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Martín Alejandro Montecino Leonard

Director

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Regulation of gene transcription; Epigenetic control of expression; Regulation of cell differentiation

Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1989
Biomedical Sciences, University of Massachusetts. Estados Unidos, 1996
Biochemistry, Universidad de Concepción. Chile, 1991

Assistant Professor Full Time

University of Concepcion

Biological Sciences

Concepcion, Chile

1996 - 1997
Associate Professor Full Time

University of Concepcion

Biological Sciences

Concepcion, Chile

1997 - 2004
Professor Full Time

University of Concepcion

Biological Sciences

Concepcion, Chile

2004 - 2009
Professor and Director of Institute of Biomedical Sciences Full Time

Andres Bello University

Biological Sciences

Santiago, Chile

2009 - At present

Direction of Post-doctoral fellows:

“Function and evolution of the Runx2-VDR interaction in vertebrate osteoblasts”. (2006-2008).
Dr. Sylvain Marcellini
“Regulación transcripcional de genes en cancer gastrointestinal”. (2007-2009).
Dr. Fernando Cruzat
“Regulación transcripcional de genes en cancer gastrointestinal”. (2008-2010).
Dra. Berta Henríquez
“Modelamiento In Silico de la diferenciación mesenquimal hacia los fenotipos óseo, muscular y adiposo”. (2011-2014).
Dr. Rodrigo Assar
“Análisis bioinformático de la respuesta transcripcional global durante la diferenciación celular”. (terminated 2015).
Dr. Felipe Veloso
“Regulación transcripcional del gen Runx2/p57 mediado por los niveles de glucosa durante el proceso de diferenciación ósea”. (Terminated in 2017).
Dr. Gino Nardocci
“Control de la expresión de Ezh1 y Ezh2 durante la maduración neuronal”. (Terminated in 2017).
Dra. Laura Guajardo
“Contribucion de las demetilasas de histona utx y jmjd3 a la mantencion del potencial de expresion de genes del linaje neuronal-hpocampal”. (Terminated in 2017).
Dra. Karen Jaramillo
“Complejo Polycomb Ezh1: genes blancos y mecanismos de control epigenético durante la maduración de neuronas hipocampales”. (Terminated in 2017).
Dr. Mauricio Saéz
“La proteína Rlf como regulador epigenético del proceso de adaptación de Orestias Ascotanensis”. (Terminado 2018, co-dirigida por Miguel Allende y Martín Montecino).
Nombre: Dra. Raquel Marina
“Higher order chromatin organization”. FONDAP 15090007 (Ongoing).
Nombre: Ingrid Araya
“Non-coding RNAs and adaptation of altiplanic fishes to environmental stress”. FONDAP 15090007 (Ongoing).
Nombre: Rodrigo Maldonado
“Control epigenético de la plasticidad hipocampal”. FONDAP 15090007 (Ongoing).
Nombre: Yennifer Arancibia

Doctoral thesis direction:

“Análisis del mecanismo de remodelamiento nucleosomal asociado con la expresión temporal de genes de histonas alfa durante la embriogénesis temprana del erizo de mar Tetrapygus niger”.(Finished).
Ricardo Medina Díaz
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Rol de factores inductores de transcripción basal en la reorganización nucleosomal de la región promotora proximal en el gen osteocalcina”. (Finished).
José Gutierrez
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Regulación de la transcripción del gen de osteocalcina en células osteoblásticas: Rol de la organización nucleosomal del promotor y de cofactores regulatorios generales”. (Finished).
José Sierra
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Modulación de la transactivación del gen de osteocalcina inducida por vitamina D mediante la fosforilación del receptor nuclear de 1alfa,25-dihidroxivitamina D3”. (Finished).
Roberto Paredes
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Participación de complejos remodeladores de cromatina SWI/SNF en la activación transcripcional del gen de osteocalcina: mecanismo de reclutamiento de estos complejos a la región promotora”. (Finished).
Alejandro Villagra
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Mecanismo de estimulación transcripcional del gen de osteocalcina por vitamina D3: reclutamiento de complejos coactivadores p160/p300/pCAF y/o DRIP en osteoblastos”. (Finished).
Loreto Carvallo
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Determinación de secuencias reguladoras dentro del promotor del factor de transcripción Runx2/Cbfa1”. (Finished).
Fernando Cruzat
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Resolución de la estructura terciaria de los dominios de transactivación y señalización a la matriz nuclear del factor de transcripción Cbfa1: Interacciones proteína-proteína que modulan la función de Cbfa1 en la diferenciación osteoblástica”. (Finished).
Carola Bruna
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Asociación del receptor de 1alfa,25-dihidroxivitamina D3 a dominios subnucleares: rol de la fosforilación y de la interacción con proteínas correguladoras”. (Finished).
Gloria Arriagada
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Mecanismos epigenéticos involucrados en la regulñación transcripcional del gen RUNX2: Rol de las modificaciones covalentes de las histonas H3 y H4 en el promotor P1”. (Finished).
Berta Henríquez
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Estudio de la regulación transcripcional del promotor del gen REG-1alfa mediante la vía de señalización Wnt canónica en células de cáncer gástrico”. (Finished).
Soraya Bravo
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción.

“Mecanismo de regulacion transcripcional de genes que codifican para receptores/canales nociceptivos del dolor TRPV1 y P2X3: Rol de Runx1”. (Finished, co-directed with Brigitte van Zundert).
Giorgia Ugarte
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción.

“Caracterización del promotor del gen RIC-8B humano: Estudio de elementos de regulación tejido-específicos”. (Finished).
Rodrigo Grandy
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción.

“Rol de la proteína de andamiaje PSD-95 en la regulación de la arquitectura dendrítica: patrones epigenéticos involucrados en el control de su expresión durante el desarrollo”. (Finished, co-directed with Brigitte van Zundert).
Fernando Bustos
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción.

“Regulación epigenética del gen Runx2 en células óseas: Identificación de proteínas involucradas en la metilación y demetilación de las histonas H3 y H4 en el promotor P1”. (Ongoing).
Adriana Rojas
Program: Doctorado en Ciencias mención Biología Celular y Neurociencias, Universidad de Chile.

“Estudio de los complejos de represión y/o silenciamiento transcripcional presentes en los promotores de genes linaje-específicos”. (Ongoing).
Hugo Sepúlveda
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Asociación del receptor de vitamina D a la matriz nuclear: dominio de interacción y modulación por fosforilación”. (Ongoing).
Cinthya Ruíz-Tagle
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Mecanismos de regulación transcripcional mediados por el receptor de vitamina D: Rol de la sumoilación de los coactivadores SRCs y DRIP205 en células osteoblásticas”. (Ongoing).
Paola Merino
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Determinantes moleculares asociadas a la actividad transcripcional de genes del programa de diferenciación osteoblástica”. (Ongoing).
Rodrigo Aguilar
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Contribución del patrón de modificaciones epigenéticas en el mecanismo de control transcripcional mediado por Vitamina D3 en osteoblastos”. (Ongoing).
Daniel Moena
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Rol del factor de transcripción C/EBPß1 en terapia celular ósea”. (Ongoing).
Margarita Carrasco
Program: Doctorado en Biotecnología, Universidad Andrés Bello.

-Master thesis direction:

“Evaluación de la participación del receptor clásico VDR en las acciones no genómicas de 1alfa,25 (OH)2D3 en células osteoblásticas ROS 17/2.8 y ROS24/1”. (Finished).
Soraya Bravo
Program: Magister en Ciencias mención Bioquímica, Universidad de Concepción

“Evaluación in vitro de las interacciones entre el receptor de vitamina D3 y los coactivadores SRC-1 y DRIP205: Ro del la fosforilación”. (Finished).
Cinthya Ruíz-Tagle
Program: Magister en Ciencias mención Bioquímica y Bioinformática, Universidad de Concepción

“Mecanismos epigenéticos que regulan la expresión de genes durante la diferenciación ósea”. (Finished).
Hugo Sepúlveda
Program: Magister en Ciencias mención Bioquímica y Bioinformática, Universidad de Concepción


Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells Moena, Daniel; Nardocci, Gino; Acevedo, Elvis; Lian, Jane; Stein, Gary; Stein, Janet; Montecino, Martin Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2020)
Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts Cappelli, Claudio; Sepulveda, Hugo; Rivas, Solange; Pola, Víctor; Urzúa, Ulises; Donoso, Gerardo; Sagredo, Eduardo; Carrero, David; Casanova-Ortiz, Emmanuel; Sagredo, Alfredo; González, Marisel; Manterola, Marcia; Nardocci, Gino; Armisén, Ricardo; Montecino, Martin; Marcelain, Katherine Article ISI SCOPUS JOURNAL OF MOLECULAR BIOLOGY (2020)
Switches in histone modifications epigenetically control vitamin D3-dependent transcriptional upregulation of the CYP24A1 gene in osteoblastic cells Moena D.; Merino P.; Lian J.B.; Stein G.S.; Stein J.L.; Montecino M. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2020)
Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors Fitzpatrick, Christopher; Bendek, Maximiliano F.; Briones, Macarena; Farfan, Nicole; Silva, Valeria A.; Nardocci, Gino; Montecino, Martin; Boland, Anne; Deleuze, Jean-Francois; Villegas, Jaime; Villota, Claudio; Silva, Veronica; Lobos-Gonzalez, Lorena; Borgna, Vincenzo; Barrey, Eric; Burzio, Luis O.; Burzio, Veronica A. Article ISI SCOPUS CELL DEATH & DISEASE (2019)
Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts. Rojas, Adriana; Sepulveda, Hugo; Henriquez, Berta; Aguilar, Rodrigo; Opazo, Tatiana; Nardocci, Gino; Bustos, Fernando; Lian, Jane B; Stein, Janet L; Stein, Gary S; van Zundert, Brigitte; van Wijnen, Andre J; Allende, Miguel L; Montecino, Martin Article Journal of cellular physiology (2019)
Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans Vidal, Elena A; Moyano, Tomas C.; Bustos, Bernabe, I; Perez-Palma, Eduardo; Moraga, Carol; Riveras, Eleodoro; Montecinos, Alejandro; Azocar, Lorena; Soto, Daniela C.; Vidal, Mabel; Di Genoval, Alex; Puschel, Klaus; Nurnberg, Peter; Buch, Stephan; Hampe, Jochen; Allende, Miguel L.; Cambiazo, Veronica; Gonzalez, Mauricio; Hodar, Christian; Montecino, Martin; Munoz-Espinoza, Claudia; Orellana, Ariel; Reyes-Jara, Angelica; Travisanyl, Dante; Vizoso, Paula; Moraga, Mauricio; Eyheramendy, Susana; Maass, Alejandro; De Ferrari, Giancarlo, V; Mique, Juan Francisco; Gutierrez, Rodrigo A. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Wnt/Î²-catenin signaling enhances transcription of the CX43 gene in murine Sertoli cells. López, Camila; Aguilar, Rodrigo; Nardocci, Gino; Cereceda, Karina; Vander Stelt, Karen; Slebe, Juan Carlos; Montecino, Martin; Concha, Ilona I Article Journal of cellular biochemistry (2019)
Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2. Araya, H.; Sepulveda, H.; Lizama, C.; Vega. O., Jerez; S., Briceño; P., Thaler; R., Riester; S., Antonelli; M., Salazar-Onfray; F., Rodríguez; J. P., Moreno; R., Montecino; M., Charbonneau; M., Dubois; C. M., Stein; G. S., van Wijnen; A. J., Galindo Article JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
Identification of a novel lncRNA that promotes osteoblast differentiation Nardocci, G.; Carrasco, M. E.; Acevedo, E.; Hodar, C.; Meneses, C.; Montecino, M. Article JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia. Nuñez-Badinez, P.; Sepulveda, H.; Diaz, E.; Greffrath, W.; Treede, R-D.; Stehberg, J.; Montecino, M.; van Zundert, B. Article JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
A functional IL1RL1 gene variant regulates steroid-induced sST2 expression. Diaz-Jimenez, D.; Nuñez, L.; De la Fuente, M.; Dubois-Camacho, K.; Sepulveda, H.; Montecino, M.; Torres-Riquelme, A.; García-González, P.; Chnaiderman, J.; Vossenkamper, A.; MacDonald, T. T.; Simian, D.; Gonzalez, M-J.; Cidlowsky, J. A.; Quera, R. Article SCIENTIFIC REPORTS (2017)
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells. Diaz-Valdivia, N.; Calderon, C. C.; Diaz, J.; Lobos-Gonzalez, L.; Sepulveda, H.; Ortiz, R. J.; Martinez, S.; Silva, V.; Maldonado, H. J.; Silva, P.; Wehinger, S.; Burzio, V. A.; Torres, V. A.; Montecino, M.; Leyton, L.; Quest, A. Article ONCOTARGET (2017)
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice Bustos, Fernando J; Ampuero, Estibaliz; Jury, Nur; Aguilar, Rodrigo; Falahi, Fahimeh; Toledo, Jorge; Ahumada, Juan; Lata, Jaclyn; Cubillos, Paula; Henríquez, Berta; Guerra, Miguel V; Stehberg, Jimmy; Neve, Rachael L; Inestrosa, Nibaldo C; Wyneken, Ursula; Fuenzalida, Marco; Härtel, Steffen; Sena-Esteves, Miguel; Varela-Nallar, Lorena; Rots, Marianne G; Montecino, Martin; van Zundert, Brigitte Article ISI SCOPUS Brain (2017)
Epigenetic signatures at the RUNX2-P1 and SP7 gene promoters control osteogenic lineage commitment of umbilical cord-derived mesenchymal stem cells. Sepulveda, H.; Aguilar, R.; Prieto, C.; Bustos, F.; Aedo, S.; Lattus, J.; van Zundert, B.; Palma, V.; Montecino, M. Article JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Functional Analysis of All Salmonid Genomes (FAASG)=> an international initiative supporting future salmonid research, conservation and aquaculture. Macqueen, D. J.; Primmer, C. R.; Houston, R. R.; Nowak, B. F.; Bernatchez, L.; Bergseth, S.; Davidson, W. S.; Gallardo-Escárate, C.; Goldammer, T.; Guiguen, Y.; Iturra, P.; Kijas, J. W.; Koop, B. F.; Lien, S.; Maass, A.; Martin, S. A. M.; McGinnity, P. Article BMC GENOMICS (2017)
Global gene expression analysis provides insight into local adaptation to geotermal streams in tadpoles of the Andean toad Rhinella spinulosa (Anura, Bufonidae) Pastenes, L.; Valdivieso, C.; Di Genova, A.; Travisany, D.; Montecino, M.; Orellana, A.; González, M.; Gutiérrez, R.; Allende, M. L.; Maass, A.; Mendez, M. A. Article SCIENTIFIC REPORTS (2017)
Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase. Bustos, F.; Sepulveda, H.; Prieto, C. P.; Carrasco, M.; Diaz, L.; Palma, J.; Lattus, J.; Montecino, M.; Palma, V. Article STEM CELLS (2017)
Tet-mediated DNA demethylation is required for SWI/SNF-dependent chromatin remodeling and histone modifying activities that trigger expression of the Sp7 osteoblast master gene during mesenchymal lineage commitment. Sepulveda, H.; Villagra, A.; Montecino, M. Article MOLECULAR AND CELLULAR BIOLOGY (2017)
Essential role of HDAC6 in the regulation of PD-L1 in melanoma Lienlaf M.; Perez-Villarroel P.; Knox T.; Pabon M.; Sahakian E.; Powers J.; Woan K.V.; Lee C.; Cheng F.; Deng S.; Smalley K.S.M.; Montecino, M.; Kozikowski A.; Pinilla-Ibarz J.; Sarnaik A.; Seto E.; Weber J.; Sotomayor E.M.; Villagra, A Article ISI SCOPUS MOLECULAR ONCOLOGY (2016)
Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells Varela, N; Aranguiz, A; Lizama C.; Sepulveda, H; Antonelli M.; Thaler R.; Moreno, RD; Montecino, M.; Stein, GS; van Wijnen, AJ; Galindo, M Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2016)
Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus. Aguilar, R., Bustos, F., Saez, M., Rojas, A., Allende, M., van Wijnen, A., van Zundert, B., Montecino, M*. Article Biochimica et Biophysica Acta-Gene Regulatory Mechanisms (2016)
The chromatin modifying complex CoREST/LSD1 negatively regulates Notch pathway during cerebral cortex development. Lopez, Cecilia I; Saud, Katherine E; Aguilar, Rodrigo; Berndt, F Andrés; Cánovas, José; Montecino, Martín; Kukuljan, Manuel Article Developmental neurobiology (2016)
Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B Rojas A.; Aguilar R.; Henriquez, B; Lian, JB; Stein, JL; Stein, GS; van Wijnen, AJ; van Zundert, B; ALLENDE, ML; Montecino, M. Article ISI SCOPUS Journal of Biological Chemistry (2015)
Histone Deacetylase Inhibition Destabilizes the Multi-Potent State of Uncommitted Adipose-Derived Mesenchymal Stromal Cells Dudakovic, A; Camilleri E.T.; Lewallen E.A.; Mcgee-Lawrence M.E.; Riester S.M.; Kakar S.; Montecino, M.; Stein G.S.; Ryoo H.-M.; Dietz A.B.; Westendorf J.J.; van Wijnen A.J. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2015)
Prenatal Stress Down-Regulates Reelin Expression by Methylation of Its Promoter and Induces Adult Behavioral Impairments in Rats Palacios-Garcia, I; Lara-Vasquez A.; Montiel J.F.; Diaz-Veliz G.F.; Sepulveda, H; Utreras, E; Montecino, M.; Gonzalez-Billault, C; Aboitiz F. Article ISI SCOPUS PLOS ONE (2015)
The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a Canovas, J.; Berndt, FA; Sepulveda, H; Aguilar R.; Veloso FA; Montecino, M.; Oliva, C; Maass JC; Sierralta, J; Kukuljan M. Article ISI SCOPUS Journal of Neuroscience (2015)
A Functional N-terminal Domain in C/EBP beta-LAP* is Required for Interacting with SWI/SNF and to Repress Ric-8B Gene Transcription in Osteoblasts Aguilar R.; Grandy, R; Meza D.; Sepulveda, H; Pihan, P; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2014)
Symbolic Extensions Applied to Multiscale Structure of Genomes Downarowicz T; Travisany, D; Montecino, M.; Maass A. Article ISI SCOPUS ACTA BIOTHEORETICA (2014)
Enhanced CRAd Activity Using Enhancer Motifs Driven by a Nucleosome Positioning Sequence Bravo S.; Nuñez, F.; Cruzat F.; Cafferata, EG; De Ferrari, GV; Montecino, M.; Podhajcer, OL Article ISI SCOPUS Molecular Therapy (2013)
Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons Henriquez, B; Bustos, FJ; Aguilar R.; Becerra, A; Simon F.; Montecino, M.; van Zundert, B Article ISI SCOPUS MOLECULAR AND CELLULAR NEUROSCIENCE (2013)
Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene Hovhannisyan, H; Zhang, Y.; Hassan, MQ; Wu, H; Glackin, C; Lian, JB; Stein, JL; Montecino, M.; Stein, GS; van Wijnen, AJ Article ISI SCOPUS Journal of Cellular Physiology (2013)
Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBP ss factors Ugarte, GD; Diaz, E.; Biscaia, M; Stehberg, J; Montecino, M.; van Zundert, B Article ISI SCOPUS Journal of Cellular Physiology (2013)
Epigenetic Control of Cell Cycle-Dependent Histone Gene Expression Is a Principal Component of the Abbreviated Pluripotent Cell Cycle Medina R.; Ghule P.N.; Cruzat F.; Barutcu A.R.; Montecino, M.; Stein J.L.; van Wijnen A.J.; Stein G.S. Article ISI SCOPUS Molecular and Cellular Biology (2012)
Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility van der Deen, M; Akech J.; Lapointe, D; Gupta, S; Young D.W.; Montecino M.A.; Galindo, M; Lian J.B.; Stein J.L.; Stein G.S.; van Wijnen A.J. Article ISI SCOPUS Journal of Biological Chemistry (2012)
Reusing and composing models of cell fate regulation of human bone precursor cells Assar, R; Leisewitz A.V.; Garcia, A.; Inestrosa, N. C.; Montecino M.A.; Sherman D.J. Article ISI SCOPUS BioSystems (2012)
Ric-8: Different cellular roles for a heterotrimeric G-protein GEF Hinrichs M.V.; Torrejón M.; Montecino, M.; Olate, J Article ISI SCOPUS Journal of Cellular Biochemistry (2012)
Runx1 and C/EBP ss transcription factors directly up-regulate P2X3 gene transcription Ugarte G.D.; Opazo, T; Leisewitz, F; van Zundert, B; Montecino, M. Article ISI SCOPUS Journal of Cellular Physiology (2012)
C/EBP beta Binds the P1 Promoter of the Runx2 Gene and Up-Regulates Runx2 Transcription in Osteoblastic Cells Henriquez, B; Hepp, M.; Merino, P; Sepulveda, H; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS Journal of Cellular Physiology (2011)
The Ric-8B Gene Is Highly Expressed in Proliferating Preosteoblastic Cells and Downregulated during Osteoblast Differentiation in a SWI/SNF- and C/EBP beta-Mediated Manner Grandy, R; Sepulveda, H; Aguilar R.; Pihan, P; Henriquez, B; Olate, J; Montecino, M. Article ISI SCOPUS Molecular and Cellular Biology (2011)
Wnt/beta-Catenin Signaling Enhances Cyclooxygenase-2 (COX2) Transcriptional Activity in Gastric Cancer Cells Nuñez, F.; Bravo S.; Cruzat F.; Montecino, M.; De Ferrari, GV Article ISI SCOPUS PLOS ONE (2011)
1 alpha,25-Dihydroxy Vitamin D-3 Induces Nuclear Matrix Association of the 1 alpha,25-Dihydroxy Vitamin D-3 Receptor in Osteoblasts Independently of Its Ability to Bind DNA Arriagada, G; Paredes, R.; van Wijnen, AJ; Lian, JB; van Zundert, B; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS Journal of Cellular Physiology (2010)
Architectural Genetic and Epigenetic Control of Regulatory Networks: Compartmentalizing Machinery for Transcription and Chromatin Remodeling in Nuclear Microenvironments Stein, GS; van Wijnen, AJ; Imbalzano, AN; Montecino, M.; Zaidi, SK; Lian, JB; Nickerson, JA; Stein, JL Article ISI SCOPUS Critical Reviews in Eukaryotic Gene Expression (2010)
Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1 Sepulveda, FJ; Bustos, FJ; Inostroza, E; Zuniga, FA; Neve, RL; Montecino, M.; van Zundert, B Article ISI SCOPUS JOURNAL OF NEUROPHYSIOLOGY (2010)
Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblasto]genesis Marcellini, S; Bruna, C; Henriquez, JP; Albistur, M; Reyes, AE; Barriga, EH; Henriquez, B; Montecino, M. Article ISI SCOPUS BMC EVOLUTIONARY BIOLOGY (2010)
Mitotic bookmarking of genes: a novel dimension to epigenetic control Zaidi, SK; Young, DW; Montecino MA; Lian, JB; van Wijnen, AJ; Stein, JL; Stein, GS Article ISI SCOPUS Nature Reviews Genetics (2010)
Pbx1 Represses Osteoblastogenesis by Blocking Hoxa10-Mediated Recruitment of Chromatin Remodeling Factors Gordon, JAR; Hassan, MQ; Saini, S; Montecino, M.; van Wijnen, AJ; Stein, GS; Stein, JL; Lian, JB Article ISI SCOPUS Molecular and Cellular Biology (2010)
Recruitment and subnuclear distribution of the regulatory machinery during 1 alpha,25-dihydroxy vitamin D-3-mediated transcriptional upregulation in osteoblasts Arriagada, G; Henriquez, B; Moena D.; Merino, P; Ruiz-Tagle, C; Lian, JB; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)
Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer Stein G.S.; Stein J.L.; van Wijnen A.J.; Lian J.B.; Ali S.A.; Pande S.; Hassan M.Q.; Zaidi S.K.; Montecino, M.; Croce C.M.; Choi, J.-Y.; Young D.W. Article Advances in Enzyme Regulation (2010)
Altered Chromatin Modifications in AML1/RUNX1 Breakpoint Regions Involved in (8;21) Translocation Stuardo, M.; Martínez M; Hidalgo K.; Montecino, M.; Javed, A; Lian, JB; Stein, GS; Stein, JL; Gutierrez, SE Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway Arrazola, MS; Varela-Nallar, L; Colombres M.; Toledo EM; Cruzat F.; Pavez, L.; Assar, R; Aravena, A.; Gonzalez, M.; Montecino, M.; Maass A.; Martínez, S.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Co-stimulation of the Bone-related Runx2 P1 Promoter in Mesenchymal Cells by SP1 and ETS Transcription Factors at Polymorphic Purine-rich DNA Sequences (Y-repeats) Zhang, Y.; Hassan, MQ; Xie, RL; Hawse, JR; Spelsberg, TC; Montecino, M.; Stein, JL; Lian, JB; van Wijnen, AJ; Stein, GS Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Molecular Switches Involving Homeodomain Proteins, HOXA10 and RUNX2 Regulate Osteoblastogenesis Hassan, MQ; Saini, S; Gordon, JAR; van Wijnen, AJ; Montecino, M.; Stein, JL; Stein, GS; Lian, JB Article ISI SCOPUS Cells Tissues Organs (2009)
Organization, Integration, and Assembly of Genetic and Epigenetic Regulatory Machinery in Nuclear Micro environments Implications for Biological Control in Cancer Stein, GS; Zaidi, SK; Stein, JL; Lian, JB; van Wijnen, AJ; Montecino, M.; Young, DW; Javed, A; Pratap, J; Choi, JY; Ali, SA; Pande S.; Hassan, MQ Article ISI SCOPUS Annals of the New York Academy of Sciences (2009)
Subnuclear Targeting of the Runx3 Tumor Suppressor and Its Epigenetic Association With Mitotic Chromosomes Pande S.; Ali, SA; Dowdy, C; Zaidi, SK; Ito, K.; Ito, Y; Montecino MA; Lian, JB; Stein, JL; van Wijnen, AJ; Stein, GS Article ISI SCOPUS Journal of Cellular Physiology (2009)
SWI/SNF-Independent Nuclease Hypersensitivity and an Increased Level of Histone Acetylation at the P1 Promoter Accompany Active Transcription of the Bone Master Gene Runx2 Cruzat F.; Henriquez, B; Villagra, A; Hepp, M.; Lian, JB; van Wijnen, AJ; Stein, JL; Imbalzano, AN; Stein, GS; Montecino, M. Article ISI SCOPUS BIOCHEMISTRY (2009)
Transcription-factor-mediated epigenetic control of cell fate and lineage commitment Stein, GS; Zaidi, SK; Stein, JL; Lian, JB; van Wijnen, AJ; Montecino, M.; Young, DW; Javed, A; Pratap, J; Choi, JY; Ali, SA; Pande S.; Hassan, MQ Article ISI SCOPUS Biochemistry and Cell Biology (2009)
1 alpha,25-dihydroxy vitamin D-3-Enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1 alpha,25-dihydroxy vitamin D-3 Receptor-SRC-1 coactivator complex Carvallo L; Henriquez, B; Paredes, R.; Olate, J; Oñate S.; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Chromatin immunoprecipitation assays: Application of chip-on-chip for defining dynamic transcriptional mechanisms in bone cells van der Deen, M; Hassan M.Q.; Pratap, J; Teplyuk N.M.; Zaidi S.K.; Montecino, M.; Stein J.L.; Stein G.S.; van Wijnen A.J.; Young D.W.; Javed, A; Lian J.B. Article SCOPUS NEISSERIA MENINGITIDIS (2008)
G alpha q negatively regulates the Wnt-beta-catenin pathway and dorsal embryonic Xenopus laevis development Soto, X; Mayor, R; Torrejón M.; Montecino, M.; Hinrichs, MV; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer Stein, GS; Zaidi, SK; Stein, JL; Lian, JB; van Wijnen, AJ; Montecino, M.; Young, DW; Javed, A; Pratap, J; Choi, JY; Ali, SA; Pande S.; Hassan, MQ Article ISI JOURNAL OF CELLULAR BIOCHEMISTRY (2008)
In situ nuclear organization of regulatory machinery Pockwinse S.M.; Zaidi S.K.; Medina R.F.; Bakshi, R; Kota K.P.; Ali S.A.; Nickerson J.A.; van Wijnen A.J.; Lian J.B.; Stein J.L.; Stein G.S.; Young D.W.; Javed, A; Montecino, M. Article SCOPUS NEISSERIA MENINGITIDIS (2008)
Phenotypic transcription factors epigenetically mediate cell growth control Ali, SA; Zaidi, SK; Dacwag, CS; Salma, N; Young, DW; Shakoori, AR; Montecino MA; Lian, JB; van Wijnen, AJ; Imbalzano, AN; Stein, GS; Stein, JL Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes Bakshi, R; Zaidi, SK; Pande S.; Hassan, MQ; Young, DW; Montecino, M.; Lian, JB; van Wijnen, AJ; Stein, JL; Stein, GS Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2008)
Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery Montecino, M.; Stein, GS; Stein, JL; Lian, JB; van Wijnen, AJ; Carvallo L; Marcellini, S; Cruzat F.; Arriagada, G Article ISI CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2008)
xRic-8 is a GEF for Gs alpha and participates in maintaining meiotic arrest in Xenopus laevis oocytes Romo, X.; Pasten, P; Martínez, S.; Soto, X; Lara P.; de Arellano AR; Torrejón M.; Montecino, M.; Hinrichs, MV; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
An architectural perspective of vitamin D responsiveness Montecino, M.; Stein, GS; Cruzat F.; Marcellini, S; Stein, JL; Lian, JB; van Wijnen, AJ; Arriagada, G Article ISI SCOPUS ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter Gutierrez J.; Paredes, R.; Cruzat F.; Hill, DA; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Imbalzano, AN; Montecino, M. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Classical Xenopus laevis progesterone receptor associates to the plasma membrane through its ligand-binding domain Martínez, S.; Pasten, P; Suárez K.; Garcia, A.; Nualart, F.; Montecino, M.; Hinrichs, MV; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Crystallization and preliminary X-ray analysis of a domain in the Runx2 transcription factor that interacts with the 1 alpha, 25 dihydroxy vitamin D3 receptor Bruna, C; Arriagada, G; Lian, JB; Stein, GS; Bunster, M; Martinez-Oyanedel, J; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes Hassan, MQ; Tare, R; Lee, SH; Mandeville, M; Weiner, B; Montecino, M.; van Wijnen, AJ; Stein, JL; Stein, GS; Lian, JB Article ISI SCOPUS MOLECULAR AND CELLULAR BIOLOGY (2007)
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2 Young, DW; Hassan, MQ; Pratap, J; Galindo, M; Zaidi, SK; Lee, SH; Yang, XQ; Xie, RL; Javed, A; Underwood, JM; Furcinitti, P; Imbalzano, AN; Penman, S; Nickerson, JA; Montecino MA; Lian, JB; Stein, JL; van Wijnen, AJ; Stein, GS Article ISI SCOPUS NATURE (2007)
Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2 Young, DW; Hassan, MQ; Yang, XQ; Galindo, M; Javed, A; Zaidi, SK; Furcinitti, P; Lapointe, D; Montecino, M.; Lian, JB; Stein, JL; van Wijnen, AJ; Stein, GS Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence Montecino, M.; Stein, JL; Stein, GS; Lian, JB; van Wijnen, AJ; Cruzat F.; Gutierrez S. ; Olate, J; Marcellini, S; Gutierrez, JL Article ISI Biochemistry and Cell Biology (2007)
Organization of transcriptional regulatory machinery in nuclear microenvironments: Implications for biological control and cancer Stein G.S.; Lian J.B.; van Wijnen A.J.; Stein J.L.; Vradii, D; Zaidi S.K.; Pratap, J; Javed, A; Montecino, M.; Choi, J.-Y.; Young D. Article SCOPUS Advances in Enzyme Regulation (2007)
Phosphorylation at serine 208 of the 1 alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators Arriagada, G; Paredes, R.; Olate, J; van Wijnen A.; Lian, JB; Stein, GS; Stein, JL; Oñate S.; Montecino, M. Article ISI SCOPUS JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
The 1 alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene Carvallo L; Henriquez, B; Olate, J; van Wijnen, AJ; Lian, JB; Stein, GS; Oñate S.; Stein, JL; Montecino, M. Article ISI SCOPUS JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes Vradii, D; Wagner S.; Doan, DN; Nickerson, JA; Montecino, M.; Lian, JB; Stein, JL; van Wijnen, AJ; Imbalzano, AN; Stein, GS Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity Villagra, A; Cruzat F.; Carvallo L; Paredes, R.; Olate, J; van Wijnen, AJ; Stein, GS; Lian, JB; Stein, JL; Imbalzano, AN; Montecino, M. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Plasma membrane destination of the classical Xenopus laevis progesterone receptor accelerates progesterone-induced oocyte maturation Martínez, S.; Grandy, R; Pasten, P; Montecinos, H.; Montecino, M.; Olate, J; Hinrichs, MV Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
The classic receptor for 1 alpha,25-dihydroxy vitamin D3 is required for non-genomic actions of 1 alpha,25-dihydroxy vitamin D3 in osteosarcoma cells Bravo S.; Paredes, R.; Izaurieta, P; Lian, JB; Stein, JL; Stein, GS; Hinrichs, MV; Olate, J; Aguayo, LG; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
A g beta gamma stimulated adenylyl cyclase is involved in Xenopus laevis oocyte maturation Guzman, L; Romo, X.; Grandy, R; Soto, X; Montecino, M.; Hinrichs, M; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Bone-specific transcription factor Runx2 interacts with the 1 alpha,25-dihydroxyvitamin D-3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells Paredes, R.; Arriagada, G; Cruzat F.; Villagra, A; Olate, J; Zaidi, K; van Wijnen A.; Lian, JB; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS MOLECULAR AND CELLULAR BIOLOGY (2004)
Dlx3 transcriptional regulation of osteoblast differentiation: Temporal recruitment of Msx2 Dlx3 an Dlx5 homeodomain proteins to chromatin of the osteocalcin gene Hassan, MQ; Javed, A; Morasso, MI; Karlin, J; Montecino, M.; van Wijnen, AJ; Stein, GS; Stein, JL; Lian, JB Article ISI SCOPUS MOLECULAR AND CELLULAR BIOLOGY (2004)
Mutation of the highly conserved Arg(165) and Glu(168) residues of human Gs alpha disrupts the alpha D-alpha E loop and enhances basal GDP/GTP exchange rate Hinrichs, MV; Montecino, M.; Bunster, M; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals Stein, GS; Stein, JL; Lian, JB; van Wijnen, AJ; Montecino, M.; Javed, A; Zaidi, SK; Young D.; Choi, JY; Pockwinse, S Article ISI EUROPEAN JOURNAL OF HISTOCHEMISTRY (2004)
The Runx2 transcription factor plays a key role in the 1 alpha,25-dihydroxy vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells Paredes, R.; Arriagada, G; Cruzat F.; Olate, J; van Wijnen A.; Lian J.; Stein G.; Stein, J; Montecino, M. Article ISI JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2004)
The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain Gutierrez S. ; Liu, JL; Javed, A; Montecino, M.; Stein, GS; Lian, JB; Stein, JL Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Conservative segregation of maternally inherited CS histone variants in larval stages of sea urchin development Oliver, MI; Rodriguez, C; Bustos, P; Morin, V; Gutierrez S. ; Montecino, M.; Geneviere, AM; Puchi, M; Imschenetzky M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2003)
Human brain synembryn interacts with Gs alpha and Gq alpha and is translocated to the plasma membrane in response to isoproterenol and carbachol Klattenhoff, C; Montecino, M.; Soto, X; Guzman, L; Romo, X.; Garcia, MD; Mellstrom, B; Naranjo, JR; Hinrichs, MV; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2003)
Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer Stein, GS; Lian, JB; Stein, JL; van Wijnen, AJ; Montecino, M.; Pratap, J; Choi J.; Zaidi, SK; Javed, A; Gutierrez S. ; Harrington, K; Shen, JL; Young D. Article ISI SCOPUS BLOOD CELLS MOLECULES AND DISEASES (2003)
Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells Hovhannisyan, H; Cho B.; Mitra, P; Montecino, M.; Stein, GS; van Wijnen, AJ; Stein, JL Article ISI SCOPUS MOLECULAR AND CELLULAR BIOLOGY (2003)
Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D-3 receptor but not p300 intrinsic histone acetyltransferase activity Sierra, J; Villagra, A; Paredes, R.; Cruzat F.; Gutierrez S. ; Javed, A; Arriagada, G; Olate, J; Imschenetzky M.; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS MOLECULAR AND CELLULAR BIOLOGY (2003)
Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions Lian, JB; Stein, JL; Stein, GS; van Wijnen, AJ; Montecino, M.; Javed, A; Gutierrez S. ; Shen, J; Zaidi, SK; Drissi, H Article ISI CONNECTIVE TISSUE RESEARCH (2003)
Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histories H3 and H4 Shen, J; Hovhannisyan, H; Lian, JB; Montecino MA; Stein, GS; Stein, JL; van Wijnen, AJ Article ISI SCOPUS MOLECULAR ENDOCRINOLOGY (2003)
CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression Gutierrez S. ; Javed, A; Tennant, DK; van Rees, M; Montecino, M.; Stein, GS; Stein, JL; Lian, JB Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Historic acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription. Shen, JL; Montecino, M.; Lian, JB; Stein, GS; van Wijnen, AJ; Stein, JL Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Interaction of the 1 alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling Paredes, R.; Gutierrez J.; Gutierrez S. ; Allison, L; Puchi, M; Imschenetzky M.; van Wijnen A.; Lian J.; Stein G.; Stein, J; Montecino, M. Article ISI SCOPUS BIOCHEMICAL JOURNAL (2002)
Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts Villagra, A; Gutierrez J.; Paredes, R.; Sierra, J; Puchi, M; Imschenetzky M.; van Wijnen A.; Lian J.; Stein G.; Stein, J; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Remodeling of sperm chromatin after fertilization involves nucleosomes formed by sperm histones H2A and H2B and two CS histone variants Oliver, MI; Concha, C; Gutierrez S. ; Bustos, A.; Montecino, M.; Puchi, M; Imschenetzky M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Cytoplasm of sea urchin unfertilized eggs contains a nucleosome remodeling activity Medina R.; Gutierrez J.; Puchi, M; Imschenetzky M.; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2001)
Developmentally-regulated interaction of a transcription factor complex containing CDP/cut with the early histone H3 gene promoter of the sea urchin Tetrapygus niger is associated with changes in chromatin structure and gene expression Medina R.; Paredes, R.; Puchi, M; Imschenetzky M.; Montecino, M. Article ISI SCOPUS GENE (2001)
Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site Gutierrez J.; Sierra, J; Medina R.; Puchi, M; Imschenetzky M.; van Wijnen A.; Lian J.; Stein G.; Stein, J; Montecino, M. Article ISI SCOPUS BIOCHEMISTRY (2000)
Intranuclear trafficking of transcription factors: implications for biological control Stein, GS; van Wijnen, AJ; Stein, JL; Lian, JB; Montecino, M.; Choi, JY; Zaidi, K; Javed, A Article ISI JOURNAL OF CELL SCIENCE (2000)
Nuclear matrix proteins as cancer markers Stein G.S.; van Wijnen A.J.; Stein J.L.; Lian J.B.; Zaidi, K; Javed, A; Montecino, M. Article JOURNAL OF CELLULAR BIOCHEMISTRY (2000)
Nuclear structure-gene expression interrelationships: Implications for aberrant gene expression in cancer Stein, GS; Montecino, M.; van Wijnen, AJ; Stein, JL; Lian, JB Article CANCER RESEARCH (2000)
Phosphorylation protects sperm-specific histones H1 and H2B from proteolysis after fertilization Morin, V; Acuna P.; Diaz, F.; Inostroza, D; Martinez, J.; Montecino, M.; Puchi, M; Imschenetzky M. Article ISI JOURNAL OF CELLULAR BIOCHEMISTRY (2000)
Subnuclear organization and trafficking of regulatory proteins: Implications for biological control and cancer Stein, GS; van Wijnen, AJ; Stein, JL; Lian, JB; Montecino, M.; Zaidi, K; Javed, A Article ISI JOURNAL OF CELLULAR BIOCHEMISTRY (2000)
Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo Montecino, M.; Frenkel B.; van Wijnen A.J.; Lian J.B.; Stein G.S.; Stein J.L. Article BIOCHEMISTRY (1999)
Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization Javed, A; Gutierrez S. ; van Wijnen A.J.; Stein J.L.; Stein G.S.; Lian J.B.; Montecino, M. Article MOLECULAR AND CELLULAR BIOLOGY (1999)
Nuclear structure/gene expression interrelationships Stein G.S.; van Wijnen A.J.; Stein J.L.; Lian J.B.; Montecino, M. Article JOURNAL OF CELLULAR PHYSIOLOGY (1999)
Phosphorylation-mediated control of chromatin organization and transcriptional activity of the tissue-specific osteocalcin gene van Wijnen A.J.; Lian J.B.; Stein J.L.; Stein G.S.; Montecino, M. Article JOURNAL OF CELLULAR BIOCHEMISTRY (1999)
Poly(ADP-ribosylation) protects maternally derived histones from proteolysis after fertilization Morin, V; Diaz, F.; Montecino, M.; Puchi, M; Imschenetzky M.; Fothergill-Gilmore L. Article BIOCHEMICAL JOURNAL (1999)
Identification of a cysteine protease responsible for degradation of sperm histones during male pronucleus remodeling in sea urchins Imschenetzky M.; Diaz, F.; Montecino, M.; Puchi, M; Sierra, F Article JOURNAL OF CELLULAR BIOCHEMISTRY (1997)
Decreased heterogeneity of CS histone variants after hydrolysis of the ADP-ribose moiety Imschenetzky M.; Morin, V; Carvajal N.; Montecino, M.; Puchi, M Article JOURNAL OF CELLULAR BIOCHEMISTRY (1996)
Requirement of distal and proximal promoter sequences for chromatin organization of the osteocalcin gene in bone-derived cells Montecino, M.; Frenkel B.; Lian J.; Stein, J; Stein G. Article JOURNAL OF CELLULAR BIOCHEMISTRY (1996)


Inhibition of progesterone-induced Xenopus oocyte maturation by synembryn Romo, X.; Hinrichs, MV; Martínez, S.; Montecino, M.; Olate, JA Abstract MOLECULAR BIOLOGY OF THE CELL (2004)


Control of the human pluripotent cell cycle Stein G.S.; van Wijnen A.; Stein J.L.; Lian J.B.; Ghule P.N.; Medina R.; Becker K.; Montecino, M.; Zaidi S.K.; Qiao M. BookWhole SCOPUS Stem Cells: From Bench to Bedside, Second Edition (2010)


Modeling cell decisions in bone formation Assar, R; Maass A.; Fernandez, J; Kofman E.; Montecino M.A. ConferencePaper SCOPUS Springer Proceedings in Mathematics and Statistics (2015)
Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex Gordon J.A.R.; Hassan M.Q.; van Wijnen A.J.; Stein J.L.; Stein G.S.; Lian J.B.; Koss, M.; Selleri L.; Montecino, M. ConferencePaper CELLS TISSUES ORGANS (2011)
Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: Implications for biological control in cancer Stein G.S.; Zaidi S.K.; Stein J.L.; Lian J.B.; van Wijnen A.J.; Montecino, M.; Young D.W.; Choi, J.-Y.; Javed, A; Pratap, J; Ali S.A.; Pande S.; Hassan M.Q. ConferencePaper ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2009)


Epigenetic silencing of the osteogenic master regulator Runx2-p57 in pluripotent cells FONDECYT (1170878) Proyecto 2017-2021 Inv. Responsable
“C/EBPbeta-mediated control of transcription during osteoblast differentiation” FONDECYT (1130706.) Proyecto 2013-2017 Inv. Principal
“Molecular Mechanisms Regulating Nociceptor Expression” Núcleo de Investigación Avanzada UNAB (DI-02-11/N) Proyecto 2011-2014 Director(a)
“Center for Genome Regulation” FONDAP (15090007) Proyecto 2010-2020 Inv. Principal
“Reactivation of dendritic arbor development and plasticity in developing and adult brain=> role of NMDA receptors, CAMKII and PSD95” FONDECYT (1101012) Proyecto 2010-2014 Coinvestigador(a)
“Characterization of Ric-8, a novel non-receptor G-protein regulator” FONDECYT (1090150) Proyecto 2009-2013 Coinvestigador(a)
“Mechanisms that control transcriptional responsiveness to 1a,25-dihydroxy vitamin D3 in osteoblasts” FONDECYT (1095075) Proyecto 2009-2013 Inv. Principal
Leyes de la Física II Cornejus, M.; Orrego R. Proyecto (2006)
“Consorcio de Tecnológica e Innovación para la Salud CTI-Salud” PIA (PBCT-6) Proyecto 2006-2010 Inv. Principal
“Estudios Avanzados en Señalización Celular y Regulación Génica” PIA (PBCTACT044) Proyecto 2005-2008 Director(a)
“Acción no genómica del receptor de progesterona. El ovocito de Xenopus laevis como sistema de estudio" FONDECYT (1030806) Proyecto 2003-2006 Coinvestigador(a)
“Mecanismo de reclutamiento de complejos que remodelan cromatina y regulan la transcripción de un gen específico de células óseas” FONDECYT (1030479) Proyecto 2003-2006 Inv. Principal
“Bone cell structure and gene expression” National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH) Proyecto 2002-2012 Coinvestigador(a)
POSICIONAMIENTO NUCLEOSOMAL ESPECIFICO Y DISPOSICION ESPACIAL DEL PROMOTOR DE OSTEOCALCINA=> ROL EN LA TRANSCRIPCION BASAL Y ESTIMULADA POR VITAMIVA D3 FONDECYT (1000361) Proyecto 2000-2003 Inv. Responsable
”Chromatin structure in expression of osteocalcin gene” Fogarty International Research Collaboration Award (FIRCA) 5R03 TW00990-06, dependiente del National Institutes of Health (NIH) Proyecto 1998-2004 Inv. Principal
MECANISMOS MOLECULARES INVOLUCRADOS EN EL REMODELAMIENTO NUCLEOSOMAL DEL GEN OSTEOCALCINA ASOCIADO CON LA ACTIVACION TRANSCRIPCIONAL=> ROL DE LOS FACTORES DE TRANSCRIPCION. FONDECYT (1971077) Proyecto 1997-2000 Inv. Responsable


Multiple levels of epigenetic control for bone biology and pathology Montecino, M.; Stein G.; Stein, J; Zaidi, K; Aguilar R. Review ISI SCOPUS Bone (2015)
Bookmarking Target Genes in Mitosis: A Shared Epigenetic Trait of Phenotypic Transcription Factors and Oncogenes? Zaidi, SK; Grandy, RA; Lopez-Camacho, C; Montecino, M.; van Wijnen, AJ; Lian, JB; Stein, JL; Stein, GS Review ISI CANCER RESEARCH (2014)
The Dynamic Architectural and Epigenetic Nuclear Landscape: Developing the Genomic Almanac of Biology and Disease Tai, PWL; Zaidi, SK; Wu, H; Grandy, RA; Montecino, M.; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL Review ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2014)
The Architectural Organization of Human Stem Cell Cycle Regulatory Machinery Stein G.S.; Stein J.L.; van Wijnen A.J.; Lian J.B.; Montecino, M.; Medina R.; Kapinas K.; Ghule P.; Grandy, R; Zaidi S.K.; Becker K.A. Review SCOPUS CURRENT PHARMACEUTICAL DESIGN (2012)
An architectural genetic and epigenetic perspective Stein, GS; Stein, JL; van Wijnen, AJ; Lian, JB; Zaidi, SK; Nickerson, JA; Montecino MA; Young, DW Review ISI SCOPUS Integrative Biology (2011)
Bookmarking the Genome: Maintenance of Epigenetic Information Zaidi, SK; Young, DW; Montecino, M.; van Wijnen, AJ; Stein, JL; Lian, JB; Stein, GS Review ISI SCOPUS Journal of Biological Chemistry (2011)
Architectural Epigenetics: Mitotic Retention of Mammalian Transcriptional Regulatory Information Zaidi, SK; Young, DW; Montecino, M.; Lian, JB; Stein, JL; van Wijnen, AJ; Stein, GS Review ISI SCOPUS Molecular and Cellular Biology (2010)
Nuclear microenvironments in biological control and cancer Zaidi, SK; Young, DW; Javed, A; Pratap, J; Montecino, M.; van Wijnen A.; Lian, JB; Stein, JL; Stein, GS Review ISI NATURE REVIEWS CANCER (2007)
An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition Stein, GS; van Wijnen, AJ; Stein, JL; Lian, JB; Montecino, M.; Zaidi, SK; Braastad, C Review ISI JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Networks and hubs for the transcriptional control of osteoblastogenesis Lian, JB; Stein, GS; Javed, A; van Wijnen, AJ; Stein, JL; Montecino, M.; Hassan, MQ; Gaur, T; Lengner, CJ; Young, DW Review ISI REVIEWS IN ENDOCRINE METABOLIC DISORDERS (2006)
Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer Stein, GS; Lian, JB; Stein, JL; van Wijnen, AJ; Javed, A; Montecino, M.; Zaidi, SK; Young, DW; Choi, JY; Pratap, J Review ISI SCOPUS Advances in Enzyme Regulation (2005)
The dynamic organization of gene-regulatory machinery in nuclear microenvironments Zaidi, SK; Young, DW; Choi, JY; Pratap, J; Javed, A; Montecino, M.; Stein, JL; van Wijnen, AJ; Lian, JB; Stein, GS Review ISI SCOPUS EMBO REPORTS (2005)
Intranuclear trafficking: Organization and assembly of regulatory machinery for combinatorial biological control Zaidi, SK; Young, DW; Choi, JY; Pratap, J; Javed, A; Montecino, M.; Stein, JL; Lian, JB; van Wijnen, AJ; Stein, GS Review ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation Stein, GS; Lian, JB; van Wijnen, AJ; Stein, JL; Javed, A; Montecino, M.; Zaidi, SK; Young D.; Choi, JY; Gutierrez S. ; Pockwinse, S Review ISI JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
Regulatory controls for osteoblast growth and differentiation: Role of Runx/Cbfa/AML factors Lian, JB; Javed, A; Zaidi, SK; Lengner, C; Montecino, M.; van Wijnen, AJ; Stein, JL; Stein, GS Review CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2004)
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression Stein, GS; Lian, JB; van Wijnen, AJ; Stein, JL; Montecino, M.; Javed, A; Zaidi, SK; Young, DW; Choi, JY; Pockwinse, SM Review ISI ONCOGENE (2004)
Chromatin remodeling during sea urchin early development: molecular determinants for pronuclei formation and transcriptional activation Imschenetzky M.; Puchi, M; Morin, V; Medina R.; Montecino, M. Review ISI GENE (2003)
Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair Stein, GS; Zaidi, SK; Braastad, CD; Montecino, M.; van Wijnen, AJ; Choi, JY; Stein, JL; Lian, JB; Javed, A Review ISI TRENDS IN CELL BIOLOGY (2003)
Nuclear microenvironments support physiological control of gene expression Stein, GS; Lian, JB; Montecino, M.; Stein, JL; van Wijnen, AJ; Javed, A; Pratap, J; Choi J.; Zaidi, SK; Gutierrez S. ; Harrington, K; Shen, JL; Young D.; Pockwinse, S Review ISI SCOPUS CHROMOSOME RESEARCH (2003)

127

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Fernando Cruzat

Profesor Asociado

Oceanografia

Universidad de Concepción

Concepción, Chile

Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

Soraya Gutierrez

Profesor Titular

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Sylvain Marcellini

Associate Professor

Department of Cell biology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

José Gutiérrez

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Rodrigo Assar

Adjoint Professor

Facultad de Medicina

Universidad de Chile

Santiago, Chile

Daniel Moena

Docente

Química y Medio Ambiente

Universidad Técnica Federico Santa María

Concepción, Chile

Soraya Bravo

Independiente

Independiente

Concepción, Chile

Violeta Morin

Associate Research

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

Marta Cecilia Bunster

DIRECTORA

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

Marcela Torrejon

Associate Professor

Biochemistry and Molecular Biology

Biological Sciences Faculty

Concepcion, Chile

pamela pasten

JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

Alejandro Maass

Main Researcher

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Dante Travisany

Profesor Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

Carola Bruna

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS

Concepción, Chile

José Martínez

Associate professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Matias Hepp

Profesor asistente - Investigador

Ciencias Basicas

universidad catolica de la santisima concepcion

Concepcion, Chile

Eduardo Pérez

Profesor Investigador Asociado

Centro de Genética y Genómica, Facultad de Medicina Clínica Alemana

Universidad del Desarrollo

Santiago, Chile

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

Elena Vidal

Directora Programas de Doctorado

Centro de Genomica y Bioinformatica

Universidad Mayor de Chile

Santiago, Chile

Marcela Stuardo

Asistente de Investigación

Biología Molecular

Universidad de Concepción

Concepción, Chile

Carol Moraga

Assistant professor

Instituto Ciencias de la Ingeniería

Universidad de O'Higgins

Rancagua, Chile

Servet Martinez

Full professor

Mathematical Engineering

Universidad de Chile

Santiago, Chile

Klaus Puschel

Full Professor

Family Medicine

FACULTAD MEDICINA PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Antonieta Ramirez de Arellano

Christian Hodar

ASSISTANT PROFESSOR

BIOINFORMATICS & GENEXPRESSION LAB - INTA

UNIVERSIDAD DE CHILE

Santiago, Chile

Carlos Oliva

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

Ariel Orellana

Profesor Titular

Centro de Biotecnologia Vegetal

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Solange Rivas

Postdoctoral Research Assistant

Oncología básico-clínico

Universidad de Chile

Santiago, Chile

Milka Martinez

Profesor

Instituto Profesional Virginio Gomez

Concepcion, Chile

Mauricio Moraga

Profesor Asociado

Programa de Genética Humana

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Claudio Cappelli

Technical Laboratory Manager

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

Susana Eyheramendy

Full Professor

Universidad Adolfo Ibánez

Santiago, Chile

Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

Juan Maass

Asistan Professor

universidad de chile

Santiago, Chile

Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

Claudia Muñoz

Investigadora

Biotecnología

Instituto de Investigaciones Agropecuarias INIA-La Platina

Santiago, Chile

Marcia Manterola

Profesor Asistente

Genetica Humana Block C

UNIVERSIDAD DE CHILE

Santiago, Chile

Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Veronica Cambiazo

Profesora titular

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

Alex Di Genova

Associate professor

Engineering sciences

Universidad de O'Higgins

Rancagua, Chile

Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

Angelica Reyes

Profesor Asociado

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Maximiliano Bendek

ninguno

ninguna

Santiago, Chile

FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Claudio Villota

Profesor/investigador Asociado

Facultad de Salud

Universidad Bernardo O'Higgins

Santiago, Chile

Nicole Farfán

Asistente de investigación

instituto de ciencias biomedicas

Universidad del Desarrollo

Santiago, Chile

Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

Eleodoro Riveras

Investigador postdoctoral

Instituto de Biologia Integrativa, Ibio

Santiago, Chile

Alejandra Bustos

Profesor Asociado

Bioquímica Clínica e Inmunología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Cinthya Ruiz-Tagle

Research Assistant

Department of Infectious Disease

Pontificia Universidad Católica de Chile

Santiago, Chile

Mabel Vidal

Academic

Computer Science

Universidad de Concepción

Concepcion, Chile

Fredy Diaz

ASISTENTE

CIENCIAS BÁSICAS

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

Concepción, Chile

jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Ariel Lara

Profesor Asistente

College UC

Pontificia Universidad Católica de Chile

Santiago, Chile

Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Martín Alejandro Montecino Leonard

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1989

Biomedical Sciences, University of Massachusetts. Estados Unidos, 1996

Biochemistry, Universidad de Concepción. Chile, 1991

Experiencia Académica

Assistant Professor Full Time

Associate Professor Full Time

Professor Full Time

Professor and Director of Institute of Biomedical Sciences Full Time

Formación de Capital Humano

Article (115)

Abstract (1)

BookWhole (1)

ConferencePaper (3)

Proyecto (16)

Epigenetic silencing of the osteogenic master regulator Runx2-p57 in pluripotent cells

“C/EBPbeta-mediated control of transcription during osteoblast differentiation”

“Molecular Mechanisms Regulating Nociceptor Expression”

“Center for Genome Regulation”

“Reactivation of dendritic arbor development and plasticity in developing and adult brain=> role of NMDA receptors, CAMKII and PSD95”

“Characterization of Ric-8, a novel non-receptor G-protein regulator”

“Mechanisms that control transcriptional responsiveness to 1a,25-dihydroxy vitamin D3 in osteoblasts”

“Consorcio de Tecnológica e Innovación para la Salud CTI-Salud”

“Estudios Avanzados en Señalización Celular y Regulación Génica”

“Acción no genómica del receptor de progesterona. El ovocito de Xenopus laevis como sistema de estudio"

“Mecanismo de reclutamiento de complejos que remodelan cromatina y regulan la transcripción de un gen específico de células óseas”

“Bone cell structure and gene expression”