Man

ELISA IVANA BALBOA CASTILLO

Académico Investigador

Universidad Finis Terrae

SANTIAGO, Chile

Líneas de Investigación


Disfunción mitocondrial; Estrés Oxidativo; Enfermedad Neurodegenetariva, hígado graso no alcoholico, enfermedades raras, lisosoma, autofagia

Educación

  •  Doctorado en Ciencias Médicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2015
  •  Bioquímica, licenciatura en Bioquímica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Fisiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2019

Experiencia Académica

  •   Investigador para proyecto Fondecyt Regular 1141092 Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    santiago, Chile

    2015 - 2016

  •   académico investigador Full Time

    UNIVERSIDAD FINIS TERRAE

    medicina

    santiago, Chile

    2022 - At present

  •   Docente Biología Molecular y Genética Part Time

    UNIVERSIDAD SAN SEBASTIAN

    Medicina

    Chile

    2016 - 2018

  •   Postdoctorado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Chile

    2019 - 2021

Experiencia Profesional

  •   alumna en practica

    universidad de la frontera

    Chile

    2007 - 2007

  •   bioquimico

    pontificia universidad catolica de chile

    Chile

    2009 - 2010

  •   tesista alumna de pregrado

    pontificia universidad catolica de chile

    Chile

    2007 - 2009

  •   Alumna Postgrado

    pontificia universidad catolica de chile

    Chile

    2010 - 2015

  •   personal tecnico

    pontificia universidad catolica de chile

    Chile

    2009 - 2009

  •   Docente Universidad San Sebastian Part Time

    Universidad San Sebastián

    Chile

    2015 - 2016

  •   Investigador Asociado Full Time

    pontificia universidad catolica de chile

    Chile

    2015 - 2016

  •   Académico Investigador Full Time

    Universidad Finis Terrae

    Santiago, Chile

    2022 - At present

Formación de Capital Humano


Alumna: Faride Saud, Tesis de Pregrado para optar al título de Bioquímica; Universidad Católica de Chile; AÑO 2023
Alumna: Catalina Valladares, Tesis de Pregrado para optar al título de Biotecnología; Universidad Mayor; AÑO 2024
Alumno: Sebastián Solís, Tesis de Pregrado para optar al título de Biotecnología, Universidad Mayor; AÑO 2025


Premios y Distinciones

  •   Concurso Historia de la Ciencia Chilena

    LABORATORIO MERCK S.A.

    Chile, 2023

    3er lugar Categoría: Profesores investigadores que presenten un un proyecto de investigación relacionado a cualquiera de las ciencias aplicadas

  •   Beca Doctorado ANID

    Conicyt

    Chile, 2012

    Beca para estudios de doctorado en Chile


 

Article (18)

c-Abl/TFEB Pathway Activation as a Common Pathogenic Mechanism in Lysosomal Storage Diseases: Therapeutic Potential of c-Abl Inhibitors

Guerra, MV; Castro, J; Moreno, A; Balboa, E; Marugan, JJ; Alvarez, AR; Zanlungo, S

Article ISI
ANTIOXIDANTS  (2025)

Connexin hemichannels and early atrophic signaling in muscle during sepsis

Balboa, E; Saavedra, F; Cea L.A.; Vargas AA; Regueira T.; Sáez, J.C.

Article ISI
FRONTIERS IN PHYSIOLOGY  (2025)

Pannexin-1 expression in tumor cells correlates with colon cancer progression and survival

Fierro-Arenas, A; Landskron, G; Camhi-Vainroj, I; Basterrechea, B; Parada-Venegas, D; Lobos-Gonzalez, L.; Dubois-Camacho, K; Araneda C.; Romero, C; Dominguez, A; et al.

Article ISI
LIFE SCIENCES  (2024)

Genistein Activates Transcription Factor EB and Corrects Niemann-Pick C Phenotype

Balboa, Elisa; Mattar, Pamela; Pulgar, Rodrigo

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2021)

Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage

Balboa, Elisa; Marin, Tamara; Hardt, Robert; van den Bosch, Thea

Article ISI
CELLS  (2021)

c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder

Heras, Macarena Las; Martinez, Alexis; Balboa, Elisa

Article ISI
ISCIENCE  (2020)

Finding pathogenic commonalities between Niemann-Pick type C and other lysosomal storage disorders: Opportunities for shared therapeutic interventions

Yanez, M. J.; Alvarez, A. R.

Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2020)

Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles

Balboa, Elisa; Regueira, Tomas

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2020)

De novo expression of functional connexins 43 and 45 hemichannels increases sarcolemmal permeability of skeletal myofibers during endotoxemia

Balboa, Elisa; Regueira, Tomas; Saez, Juan C

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2019)

SEPSIS-INDUCED CHANNELOPATHY IN SKELETAL MUSCLES IS ASSOCIATED WITH EXPRESSION OF NON-SELECTIVE CHANNELS

Vargas AA; Escamilla, R

Article ISI
SHOCK  (2018)

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease

Torres, Sandra; Mat?as, Nuria; Baulies, Anna; Nu?ez, Susana; Alarcon-Vila, Cristina; Martinez, Laura; Nu?o, Natalia; Fernandez, Anna; Caballeria, Joan; Levade, Thierry; et al.

Article ISI SCOPUS
REDOX BIOLOGY  (2017)

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content

Pinochet, Mar?a-Jos?; Mat?as, Nuria; Jos? S?ez, Pablo; Mart?nez, Alexis; ?lvarez, Alejandra R.; Garcia-Ruiz, Carmen; Fernandez-Checa, Jos? C.

Article ISI SCOPUS
REDOX BIOLOGY  (2017)

Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels

Vargas, An?bal A.; Escamilla, Rosalba; Regueira, Tom?s; S?ez, Juan C.

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2016)

Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability

Busso D, Oñate-Alvarado MJ, Balboa E, Castro J, Lizama C, Morales G, Vargas S, Härtel S, Moreno RD and S Zanlungo

Article ISI SCOPUS
REPRODUCTION FERTILITY AND DEVELOPMENT  (2014)

Vitamin E Dietary Supplementation Improves Neurological Symptoms and Decreases c-Abl/p73 Activation in Niemann-Pick C Mice

Marin, Tamara; Contreras, Pablo; Castro, Juan Francisco; Chamorro, David.; Balboa, Elisa; Bosch-Morató, Mònica; Muñoz, Francisco; Alvarez, Alejandra; Zanlungo, Silvana

Article ISI SCOPUS
NUTRIENTS  (2014)

Niemann-Pick C2 Protein Expression Regulates Lithogenic Diet-Induced Gallstone Formation and Dietary Cholesterol Metabolism in Mice

Balboa, E; Morales, G.; Aylwin, P; Carrasco G.; Amigo, L; Castro, J; Rigotti, A; Zanlungo, S

Article ISI SCOPUS
Lipids  (2012)

Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice

Amigo, L; Balboa, E; Acuña, M.; Castro, J; Molina, H; Nervi, F; Rigotti, A; Zanlungo, S

Article ISI SCOPUS
Liver International  (2010)

Female infertility due to anovulation and defective steroidogenesis in NPC2 deficient mice

Busso, D.; Onate-Alvarado, MJ; Balboa, E; Zanlungo, S

Article ISI SCOPUS
Molecular and Cellular Endocrinology  (2010)

Abstract (3)

LUTEIN MITIGATES LIPID ACCUMULATION IN HEPATIC CELLS VIA TFEB ACTIVATION: A POTENTIAL THERAPEUTIC APPROACH FOR MASLD

Balboa, E; Saud, F

Abstract ISI
HEPATOLOGY  (2024)

Mitochondrial GSH resplenishment prevents progressive liver injury and extends life span in Niemann Pick Disease type C

Matias, N; Balboa, E; Zanlungo, S; Levade, T; Garcia-Ruiz, C; Fernandez-Checa, J

Abstract ISI
HEPATOLOGY  (2012)

Overexpression of MLN64 in hepatic cells induces mitochondrial dysfunction associated with increased transport of cholesterol into mitochondria

Balboa, E; Pinochet, MJ; Matias, N; Fernandez-Checa, J; Zanlungo, S

Abstract ISI
HEPATOLOGY  (2012)

Errata (1)

Exploring the lutein therapeutic potential in steatotic liver disease: mechanistic insights and future directions (vol 15, 1406784, 2024)

Balboa, E; Saud, F; Parra-Ruiz, C; de la Fuente, M; Landskron, G; Zanlungo, S

Errata ISI
FRONTIERS IN PHARMACOLOGY  (2025)

Proyecto (4)

RELEVANCIA DEL ESTRÉS OXIDATIVO, LA DISFUNCIÓN MITOCONDRIAL Y LA EXPRESIÓN DE CONEXINAS EN LA INDUCCIÓN DE ATROFIA MUSCULAR POR DEXAMETASONA



Proyecto
 (2016)

Connexin hemichannels as mediators of sarcolemmal and mitochondrial dysfunction in respiratory and peripheral muscle in the pathogenesis of sepsis associated-Intensive Care Unit Acquired Weakness (ICUAW)

FONDECYT (1141092)

Proyecto
2014-2018
Investigador(a)

RELEVANCE OF OXIDATIVE DAMAGE DUE TO MITOCHONDRIAL DYSFUNCTION AND/OR DECREASED ANTIOXIDANT DEFENSES IN THE PATHOGENESIS OF NIEMANN PICK TYPE C DISEASE

FONDECYT (11103010)

Proyecto
2011-2015
Tesista

RELEVANCIA DE LAS PROTEINAS NIEMANN PICK C EN FISIOLOGIA Y FISIOPATOLOGIA.

FONDECYT (1070622)

Proyecto
2007-2011
Tesista

Review (5)

Exploring the lutein therapeutic potential in steatotic liver disease: mechanistic insights and future directions

Balboa, Elisa; Saud, Faride; Parra-Ruiz, Claudia; de la Fuente, Marjorie; Landskron, Glauben; Zanlungo, Silvana

Review ISI
FRONTIERS IN PHARMACOLOGY  (2024)

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease

Enrich, C; Fernandez-Checa, JC

Review ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2017)

Recent insights on the role of cholesterol in non-alcoholic fatty liver disease

Arguello, G; Balboa, E; Arrese, M; Zanlungo, S

Review ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2015)

Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick Type C Disease

Vazquez M.C.; Balboa, E; Zanlungo, S

Review ISI SCOPUS
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY  (2012)

Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease.

Balboa, E

Review SCOPUS
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY  (2012)

1
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

6
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

3
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

3
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Rodrigo Pulgar

Profesor/Investigador asistente

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

3
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

15
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Mary Carmen Vázquez

Universidad San Sebastián

Santiago, Chile

28
ELISA BALBOA

Académico Investigador

Facultad de Medicina

Universidad Finis Terrae

SANTIAGO, Chile

2
GRACIELA ARGÜELLO

Académico

Universidad Católica del Maule

Curicó, Chile

1
Gonzalo Cancino

Associate Professor

Faculty of Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Boris Rebolledo

Assistant Professor

Center for Genetics and Genomics

Universidad del Desarrollo

Santiago, Chile

2
Maria Yañez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

2
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

2
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

2
Tamara Marín

PhD en Ciencias médicas

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alexis Martinez

Investigador postdoctoral senior

Facultad de medicina

Instituto de Neurcoeincia Biomedica

Santiago, Chile

3
ROSALBA ESCAMILLA

Investigador asociado

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
PABLO TAPIA

Investigador postdoctoral

Centro de Biología Celular y Biomedicina (CEBICEM)

Universidad San Sebastián

Santiafgo, Chile

1
Macarena Las Heras

Investigadora postdoctoral

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile