Man

Jorge Campusano

Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Biogenic amines; Receptors; Gap Junctions; Behavior; Neurodegeneration; Drosophila; Medicinal Chemistry; Pharmacology; Neurochemistry; Neurobiology; Animal models for brain diseases

Educación

  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 1997
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1995

Experiencia Académica

  •   Postdoctoral fellow Full Time

    UNIVERSITY OF CALIFORNIA-IRVINE

    Estados Unidos

    2002 - 2008

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile

    2009 - 2015

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile

    2015 - At present

Experiencia Profesional

  •   Postdoctoral fellow Full Time

    University of California Irvine

    Estados Unidos

    2002 - 2008

  •   Assistant Professor Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2009 - At present

  •   Profesor Visitante Full Time

    Universidad de Puerto Rico

    Puerto Rico

    2014 - 2014

Formación de Capital Humano


Training of students.

Postgraduate training. Finished.
Biological Sciences Doctoral Program (PUC)
• Dr. Nicolás Fuenzalida (mention Cell & Molecular Biology). PhD Thesis Title: Study of chemotaxis in Drosophila and neural pathways involved. Thesis Director Jorge Campusano, PhD. 2016.
• Dr. Sergio Hidalgo (mention Cell & Molecular Biology). PhD Thesis Title: Using Drosophila to model Schizophrenia symptoms. Thesis Director Jorge Campusano, PhD. Co-Director James Hodge, PhD (University of Bristol, UK). 2020. Dual PhD degree supported by Conicyt.
• Dr. Rafaella Zárate (mention Cell & Molecular Biology). PhD Thesis Title: Parkinsonian phenotype in a PINK1 Drosophila mutant: Study of the serotonergic neural system in pre-symptomatic stages. Thesis co-directed by Jorge Campusano, PhD and Pedro Zamorano, PhD. 2020.
• Dr. Elsa Fritz (mention Physiological Sciences). PhD Thesis Title: Role of innexins on behaviour coordinated by the circadian rhythm of Drosophila melanogaster. Thesis directed by Juan Carlos Sáez, PhD, co-directed by Jorge Campusano, PhD. 2021.
• Dr. Francisca Rojo (mention Cell & Molecular Biology). PhD Thesis Title: Functional characterization of Lipophorin Receptors in the mushroom body of D. melanogaster. Thesis co-directed by Jorge Campusano, PhD and María-Paz Marzolo, PhD. 2022.

Interdisciplinary Neuroscience Doctoral Program, PUC
• Dr. Daniela Molina. PhD Thesis Title: Changes in dopamine and serotonin levels induced by dysbiosis aggravate the parkinsonian phenotype in Parkinson´s disease model. Thesis Director Jorge Campusano, PhD. 2022.

Masters in Biochemistry Program (Universidad de Chile)
• Vicente Leyton. Thesis Title: Study of the contribution of octopaminergic and muscarinic receptors in Antennal Lobe, on olfactory information processing in Drosophila melanogaster. Thesis Director Jorge Campusano, PhD. 2018.

Postgraduate training. In progress.
Biological Sciences Doctoral Program (PUC)
• Ivana Gajardo (mention Cell & Molecular Biology). PhD Thesis Title: Study of the role of serotonin on a behavioral paradigm for visuo-spatial learning in Drosophila melanogaster. Thesis co-Directed by Jorge Campusano, PhD and Jimena Sierralta, PhD. In progress.

Chemistry Doctoral Program (PUC)
• Jose A Lozada. PhD Thesis Title: Diseño y síntesis de derivados de 2,3-DICLORONAFTALENO-1,4-DIONA, como potenciales inhibidores de acetilcolinesterasa de Drosophila melanogaster. Thesis co-directed by Flavia Zacconi, PhD and Jorge Campusano, PhD. In progress.

Undergraduate Programs (in all Jorge Campusano acts as Thesis Director to obtain Professional Title, except when indicated)
• Carolina Vallejos (Biology).
• Nicolás Fuenzalida (Biochemistry).
• Nicolás Goles (Biology).
• Bryon Silva (Biochemistry).
• Francisca Herreros (Biochemistry).
• Sergio Hidalgo (Biochemistry).
• Daniela Molina (Biochemistry).
• Francisca Rojo (Biochemistry). Co-directed by Dr María Paz Marzolo (Faculty Biological Sciences, PUC).
• Nicole Navarro (Biology).
• Benjamin Valderrama (Biology).
• Agustín Robles (Chemistry). Directed by Dr Angélica Fierro (Faculty Chemistry, PUC); Dr Campusano co-director.
• Victoria Tapia (Biology).
• Alejandra Trujillo (Biology).
• Candy Roa (Biochemistry). Directed by Dr María Paz Marzolo (Faculty Biological Sciences, PUC); Dr Campusano co-director
• Antonia Soto (Biochemistry). Directed by Dr M. Estela Andrés (Faculty Biological Sciences, PUC); Dr Campusano co-director
• Vicente Arriagada (Biochemistry).
• Simón Guerra (Biochemistry).

Undergraduate Research Seminars (1 semester)
• Montserrat Martínez (Biology).
• María Beatriz Ugalde (Biology).
• Eduardo Tognarelli (Biochemistry).
• Karina Pérez (Marine Biology).
• Victoria Tapia (College in Natural Sciences and Mathematics, PUC).
• Candy Roa (Biochemistry).
• Isabella Polizzi (Biology).
• Antonia Soto (Biochemistry).
• Vicente Arriagada (Biochemistry).
• Simón Guerra (Biochemistry).
• Javiera Sánchez (Biology).
• Isidora Almonacid (Biochemistry).

Courses.
Responsible Professor for course "Laboratory of Cell Biology and Biochemistry" for undergraduate students of Biology, Marine Biology, Engineering, College and Education Schools (2017-2022).
Responsible Professor for course "Laboratory of Biochemistry I" for undergraduate students of Biochemistry Program (2022).
Responsible Professor for course "Cell and Molecular Biomedicine" for undergraduate students of the Biochemistry and Biology programs (2020-2021).
Responsible Professor for course "Cell Biology, Bio141c" for undergraduate College Program-PUC (years 2009-2016).
Invited Professor for graduate courses "Neuroscience", "Neurophysiology", "Cell and Molecular Basis of Neurobiology" and "Cell and Molecular Basis of Parkinson's Disease" (all PUC) and "Drosophila Neurobiology" at University of Chile.
International Graduate Course "Small Brains, Big Ideas" (2010 and 2014).


Difusión y Transferencia


Dissemination

Transfer
Inventor, WO2024138277 - 2-Benzyloxyphenylethylamines as inhibitors of monoamine transporters in the brain


Premios y Distinciones

  •   Travel Grant-Junior Faculty

    International Behavioral and Neural Genetics Society

    Bélgica, 2013

    Travel grant to assist and participate of the annual meeting of the International Behavioral and Neural Genetics Society

  •   Travel Grant

    Freie Universitat

    Alemania, 2012

    For the meeting "Biogenic amines as coordinators and controllers of physiological processes and behaviors”, held in Germany, I was invited to give a talk. I was the only latinamerican scientist invited.

  •   Best Research and Presentation Award-PI Category

    Brain in Flux Meeting

    Francia, 2017

    Prize for the best research and presentation in the Brain in Flux Meeting-PI Category


 

Article (34)

The innexin 7 gap junction protein contributes to synchronized activity in the Drosophila antennal lobe and regulates olfactory function
Kanamycin treatment in the pre-symptomatic stage of a Drosophila PD model prevents the onset of non-motor alterations
Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment
An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in Drosophila melanogaster
Autocrine/Paracrine Slit-Robo Signaling Controls Optic Lobe Development in Drosophila melanogaster
Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila
Nicotine suppresses Parkinson’s Disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
Slit/Robo signaling regulates multiple stages of the development of the Drosophila motion detection system
Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?
Dop1R1, a type 1 dopaminergic receptor expressed in Mushroom Bodies, modulates Drosophila larval locomotion
Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila
Study of the release of endogenous amines in Drosophila brain in vivo in response to stimuli linked to aversive olfactory conditioning
The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms
Modeling of the Binding of Octopamine and Dopamine in Insect Monoamine Transporters Reveals Structural and Electrostatic Differences
Unveiling the Dual Role of the Dopaminergic System on Locomotion and the Innate Value for an Aversive Olfactory Stimulus in Drosophila
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors
Characterization of a presymptomatic stage in a Drosophila Parkinson's disease model: Unveiling dopaminergic compensatory mechanisms
Study of the Contribution of Nicotinic Receptors to the Release of Endogenous Biogenic Amines in Drosophila Brain
Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila
Dopamine D-1 and corticotrophin-releasing hormone type-2 alpha receptors assemble into functionally interacting complexes in living cells
Octopamine and Dopamine differentially modulate the nicotine-induced calcium response in Drosophila Mushroom Body Kenyon Cells
Serotonin Receptors Expressed in Drosophila Mushroom Bodies Differentially Modulate Larval Locomotion
nAChR-induced octopamine release mediates the effect of nicotine on a startle response in Drosophila melanogaster
An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease
Cav2-Type Calcium Channels Encoded by cac Regulate AP-Independent Neurotransmitter Release at Cholinergic Synapses in Adult Drosophila Brain
Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin
NMDA Receptors Mediate an Early Up-regulation of Brain-derived Neurotrophic Factor Expression in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease
Ultrastructural Analysis of Chemical Synapses and Gap Junctions Between Drosophila Brain Neurons in Culture
nAChR-Mediated Calcium Responses and Plasticity in Drosophila Kenyon Cells
Primary Neuronal Cultures from the Brains of Late Stage Drosophila Pupae
Drosophila Mushroom Body Kenyon Cells Generate Spontaneous Calcium Transients Mediated by PLTX-Sensitive Calcium Channels
Novel alternative splicing predicts a truncated isoform of the NMDA receptor subunit 1 (NR1) in embryonic rat brain
Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain
Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra

Abstract (5)

Behavioral and anatomical phenotypes in a mutant for the transglutaminase enzyme
Increased serotonin release in the brain underlies the effect of 4-MTA on olfactory responses in drosophila
Synthesis, evaluation, and docking of new 4-alkoxybenzyl bicyclic amine ethers as nicotinic acetylcholine receptor antagonists
Octopamine and dopamine modulate nicotine-induced calcium increase in Drosophila Kenyon Cells
The expression of NMDA receptor subunit 1 and metabotropic glutamate receptor subtypes 1 and 3, is differentially modulated by BDNF and glutamate receptor agonists in mesencephalic cultures

Review (2)

Beyond vertebrates: Drosophila melanogaster as a model to study negative symptoms of schizophrenia
Navigating Like a Fly: Drosophila melanogaster as a Model to Explore the Contribution of Serotonergic Neurotransmission to Spatial Navigation
3
Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

1
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

44
Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
María Andrés

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Beatriz Diez

PROFESORA TITULAR

Universidad Mayor de Chile

Santiago, Chile

2
Eduardo Riquelme

Director de Analítica y Tecnología

Merken Biotech

Santiago, Chile

3
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

4
Carlos Oliva

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Elías Blanco

Profesor Asistente

Biomédico

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
Maria Forray

PROFESOR ASOCIADO

FARMACIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Esteban Aliaga

Profesor

Kinesiología

Universidad Católica el Maule

Talca, Chile

2
Nicolás Fuenzalida

Becario BNI (Postdoc)

Instituto de Neurociencias Biomedicas

Santiago, Chile

1
Duxan Arancibia

Investigador Posdoctoral

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

4
Rafaella Zárate

Investigadora Postdoctoral

Instituto Antofagasta

Universidad de Antofagasta

Antofagasta, Chile

1
Paula Slater

Postdoctoral researcher

Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Reinaldo Figueroa

Instructor Adjunto

Facultad de Medicina y Ciencias de la Salud

Universidad Mayor de Chile

Santiago, Chile

1
maria gonzalez

candidata a Phd

Ciencias Biológicas

Pontificia Universidad Católica de Chile

santiago, Chile

1
Vicente Leyton

Ejecutivo de innovación

Vicerrectoría de Investigación y Desarrollo

Universidad de Chile

Santiago, Chile

1
Ivana Gajardo

Investigadora Postdoctoral

Ciencias

Universidad de Chile

Santiago, Chile