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Marcia Carolina Manterola Zuñiga

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Genetic and Epigenetics Mechanisms that regulate the genome. Mechanisms that regulate the genome and epigenome in the germ line Role of bromodomain proteins in mammalian gametogenesis

Educación

  •  Tecnologo Medico, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Doctor, UNIVERSIDAD DE CHILE. Chile, 2010
  •  Post Doctoral Training, COLUMBIA UNIVERSITY. Estados Unidos, 2016

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2016 - At present

Experiencia Profesional

  •   Postdoctoral Fellow; Advisor: Debra J Wolgemuth

    Columbia University

    Estados Unidos

    2011 - 2016

  •   Graduate Researcher; Advisor: Jesus Page

    Autonomous University of Madrid

    España

    2007 - 2009

  •   Graduate Researcher; Advisor: Silvia Garagna

    Università degli studi di Pavia

    Italia

    2009 - 2009

Premios y Distinciones

  •   Beca de Postgrado

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2004

    Beca Doctorado, Programa de Formacion Capital Humano Avanzados

  •   Postdoctoral Fellowship

    LEBEDEV PHYSICAL INSTITUTE

    Estados Unidos, 2014

    Beca postdoctorado


 

Article (11)

Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts
Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice
BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis.
Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins
Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins.
Robertsonian chromosomes and the nuclear architecture of mouse meiotic prophase spermatocytes.
Inactivation or non-reactivation: what accounts better for the silence of sex chromosomes during mammalian male meiosis?
The frequency of heterologous synapsis increases with aging in Robertsonian heterozygous male mice.
The frequency of heterologous synapsis increases with aging in Robertsonian heterozygous male mice.
The frequency of heterologous synapsis increases with aging in Robertsonian heterozygous male mice.
A high incidence of meiotic silencing of unsynapsed chromatin is not associated with substantial pachytene loss in heterozygous male mice carrying multiple simple robertsonian translocations.

Proyecto (7)

Role of epigenetic factors in regulating the epigenome of sexual chromosomes during the spermatogenesis.
Role of the epigenetic reader Brdt in regulating genome stability through formation and localization of crossovers in meiosis
Role of the epigenetic reader BRDT in the organization and epigenetic reprograming of the chromatin during meiosis
Function of the Bromodomain Protein Brdt in Spermatogenesis
Functions of Brdt and its Bromodomain Motifs during Spermatogenesis
PROPAGACION DE LOS CAMBIOS CROMOSOMICOS ROBERTSONIANOS EN POBLACIONES NATURALES DE MAMIFEROS=> IMPORTANCIA DE LOS MECANISMOS DE CONTROL DE LA MEIOSIS
MECANISMOS MEIOTICOS EN LA PROPAGACION DE CAMBIOS CROMOSOMICOS ROBERTSONIANOS=> PARTICIPACION DE LA SINAPSIS Y DE LA RECOMBINACION HETEROLOGAS
2
Marcia Manterola

Profesor Asistente

Genetica Humana Block C

UNIVERSIDAD DE CHILE

Santiago, Chile

1
estibaliz ampuero

Profesor Asistente

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Claudio Cappelli

Technical Laboratory Manager

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Solange Rivas

Postdoctoral Research Assistant

Oncología básico-clínico

Universidad de Chile

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

1
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile