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Maria Jose Yañez Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

Diseases related to pregnancy: a) alterations in cholesterol transport and its effect on the function of the syncytiotrophoblast organelles; b) role of leptin in serum and its effect on hepatic cholesterol metabolism.

Doctorado en Ciencias Biológicas, mención Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
Doctorado en Ciencias Biológicas, mención Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2016
Bioingeniero, UNIVERSIDAD DE CONCEPCION. Chile, 2009

Tesista

Universidad de Concepción

Chile

2008 - 2009
Ayudante

Pontificia Universidad Catolica de Chile

Chile

2010 - 2010
Ayudante

Pontificia Universidad Catolica de Chile

Chile

2011 - 2011
Practicante

Laboratorio de Criminalística de la Policia de Investigaciones de Chile

Chile

2009 - 2009
Profesora Titular

Universidad Bernardo O´higgins.

Chile

2014 - 2014
Profesora Titular

Universidad San Sebastián

Chile

2014 - 2014
Profesora Titular

Universidad San Sebastián

Chile

2015 - 2015
Profesora Titular

Universidad San Sebastián

Chile

2016 - At present


Evidence for hypoxia-induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues Fuenzalida, Barbara; Yanez, Maria Jose; Mueller, Martin; Mistry, Hiten D.; Leiva, Andrea; Albrecht, Christiane Article ISI FASEB JOURNAL (2024)
c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases Gutierrez, Daniela A.; Chandia-Cristi, America; Yanez, Maria Jose; Zanlungo, Silvana; Alvarez, Alejandra R. Article ISI NEURAL REGENERATION RESEARCH (2023)
c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease Marin, Tamara; Dulcey, Andres E.; Campos, Fabian; de la Fuente, Catalina; Acuna, Mariana; Castro, Juan; Pinto, Claudio; Yanez, Maria Jose; Cortez, Cristian; McGrath, David W.; Saez, Pablo J.; Gorshkov, Kirill; Zheng, Wei; Southall, Noel; Carmo-Fonseca, Maria; Marugan, Juan; Alvarez, Alejandra R.; Zanlungo, Silvana Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
Human Placental Intracellular Cholesterol Transport: A Focus on Lysosomal and Mitochondrial Dysfunction and Oxidative Stress Yanez, Maria Jose; Leiva, Andrea Article ISI ANTIOXIDANTS (2022)
Neuronopathic Gaucher disease: Beyond lysosomal dysfunction Arevalo, Nohela B.; Lamaizon, Cristian M.; Cavieres, Viviana A.; Burgos, Patricia V.; alvarez, Alejandra R.; Yanez, Maria J.; Zanlungo, Silvana Article ISI FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)
c-Abl activates RIPK3 signaling in Gaucher disease Yanez, M. J.; Campos, F.; Marin, T.; Klein, A. D.; Futerman, A. H.; Alvarez, A. R.; Zanlungo, S. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)
Genistein Activates Transcription Factor EB and Corrects Niemann-Pick C Phenotype Arguello, Graciela; Balboa, Elisa; Tapia, Pablo J.; Castro, Juan; Yanez, Maria Jose; Mattar, Pamela; Pulgar, Rodrigo.; Zanlungo, Silvana Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Finding pathogenic commonalities between Niemann-Pick type C and other lysosomal storage disorders: Opportunities for shared therapeutic interventions Yanez, M. J.; Marin, T.; Balboa, E.; Klein, A. D.; Alvarez, A. R.; Zanlungo, S. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)
c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease Yáñez, M.J.; Belbin, O.; Estrada, L.D.; Leal, N.; Contreras, P.S.; Lleó, A.; Burgos, P.V.; Zanlungo, S.; Alvarez, A.R. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway Contreras PS; Gonzalez-Zuniga, M; Gonzalez-Hodar, L; Yanez, MJ; Dulcey, A; Marugan, J.; Seto E.; Alvarez, AR; Zanlungo S. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)
Reduction of Blood Amyloid-beta Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition Estrada, Lisbell D.; Chamorro, David; Ya?ez, Mar?a Jos?; González, Marcelo; Leal, Nancy; von Bernhardi, Rommy; Dulcey, Andr?s E.; Marugan, Juan; Ferrer, Marc; Soto, Claudio; Zanlungo, Silvana; Inestrosa, Nibaldo C.; Alvarez, Alejandra R. Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2016)
Dynamic Localization of Glucokinase and Its Regulatory Protein in Hypothalamic Tanycytes. Salgado M, Tarifeño-Saldivia E, Ordenes P, Millán C, Yáñez MJ, Llanos P, Villagra M, Elizondo-Vega R, Martínez F, Nualart F, Uribe E and García-Robles M. Article PLoS One (2014)
Glial glucokinase expression in adult and post-natal development of hypothalamic región. Millán C, Martínez F, Cortés-Campos C, Lizama I, Yáñez MJ, Llanos P, Reinicke K, Rodríguez F, Peruzzo B, Nualart F and García MA. Article ASN Neuro (2010)


THE SYNAPTIC C-ABL KINASE REGULATES SYNAPTIC PLASTICITY IN ADULT BRAIN. ITS DYSREGULATION IS INVOLVED IN SYNAPTIC LOSS IN ALZHEIMER DISEASE FONDECYT (1120512) Proyecto 2012-2016 Tesista
IDENTIFICACIÓN DE INHIBIDORES DE LA QUINASA C-ABL PARA EL POTENCIAL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER FONDEF (D10I1077) Proyecto 2011-2014 Tesista
RELEVANCE OF OXIDATIVE DAMAGE DUE TO MITOCHONDRIAL DYSFUNCTION oND/OR DECREASED ANTIOXIDANT DEFENSES IN THE PATHOGENESIS OF NIEMANN PICK TYPE C DISEASE FONDECYT (1110310) Proyecto 2011-2015 Tesista