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EDWIN GREGORIO PÉREZ HERNÁNDEZ

Profesor Asociado

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Homogeneous catalysis; Organic Synthesis; copper catalysis Medicinal Chemistry; Neurochemistry; Pharmacology

Organic Synthesis, UNIVERSIDAD DE CHILE. Chile, 2008
Quimica de productos Naturales, Universidad de Antioquia. Colombia, 2003
Licenciado en Química, Universidad de Cordoba. Colombia, 1999

Profesor asistente Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Química

Santiago, Chile

2009 - 2014
Profesor Asociado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Química

Santiago, Chile

2015 - At present

Docencia
Laboratorio de Síntesis Orgánica
Química Orgánica Fundamental
Química Orgánica Avanzada

Proyectos
2010-2012
Desing, Synthesis and evaluation of possible subtype-selective antagonists of nicotinic acetylcholine receptors. Investigador responsible. CONICYT FONDECYT Iniciación.
2012-2014
The membrane proteine structural biolgy. Joven investigador. Millennium Nucleus Iniciativa Científica Milenio.
Proyecto P10-035-F.
2012-2013
Síntesis de moduladores nicotínicos de la señalización aminérgica en el modelo de Drosophila melanogaster.
Investigador responsable. Proyecto Interdisciplina UC Nº 39 2011.
2013-2017
Design, synthesis and evaluation of possible selective agonist of ALPHA9ALPHA10 nicotinic acetylcholine receptor subtypes. Investigador Responsable. CONICYT FONDECYT Regular.

2017-2021
Synthesis of possible biogenic amine neurotransmitter transporter blockers using copper catalysis. Investigador Responsable. CONICYT FONDECYT Regular.

Redes
UC
Angélica Fierro, Facultad de Química.
Jorge Campusano, Facultad de Ciencias Biológicas.
Nelson P. Barrera, Facultad de Ciencias Biológicas.
Rodrigo Chorbadjian, Facultad de Agronomía y Forestal.
Otras redes
Iriux Almodóvar, Universidad de Santiago de Chile (Chile).
Gerald Zapata, Universidad de Chile (Chile).
Kilian Muñiz, Instituto Catalán de Investigación Química (España).
José M. Eltit, Virginia Commonwealth University (USA).
Jose A. Souto, Universidad de Vigo (España)

Gestión Académica
Subdirector de Investigación de la Facultad de Química 2016-a la fecha.
Jefe de Departamento de Química Orgánica de la Facultad de Química 2014- 2015.
Comisión plan de desarrollo Facultad de Química de la Facultad de Química 2012.
COPEC-UC 2013.R.33. Insecticidas de Nueva Generación. Investigador responsable 2014-2016.

Extensión y Divulgación
252nd American Chemical Society National Meeting & Exposition. Título ponencia: Design and synthesis of new acetylcholine analogues acting as full agonists for the nicotinic acetylcholine receptor subtype alpha9alpha10. USA, 2016.
32do Congreso Latinoamericano de Química. Título ponencia: Difuncionalización de estirenos catalizadas por cobre. Chile, 2016.
16th Brazilian Meeting on Organic Synthesis. Título ponencia: Copper-catalyzed intermolecular and regioselective aminoalkoxylation of styrens. Brasil, 2015.

44th NATIONAL ORGANIC CHEMISTRY SYMPOSIUM. Título ponencia: Copper-catalyzed intermolecular and regioselective aminoalkoxylation of styrenes under different mechanisms. USA, 2015.

Diplomado en Química para profesores de ciencias y química. Relator Módulo química Orgánica, sección reactividad en Química Orgánica y laboratorio de síntesis de analgésicos y determinación cualitativa de grupos funcionales. 2012


Optoelectronic and NLO potential of styryl-functionalized nitroisoxazoles for OLED technologies Acosta-Quiroga, Karen; Polo-Cuadrado, Efraín; Percino, M. Judith; Blanco-Acuna, Edgard; Villaman, David; Perez-Gutierrez, Enrique; Patino, Maria Eugenia; Alderete, Joel B.; Gonzalez, Ricelia; Saavedra-Olavarria, Jorge; et al. Article ISI JOURNAL OF MATERIALS CHEMISTRY C (2025)
A new strategy to build electrochemical enzymatic biosensors using a nanohybrid material based on carbon nanotubes and a rationally designed schiff base containing boronic acid Dalmasso, Pablo; Rivas, Gustavo Article ISI TALANTA (2024)
Assessment of the Activity of Nitroisoxazole Derivatives against <i>Trypanosoma cruzi</i> Moncada-Basualto, Mauricio; Saavedra-Olavarria, Jorge; Rivero-Jerez, Paula S.; Rojas, Cristian; Maya, Juan D.; Liempi, Ana; Zuniga-Bustos, Matias; Olea-Azar, Claudio; Lapier, Michel; Perez, Edwin G.; et al. Article ISI MOLECULES (2024)
Effect of the introduction of ethylenedioxythiophene and styrilnitroisooxazol groups on the properties and photovoltaic performances of tryphenylamine based π -conjugated push-pull molecules Arteaga, Gean C.; Louarn, Guy; Ramos-Hernandez, Andrea; Romero, Mario; Arzel, Ludovic; Bernede, Jean Christian; Saavedra-Olavarria, Jorge; Perez, Edwin G.; Maza, Julio R.; Romero, Jonathan; et al. Article ISI MICRO AND NANOSTRUCTURES (2024)
Hydrofluoroether Synthesis through One-Pot Anodic Iodoalkoxylation of Alkenes Becerra-Ruiz, Martin; Winterson, Bethan; Perez, Edwin G.; Wirth, Thomas Article ISI ADVANCED SYNTHESIS & CATALYSIS (2024)
Quinolin-2(1<i>H</i>-)-one-isoxazole dye as an acceptor for mild addition of bisulfite in cationic or zwitterionic aqueous micellar solutions Quintero, Guillermo E.; Espinoza, Catalina; Valencia, Jhesua; Insuasty, Daniel; Tiznado, William; Leiva-Parra, Luis; Santos, Jose G.; Perez, Edwin G.; Aliaga, Margarita E. Article ISI NEW JOURNAL OF CHEMISTRY (2024)
Synthesis, Photophysical Properties, Theoretical Studies, and Living Cancer Cell Imaging Applications of New 7-(Diethylamino)quinolone Chalcones Insuasty, Daniel; Mutis, Mario; Trilleras, Jorge; Illicachi, Luis A.; Rodriguez, Juan D.; Ramos-Hernandez, Andrea; San-Juan-Vergara, Homero G.; Cadena-Cruz, Christian; Mora, Jose R.; Paz, Jose L.; et al. Article ISI ACS OMEGA (2024)
Fast and efficient synthesis of 2-(benzyloxy)-N,N-disubtituted-2-phenylethan-1-amines Rivero-Jerez, Paula S.; Saavedra-Olavarria, Jorge; Perez, Edwin G. Article ISI TETRAHEDRON LETTERS (2023)
Side Groups Convert the α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator Viscarra, Franco; Chrestia, Juan Facundo; Sanchez, Yaima; Perez, Edwin G.; Biggin, Philip C.; Bouzat, Cecilia; Bermudez, Isabel; Lopez, Jhon J. Article ISI ACS CHEMICAL NEUROSCIENCE (2023)
Fast Heating-Assisted One-Pot Copper-Catalyzed Sulfonylation and Sulfochlorination of Styrenes Almodovar, Iriux Article ISI EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2022)
Host-guest complexation of APP<SUP>+</SUP> with cucurbit[7]uril. Theoretical and experimental studies on the supramolecular inhibition of its cytotoxicity on SERT Almendras, Sebastian; Maria Zarate, Ana; Dinamarca-Villarroel, Luis; Guerra, Daniel; Fuentealba, Denis; Eltit, Jose M.; Aliaga, Margarita E.; Fierro, Angélica; Perez, Edwin G. Article ISI NEW JOURNAL OF CHEMISTRY (2022)
N-Arylation of 3-Formylquinolin-2(1H)-ones Using Copper(II)-Catalyzed Chan-Lam Coupling Valencia, Jhesua; Sanchez-Velasco, Oriel A.; Insuasty, Daniel Article ISI MOLECULES (2022)
A new porous organic polymer containing Troger's base units: Evaluation of the catalytic activity in Knoevenagel condensation reaction Velazquez-Tundidor, M. V.; Coll, Deysma; Perez, Edwin Article ISI REACTIVE & FUNCTIONAL POLYMERS (2021)
Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study Duarte, Yorley; Rojas, Maximiliano; Canan, Jonathan; Perez, Edwin G.; Gonzalez-Nilo, Fernando; Garcia-Colunga, Jesus Article ISI MOLECULES (2021)
Functionalization using biocompatible carboxylated cyclodextrins of iron-based nanoMIL-100 Gimenez-Marques, Monica Article ISI POLYHEDRON (2021)
Supramolecular Control of Reactivity toward Hydrolysis of 7-Diethylaminocoumarin Schiff Bases by Cucurbit[7]uril Encapsulation Alcazar, Jackson J.; Geue, Niklas; Valladares, Veronica; Canete, Alvaro; Perez, Edwin G.; Garcia-Rio, Luis; Santos, Jose G.; Aliaga, Margarita E. Article ISI ACS OMEGA (2021)
Synthesis of <i>N</i>-Arylcytisine Derivatives Using the Copper-Catalyzed Chan-Lam Coupling Araya-Santelices, Daniel A. A.; Cassels, Bruce K. Article ISI JOURNAL OF NATURAL PRODUCTS (2021)
Synthesis of <i>N</i>-arylsulfonamides via Chan-Lam Coupling Between Aryl Boronic Acids and <i>N</i>-[(sulfonyl)imino]phenyliodinanes Merchan-Arenas, Diego R.; Rivero-Jerez, Paula S.; Perez, Edwin G. Article ISI CHEMISTRYSELECT (2021)
Facile synthesis of a luminescent copper(I) coordination polymer containing a flexible benzotriazole-based ligand: An effective catalyst for three-component azide-alkyne cycloaddition NuÃ±ez-Dallos N. Article ISI SCOPUS INORGANICA CHIMICA ACTA (2019)
New convergent one pot synthesis of amino benzyl ethers bearing a nitrogen-containing bicycle López, Jhon J; Pérez, Edwin G. Article SYNTHETIC COMMUNICATIONS (2019)
Copper-catalyzed intermolecular aminochlorination of alkenes Arteaga, Gean C.; Saavedra-Olavarria, Jorge; Almodovar, Iriux Article ISI SCOPUS TETRAHEDRON LETTERS (2018)
Methylpiperidinium Iodides as Novel Antagonists for Î±7 Nicotinic Acetylcholine Receptors. López, Jhon J; García-Colunga, Jesús; Pérez, Edwin G; Fierro, Angélica Article Frontiers in pharmacology (2018)
Synthesis of β-alkoxy-=> N -protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening Saavedra-Olavarría, Jorge; Rojas-Madrid, Matías; Almodovar, Iriux; Hermosilla-Ibáñez, Patricio; Pérez, Edwin G. Article RSC ADVANCES (2018)
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors Molina-Mateo, Daniela; Escobedo, Pía; Zarate, Rafaella V; Reyes-Parada, Miguel; Fuenzalida-Uribe, Nicolás Article ISI SCOPUS ACS Chemical Neuroscience (2017)
New fluorescent turn-off probes for highly sensitive and selective detection of SO2 derivatives in a micellar media Bravo-Díaz C. Article ISI SCOPUS SENSORS AND ACTUATORS B-CHEMICAL (2017)
Copper-Catalyzed Intermolecular Aminooxygenation of Styrenes using N-Fluorobenzenesulfonimide and Simple Alcohols Herrera-Leyton C.; Cañete Á.; Pérez E.G. Article ISI SCOPUS CHEMCATCHEM (2016)
Regioselective Intermolecular Diamination and Aminooxygenation of Alkenes with Saccharin Martinez, C.; Pérez E.G.; Iglesias, A.; Escudero-Adán E.C.; Muñiz K. Article ISI SCOPUS ORGANIC LETTERS (2016)
Copper-catalyzed intermolecular and regioselective aminofluorination of styrenes=> facile access to beta-fluoro-N-protected phenethylamines Saavedra-Olavarria, J; Arteaga G.C., López J.J. Article CHEMICAL COMMUNICATIONS (2015)
Dual effects of a 2-benzylquinuclidinium derivative on alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal interneurons Lopez, JJ; Garcia-Colunga, J Article ISI SCOPUS Neuroscience Letters (2015)
The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptors in Mice Bagdas, D; Targowska-Duda, KM; Lopez, JJ; Arias, HR; Damaj, MI Article ISI SCOPUS Anesthesia and Analgesia (2015)
Substituent effects on reactivity of 3-cinnamoylcoumarins with thiols of biological interest Tiznado, W; Millán D.; Garcia-Beltran, O; Pavez P. Article ISI SCOPUS RSC ADVANCES (2014)
Tracking the Molecular Evolution of Calcium Permeability in a Nicotinic Acetylcholine Receptor Lipovsek, M; Fierro, A.; Boffi, JC; Millar, NS; Fuchs, PA; Katz, E; Elgoyhen, AB Article ISI SCOPUS MOLECULAR BIOLOGY AND EVOLUTION (2014)
Further mulinane diterpenoids from Azorella compacta Areche, C; Rojas-Alvarez, F; Campos-Briones, C; Lima, C; Sepulveda, B Article ISI SCOPUS Journal of Pharmacy and Pharmacology (2013)
Novel 1-(1-benzyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodides are competitive antagonists for the human alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors Ocampo, C; Feuerbach D.; Lopez, JJ; Morelo, GL; Arias, HR Article ISI SCOPUS MedChemComm (2013)
Novel 2-(substituted benzyl)quinuclidines inhibit human alpha 7 and alpha 4 beta 2 nicotinic receptors by different mechanisms Arias, HR; Lopez, JJ; Feuerbach D.; Fierro, A.; Ortells, MO Article ISI SCOPUS International Journal of Biochemistry and Cell Biology (2013)
Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives Castro-Castillo, V.; Suárez-Rozas, C.; Pabon, A; Blair, S Article ISI SCOPUS Bioorganic and Medicinal Chemistry Letters (2013)
Why is quercetin a better antioxidant than taxifolin? Theoretical study of mechanisms involving activated forms Osorio, E; Areche, C; Florez E.; Tiznado, W Article ISI SCOPUS JOURNAL OF MOLECULAR MODELING (2013)
Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors. Pérez, Edwin G; Méndez-Gálvez, Carolina; Cassels, Bruce K Article Natural product reports (2012)
Nucleophilic reactivity of biothiols toward coumarin-based derivatives containing a chalcone moiety Garcia-Beltran, O; Gonzalez C.; Millán D.; Mena N.; Pavez P. Article ISI SCOPUS Journal of Physical Organic Chemistry (2012)
Synthesis and evaluation of N-1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands Pérez E.G., Cassels B.K.; Eibl C., Gundisch D. Article Bioorganic & Medicinal Chemistry (2012)
Synthesis and evaluation of N-1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands Perez, EG; Cassels, BK; Eibl C.; Gundisch D. Article BIOORGANIC & MEDICINAL CHEMISTRY (2012)
The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study Garcia-Beltran, O; Mena N.; Werlinger F.; Zavala, D; Pavez P. Article ISI SCOPUS TETRAHEDRON LETTERS (2011)
An Intermolecular Palladium-Catalyzed Diamination of Unactivated Alkenes Iglesias, A.; Muñiz K. Article ISI SCOPUS Angewandte Chemie International Edition (2010)
Molecular modeling of the alpha 9 alpha 10 nicotinic acetylcholine receptor subtype Zapata-Torres, G Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2009)
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers Iturriaga-Vasquez, P; Slater, EY; Bermudez I. Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2007)
A CONVENIENT, RENEWABLE SOURCE OF THE ANXIOLYTIC PROAPORPHINE ALKALOID GLAZIOVINE: DUGUETIA VALLICOLA LEAVES Saez, J Article ISI SCIELO JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2005)


Synthesis, evaluation, and docking of new 4-alkoxybenzyl bicyclic amine ethers as nicotinic acetylcholine receptor antagonists Lopez, JJ; Salas, CO; Garcia-Colunga, J; Fierro-Huerta, A Abstract ISI ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2014)

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

Veronica Arancibia

Profesor horas

Quimica Inorganica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Nestor Escalona

Professor Associated

Chemical Engineering and Bioprocesses

Pontificia Universidad Católica de Chile

Santiago, Chile

Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Paulina Pavez

Associate Professor

Physical Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

Diego Venegas

Full Professor

Quimica de los Materiales

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA, DEPARTAMENTO DE QUÍMICA DE LOS MATERIALES

Santiago, Chile

Edison Osorio

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Daniela Millan

Academico investigador

Centro integrativo de biologia y quimica aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

Marlen Gutierrez

Investigador

Centro para el Desarrollo de la Nanociencia y Nanotecnologia

Universidad de Santiago de Chile

Santiago, Chile

William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Mauricio Fuentealba

Profesor Adjunto

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

Vicente Castro

Associate Professor

Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

Santiago, Chile

Ignacio Jessop

Profesor Asistente Jornada Completa

Departamento de Química

Universidad de Tarapacá

Arica, Chile

Pablo Ortiz

Profesor Asistente

Centro de Nanotecnología Aplicada

Universidad Mayor

Santiago, Chile

PATRICIO HERMOSILLA

Investigador

Química de los Materiales

UNIVERSIDAD DE SANTIAGO DE CHILE

SANTIAGO, Chile

Walter Cañón

Profesor Asociado

Matemáticas y Ciencias de la Ingeniería

Universidad Bernardo O'Higgins

Santiago, Chile

JHON LÓPEZ

Profesor Asociado

Química Orgánica

Universidad de Concepción

Concepción, Chile

Mauricio Moncada

Matías Zúñiga

Postdoctorado

Centro de Bioinformática y Simulación Molecular

Universidad de Talca

TALCA, Chile

Rafaella Zárate

Investigadora Postdoctoral

Instituto Antofagasta

Universidad de Antofagasta

Antofagasta, Chile

Iriux Almodóvar

Académico

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

Francisca Werlinger

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

Efrain Polo

Docente

Química Orgánica

Universidad de Concepción

Concepcion, Chile

EDWIN GREGORIO PÉREZ HERNÁNDEZ

Líneas de Investigación

Educación

Organic Synthesis, UNIVERSIDAD DE CHILE. Chile, 2008

Quimica de productos Naturales, Universidad de Antioquia. Colombia, 2003

Licenciado en Química, Universidad de Cordoba. Colombia, 1999

Experiencia Académica

Profesor asistente Full Time

Profesor Asociado Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (46)

Abstract (1)