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Jimena Alejandra Sierralta Jara

Full Professor

Faculty of Medicine, Universidad de Chile

Santiago, Chile

Líneas de Investigación


Research lines, A Scaffold proteins in synaptic function and plasticity. B Genes involved in neuronal morphogenesis C Neuronal-Glia energetic relationship D Blood-Brain barrier. Collaborations LF Barros; Maldonado PE; Olguín P; Oliva C,

Educación

  •  biochemistry, Pontificia Universidad Católica de Chile. Chile, 1988
  •  Sciences, BIology, UNIVERSIDAD DE CHILE. Chile, 1996
  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1988

Experiencia Académica

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2004 - At present

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Medicine

    Santiago, Chile

    1998 - 2004

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2017 - At present

Experiencia Profesional

  •   Full Professor Full Time

    Universidad de Chile

    Santiago, Chile

    1998 - At present

Formación de Capital Humano


Undergraduate thesis
Mrs Gabriela Lafferte (2001), Biochemistry thesis, Universidad de Chile; Mrs. Ximena Martínez, Veterinary thesis (2001), Universidad de Chile; Mrs. Mirna Cruz Engineer in Biotechnology thesis (2003), Universidad de Chile; Mrs. Romina Barría, Biochemistry thesis(2004), Mrs Valeria Albornoz (2004), Biochemistry thesis, Mr. Francisco Urra, Biochemistry thesis, (2005) Mr. Pablo Majóo, Biochemistry thesis (2006), Mr. Gabriel Pavez Biochemistry thesis (2014), Mrs Gabriela Insunza Veterinary thesis (2008), Hector Pacheco, Veterinary thesis (2009). Mr Orlando Chávez (2009) Informatic Engineer, Universidad de Talca, Mrs Pía Escobedo (2010), Biochemistry thesis Faculty of Sciences, Pontificia Universidad Católica de Valparaíso, Mauricio Ramírez (2011) Biology, Pontificia Universidad Católica de Valparaíso, Guillermo Moya (2012), Biochemistry thesis Universidad de Santiago, Diego Villegas, P.Universidad Católica de Chile, (2019) Biochemistry thesis

Graduate thesis
Carolina Mendoza PhD (2003-2006), Carlos Oliva PhD thesis (2007-2010), César Astorga Ph.D. thesis (2010-2014), José Cánovas, Co-advisor Ph.D. thesis (2009-2014), MGraciela Delgado Ph.D. thesis (2012-1015), Cristian de Gregorio, Co-advisor PhD Thesis (2012-2015) Francisca Bertín PhD Thesis (2017-2020), Javiera Gallardo (2018-2020) co-advisor, Andrés Kohler (2018-2021). Ximena Martínez Ms Thesis (2007-2008), Claudia Molina Ms Thesis (2009-2010), Giovanna Otarola Ms Thesis (2009-2010), Ignacio Herrera co-advisor MsThesis in Neuroscience (2014-2015), Francisca Bertín (2014-2015) MsThesis in Neuroscience.Andrés Ibacahe (2017-2018) Ms thesis in genetics.

Current PhD students: Aline Ovalle, co advisor; Andrés Ibacache, co-advisor.
Current Ms students: Liliana Spindola Ms in Neuroscience
Current Undergraduate: Rocío Verdugo , Diego Manque

Postdocs
Dr. Alvaro Glavic (2005-2006)
Dr. Diego Rojas (2013-2015)
Dr. Carlos Oliva (2014-2016)
Dr. Esteban Contreras (2015-2019)
Dr. Andrés González (2016-2020)

Teaching Graduate: Lectures in the following courses for PhD students, Cellular Biology (2000-2004), Molecular Endocrinology (2000-2003), Cellular Physiology (2000-2007), Advance Molecular Biology (2004-to-now), Introduction to Neuroscience (2004-to now), Advance Neuroscience (2001-to now) all of the Biomedical Science Program of the Faculty of Medicine. Organizer and teacher at the course Invertebrate Neurobiology (2006-)

International Workshops / Courses
Lectures in IBRO International School of Neuroscience, 2004 and 2006; Neurobiology of Drosophila (Organizer), 2003. Invited to the International Practical Course Neural Development, Montevideo, Uruguay
International Course Small Brains Big Ideas: Biomedical Insight from Invertebrate Research (Co-Organizer); www.smallbrains.org, 2010, 2012, 2014, 2016, 2019, 2022, 2024.

2023 Vice-president of the Biomedical Neuroscience (BNI) Institute Corporation
2021-2023 President Chilean Society of Biology
2022 President of the Biomedical Neuroscience Institute Corporation
2018-2021Deputy director of the Biomedical Neuroscience Institute
2018 to date Director of the Education (www.mentestranformadoras.cl) and dissemination (www.loligo.cl) Program at BNI
2017 Invited reviewer for the Canadian Grant competition
2015 Invited Member in the adjudication panel Canadian-Israel Program Grants
2009-2013 Member of the national committee for the selection of candidates to the Pew Latin American Fellowship. 2012-2013, President of the national committee.
2009-2021 President of the committee of the Master in Neuroscience Program, Faculty of Medicine, U. de Chile


Premios y Distinciones

  •   Pew Latinamerican Fellowship

    PEW LATIN AMERICAN FELLOWS PROGRAM IN BIOMEDICAL SCIENCES

    Estados Unidos, 1996

    Fellowship to do a postdoctoral training. I did 2 years at the laboratory of Dr. Charles ZUker at UCSD, La Jolla

  •   Conicyt Fellowship

    CONSEJO NACIONAL PARA INVESTIGACIONES CIENTIFICAS Y TECNOLOGICAS

    Chile, 1989

    Fellowship to carry out a PhD Program, at the Universidad de Chile


 

Article (40)

1. González-Gutiérrez A#, Gaete J, Esparza A, Toledo J, Köhler-Solis A, Sierralta J#. Visualizing Monocarboxylates and Other Relevant Metabolites in the Ex Vivo Drosophila Larval Brain Using Genetically Encoded Sensors
A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
Identification of <i>atlastin</i> genetic modifiers in a model of hereditary spastic paraplegia in <i>Drosophila</i>
Dlg Is Required for Short-Term Memory and Interacts with NMDAR in the Drosophila Brain
The Fly Blood-Brain Barrier Fights Against Nutritional Stress
Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function
Invertebrate Neuroscience: Contributions From Model and Non-model Species
Slit/Robo Signaling Regulates Multiple Stages of the Development of the Drosophila Motion Detection System
The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the Drosophila Blood Brain Barrier
Neuronal lactate levels depend on glia-derived lactate during high brain activity in Drosophila
Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila
Novel Strategies for the Generation of Neuronal Diversity: Lessons From the Fly Visual System
Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha
p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development
The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
BAX inhibitor-1 regulates autophagy by controlling the IRE1 alpha branch of the unfolded protein response (vol 30, pg 4465, 2011)
Drosophila Atlastin in motor neurons is required for locomotion and presynaptic function
Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca2+ Channels
Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex
Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in axon guidance in Drosophila
The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a
Role of the maguk protein family in synapse formation and function
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis
BAX inhibitor-1 regulates autophagy by controlling the IRE1 alpha branch of the unfolded protein response
A Perisynaptic Menage a Trois between Dlg, DLin-7, and Metro Controls Proper Organization of Drosophila Synaptic Junctions
Regulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system
Endothelial Epithelial Sodium Channel Inhibition Activates Endothelial Nitric Oxide Synthase via Phosphoinositide 3-Kinase/Akt in Small-Diameter Mesenteric Arteries
Expression of voltage-activated calcium channels in the early zebrafish embryo
DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function
Temporal and spatial expression of Drosophila DLGS97 during neural development
Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97
PDZ-containing proteins: alternative splicing as a source of functional diversity
Novel isoforms of Dlg are fundamental for neuronal development in Drosophila
Presence of Ca(2+)-dependent K(+) channels in chemosensory cilia support a role in odor transduction
PRESENCE OF CA2+-DEPENDENT K+ CHANNELS IN CHEMOSENSORY CILIA SUPPORT A ROLE IN ODOR TRANSDUCTION
A functional assay for paralytic shellfish toxins that uses recombinant sodium channels
Functionally heterogenous ryanodine receptors in avian cerebellum
Modal gating in neuronal and skeletal muscle ryanodine-sensitive Ca2+ release channels

Abstract (2)

Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in actin regulation and axon targeting in Drosophila
Jitterbug(jbug)/Filamin and Protein Tyrosine Phosphatase 69D (PTP69D) are required for tendon cell orientation and axon targeting in Drosophila.

EditorialMaterial (1)

How doth the little busy bee: unexpected metabolism

Proyecto (23)

Presynaptic calcium signal in glutamatergic synapses=> role of scaffold proteins in its modulation.
Role of the putative monocarboxylate transporter CG3409 (chaski) on the adaptive response of Drosophila melanogaster to nutritional restriction during development
Biomedical Neuroscience Institute (BNI)
Drosophila Ring in Developmental Adaptations to Nutritional Stress (DRiDANS)
Drosophila Ring in developmental adaptations to nutritional stress
The cell biology of hereditary spastic paraplegias using Drosophila as a model organism
FINE TUNNING OF THE UPR=> FUNCTIONAL ANALYSIS OF THE IRE1ALPHA INTERACTOME
Instituto de Neurociencia Biomédica
MECHANISMS OF CELL ADAPTATION TO INTER-TISSUE MECHANICAL STRESS DURING MORPHOGENESIS, THE ROLE OF DROSOPHILA FILAMIN(JITTERBUG) AND CHASCON.
ROLE OF THE DROSOPHILA MAGUK PROTEIN DLGS97 IN LEARNING AND MEMORY
Núcleo de Morfogénesis Neuronal.
ROLE OF DROSOPHILA DLG IN SYNAPTIC PLASTICITY
ROLE OF REST/NRSF, COREST AND MIR124A DURING NEUROGENESIS AND NEURONAL DIFFERENTIATION IN VIVO
Centro para el análisis de la función génica en el desarrollo neural.
ESTUDIO DE LA FUNCION DEL GEN DE DROSOPHILA D-AXUD1 COMO SUPRESOR TUMORAL Y EN EL MANTENIMIENTO DE LA INTEGRIDAD EPITELIAL, Y DE SUS INTERACCIONES CON LA RUTAS DE SENALIZACION TGF-BETA Y WNT.
PAPEL DE CANALES DE CALCIO EN EL ESTABLECIMIENTO DEL PATRON DORSOVENTRAL EN EL EMBRION DE XENOPUS LAEVIS.
PAPEL DE PRODUCTOS DE DLG EN LA DIVISION ASIMETRICA DE NEUROBLASTOS EN DROSOPHILIA
PAPEL DE PRODUCTOS DE DLG EN LA DIVISION ASIMETRICA DE NEUROBLASTOS EN DROSOPHILIA
PAPEL DE PRODUCTOS DE DLG EN LA DIVISION ASIMETRICA DE NEUROBLASTOS EN DROSOPHILIA
PAPEL DE DlgB EN LA LOCALIZACION DE INAD Y EL COMPLEJO DE FOTOTRANSDUCCION DE DROSOPHILA MELANOGASTER
ACTIVACION DE CANALES DE LIBERACION DE CA2+ SENSIBLES A RYANODINA FOTOLISIS DE COMPUESTOS ENJAULADOS. ACOPLAMIENTO CITOSOL-LUMEN Y MODOS DE ACTIVACION DE CONDICIONES DE ALTA RESOLUCION TEMPORAL
CARACTERIZACION BIOQUIMICA Y ELECTROFISIOLOGICA DE LOS CANALES DE LIBERACION DE CALCIO PRESENTES EN EL RETICULO ENDOPLASMICO DE LAS NEURONAS DE HIPOCAMPO.
SINTESIS Y DEGRADACION DE INOSITOL TRISFOSFATO EN MUSCULO ESQUELITICO
44
Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

14
Carlos Oliva

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Patricio Olguín

Assistant Professor

Facultad de Medicina, ICBM, Departamento de Neurociencia

Universidad de Chile

Santiago, Chile

4
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

4
Esteban Contreras

Postdoc

Institut für Neuro- und Verhaltensbiologie

Westfälische Wilhelms-Universität Münster

Münster, Alemania

3
Alvaro Glavic

Associate Professor

Departamento de Biología

Universidad de Chile

Santiago, Chile

2
Miguel Maureira

Estudiante de Doctorado

Facultad de Odontología

Universidad de Chile

Santiago, Chile

2
Karen Castillo

Académica Investigadora

,Centro de Investigación de Estudios Avanzados del Maule (CIEAM)

Universidad Catolica del Maule

Talca, Chile

2
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

2
Cesar Astorga

Postdoctorado

Cs Biomedicas

Universidad Andrés Bello

Santiago, Chile

2
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

2
maria gonzalez

candidata a Phd

Ciencias Biológicas

Pontificia Universidad Católica de Chile

santiago, Chile

1
Juan Maass

Asistan Professor

universidad de chile

Santiago, Chile

1
ALEX GALAZ

COFOUNDER (Co-CEO)

INFOOD PROTEIN AND BIOTECHNOLOGY

VALDIVIA, Chile

1
Andro Montoya

Docente de Laboratorio de Biología Celular

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

1
Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

1
Maria Lisbona

Postdoctorado

Biología

Universidad de Chile

Santiago, Chile

1
Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

1
Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

1
Ramon Jorquera

Assistant Professor

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Dayan Sanhueza

Postdoctorado

Universidad Andrés Bello

Santiago, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Francisca Bertin

Investigador Postdoctoral

Psicología

Universidad de Chile

Santiago, Chile

1
Andrés González

Staff Scientist

Neurociencias

Instituto de Neurociencia Biomédica

Santiago, Chile

1
Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alicia Colombo

Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Oliver Schmachtenberg

Investigador titular

Instituto de Biología

Universidad de Valparaíso, CINV

Valparaíso, Chile

1
Vicente Medel

Lead Investigator

Latin American Brain Health Institute (BrainLat)

Universidad Adolfo Ibánez

Santiago, Chile

1
Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Gonzalo Olivares

ASSISTANT PROFESSOR

NEUROCIENCIA

Universidad de Chile

SANTIAGO, Chile