Man

EDWIN GREGORIO PÉREZ HERNÁNDEZ

Profesor Asociado

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Homogeneous catalysis; Organic Synthesis; copper catalysis Medicinal Chemistry; Neurochemistry; Pharmacology

Educación

  •  Organic Synthesis, UNIVERSIDAD DE CHILE. Chile, 2008
  •  Quimica de productos Naturales, Universidad de Antioquia. Colombia, 2003
  •  Licenciado en Química, Universidad de Cordoba. Colombia, 1999

Experiencia Académica

  •   Profesor asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Química

    Santiago, Chile

    2009 - 2014

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Química

    Santiago, Chile

    2015 - At present

Formación de Capital Humano


Docencia
Laboratorio de Síntesis Orgánica
Química Orgánica Fundamental
Química Orgánica Avanzada

Proyectos
2010-2012
Desing, Synthesis and evaluation of possible subtype-selective antagonists of nicotinic acetylcholine receptors. Investigador responsible. CONICYT FONDECYT Iniciación.
2012-2014
The membrane proteine structural biolgy. Joven investigador. Millennium Nucleus Iniciativa Científica Milenio.
Proyecto P10-035-F.
2012-2013
Síntesis de moduladores nicotínicos de la señalización aminérgica en el modelo de Drosophila melanogaster.
Investigador responsable. Proyecto Interdisciplina UC Nº 39 2011.
2013-2017
Design, synthesis and evaluation of possible selective agonist of ALPHA9ALPHA10 nicotinic acetylcholine receptor subtypes. Investigador Responsable. CONICYT FONDECYT Regular.

2017-2021
Synthesis of possible biogenic amine neurotransmitter transporter blockers using copper catalysis. Investigador Responsable. CONICYT FONDECYT Regular.

Redes
UC
Angélica Fierro, Facultad de Química.
Jorge Campusano, Facultad de Ciencias Biológicas.
Nelson P. Barrera, Facultad de Ciencias Biológicas.
Rodrigo Chorbadjian, Facultad de Agronomía y Forestal.
Otras redes
Iriux Almodóvar, Universidad de Santiago de Chile (Chile).
Gerald Zapata, Universidad de Chile (Chile).
Kilian Muñiz, Instituto Catalán de Investigación Química (España).
José M. Eltit, Virginia Commonwealth University (USA).
Jose A. Souto, Universidad de Vigo (España)

Gestión Académica
Subdirector de Investigación de la Facultad de Química 2016-a la fecha.
Jefe de Departamento de Química Orgánica de la Facultad de Química 2014- 2015.
Comisión plan de desarrollo Facultad de Química de la Facultad de Química 2012.
COPEC-UC 2013.R.33. Insecticidas de Nueva Generación. Investigador responsable 2014-2016.


Difusión y Transferencia


Extensión y Divulgación
252nd American Chemical Society National Meeting & Exposition. Título ponencia: Design and synthesis of new acetylcholine analogues acting as full agonists for the nicotinic acetylcholine receptor subtype alpha9alpha10. USA, 2016.
32do Congreso Latinoamericano de Química. Título ponencia: Difuncionalización de estirenos catalizadas por cobre. Chile, 2016.
16th Brazilian Meeting on Organic Synthesis. Título ponencia: Copper-catalyzed intermolecular and regioselective aminoalkoxylation of styrens. Brasil, 2015.

44th NATIONAL ORGANIC CHEMISTRY SYMPOSIUM. Título ponencia: Copper-catalyzed intermolecular and regioselective aminoalkoxylation of styrenes under different mechanisms. USA, 2015.

Diplomado en Química para profesores de ciencias y química. Relator Módulo química Orgánica, sección reactividad en Química Orgánica y laboratorio de síntesis de analgésicos y determinación cualitativa de grupos funcionales. 2012



 

Article (46)

Optoelectronic and NLO potential of styryl-functionalized nitroisoxazoles for OLED technologies
A new strategy to build electrochemical enzymatic biosensors using a nanohybrid material based on carbon nanotubes and a rationally designed schiff base containing boronic acid
Assessment of the Activity of Nitroisoxazole Derivatives against <i>Trypanosoma cruzi</i>
Effect of the introduction of ethylenedioxythiophene and styrilnitroisooxazol groups on the properties and photovoltaic performances of tryphenylamine based π -conjugated push-pull molecules
Hydrofluoroether Synthesis through One-Pot Anodic Iodoalkoxylation of Alkenes
Quinolin-2(1<i>H</i>-)-one-isoxazole dye as an acceptor for mild addition of bisulfite in cationic or zwitterionic aqueous micellar solutions
Synthesis, Photophysical Properties, Theoretical Studies, and Living Cancer Cell Imaging Applications of New 7-(Diethylamino)quinolone Chalcones
Fast and efficient synthesis of 2-(benzyloxy)-N,N-disubtituted-2-phenylethan-1-amines
Side Groups Convert the α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator
Fast Heating-Assisted One-Pot Copper-Catalyzed Sulfonylation and Sulfochlorination of Styrenes
Host-guest complexation of APP<SUP>+</SUP> with cucurbit[7]uril. Theoretical and experimental studies on the supramolecular inhibition of its cytotoxicity on SERT
N-Arylation of 3-Formylquinolin-2(1H)-ones Using Copper(II)-Catalyzed Chan-Lam Coupling
A new porous organic polymer containing Troger's base units: Evaluation of the catalytic activity in Knoevenagel condensation reaction
Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study
Functionalization using biocompatible carboxylated cyclodextrins of iron-based nanoMIL-100
Supramolecular Control of Reactivity toward Hydrolysis of 7-Diethylaminocoumarin Schiff Bases by Cucurbit[7]uril Encapsulation
Synthesis of <i>N</i>-Arylcytisine Derivatives Using the Copper-Catalyzed Chan-Lam Coupling
Synthesis of <i>N</i>-arylsulfonamides via Chan-Lam Coupling Between Aryl Boronic Acids and <i>N</i>-[(sulfonyl)imino]phenyliodinanes
Facile synthesis of a luminescent copper(I) coordination polymer containing a flexible benzotriazole-based ligand: An effective catalyst for three-component azide-alkyne cycloaddition
New convergent one pot synthesis of amino benzyl ethers bearing a nitrogen-containing bicycle
Copper-catalyzed intermolecular aminochlorination of alkenes
Methylpiperidinium Iodides as Novel Antagonists for α7 Nicotinic Acetylcholine Receptors.
Synthesis of &#946;-alkoxy-=> N -protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors
New fluorescent turn-off probes for highly sensitive and selective detection of SO2 derivatives in a micellar media
Copper-Catalyzed Intermolecular Aminooxygenation of Styrenes using N-Fluorobenzenesulfonimide and Simple Alcohols
Regioselective Intermolecular Diamination and Aminooxygenation of Alkenes with Saccharin
Copper-catalyzed intermolecular and regioselective aminofluorination of styrenes=> facile access to beta-fluoro-N-protected phenethylamines
Dual effects of a 2-benzylquinuclidinium derivative on alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal interneurons
The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptors in Mice
Substituent effects on reactivity of 3-cinnamoylcoumarins with thiols of biological interest
Tracking the Molecular Evolution of Calcium Permeability in a Nicotinic Acetylcholine Receptor
Further mulinane diterpenoids from Azorella compacta
Novel 1-(1-benzyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodides are competitive antagonists for the human alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors
Novel 2-(substituted benzyl)quinuclidines inhibit human alpha 7 and alpha 4 beta 2 nicotinic receptors by different mechanisms
Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives
Why is quercetin a better antioxidant than taxifolin? Theoretical study of mechanisms involving activated forms
Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors.
Nucleophilic reactivity of biothiols toward coumarin-based derivatives containing a chalcone moiety
Synthesis and evaluation of N-1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
Synthesis and evaluation of N-1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study
An Intermolecular Palladium-Catalyzed Diamination of Unactivated Alkenes
Molecular modeling of the alpha 9 alpha 10 nicotinic acetylcholine receptor subtype
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers
A CONVENIENT, RENEWABLE SOURCE OF THE ANXIOLYTIC PROAPORPHINE ALKALOID GLAZIOVINE: DUGUETIA VALLICOLA LEAVES

Abstract (1)

Synthesis, evaluation, and docking of new 4-alkoxybenzyl bicyclic amine ethers as nicotinic acetylcholine receptor antagonists
1
Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

1
Veronica Arancibia

Profesor horas

Quimica Inorganica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

5
Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Nestor Escalona

Professor Associated

Chemical Engineering and Bioprocesses

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

4
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

3
Paulina Pavez

Associate Professor

Physical Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

2
Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

40
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

2
Diego Venegas

Full Professor

Quimica de los Materiales

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA, DEPARTAMENTO DE QUÍMICA DE LOS MATERIALES

Santiago, Chile

1
Edison Osorio

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Daniela Millan

Academico investigador

Centro integrativo de biologia y quimica aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

2
Marlen Gutierrez

Investigador

Centro para el Desarrollo de la Nanociencia y Nanotecnologia

Universidad de Santiago de Chile

Santiago, Chile

2
William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

4
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Mauricio Fuentealba

Profesor Adjunto

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Vicente Castro

Associate Professor

Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

Santiago, Chile

1
Ignacio Jessop

Profesor Asistente Jornada Completa

Departamento de Química

Universidad de Tarapacá

Arica, Chile

1
Pablo Ortiz

Profesor Asistente

Centro de Nanotecnología Aplicada

Universidad Mayor

Santiago, Chile

7
PATRICIO HERMOSILLA

Investigador

Química de los Materiales

UNIVERSIDAD DE SANTIAGO DE CHILE

SANTIAGO, Chile

1
Walter Cañón

Profesor Asociado

Matemáticas y Ciencias de la Ingeniería

Universidad Bernardo O'Higgins

Santiago, Chile

6
JHON LÓPEZ

Profesor Asociado

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Matías Zúñiga

Postdoctorado

Centro de Bioinformática y Simulación Molecular

Universidad de Talca

TALCA, Chile

1
Rafaella Zárate

Investigadora Postdoctoral

Instituto Antofagasta

Universidad de Antofagasta

Antofagasta, Chile

1
Iriux Almodóvar

Académico

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

1
Francisca Werlinger

Postdoctorado

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile