
Miguel Reyes Parada
Full Professor
UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA
Santiago, Chile
Medicinal Chemistry, Pharmacology, Neuropharmacology, Polypharmacology
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Chemist and Pharmacist, UNIVERSIDAD DE CHILE. Chile, 1992
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Biological Sciences, Universidad de la República Oriental de Uruguay. Uruguay, 1996
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Full professor Full Time
UNIVERSIDAD DE SANTIAGO DE CHILE
Ciencias Médicas
Santiago, Chile
1998 - At present
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Full Professor Full Time
Universidad de Santiago de Chile
Santiago, Chile
1998 - At present
- MSc. Thesis in Chemistry, University of Chile. “Synthesis, enantiomeric resolution and evaluation as MAO-inhibitors of 4-methylthio amphetamine and N-alkylated derivatives Claudio Hurtado-Guzmán. 2001.
- PhD. Thesis in Chemistry, University of Chile. “Synthesis of phenethylamine derivatives as potential MAO-inhibitors”. Alejandra Gallardo-Godoy. 2003.
- PhD. Thesis in Chemistry, University of Santiago de Chile. Quantitative structure-activity relationships of phenethylamine derivatives as potential MAO-inhibitors. Angélica Fierro. 2007
- PhD. Thesis in Biotechnology, University of Santiago de Chile. “Similarities between the binding sites of monoamine oxidase and the serotonin transporter: a study using mathematical algorithms, molecular simulation and biological assays”. Gabriel Núñez-Vivanco. 2015
- PhD. Thesis in Biotechnology, University of Santiago de Chile. “Determination of similarities between the active sites of monoaminergic proteins and nicotinic receptors: an approach for the rational design of polypharmacological drugs". Patricia Möller. 2017
- Dirección Investigacion PostDoctoral (financiamiento USACH), Rafael Barra 2012.
- Dirección Investigacion PostDoctoral (financiamiento USACH), Valeska Cid-Jofre 2024.
- Dirección Investigacion PostDoctoral (financiamiento ANID), Juan Pablo González-Gutiérrez En curso.
Delayed early morning turn ON'' in response to a single dose of levodopa in advanced Parkinson's disease: pharmacokinetics should be considered" |
Multisteric drugs: Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites |
Multisteric drugs=> Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites |
Synthesis of Novel Indole Derivatives Targeting=> Serotonergic (SERT inhibition /5-HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease |
“Synthesis of Novel Indole Derivatives Targeting: Serotonergic (SERT inhibition /5 HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease |
Designing chemical poly-bullets for nicotinic acetylcholine receptors and monoamine transporters (SERT, NET and DAT). A poly- pharmacology approach to understand the nicotine addiction and withdrawal syndrome mediated by multiple receptor targets. |
DESIGNING CHEMICAL POLY-BULLETS FOR NICOTINIC ACETYLCHOLINE RECEPTORS AND MONOAMINE TRANSPORTERS (SERT, NET AND DAT). A POLY-PHARMACOLOGY APPROACH TO UNDERSTAND THE NICOTINE ADDICTION AND WITHDRAWAL SYNDROME MEDIATED BY MULTIPLE RECEPT |
A synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1h-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at SERT, D2 and MAO-A receptors |
A synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1h-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at SERT, D2 and MAO-A receptors |
Fishing for complements: Design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites |
Fishing for complements=> Design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites” |
Design, Synthesis and Pharmacological Evaluation of Dual Nicotinic Agonist and MAO-B Inhibitors Activity for Regulation of Dopamine Level in the Brain |
Design, Synthesis and Pharmacological Evaluation of Dual Nicotinic Agonist and MAO-B Inhibitors Activity for Regulation of Dopamine Level in the Brain. |
A Rational Synthetic Approach to 3-Indolealkyl(Aryl)Piperazine Derivatives as New Hetero and Homobivalent Ligands With Potential Serotonergic Activity |
A Rational Synthetic Approach to 3-Indolealkyl(Aryl)Piperazine Derivatives as New Hetero and Homobivalent Ligands With Potential Serotonergic Activity |
The Monoaminergic "Receptophore". Similarities Among the Active Sites of Monoaminergic Target Proteins, Based on their Crystal Structures: Implications for the Development of Selective and Non-Selective Ligands |
The Monoaminergic "Receptophore". Similarities Among the Active Sites of Monoaminergic Target Proteins, Based on their Crystal Structures=> Implications for the Development of Selective and Non-Selective Ligands. |
Monoamine Oxidase Inhibitors. Binding Mode, Rational Design, Synthesis and Pharmacological Evaluation Based on the Enzymes Crystal Structures |
Monoamine Oxidase Inhibitors. Binding Mode, Rational Design, Synthesis and Pharmacological Evaluation Based on the Enzymes Crystal Structures |
Phenethylamine as probes for exploring the MAO active site |

Miguel Reyes
Full Professor
Facultad de Ciencias Médicas
UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA
Santiago, Chile
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Ramón Sotomayor
Full Professor
Institute of Physiology
UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA
Valparaíso, Chile

Bruce Cassels
Profesor Titular
Departamento de Química
UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA
Santiago, Chile

Gabriel Nuñez
Jefe de Carrera, Ingeniería Civil Informática
Ciencias Naturales y Tecnología
Universidad de Aysén
Coyhaique, Chile

Patricio Iturriaga
Profesor Asociado A
Ciencias Quimicas y Recursos Naturales
UNIVERSIDAD DE LA FRONTERA
Temuco, Chile

Katia Gysling
Professor
Cellular and Molecular Biology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

JAIME MELLA
PROFESOR ADJUNTO
INSTITUTO DE QUIMICA Y BIOQUIMICA
UNIVERSIDAD DE VALPARAISO
VALPARAISO, Chile

Pedro Chana Cuevas
Profesor Titular
Facultad de Ciencias Medicas
Universidad de Santiago
Santiago, Chile

Sebastián Loyola
Académico Investigador
Ciencias de la Salud
Universidad Católica Silva Henriquez
Santiago, Chile

Rommy von Bernhardi
Full Professor
Neurology
DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Floria Pancetti
Director de Departamento
Ciencias Biomédicas
UNIVERSIDAD CATOLICA DEL NORTE
Coquimbo, Chile

HERNAN PESSOA
Profesor Asociado
Química Orgánica y Fisicoquímica
UNIVERSIDAD DE CHILE
SANTIAGO, Chile

Carlos Pessoa
Profesor Titular
Departamento de Farmacia
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile
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David Ramirez
Profesor Asistente
Facultad de Ciencias Biológicas
Universidad de Concepción
Concepcion, Chile

Claudio Coddou
Profesor Asociado
Departamento de Ciencias Biomédicas
Universidad Católica del Norte
Coquimbo, Chile

Georgina Renard
Associate professor - Directora CIBAP
School of Medicine
Universidad de Santiago de Chile
Santiago, Chile

Ana Martinez
Research Professor
Centro Investigaciones Biológicas (CIB)
Consejo Superior de Investigaciones Científicas (CSIC)
Madrid, Chile

Oscar Forero
Investigador
Instituto de Química de Recursos Naturales
Universidad de Talca
Talca, Chile

EDWIN PÉREZ
Profesor Asociado
Departamento de Química Orgánica
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Cecilia Rojas
Asistente de investigación
Virologia Molecular y Celular
Universidad de Chile
Santiago, Chile

Cristian Salas
Associate professor
Organic Chemistry
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Jorge Campusano
Associate Professor
Cell & Molecular Biology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Rafaella Zárate
Investigadora Postdoctoral
Instituto Antofagasta
Universidad de Antofagasta
Antofagasta, Chile

Felipe Moraga
Profesor a Contrata
Departamento de Ciencias Químicas y Recursos Naturales
Universidad de La Frontera
Temuco, Chile

Macarena Gárate
Asistente de investigación
Centro de Investigación Biomédica Aplicada (CIBAP)
Universidad de Santiago de Chile
Santiago, Chile

CLAUDIO SAITZ
Associate Prof.
Organic and Phisycal Chemistry
UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS
Santiago, Chile

Patricio Rojas
Assistant Professor
Departamento de Biologia
UNIVERSIDAD DE SANTIAGO DE CHILE
Santiago, Chile

Nelson Barrera
Associate Professor
Physiology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

rafael barra
Academico investigador
Escuela de Medicina
universidad de santiago de Chile
Santiago de Chile, Chile

Wendy Gonzalez
Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)
Bioinformática
CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA
Talca, Chile

Guillermo Díaz
Académico
Química Farmacológica y Toxicológica
UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS
Santiago, Chile

Fanny Guzman
Investigador Senior
Núcleo de Biotecnología Curauma
Pontificia Universidad Católica de Valparaiso
Valparaiso, Chile

ANTONIO GALDAMEZ
ASSOCIATE PROFESSOR
CHEMISTRY
DEPARTAMENTO DE QUÍMICA, FACULTAD DE CIENCIA, UNIVERSIDAD DE CHILE
SANTIAGO, Chile