Rommy Edith von Bernhardi Montgomery
Full Professor
DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile
Neurodegenerative diseases; Alzheimer's disease; Neuroinflammation; TGFbeta; Signaling transduction pathways; Glial cells; Astrocytes, Microglia; Aging; Memory and behavior
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Medical Doctor, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1987
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Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1993
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PhD (c) - development of PhD thesis Full Time
UNIVERSITY OF UTAH
Biology
Salt Lake City, Estados Unidos
1990 - 1992
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PostDoc Full Time
UNIVERSITY BASEL
Biozentrum
Basel, Suiza
1993 - 1995
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PUC Postgraduate Studies Coodinator Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Academic Vicepresidency
Santiago, Chile
1995 - 1997
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Professor Full Time
UNIVERSIDAD DE LOS ANDES
Medicine
Santiago, Chile
1997 - 2001
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Full Professor Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Medicine
Santiago, Chile
2001 - At present
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Coordinator for postgraduate Studies Full Time
Pontificia Universidad Catolica de Chile
Santiago, Chile
1995 - 1997
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Professor Full Time
Universidad de los Andes
Santiago, Chile
1997 - 2001
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Full Professor Full Time
Pontificia Universidad Catolica de Chile
Santiago, Chile
2001 - At present
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Director of Research and Doctoral Programs School of Medicine Part Time
Pontificia Universidad Catolica de Chile
Santiago, Chile
2010 - 2014
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Director Center for Medical Research (Centro Investigaciones Médicas), Faculty of Medicine Part Time
Pontificia Universidad Católica de Chile.
Santiago, Chile
2008 - 2010
Postdocs:
2004-2005: Dr. Alejandro Roth. Project "Toxicity of Abeta on Oligodendrocytes in Culture: Dependence on the Degree of Cell Differentiation”.
2009-2011: Dr. Dagobero Soto. Project “Participation of prenatal programming in adult neurodegenerative diseases”.
2011-2013: Dr. Juan Andrés Orellana. Project “Effect of maternal inflammatory stimulation on signaling pathways leading to neurodegeneration in adult offsprings”
2018-2020: Dr. Sebastián Beltrán. Project “Role of microglia in D-serine-mediated synaptic impairment, neurodegeneration, and neurobehavioral deficits associated to the dysfunction of TGFbeta signaling
in aging”.
Postgraduate Theses:
2010 - 2012: PhD Biological Sciences PUC: Paola Murgas. “Modulatory Role of Scavenger Receptor Class A in the inflammatory response of glial cells”. Ph D Program in Biologycal Sciences, Cellular and
Molecular Biology. PUC.
2009 - 2013: PhD: Maximiliano Rovegno (Co-tutor: Dr. Juan Carlos Saez. Dept. Physiology, Fac. Biological Sciences, PUC). “Biological Mechanisms of the Determination of Penumbra in Neurotrauma”
(Connein 43 Hemichannels mediate propagation of secondary cell damage in a in vitro trauma model in cortical astrocytes). PhD Medical Sciences Program PUC.
2010 - 2013: PhD Medical Sciences PUC: Bernardita Soler. Role of murine Qa-2 in the modulation of Neuroinflammation of the Central Nervous System. Experimental/Clinical Projections in Stem Cell
Therapy.” PhD Medical Sciences Program PUC.
2011 - 2011: Research Master in Science - Emeline Redoulez. Université Claude Bernard -LYON 1. France.
2013 - 2017: PhD Medical Sciences PUC: Francisca Cornejo. “Changes on the expression of SR-A and their effect on Alzheimer´s Disease: participation of TGFbeta signaling pathways”. PhD Medical
Sciences Program PUC.
2010 - 2013: PhD Medical Sciences PUC: Bernardita Soler. Role of murine Qa-2 in the modulation of Neuroinflammation of the Central Nervous System. Experimental/Clinical Pr
2014 - 2014: Research Master Programme Behavioural and Cognitive Neurosciences - Marianne Vruwink. University of Groningen, The Netherlands. “Does expression of Scavenger receptor A depend on
the age and inflammatory status?”
2018-2019: Master in Medical Sciences, PUC. Thesis Francisco Novillo “Effect of systemic inflammation on the TREM2 receptor expression on APP/PS1 mice microglial cells”
Pregraduate Theses:
2012: Tutor Thesis Lic. Biochemistry. Fac. Cs. Biológicas PUC – Betsi Flores. “Modulation of glial activation by TGFbeta”.
2012: Co-Tutor (with Dr. Alejandra Alvarez). Thesis Lic. Biochemistry. Fac. Cs. Biológicas PUC – Juan Osorio. “CytokynesTNFalpha and TGFbeta modulate signaling of c-Abl kynase in neurones
exposed exposed to Abeta peptide or hypoxia, ”.
2014: Tutor Thesis Lic. Biology Fac. Cs. Biológicas PUC – Javiera Pizarro. “Induction inflammatory response and behavioral effect in an animal model of Alzheimer's disease”.
2017 - 2018: Co-Tutor Thesis Lic. Biology Fac. Química y Biología USACH (with Dr. Jaime Eugenín, Fac Química y Biología, USACH). – Estefanía Irribarra C. “Hipercapnia induces activation and
phenotypic differentiation (M1/M2) in troncoencephalic microglia”
2018 - 2019: Tutor Thesis Lic. Biochemistry Fac. Química y Biología USACH (with Dr. Jaime Eugenín) - Valentina Rodriguez. “Aging in the crosstalk of NF-kappaB and Smad induce an increase in the
cytotoxic activity of microglia in mice”
2018 – 2019: Tutor Thesis Lic. Biochemistry Fac. Química y Biología USACH (with Dr. Jaime Eugenín) – Erick Ponce. Aging impairs the protective funtion of microgia depending on the overexpression of
TGFbeta non-SMAD signaling during inflammation in aged mice.
Other academic-professional activities:
2004- to date: Member of the Dementia & Cognitive disorders study group of SONEPSYN (Society for Neurology, Psychiatry & Neurosurgery of Chile - Sociedad Neurología, Psiquiatría y Neurocirugía de
Chile)
2007-2010: Member of the Ethics Committees for Human and Animal Research. Faculty of Medicine. Pontificia Universidad Católica de Chile.
2008-to date: Member of the Ethics Committee study group of SONEPSYN (Sociedad Neurología, Psiquiatría y Neurocirugía de Chile- Society for Neurology, Psychiatry and Neurosurgery of Chile)
2019- Member Bioethics Center and Observatory. Pontificia Universidad Católica de Chile.
Patents:
Patent Application No. PCT/US2019/021434. Tittle: C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same. March 2019
Editorial Committee and Referee:
Brain, Behavior & Immunity (Editorial Board); J. Neurotoxicity Research (Editorial Board); J. Alzheimer Disease (Associate Editor); Frontiers in Dementia (Associate Editor); Frontiers in Aging Neuroscience (Associate Editor); ARS -Antioxidants & Redox Signaling (Invited Editor); Biological Research (Invited Editor); Brain, Behavior & Immunity (Associate Editor);
Referee: Brain Research; Current Medicinal Chemistry; Current Neuropharmacology; Current Protein & Peptide Science; FEBS Letter; Frontiers in Cell Neuroscience; International Immunopharmacology; J Immunology; J. Neurochemical Research; J Neurochemistry; J. NeuroInflammation; Mini-Reviews in Medicinal Chemistry; Nature Immunology; Neuropsychiatric Disease and Treatment; Neuroscience; Neuroscience Letters; Rev. Chil Neuro-psiquiat.
Scientific Societies
1990 - : Regular Member Society for Neuroscience.
1993 - : Regular Member International Brain Research Organization (IBRO).
2002 - 2012 : Regular Member Sociedad de Biología de Chile.
2003 - : Regular Member Sociedad de Biología Celular de Chile.
2005 - : Regular Member Sociedad Chilena Neurociencia.
2005 – 2010 : President Sociedad Chilena Neurociencia
2008 - 2014 : President FALAN. Federación Asociaciones Latinoamericanas y del Caribe de Neurociencia
2012- 2018 : Regular Member Neurotoxicity Society
Research Funding Organization Reviewer
- Alzheimer's Research UK
- Medical Research Council UK
- Alzheimer's Association, USA
- Austrian Science Fund (FWF)
- EQA – European Quality Assurance
- EU-LAC Health Project, European Union. Review Panel Member
- Foundation for Alzheimer Research (SAO-FRA), Belgium.
- Irish Research Council
- Agency for Health Quality and Assessment of Catalonia (AQuAS), Spain.
- Instituto de Salud Carlos III. Ministerio de Economía y Competitividad, España
- “Programa de Desarrollo Tecnológico DICyT (Dirección Innovación, Ciencia y Tecnología) de Uruguay.”
- “Programa Nacional de Proyectos para el fortalecimiento de la Investigación, Creación e Innovación en Posgrados de la Universidad Nacional de Colombia”
- Chilean Funds: CONICYT (Programs – FONDECYT; ECOs-CONICYT; FONDEF; PAI - Academic Insertion); CORFO and others.
- Member of the Medicine Study Group for FONDECYT (2001-2004; 2016)
- Member of the Panel Biology 2 Study Group for FONDECYT (2018)
- Research Program of the Universidad de Valparaíso.
- CAN - National Accreditation Commission (Comisión Nacional Acreditación) for PhD programs.
Invited Speaker selected - (last 5 years):
von Bernhardi R. Age-related dysregulation of microglial cell activation. Institutional Seminary Instituto de Investigaciones Clemente Estable (IIBCE). Montevideo, Uruguay. April 3, 2019
von Bernhardi R. "Aging and neuroinflammation in neurodegeneratives diseases" Simposio NEUROINFLAMMATION IN HEALTH AND DISEASE. Institut Pasteur. Montevideo, Uruguay. April 3-10, 2019
von Bernhardi R. Aging-Related changes in microglia activation in Brain Aging and Neurodegenerative Diseases. Seminar Fac. Medicine, Molecular and Translational Neuroscience, Universität Ulm.
March 28, 2018
von Bernhardi R. Neuroinflammation in Alzheimer's disease: Age-related changes in microglial-mediated innate immunity. Seminar Center for Learning and Memory Research, Leibniz Institute for
Neurobiology & Otto von Guericke Universität Magdeburg, Magdeburg, Germany. March 27, 2018
von Bernhardi R. Age-related dysregulation of microglial cell activation in Alzheimer’s Disease. Seminar Institute of Developmental Biology and Neurobiology, Johannes Gutenberg Universität, Mainz,
Germany. March 23, 2018
von Bernhardi R. Age-related changes in glial activation in Alzheimer's disease. In Symposium SONEPSYN Update in Neurodegenerative Disorders and Neuroscience. Santiago, Chile. Dec. 15-16, 2017
von Bernhardi R. Age-related dysregulation of glial cells in neurodegenerative diseases. IV International Symposium on Pathophysiology of the Glial Cell”, Salvador de Bahía, Brazil. April 17 – 20. 2017.
von Bernhardi R. “Age-related dysregulation of microglia and Alzheimer Disease”. International Symposium Alzheimer’s disease challenges and new views. U. Autonoma, Santiago, Chile. 8 August, 2016.
von Bernhardi R. Age-Related Changes of Microglia: a New Perspective for Neurodegenerative Diseases. Saarland University. Center for Integrative Physiology and Molecular Medicine. Homburg,
Germany. June 8, 2016, 2016.
von Bernhardi R. Glial cells: untangling the effect of aging in Alzheimer's disease. Johannes Gutenberg Universität. Mainz, Germany. May 25, 2016.
von Bernhardi R. Glial Cells and Aging: a New Perspective for Alzheimer’s Disease. Seminar Center for Integrative Brain Research, U. Washington. October 6, 2015.
von Bernhardi R. SONEPSYN- GdT Dementia: "Relevance of glial cell reactivity changes associated to aging in the pathogenesis of Alzheimer's disease. Santiago, August 14th, 2015
von Bernhardi R. Microglia-mediated neurotoxicity offers a novel insight into the role of neuroinflammation in Alzheimer’s disease in Symposium “New perspectives on glial cells functions in the CNS”.
Morphological Science Graduate Program. Institute of Biomedical Sciences. Federal University of Rio de Janeiro. Rio de Janeiro, Brazil, July 6, 2015.
von Bernhardi R. Seminar “Cambios de la función de la glía en el envejecimiento: Una nueva perspectiva para entender la Enfermedad de Alzheimer”. Universidad de Atacama, December 12, 2014.
von Bernhardi R. “RS-A en la Enfermedad de Alzheimer: de la captura del A? a la activación glial citotóxica”. Encuentro Vasco-Chileno de Investigación Biomédica. Bilbao, Spain, December 1-2, 2014.
von Bernhardi R. “Enfermedad de Alzheimer: una mirada distinta de la genética y el envejecimiento”. Instituto de Genética de la Universidad Nacional, Bogotá, Colombia. Mayo 13-14 2014
Abstracts & Scientific Meeting Presentations (Last 5 Years)
von Bernhardi R. Chair Symposium: Glial cells function and neuroinflammation in the healthy and diseased nervous system. Speakers: SL Costa (Brazil), D Loane (USA), S Olivera (Uruguay), R von
Bernhardi. 2nd Panamerican Congress of Physiological Sciences- Physiology without borders. Havana, Cuba. May 27-31, 2019.
von Bernhardi R. Talk: Scavenger receptor-A in Alzheimer’s disease: age-associated changes and glial cell dysfunction. 2nd Panamerican Congress of Physiological Sciences- Physiology without borders.
Havana, Cuba. May 27-31, 2019.
Triviño JJ, von Bernhardi R. Effect of ?-amyloid and neuroinflammation on Neurocan in an Alzheimer´s disease mouse model. LXI Reunión Anual Soc. Biología de Chile y XIV LXI Reunión Anual Soc.
Chilena de Neurociencia. Puerto Varas, Chile. Nov. 21 – 22, 2018
Beltrán-Castillo S, von Bernhardi R. Increased expression of serine racemase in the Brain induced by Aging and systemic Inflammation. LXI Reunión Anual Soc. Biología de Chile y XIV LXI Reunión Anual
Soc. Chilena de Neurociencia. Puerto Varas, Chile. Nov. 21 – 22, 2018
Marca S, Irribarra E, Cáceres-Vergara D, Olivares MJ, von Bernhardi R, Eugenín J. Activation of Brainstem Microglia by Gliotransmitters. LXI Reunión Anual Soc. Biología de Chile y XIV LXI Reunión Anual
Soc. Chilena de Neurociencia. Puerto Varas, Chile. Nov. 21–22, 2018
Irribarra E, Cáceres D, Beltrán-Castillo S, von Bernhardi R, Eugenín J. Hypercapnia-Induced Brainstem Microglial Cell Activation in Adult Mice. LXI Reunión Anual Soc. Biología de Chile y XIV LXI Reunión
Anual Soc. Chilena de Neurociencia. Puerto Varas, Chile. Nov. 21 – 22, 2018
Beltrán-Castillo S, Eugenín J, von Bernhardi R. Effect of in vivo activation of Fas-mediated apoptosis cascade by AP20187 on microglia in MaFIA mice. 48th Annual Meeting Society for Neuroscience (SfN).
San Diego, California, USA. November 3-7, 2018
von Bernhardi R. F. Cornejo, P. Muñoz. Scavenger receptor-A in the pathophysiology of Alzheimer’s disease: age-associated changes in glial cell inflammatory activation. EMBO Workshop – Microglia 2018.
Heidelberg, Germany. March 18 - 21, 2018
von Bernhardi R, Heredia F, Muñoz P, Eugenín-von Bernhardi L, Cornejo F. Participation of SR-A in the neurotoxic activation of microglia by A? and inflammatory mediators. 47th Annual Meeting Society for
Neuroscience (SfN). Washington DC, USA. November 11-15, 2017
Durand D, Turati J, Carniglia L, Ramírez D, Saba J, Caruso C, von Bernhardi R, Lasaga M.. Metabotropic glutamate receptor 3 - sAPP?: novel pathway in ?-Amyloid clearance by astrocytes mediated by
class A scavenger receptor. LXII Reunión Anual de la Sociedad Argentina de Investigación Clínica. Buenos Aires, November 13-17, 2017
von Bernhardi R. Chair symposium “Glial cell-neuron Crosstalk in health and disease” Speakers: Felipe Barros, Jaime Eugenín, Felipe Court, Rommy von Bernhardi. Talk: Glial activation goes wrong as we
age. XIII Annual Meeting Sociedad Chilena de Neurociencia. Castro, Chile. October 1-3, 2017
Rojas C, Cornejo F, von Bernhardi R. Age-related changes in the activation of canonical and non-canonical TGF? pathways contributing to the pathogenesis of Alzheimer’s Disease. XIII Annual Meeting
Sociedad Chilena de Neurociencia. Castro, Chile. October 1-3, 2017
von Bernhardi R, Cornejo F, Heredia F, Muñoz P, Poblete J. Age-associated changes of Scavenger-A in the pathophysiology of Alzheimer’s disease and neurodegeneration. XIII European Meeting on Glial
Cells in Health and Disease. Edinburgh, Scotland. July 8-11, 2017
Eugenín J, Beltrán-Castillo S, Olivares M J, Contreras R, Llona I, Zúñiga G, von Bernhardi R. Metabolic inhibition of astrocytes impairs central chemoreception in caudal brainstem slices. XIII European
Meeting on Glial Cells in Health and Disease. Edinburgh, Scotland. July 8-11, 2017
von Bernhardi R., Cornejo F., Heredia F., Muñoz P. Increased neuroinflammation and neurodegenerative changes secondary to age-associated changes of Scavenger-A as a novel pathophysiological
mechanism for Alzheimer’s disease. International Neurotoxicology Association (INA) and Neurotoxicity Society (NTS) Joint Meeting, Florianopolis, Brazil, May 20-24, 2017.
von Bernhardi R. Chair Symposium Symposium Neuroinflammation: Reaction & Regulation. Speakers: R von Bernhardi (Chile); R de Paula Martins (Brazil), J Harry (USA). International Neurotoxicology
Association (INA) and Neurotoxicity Society (NTS) Joint Meeting, Florianopolis, Brazil, May 20-24, 2017.
von Bernhardi R. Age-related dysregulation of glial cells in neurodegenerative diseases. IV International Symposium on Pathophysiology of the Glial Cell”, Salvador de Bahía, Brazil. April 17 – 20. 2017.
von Bernhardi R, Cornejo F, Heredia F, Cárdenas JT. Aging-related dysregulation of glial cells: untangling their participation in Alzheimer's disease, in Nanosymposium Glia and Immune Responses in
Alzheimer's Disease. 46th Annual Meeting Society for Neuroscience (SfN). San Diego, USA. November 12-16, 2016.
Cornejo F, Vruwink M, Muñoz P, von Bernhardi R. Class A Scavenger Receptor deficiency impairs immune response of microglia and astrocytes in APP/PS1 transgenic mice. 46th Annual Meeting Society
for Neuroscience (SfN). San Diego, USA. November 12-16, 2016.
Salgado N, Muñoz P, Mundaca M, von Bernhardi R. Effect of chronic inflammatory conditions on microglial cell morphology and function in the hippocampus of adult APP/PS1 mice. 2nd FALAN Congress
2016 (Federation of Neuroscience Societies in Latin America, Caribbean and the Iberian Peninsula). Buenos Aires, Argentina. October 17-20, 2016.
von Bernhardi R. Talk: Microglial cell dysregulation in brain aging and neurodegeneration in Symposium “Function, repair and training of the nervous system”. 2nd FALAN Congress 2016 (Federation of
Neuroscience Societies in Latin America, Caribbean and the Iberian Peninsula). Buenos Aires, Argentina. October 17-20, 2016.
von Bernhardi R. Chair symposium “The Glial Cell-Neuron Regulatory Crosstalk” Speakers: F Kirchhoff (Germany), A Rodrigues de Oliveira (Brazil), F Silveira (Brazil) and R von Bernhardi (Chile).
Talk: Regulation of microglia-mediated neurodegeneration. 2nd FALAN Congress 2016 (Federation of Neuroscience Societies in Latin America, Caribbean). Buenos Aires, Argentina. Oct. 17-20, 2016.
von Bernhardi R. Muñoz P, Cornejo F. Aging-associated neuroinflammation: the effect of changes on TGF? signaling and Scavenger receptor on glial cell function. 10th FENS Forum of Neuroscience.
Copenhagen, Denmark. July 2-6, 2016
von Bernhardi R. Talk Aging-dependent changes of glial cell function and Alzheimer’s disease (Topic: Advances in Neurosciences) XXII World Congress of Neurology – Changing Neurology Worldwide.
Santiago, Chile. October 31 – November 3, 2015.
von Bernhardi R. Chair Symposium Advances in Neurosciences. Speakers: P Magistretti (Switzerland); R von Bernhardi (Chile); G. Rizzolati (Italy). XXII World Congress of Neurology – Changing Neurology
Worldwide. Santiago, Chile. October 31 – November 3, 2015.
von Bernhardi R, Salgado N, Ramírez G, Navarro P. Effect of inflammation and anti-A? immunotherapy on the pattern of microglia activation and their association with ? amyloid plaques in an Alzheimer's
disease animal model. 45th Annual Meeting Society for Neuroscience (SfN). Chicago, USA. October 17-21, 2015.
Eugenín-von Bernhardi L, Peñailillo A, Salgado N, von Bernhardi, R. Gender related cognitive differences in response to chronic inflammation and passive immunotherapy in an Alzheimer´s disease mouse
model. 45th Annual Meeting Society for Neuroscience (SfN). Chicago, USA. October 17-21, 2015.
Cornejo F, Salgado N, Andrés ME, von Bernhardi, R. Changes in SR-A expression in aged APP/PS1 mice: their dependence on activation of the TGF? pathway and their consequence in inflammatory
activation of glia. 45th Annual Meeting Society for Neuroscience (SfN). Chicago, USA. October 17-21, 2015.
von Bernhardi R. Present Symposium Astrocyte-derived TGF? in the regulation of age-related changes in microglia and neurodegeneration. 12th European Meeting on Glial Cell Function in Health and
Disease. Bilbao, Spain. July 15-18, 2015. Glia 63 Supp. 1pp: E54-E55 Abstract: S21-02 Published: Aug 2015
Eugenin J, Beltran-Castillo S, Llona I, Zuñiga G, von Bernhardi R. D-serine acting on raphe nucleus and ventral respiratory column can mediate respiratory responses induced by hypercapnia in neonatal
mice. 12th European Meeting on Glial Cell Function in Health and Disease. Bilbao, Spain. July 15-18, 2015. Glia 63 Supp. 1 pp. E204-E205 Meeting Abstract: T08-06A Published: Aug 2015
Orellana JA, Avendano B, Montero T, Chavez C, von Bernhardi R. Prenatal exposure to inflammatory conditions increases hemichannel opening and activation of astrocytes in the offspring: repercussion on
neuronal survival. 12th European Meeting on Glial Cell Function in Health and Disease. Bilbao, Spain. July 15-18, 2015. Glia 63 Supp. 1 pp: E446-E446 Abstract: T15-06A Published: Aug 2015
von Bernhardi R. Aged microglia: of receptors and functional changes, and their deleterious effects in neurodegenerative diseases in “New perspectives on microglial cells as essential components of the
CNS”. 9th IBRO World Congress. Rio de Janeiro, Brazil, July 7-11, 2015.
von Bernhardi R. Alzheimer’s disease: a broad view on its pathogenic mechanisms and its impact in the region. Primer Congreso Nacional e Internacional de la Academia de Neurociencias del Perú y
Primera Jornada Internacional de la Sociedad para las Neurociencias del Perú. Lima, Perú. June 26-28, 2015.
von Bernhardi R. “Participation of Scavenger Receptor A in the activation of Glial cells in an Alzheimer's disease transgenic model.” VII Neurotoxicity Society Meeting. Cuenca, Spain. April 12-16, 2015
von Bernhardi R, Salgado N, Giacaman A, Ramírez G, Gimpel J, Eugenín-von Bernhardi V, Peñailillo A, Mundaca M, Pizarro J, Eugenín-von Bernhardi L. Changes on cognitive performance and glia
activation pattern after sustained anti-A? immunotherapy. 44th Annual Meeting Society for Neuroscience (SfN). Washington DC, USA. November 15-19, 2014.
Cornejo FA, Vruwink M, Metz C, Ramírez G, von Bernhardi R. Role of Scavenger Receptor Class A in glial cell activation in Alzheimer’s disease. 44th Annual Meeting Society for Neuroscience (SfN).
Washington DC, USA. November 15-19, 2014.
von Bernhardi R, Cornejo F, Vruwink M, Ramirez G, Metz C. Aging-Associated Changes On CNS Innate Immunity: A New Edge On Neurodegenerative Diseases. PANAM - 1st PanAmerican Congress of
Physiological Sciences. Foz de Iguazú, Brazil, August 2-6, 2014
von Bernhardi R. (2014) Age-dependent changes on the regulation of microglia by TGF?1: novel mechanisms for understanding neurodegenerative diseases. IX Congreso Nacional Colegio Colombiano de
Neurociencia / X Seminario Internacional de Neurociencias. Cartagena de Indias Mayo 15 – 17, 2014
von Bernhardi R, Cornejo F, Ramírez G, Eugenín-von Bernhardi L. Age-dependent changes on the regulation of microglia activation by TGF?1: its importance for cytotoxicity in neurodegenerative disease
models. EMBL Conference - Microglia: Guardians of the Brain. Heidelberg, Germany. March 26 - 29, 2014
- “Symposium on Excellence in Higher Education”. Brazilian Academy of Sciences FAPERJ and TWAS ROLAC. Rio de Janeiro, September 22-24, 2014.
- von Bernhardi R. “Understanding the Mind from the Neurosciences: Proposals, Approaches and Shortcomings” International meeting: Neuroscience: theory, practic and reconfigurations of free will.
Santiago, Chile. November 10-12, 2014.
- von Bernhardi R. Seminar “An updated look at Alzheimer's disease”. Universidad de Atacama, Social Work and COPRAD. December 12, 2014.
- von Bernhardi R. Participation in the Community oriented program “Tertulias Porteñas” - What we know about memory? Valparaíso, Chile. 1 September 2014
- von Bernhardi R. “New Horizons in Brain Health: Alzheimer’s disease & other age-related dementias” Talk at the Bainbridge Public Library– Series “What's New in Neuroscience?” September 26, 2015.
- Organizing Committee and Convenor of the World Congress of Neurology; Santiago, Chile October 31 to November 6, 2015.
- von Bernhardi R. “Neurosciences: From the laboratory to the Clinic”. Congreso Chileno de Estudiantes de Medicina. Santiago, Chile. July 19-23, 2016
- von Bernhardi R. Conference “Ethical dilemmas associated with dementia” II Congreso Peruano y II Seminario Internacional de Neuropsicología “Current State of Neuropsychology in the Region”. Lima,
Peru. 4-6 August, 2016
- Explora program for Highschool Students. 2017
- von Bernhardi R. – Talk "Religion and Science: No Need to Choose", Seminar: Neuroscientists study religious phenomena, an endorsement for religiosity? USACH, April 8, 2019
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Residence-Fellowship in Biological Sciences
PONTIFICIA UNIVERSIDAD CATOLICA CAMPINAS
Chile, 1987
Fellowship for Doctoral Studies
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Organization of American States Training Fellowship
ORGANIZACION DE LOS ESTADOS AMERICANOS
Estados Unidos, 1991
Fellowship for PhD Thesis research in USA
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Organization of American States Training Fellowship
ORGANIZACION DE LOS ESTADOS AMERICANOS
Chile, 1992
Fellowship for PhD Thesis research in USA
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1993 Marine Biology Laboratory Training Award
Marine Biology Laboratory Woods Hole, Massachussets
Chile, 1993
Fellowship for a summer research course in Woods Hole
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Junior Research Award
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Chile, 2005
Recognition for research accomplishment
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President for the Chilean Society for Neuroscience
Sociedad Chilena Neurociencia
Chile, 2005
President for the Chilean Society for Neuroscience (Sociedad Chilena Neurociencia) – 2 terms. From 2005 until 2010
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President FALAN (Federación de Asociaciones Latinoamericanas y del Caribe de Neurociencias) – 2 terms.
FALAN
Estados Unidos, 2009
President FALAN - Federation of Latinoamerican and Caribbean Associations of Neuroscience (Federación de Asociaciones Latinoamericanas y del Caribe de Neurociencias) – reelected for 2 terms. From 2009 to 2014
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Research Award in Aging Santander-Universia
Santander-Universia
Chile, 2018
Award for the trajectory in aging research
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Research Award Faculty of Medicne
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Chile, 2019
Research Award Senior category
Reactivity and phagocytic behaviour of glial cells exposed to amyloid precursor protein |
Aging and Dementia |
Pathophysiology of Alzheimer's disease |
Risk Factors and prevention of Alzheimer's disease |
The Plastic Brain |
Glial Cells in Health and Disease of the CNS |
Aging |
Participation of Glial Cells in the Pathogenesis of AD: A Different View on Neuroinflammation |
Clinical research in Chile: do not block the way of inquiry |
Comment on the ongoing need for good physiological investigation: Obstructive sleep apnea in HIV patients as a paradigm |
Nuevos horizontes para un buen envejecimiento=> Efecto de la desregulación microglial en la funcionalidad neuronal y la enfermedad de Alzheimer. En búsqueda de un biomarcador funcional temprano |
Age-related changes in the regulation of neuroinflammation => relevance in Neurodegerative processes. |
Microglia as a new player in the chemosensory control of breathing in health and disease |
Uncovering the role of hemichannels in glial and neuronal dysfunction induced by alpha-synuclein. |
NEURON-GLIA INTERACTION IN CENTRAL CHEMORECEPTION AND PRENATAL NICOTINE EXPOSURE=> LOOKING FOR PATHOGENIC MECHANISMS LINKING MATERNAL CIGARETTE SMOKING WITH SUDDEN INFANT DEATH SYNDROME |
PARTICIPATION OF SCAVENGER RECEPTOR A IN THE INFLAMMATORY ACTIVATION OF GLIAL CELLS=> A POTENTIAL TARGET FOR THERAPEUTIC INTERVENTION IN ALZHEIMERS DISEASE. |
Strengthening Biomedical Research through the development of Animal Welfare Research in laboratory rodents and implementation of institutional animal care systems according to international standards |
Fortalecimiento de la Investigación Biomédica mediante el desarrollo de Investigación en Bienestar Animal en roedores de laboratorio e implementación de sistemas de cuidado animal institucional acorde a los estándares internacionales |
Identificación de inhibidores de la quinasa C-ABL para el potencial tratamiento de la enfermedad de Alzheimer |
IMPAIRMENT OF PRO- AND ANTI-INFLAMMATORY SIGNALING MEDIATES GLIAL DYSFUNCTION AND PROMOTES DEVELOPMENT OF ALZHEIMER DISEASE. |
La inflamación, un elemento clave en los procesos neurodegenerativos=> Activación de la quinasa c-Abl en el envejecimiento en un modelo murino de Alzheimer |
Plataforma de equipamiento mayor para la formación interdisciplinaria de capital humano avanzado en el marco del Colegio de Programas Doctorales UC |
PRENATAL NICOTINE AND SEROTONERGIC DRIVE OF THE NEONATAL RESPIRATORY RHYTHM=> A PROBABLE LINK TO SUDDEN INFANT DEATH SYNDROME |
Scavenger Receptors Type-A of Microgia Promote Abeta Uptake after Abeta Immunotherapy |
TGFbeta como modulador de la capacidad de células macrofágicas de fagocitar Abeta=> estudio en microglías de un modelo murino y en monocitos de pacientes con Enfermedad de Alzheimer. |
Regulation of excitatory synapses by non-aggregated beta-amyloide peptide. |
Critical period and effect of prenatal nicotine exposure upon properties of chemosensory respiratory nuclei in neonatal mice=> an approach to the Sudden Infant Death Syndrome. |
Senescence and inflammation=> Triggering Factors or modulators of neurodegeneration? An experimental approach to evaluate their relevance for the pathogenics of Alzheimer’s disease. |
EFECTO DE LA EXPOSICION PRENATAL CRONICA DE NICOTINA SOBRE LA ONTOGENIA TEMPRANA DE LA QUIMIORRECEPCION CENTRAL RESPIRATORIA EN RATONES.EN BUSQUEDA DE LA ETIOPATOGENIA DEL SINDROME DE MUERTE SUBITA DEL LACTANTE (SIDS) |
LA GLIA EN LA ENFERMEDAD DE ALZHEIMER=> SU PARTICIPACION EN EL PROCESAMIENTO DEL APP Y SUS DERIVADOS |
LA GLIA EN LA ENFERMEDAD DE ALZHEIMER=> SU PARTICIPACION EN EL PROCESAMIENTO DEL APP Y SUS DERIVADOS |
QUIMIORRECEPTORES CENTRALES=> IDENTIFICACION Y ESTUDIO DE SU SELECTIVIDAD DE ACCION SOBRE LA AMPLITUD Y LA DURACION DEL CICLO RESPIRATORIO EN RATONES NEONATOS |
LA GLIA EN LA GENERACION Y NEUROTOXICIDAD DE LOS AGREGADOS DE B-AMILOIDE EN LA ENFERMEDAD DE ALZHEIMER=> SU ESTUDIO Y DISENO DE UN POSIBLE INSTRUMENTO DIAGNOSTICO DE LA POBLACION SUSCEPTIBLE |
REGENERACION DEL NERVIO PERIFERICO=> ACELERACION POR FACTOR DE CRECIMIENTO. |
MECANISMOS DEL DANO CELULAR INDUCIDO POR CALCIO EN LAS DISTROFIAS MUSCULARES Y SU PREVENCION. |
Grant 1R03TW008019-01A2 “Scavenger Receptors Type-A of Microgia Promote Abeta Uptake after Abeta Immunotherapy” |