Man

Cristian Osvaldo Salas Sanchez

Associate professor

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Líneas de Investigación


QUÍMICA DE HETEROCICLOS; QUÍMICA MEDICA; SÍNTESIS ORGÁNICA; DISEÑO Y SÍNTESIS DE COMPUESTOS CON PROPIEDADES BIOLÓGICAS

Educación

  •  Licenciado en Quimica, Universidad de Tarapaca. Chile, 1998
  •  Quimica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chemistry

    Santiago, Chile

    2005 - At present

Experiencia Profesional

  •   Profesor Full Time

    Pontificia Universidad Catolica de Chile

    santiago, Chile

    2005 - At present

Formación de Capital Humano


Number of Licenciatura/Bachillerato/Bachelor Thesis supervised: 10
Number of Doctorate/PhD Thesis supervised: 5

PhD Students
Pablo Thomas Riveros. Pontificia Universidad Católica de Chile. PhD in Chemistry. Tutor: Ricardo Tapia, Co-Tutor: Cristian Salas.
Ana Zarate. Pontificia Universidad Católica de Chile. PhD in Chemistry. Tutor: Cristian Salas.
Karina Vazuqez. Pontificia Universidad Católica de Chile. PhD in Chemistry. Tutor: Cristian Salas.
Natalia Quiñones I. Universidad de Valparaíso. Tutor: Mauricio Cuellar, Co-Tutor: Cristian Salas.
Marcos Mellado. Universidad de Valparaíso. Tutor: Mauricio Cuellar, Co-Tutor: Cristian Salas.



 

Article (34)

Hanschs analysis application to chalcone synthesis by Claisen-Schmidt reaction based in DFT methodology

Cuellar, Mauricio; Mella, Jaime; Mellado, Marco; Salas, Cristian O.; Martinez, Ursula; Madrid, Alejandro

Article ISI SCOPUS
CHEMICAL PAPERS  (2018)

Fluorescence properties of aurone derivatives: an experimental and theoretical study with some preliminary biological applications

Espinosa-Bustos, Christian; Cortés-Arriagada, Diego; Soto-Arriaza, Marco A.; Robinson-Duggon, José; Pizarro, Nancy; Cabrera, Alan R.; Fuentealba, Denis; Salas, Cristian O.

Article ISI SCOPUS
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES  (2017)

New imidoyl-indazole platinum (II) complexes as potential anticancer agents: Synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies

Cabrera, Alan R.; Espinosa-Bustos, Christian; Faúndez, Mario; Meléndez, Jaime; Jaque, Pablo; Daniliuc, Constantin G.; Aguirre, Adam; Rojas, René S.; Salas, Cristian O.

Article ISI SCOPUS
JOURNAL OF INORGANIC BIOCHEMISTRY  (2017)

Nutritional composition, antioxidant activity and isolation of scopoletin from Senecio nutans: support of ancestral and new uses

Parra, Claudio; Soto, Emilio; Le?n, Gloria; Salas, Cristian O.; Heinrich, Michael; Echibur?-Chau, Carlos

Article ISI SCOPUS
NATURAL PRODUCT RESEARCH  (2017)

Structural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data

Vera, Brenda; Vazquez, Karina; Tapia, Ricardo A.; Mascayano, Carolina; Espinosa, Victoria; Soto-Delgado, Jorge; Salas, Cristian O.; Paulino, Margot

Article ISI SCOPUS
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS  (2017)

New air stable cationic methallyl Ni complexes bearing imidoyl-indazole carboxylate ligand: Synthesis, characterization and their reactivity towards ethylene

Cabrera, AR; Martínez I.; Daniliuc, CG; Galland, GB; Salas, CO; Rojas, RS

Article ISI SCOPUS
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL  (2016)

Synthesis of new phosphorescent imidoyl-indazol and phosphine mixed ligand Cu(I) complexes structural characterization and photophysical properties

Cabrera, AR; Gonzalez, IA; Cortes-Arriagada, D; Natali, M; Berke, H; Daniliuc, CG; Camarada, MB; Toro-Labbe, A; Rojas, RS; Salas, CO

Article ISI SCOPUS
RSC ADVANCES  (2016)

Gramicidin conformational changes during riboflavin photosensitized oxidation in solution and the effect of N-methylation of tryptophan residues

Fuentealba, D; Lopez, JJ; Palominos, M; Salas, CO; Soto-Arriaza, MA

Article ISI SCOPUS
Photochemical and Photobiological Sciences  (2015)

MULTI-INSTRUMENTAL CHARACTERIZATION OF TWO RED PIGMENTS IN FUNERARY ARCHAEOLOGICAL CONTEXTS FROM NORTHERN CHILE

Ogalde, JP; Arriaza, B.; Paipa, C.; Leyton, P.; Campos-Vallette, M; Lara, N; Salas C.; Tapia, P

Article ISI
INTERCIENCIA  (2015)

New aryloxy-quinone derivatives as potential antiChagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis

Vazquez, K; Espinosa-Bustos, C; Soto-Delgado, J; Tapia, RA; Varela, J; Birriel, E; Segura, R; Pizarro J.; Cerecetto, H.; Gonzalez, M.; Paulino M.; Salas, CO

Article ISI SCOPUS
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING  (2015)

Preliminary Studies on the Synthesis of (-)-Shikimic Acid Based 1,2,3,4-Tetrahydrobenzo[b]phenanthridine-7,12-diones

Cuellar M.A.; Quinones, N; Vera V.; Salas, C. O.; Estevez J.C.; Estevez R.J.

Article ISI SCOPUS
Synlett  (2015)

Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines

Calderon-Arancibia, J; Espinosa-Bustos, C; Canete-Molina, A; Tapia, RA; Faundez, M; Torres, MJ; Aguirre A.; Paulino M.; Salas, CO

Article ISI SCOPUS
MOLECULES  (2015)

Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO-B Inhibitors

Morales-Camilo, N; Salas, CO; Sanhueza C.; Espinosa-Bustos, C; Sepulveda-Boza, S; Reyes-Parada, M; Gonzalez-Nilo, F; Caroli-Rezende, M; Fierro, A.

Article ISI SCOPUS
Chemical Biology & Drug Design  (2015)

Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi

Maya J.D.; Salas, C. O.; Aguilera-Venegas, B; Diaz M V; López-Muñoz R.

Article SCOPUS
Current Medicinal Chemistry  (2014)

Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents

Tapia, RA; Salas, CO; Vazquez, K; Espinosa-Bustos, C; Soto-Delgado, J; Varela, J; Birriel, E; Cerecetto, H.; Gonzalez, M.; Paulino M.

Article ISI SCOPUS
BIOORGANIC MEDICINAL CHEMISTRY LETTERS  (2014)

}The selective cytotoxicity elicited by phytochemical extract from Senecio graveolens ( Asteraceae) on breast cancer cells is enhanced by hypoxia

Echiburu-Chau, C; Alfaro-Lira, S; Brown, N; Salas, CO; Cuellar, M; Santander, J; Ogalde, JP; ROTHHAMMER, F.

Article ISI
INTERNATIONAL JOURNAL OF ONCOLOGY  (2014)

Efficient Indium-Mediated Dehalogenation of Aromatics in Ionic Liquid Media

Canete, AF; Salas, CO; Zacconi, FC

Article ISI SCOPUS
MOLECULES  (2013)

Intramolecular Diels-Alder Furan-Mediated Synthesis of 8-Aryl-3,4-dihydroisoquinolin-1(2H)-ones, Convenient Precursors of Indeno[1,2,3-ij] iso-quinolines

Treus, M; Harwood, LM; Estevez, JC; Salas C.; Drew, MGB; Estevez, RJ

Article ISI SCOPUS
Synlett  (2013)

New Short Strategy for the Synthesis of the Dibenz[b,f]oxepin Scaffold

Moreno, DRR; Giorgio, G; Salas, CO; Tapia, RA

Article ISI SCOPUS
MOLECULES  (2013)

Efficient indium-mediated dehalogenation of aromatics in ionic liquid media.

Cañete A.F.; Salas, C. O.; Zacconi, F.C.

Article SCOPUS
MOLECULES  (2012)

Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione

Lagos, C. F.; Araya-Secchi R.; Thomas P.; Perez-Acle, T; Tapia, R.A.; Salas, C. O.

Article ISI SCOPUS
Journal of Molecular Modeling  (2012)

Studies on the Michael addition of naphthoquinones to sugar nitro olefins: first synthesis of polyhydroxylated hexahydro-11H-benzo[a]carbazole-5,6-diones and hexahydro-11bH-benzo[b]carbazole-6,11-diones

Otero J.M.; Barcia J.C.; Salas, C. O.; Thomas P.; Estevez J.C.; Estevez R.J.

Article ISI SCOPUS
Tetrahedron  (2012)

6,9-Dimethoxy-3,4-dihydro-1H-1,4-oxazino[4,3-a]indol-1-one

Salas, C. O.; Tapia, R.A.; Prieto, Y

Article ISI SCOPUS
Acta Crystallographica Section E: Structure Reports Online  (2011)

7-(tert-Butyldiphenylsilyloxy)-2,2-dimethyl-1-benzofuran-3(2H)-one

Salas, C. O.; Tapia, R.A.; Macias, A

Article ISI SCOPUS
Acta Crystallographica Section E: Structure Reports Online  (2011)

(Z)-Ethyl 2-phenyl-1-(2-vinylphenyl)vinylcarbamates. Part 1: Synthesis and preliminary studies on their divergent transformation into benzo[c]phenanthridines and 2-phenyl-1,4-naphthoquinones

Treus, M; Salas, CO; Gonazalez, MA; Estevez, JC; Tapia, RA; Estevez, RJ

Article ISI SCOPUS
Tetrahedron  (2010)

Gold-Facilitated '6-Exo-dig' Intramolecular Cyclization of 2-[(2-Nitrophenyl)ethynyl]phenylacetic Acids: General Access to 5H-Benzo[b]carbazole-6,11-diones

Salas, CO; Reboredo, FJ; Estevez, JC; Tapia, RA; Estevez, RJ

Article ISI SCOPUS
SYNLETT  (2009)

(13)C NMR studies of heterocyclic naphtho- and anthraquinones. Deshielding effect on the carbonyl carbon with methyl substitution

Salas C.; Armstrong, V; López C.; Tapia, RA

Article ISI SCOPUS
MAGNETIC RESONANCE IN CHEMISTRY  (2008)

Trypanosoma cruzi: Activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms

Salas C.; Tapia, RA; Ciudad, K; Armstrong, V; Orellana M.; Kemmerling U.; Ferreira J.; Maya, JD; Morello A.

Article ISI SCOPUS
BIOORGANIC & MEDICINAL CHEMISTRY  (2008)

A convenient preparation of 7-bromo-2H-1,4-benzothiazine-3,5,8(4H)-trione and its application in the synthesis of the conaquinone B skeleton

Tapia, RA; Villalobos, L.; Salas C.

Article ISI SCOPUS
SYNTHESIS-STUTTGART  (2007)

Synthesis of 2-spironaphtho[2,3-b]pyranoquinones

Tapia, RA; Bau, A; Salas C.

Article ISI SCOPUS
SYNTHETIC COMMUNICATIONS  (2006)

Synthesis of dihydronaphthofurandiones and dihydrofuroquinolinediones with trypanocidal activity and analysis of their stereoelectronic properties

Tapia, RA; Salas C.; Morello A.; Maya, JD; Toro-Labbe, A

Article ISI SCOPUS
BIOORGANIC & MEDICINAL CHEMISTRY  (2004)

Synthesis and antiprotozoal activity of naphthofuranquinones and naphthothiophenequinones containing a fused thiazole ring

Tapia, RA; Alegria, L; Pessoa, CD; Salas C.; Cortes, MJ; VALDERRAMA, JA; Sarciron, ME; Pautet, F; Walchshofer, N; Fillion, H

Article ISI SCOPUS
BIOORGANIC & MEDICINAL CHEMISTRY  (2003)

Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives

Cuellar, MA; Salas C.; Cortes, MJ; Morello A.; Maya, JD; Preite, MD.

Article ISI SCOPUS
BIOORGANIC & MEDICINAL CHEMISTRY  (2003)

Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents

Tapia, RA; Carrasco C.; Ojeda, S; Salas C.; VALDERRAMA, JA; Morello A.; Repetto Y

Article ISI SCOPUS
JOURNAL OF HETEROCYCLIC CHEMISTRY  (2002)

Abstract (4)

Metabolomic variation in Senecio graveolens (Asteraceae) in altitudinal populations

López N.; Booker, A; Simirgiotis, M.; León G.; Alfaro-Lira, S; Salas, CO; Santander, R; Heinrich M.; Echiburu-Chau, C

Abstract ISI
PLANTA MEDICA  (2015)

Phytochemical extract from Senecio graveolens (Chachacoma): Searching new candidates for anti-cancer drugs

Echiburu-Chau, C; Salas C.; Cuellar, M; Santander, J; Ogalde, JP; Brown, N; Alfaro-Lira, S; López N.; ROTHHAMMER, F.

Abstract ISI
EUROPEAN JOURNAL OF CANCER  (2014)

Synthesis, evaluation, and docking of new 4-alkoxybenzyl bicyclic amine ethers as nicotinic acetylcholine receptor antagonists

Perez, EG.; Lopez, JJ; Salas, CO; Garcia-Colunga, J; Fierro-Huerta, A; Campusano, JM.

Abstract ISI
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  (2014)

Spectroelectrochemistry of 1,4-naphthoquinones and 5-nitroindazoles: Reduction mechanisms and free radical stability

Pozo, B; Aguilera-Venegas, B; Olea Azar C.; Aran, VJ; Salas, CO; Zuniga, MC

Abstract ISI
FREE RADICAL BIOLOGY AND MEDICINE  (2013)

Review (1)

Natural and Synthetic Naphthoquinones Active Against Trypanosoma Cruzi: An Initial Step Towards New Drugs for Chagas Disease

Salas, CO; Faundez, M; Morello A.; Maya, JD; Tapia, RA

Review ISI SCOPUS
Current Medicinal Chemistry  (2011)

45
Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

9
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Mauricio Cuellar

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

3
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

3
Rene Rojas

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Alejandro Toro

PROFESOR TITULAR

Química Física

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Flavia Zacconi

Associate Professor

Organic Chemistry

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Denis Fuentealba

PROFESOR ASOCIADO

QUIMICA FISICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

2
Alan Cabrera

Profesor Asistente

Departamento de Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Francisco Rothhammer

2
Nelson Brown

Associate Professor

University of Talca

Talca, Chile

2
Diego Cortés

Académico No Regular

Programa Institucional de Fomento a la Investigación, Desarrollo e Innovación

Universidad Tecnológica Metropolitana

Santiago, Chile

1
natalia quiñones

profesor titular

UNIVERSIDAD DE VALPARAISO

valparaiso, Chile

1
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Emilio Soto

Jefe de laboratorio

Centro de Investigaciones del Hombre en el Desierto (CIHDE)

Arica, Chile

1
JHON LÓPEZ

Assistant Professor

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Pablo Jaque

Profesor Asociado

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Alejandro Madrid

Academico Asociado

Química

Universidad de Playa ancha

Valparaíso, Chile

1
CLAUDIO PARRA

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Ivan Martinez

Profesor Asociado

Ciencias Quimicas y Biologicas

UNIVERSIDAD BERNARDO O'HIGGINS

Santiago, Chile

1
MARIO SIMIRGIOTIS

full professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
PATRICIO LEYTON

Profesor Asociado

INSTITUTO DE QUÍMICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Bernardo Arriaza

Investigador

INSTITUTO DE ALTA INVESTIGACIÓN

Arica, Chile

1
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
RODRIGO SEGURA

Academico

DEPARTAMENTO DE QUIMICA DE LOS MATERIALES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
Susana Alfaro

Encargada de contenidos y soporte metodológico

Universidad de Tarapacá

Arica, Chile

1
Marco Mellado

Profesor / Investigador

Facultad de Medicina y Ciencias de la Salud

Universidad Central de Chile

Santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Raul Araya

Profesor Asistente

Facultad de Ingenieria y Tecnologia

Universidad San Sebastián

Santiago, Chile

1
Marco Soto

Profesor Asociado

Química Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Iván González

Profesor

Química

Universidad Tecnológica Metropolitana

Santiago, Chile

1
María José Torres

Docente

Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jaime Pizarro

Postdoctorando

Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile