; Sobrevia, L

Article ISI SCOPUS
PLOS ONE  (2012)

Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes

Guzman-Gutierrez, E; Abarzua, F; Belmar, C.; Nien JK; Ramirez, MA; Arroyo P.; Salomon, C; Westermeier, F; Puebla, C; Leiva, A; et al.

Article ISI SCOPUS
CURRENT VASCULAR PHARMACOLOGY  (2011)

Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium

Westermeier, F; Salomon, C; Gonzalez, M.; Puebla, C; Guzman-Gutierrez, E; Cifuentes, F; Leiva, A; Casanello, P; Sobrevia, L

Article ISI SCOPUS
DIABETES  (2011)

Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes

Sobrevia, L; Salomon, C; Westermeier, F; Puebla, C; Cifuentes, F; Guzman-Gutierrez, E; Leiva, A; Casanello, P; Abarzua, F; Nien, J. K.

Article ISI SCOPUS
Placenta  (2011)

Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP alpha in human umbilical vein endothelial cells from gestational diabetes

"Farias, M".; Puebla, C; Westermeier, F; Jo, MJ; Pastor-Anglada, M; Casanello, P; Sobrevia, L

Article ISI SCOPUS
CARDIOVASCULAR RESEARCH  (2010)

Equilibrative nucleoside transporters in fetal endothelial dysfunction in diabetes mellitus and hyperglycaemia.



Article ISI
Curr Vasc Pharmacol  (2009)

Potential cell signalling mechanisms involved in differential placental angiogenesis in mild and severe pre-eclampsia.



Article ISI
Curr Vasc Pharmacol  (2009)

TGF-beta 1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium

Vega, JL; Puebla, C; Vasquez R.; "Farias, M".; Alarcón, J; Pastor-Anglada, M; Krause, B; Casanello, P; Sobrevia, L

Article ISI SCOPUS
CARDIOVASCULAR RESEARCH  (2009)

High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium

Puebla, C; "Farias, M".; Gonzalez, M.; Vecchiola, A; Aguayo, C; Krause, B; Pastor-Anglada, M; Casanello, P; Sobrevia, L

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2008)

Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endotheliurn from gestational diabetes

"Farias, M".; Puebla, C; Pearson, JD; Casado, JF; Pastor-Anglada, M; Casanello, P; Sobrevia, L

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2006)

Abstract (14)

Permeability properties of pannexin1 hemichannels activated by mechanical stress

Subiabre, M; Puebla, C; Vargas, A; Fernandez, P

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2014)

Denervation induces functional expression of connexin hemichannels followed by an inflammatory state in fast skeletal muscles.

Cisterna, BA; Puebla, C

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2012)

Dexamethasone induces inflammation through expression of functional connexin hemichannels in skeletal muscle fibers.

Puebla, C; Vargas AA; Benvenuto, MA; Frank M.; Willecke K.

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2012)

INSULIN RECEPTOR A IS INVOLVED IN GESTATIONAL DIABETES-REDUCED ADENOSINE TRANSPORT VIA HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

Westermeier, F; Salomon, C; Guzman-Gutierrez, E; Puebla, C; Leiva, A; Casanello, P; Sobrevia, L

Abstract ISI
PLACENTA  (2011)

Insulin Reverses Gestational Diabetes-Increased L-Arginine Transport Via A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium

Guzman-Gutierrez, E; Puebla, C; Salomon, C; Westermeier, F; Leiva, A; Casanello, P; Sobrevia, L

Abstract ISI
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE  (2011)

ACTIVITY AND EXPRESSION OF HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IS REGULATED BY D-GLUCOSE UPTAKE AND METABOLISM IN UMBILICAL VEIN ENDOTHELIUM

Puebla, C; Casanello, P; Sobrevia, L

Abstract ISI
PLACENTA  (2010)

Expression and Activity of Human Equilibrative Nucleoside Transporter 1 Depends on D-Glucose Uptake in Umbilical Vein Endothelial Cells.

Puebla, C; Sepulveda, CA; Casanello, P; Sobrevia, L

Abstract ISI
REPRODUCTIVE SCIENCES  (2010)

HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS EXHIBIT GLUTS-LIKE TRANSPORT ACTIVITY MODULATED BY INSULIN

Sepúlveda, C; Puebla, C; Casanello, P; Sobrevia, L

Abstract ISI
PLACENTA  (2010)

Gestational diabetes mellitus is associated with NO and PKC-dependent repressor effect of hCHOP-C/EBPalpha on equilibrative nucleoside transporter 1 expression human umbilical vein endothelium

"Farias, M".; Puebla, C; Vega, JL; Pastor-Anglada, M; Casanello, P; Sobrevia, L

Abstract ISI
PLACENTA  (2008)

TGF-beta 1 inhibits adenosine transport in human fetal endothelium

Vega, JL; "Farias, M".; Puebla, C; Casanello, P; Sobrevia, L

Abstract ISI
PURINERGIC SIGNALLING  (2008)

The transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose rfsponses to transcription factor Sp1 and ZBP-89 in human foetal endothelium

Puebla, C; "Farias, M".; Vega, JL; Pastor-Anglada, M; Casanello, P; Sobrevia, L

Abstract ISI
PLACENTA  (2008)

Transforming growth factor beta 1 is involved in the inhibitory effect of high D-glucose on human equilibrative nucleosidie transporter 1 in human fetal endothelium

Vega, JL; "Farias, M".; Puebla, C; Gonzalez, M.; Casanello, P; Sobrevia, L

Abstract ISI
PLACENTA  (2008)

Transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose involves nitric oxide and Sp1 in human foetal endothelium

Puebla, C; "Farias, M".; Vecchiola, A; Casanello, P; Sobrevia, L

Abstract ISI
PLACENTA  (2007)

Post-translational modulation of equilibrative nucleoside transporter 1 by D-glucose in human umbilical vein endothelium

Puebla, C; Casanello, P; Sobrevia, L

Abstract ISI
PLACENTA  (2006)

BookSection (2)

Maternal and fetal metabolic dysfunction in pregnancy diseases associated with vascular oxidative and nitrative stress

Gonzalez, Marcelo; Muñoz, Ernesto; Puebla, C; Guzman-Gutierres, Enrique; Cifuentes, Fredi; Nien, Ji Kae; Abarzua, Fernando; Leiva, A; Cassanello, Paola; Sobrevia, Paola

BookSection
 (2011)

Role of equilibrative nucleoside transporters in fetal endothelial dysfunction in gestational diabetes

Sobrevia, Luis; Puebla, Carlos; Farias, Marcelo; Casanello, Paola; Sobrevia, Luis; Casanello, Paola

BookSection
 (2009)

Proyecto (4)

Regulation of potentiation of skeletal muscle contraction by polyunsaturated fatty acids

Puebla Aracena, Carlos Alberto

Proyecto
 (2016)

Neuronal derived factor(s) and mechanism(s) that repress the expression of non-selective ion channels in normal adult skeletal muscles

Escamilla, Rosalba

Proyecto
 (2015)

Regulación del transporte de glucosa, a través de sus transportadores específicos y hemicanales, por ácidos grasos esenciales en intestino delgado

Puebla Aracena, Carlos Alberto

Proyecto
 (2012)

Role of Zonula occludens toxin in the virulence of non-toxigenic Vibrio parahaemolyticus strains

Blondel, Carlos

Proyecto
 (0)

Review (1)

Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy

Cea L.A.; Riquelme, M. A.; Puebla, C; Vega, J. L.; Rovegno, M; Sáez, J.C.

Review ISI SCOPUS
Journal of Membrane Biology  (2012)

2
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

2
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

11
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

1
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

1
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

3
Marcelo González

Profesor Asociado

Obstetricia y Ginecología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

7
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

2
Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

1
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

6
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

31
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

3
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

10
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Fernando Delgado

Associate Professor

Division of Medicine

Universidad Catolica del Maule

Talca, Chile

1
MARCO RAMIREZ

Associate Professor

Universidad de Antofagasta

Antofagasta, Chile

3
Fernando Abarzua

medico staff

obstetricia

Hospital Hernan Henriquez Aravena

Temuco, Chile

21
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

5
Francisco Westermeier

Universidad de Chile

Santiago, Chile

1
David Contador

Universidad del Desarrollo

Santiago, Chile

1
Rodrigo Acuña

Profesor Asistente Investigador

Medicina

Universidad del Desarrollo

Santiago, Chile

2
ELISA BALBOA

Académico Investigador

Facultad de Medicina

Universidad Finis Terrae

SANTIAGO, Chile

6
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

3
Enrique Guzman

Profesor Asociado

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Fernando Ortiz

profesor asistente

Departmento de Biología, Facultad de Quimica y Biología

Universidad de Santiago de Chile

Santiago, Chile

20
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

42
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

2
Daniela Salas

1
Aníbal Vargas

Investigador postdoctoral

Universidad Mayor

Santiago, Chile

3
ROSALBA ESCAMILLA

Investigador asociado

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile