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Andrea Leonor Calixto Mohor

Full professor

Universidad de Valparaíso

Valparaiso, Chile

The role of microbial metabolites and small RNAs on life history traits such as neuronal survival after injury and transgenerational behavior. We study the mechanisms underlying heritable adaptations using the nematode C. elegans as a model organism.

Biological Sciences, COLUMBIA UNIVERSITY. Estados Unidos, 2009
Molecular Neuroscience, COLUMBIA UNIVERSITY. Estados Unidos, 2006
Microbiology, UNIVERSIDAD DE LA HABANA. Cuba, 1997

Postdoctoral Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Chile

2009 - 2012
Assistant Professor Full Time

Universidad Mayor

Ciencias

Santiago, Chile

2012 - At present
Investigador Asociado Other

UNIVERSIDAD DE VALPARAISO

Centro Interdisciplinario de Neurociencia de Valparaiso (CINV)

Valparaiso, Chile

2015 - At present
Principal Investigator Full Time

Centro Interdisciplinario de Neurociencia de Valparaiso

Valparaiso, Chile

2017 - At present

Graduate Student Full Time

Columbia University

New York, Estados Unidos

2002 - 2008
Postdoctoral Researcher Full Time

P. Universidad Catolica de Chile

Santiago de Chile, Chile

2009 - 2012
Assistant Professor Full Time

Universidad Mayor

Santiago de Chile, Chile

2012 - 2019
Investigadora Principal Full Time

Centro Interdisciplinario de Neurociencia de Valparaiso

Valparaiso, Chile

2016 - At present

Mentoring of Postdoctoral investigators
Florence Gutzwiller, University of Manchester, Postdoctoral researcher (2017-2018)
Victor Antonio Garcia, UNAM Postdoctoral researcher (2014-2016)
Federico Camicia, UBA Postdoctoral researcher (2014-2015)
Ivan Neira, Universidad de Sao Paulo, Postdoctoral researcher (2009-2012)

Mentoring of Doctoral Students
Carolaing Gabaldon, Doctorado en Genomica Integrativa, Universidad Mayor (2015-2020)
Marcela Legue, Doctorado en Genomica Integrativa, Universidad Mayor (2015-2020)
Arles Urrutia, Doctorado en Genomica Integrativa, Universidad Mayor (2016-2020)
Scarlett Delgado, Doctorado en Neurociencia, Universidad de Valparaiso (2017-
Blanca Aguila, Doctorado en Ciencias mencion Microbiologia, Universidad de Chile (2020-

Mentoring of Masters Students
MFernanda Palominos, Ms Sc.Biological Sciences Program Universidad de Chile (2013-2014)
Mauricio Caneo, Ms Sc Biomedical Sciences Program Universidad de Valparaiso (2013-2016)
Daniela Ponce, Magister en Ciencia de la Ingenieria Mencion Quimica, Universidad de Chile (2014-2017)

Mentoring of Undergraduate Students
Andres Fuentes, Undergraduate Biotechnology, Universidad Mayor (2012-2014)
Bernardo Pollak, Undergraduate Biochemistry, Universidad Catolica (2009-2011)
Sebastian Urquiza, Undergraduate Biotechnology, Universidad Mayor (2018-2020)
Romina Valenzuela, Undergraduate Biotechnology, Universidad Mayor (2019-
Javiera Roman, Undergraduate Biotechnology, Universidad Mayor (2020-
Tomas Canepa, Undergraduate Biotechnology, Universidad Mayor (2020-

Teaching and Organization of the following International Courses:

Small Brains Big Ideas Plus. Las Cruces, Chile. April, 2019
Small Brains Big Ideas Plus. Las Cruces, Chile. November 2016
Neural Systems and Behavior. Woodshole Massachusetts. July 2014.
Small Brains Big Ideas Plus. Santiago/Valparaiso October 2014
Small Brains Big Ideas Plus. Santiago/Valparaiso November 2012
Small Brains Big Ideas Plus. Santiago/Valparaiso November 2010

Organization of the First Latinamerican C. elegans Meeting
Pasteur Institute, Montevideo, Uruguay, February, 2017.

Organization of the Second Latinamerican C. elegans Meeting
Rosario,Santa Fe, Argentina , February, 2020.

Organization of the Third Latinamerican C. elegans Meeting
Valparaiso, Chile, March 2022.

Diffusion
Tertulias Porteñas: (http://centex.cl/somos-lo-que-comemos-regresan-a-centex-las-tertulias-portenas/)
Programas de Radio: Radio pauta (10 de Enero, 2019). La Invencion del Futuro, conduce Alejandro Alaluf (https://youtu.be/bHSOPn5CreI)

In the press:
Diario el Mercurio de Valparaiso (3 de Enero, 2019) "Usan gusanos para estudiar posible tratamiento contra el Alzheimer" (http://www.mercuriovalpo.cl/impresa/2019/01/03/full/cuerpo-principal/3/)
Diario Hoy por hoy "Cientificos investigan la regeneracion de neuronas con gusanos" (http://www.hoyxhoy.cl/2019/01/07/full/cuerpo-principal/6/)
Diadio Las Ultimas Noticias "Investigadora descubre como gusanos heredan mecanismos de defensa a su descendencia" (http://www.lun.com/Pages/NewsDetail.aspx?dt=2017-12-26&PaginaId=32&bodyid=0)
El Mercurio de Valparaiso (http://www.mercuriovalpo.cl/impresa/2018/04/19/full/cuerpo-principal/27/)

National Prize of the Academy osf Sciences of Cuba

Academia de Ciencias de Cuba

Cuba, 1998

National Scientific Prize
Conicyt Doctorate Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 1998

Doctorate CONICYT Fellowship
Columbia Unversity Felowship

COLUMBIA UNIVERSITY

Estados Unidos, 2002

Fellowship for Graduate Work
Fondecyt Postdoctoral Fellowship

FONDO NACIONAL DE CIENCIA,TECNOLOGIA E INNOVACION

Chile, 2009

Psotdoctoral Fellowsip for studies in neuronal degeneration and RNAi


The Assembly of Bacteria Living in Natural Environments Shapes Neuronal Integrity and Behavioral Outputs in Caenorhabditis elegans Urquiza-Zurich, Sebastian; Garcia-Angulo, Victor Antonio; Burdisso, Paula; Palominos, M. Fernanda; Fernandez-Hubeid, Lucia; Harcha, Paloma A.; Castillo, Juan P.; Calixto, Andrea Article ISI MBIO (2023)
Interspecies effectors of a transgenerational memory of bacterial infection in Caenorhabditis elegans Legue, Marcela; Caneo, Mauricio; Aguila, Blanca; Pollak, Bernardo; Calixto, Andrea Article ISI ISCIENCE (2022)
Cross-kingdom RNA interactome in a paradigm of host defense against pathogens in C. elegans Legüe, Marcela; Aguila, Blanca; Calixto, Andrea Article ISI FRONTIERS IN MICROBIOLOGY (2021)
The Heritability of Behaviors Associated With the Host Gut Microbiota Manterola, Marcia; Palominos, M. Fernanda; Calixto, Andrea Article Wos, ISI FRONTIERS IN IMMUNOLOGY (2021)
Bacterially produced metabolites protect C. elegans neurons from degeneration Urrutia, Arles; Garcia-Angulo, VA; Fuentes, Andrea; Caneo, Mauricio; Legüe C, Marcela; Urquiza, Sebastian; Delgado, Scarlett; Ugalde, Juan; Burdisso, Paula; Calixto, Andrea Article WOS, ISI, Scopus, Pubmed PLoS Biology (2020)
Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243 Gabaldon, Carolaing; Legue, Marcela; Palominos, M. Fernanda; Verdugo, Lidia; Gutzwiller, Florence; Calixto, Andrea Article ISI MBIO (2020)
Quantification of Bacteria Residing in Caenorhabditis elegans Intestine Palominos, M. Fernanda; Calixto, Andrea Article BIO-PROTOCOL (2020)
Diapause induces functional axonal regeneration after necrotic insult in C. elegans Caneo, Mauricio; Julian, Victoria; Byrne, Alexandra; Alkema, Mark; Calixto, Andrea Article WOS, ISI, SCOPUS, Pubmed PLOS GENETICS (2019)
Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis Dubois-Camacho, Karen; Diaz-Jimenez, David; De la Fuente, Marjorie; Quera, Rodrigo; Simian, Daniela; Martinez, Maripaz; Landskron, Glauben; Olivares-Morales, Mauricio; Cidlowski, John A.; Xu, Xiaojiang; Gao, Guangping; Xie, Jun; Chnaiderman, Jonas; Soto-Rifo, Ricardo; Gonzalez, Maria-Julieta; Calixto, Andrea.; Hermoso, Marcela A. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Opposing action of NCoR1 and PGC-1 alpha in mitochondrial redox homeostasis Lima, Tanes I.; Guimaraes, Dimitrius Santiago P. S. F.; Oliveira, Andre G.; Araujo, Hygor; Sponton, Carlos H. G.; Souza-Pinto, Nadja C.; Saito, Angela; Figueira, Ana Carolina M.; Palameta, Soledad; Bajgelman, Marcio Chaim; Calixto, Andrea.; Pinto, Silas; Mori, Marcelo A.; Orofino, Joey; Perissi, Valentina; Mottis, Adrienne; Auwerx, Johan; Silveira, Leonardo Reis Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2019)
RNA language in Caenorhabditis elegans and bacteria interspecies communication and memory Legüe, Marcela; Calixto, Andrea Article INSPEC Current Opinion in Systems Biology (2019)
Worm corpses affect quantification of dauer recovery. Gabaldon, Carolaing; Calixto, Andrea Article PMC, PubMed, EuropePMC microPublication Biology (2019)
Transgenerational Diapause as an Avoidance Strategy against Bacterial Pathogens in Caenorhabditis elegans Palominos, M. Fernanda; VERDUGO, LIDIA; Gabaldon, Carolaing; Pollak, Bernardo; Ortiz-Severin, Javiera; Varas, Macarena A.; Chavez, Francisco P.; Calixto, Andrea Article WOS, Pubmed, MEDLINE MBIO (2017)
FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C-elegans embryogenesis Kelley M.; Yochem J.; Krieg M.; Calixto, A; Heiman, MG; Kuzmanov A.; Meli V.; Chalfie, M; Goodman, MB; Shaham S.; Frand A.; Fay, DS Article ISI ELIFE (2015)
Life without Food and the Implications for Neurodegeneration Calixto, Andrea Article ISI, Pubmed ADVANCES IN GENETICS (2015)
Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss Calixto, A; Jara J.S.; Court, F. A. Article ISI SCOPUS PLoS Genetics (2012)
Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans Calixto, A; Ma C.; Chalfie, M Article SCOPUS Nature Methods (2010)
Enhanced neuronal RNAi in C. elegans using SID-1 Calixto, A; Chelur D.; Topalidou I.; Chen X.; Chalfie, M Article SCOPUS Nature Methods (2010)
Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference Lehner, B; Calixto, A; Crombie, C; Tischler, J; Fortunato, A; Chalfie, M; Fraser, AG Article ISI GENOME BIOLOGY (2006)
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels Huber, Tobias B.; Schermer, Bernhard; Mueller, Roman Ulrich; Hoehne, Martin; Bartram, Malte; Calixto, Andrea; Hagmann, Henning; Reinhardt, Christian; Koos, Fabienne; Kunzelmann, Karl; Shirokova, Elena; Krautwurst, Dietmar; Harteneck, Christian; Simons, Matias; Pavenstaedt, Hermann; Kerjaschki, Dontscho; Thiele, Christoph; Walz, Gerd; Chalfie, Martin; Benzing, Thomas Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)


Use of C. elegans Diapause to Study Transgenerational Responses to Pathogen Infection ChÃ¡vez F.P.; Calixto A. BookWhole SCOPUS Methods in Molecular Biology (2019)


Interspecies effectors of a transgenerational memory of bacterial infection in C. elegans. Andrea Calixto Proyecto (2022)
Discovery of neuroprotective bacterial metabolites and their mechanism of action in C. elegans PCI (REDES18013) Proyecto 2019-2022 Inv. Responsable
Functional innovations under energy constraints and the evolution of animal diapause. Ferrada, Evandro; Calixto, Andrea Proyecto (2019)
Desarrollo de Consorcios Bacterianos para el tratamiento de enfermedades neurodegenerativas. PCI (P918PTE026) Proyecto 2018-2021 Inv. Responsable
Development of computational methods for the determination of causal-condition specific gene regulatory networks FONDECYT (1181089) Proyecto 2018-2022 Coinvestigador(a)
Analysis of gene regulatory networks that modulate behavior upon bacterial pathogenesis PCI (USA2013-00) Proyecto 2013-2016 Inv. Responsable
DIAPAUSE FORMATION SIGNALED BY THE RNAI MACHINERY AS A NOVEL INNATE DEFENSE MECHANISM AGAINST BACTERIAL PATHOGENS. FONDECYT (1131038) Proyecto 2013-2017 Inv. Responsable
The Neuronal network initiative. Understanding Differential neuronal vulnerability in neurological diseases PIA (Anillo ACT) Proyecto 2012-2015 Investigador(a)
Millennium Institute Interdisciplinary Center of Neuroscience of Valparaíso – CINV Latorre, Ramon Proyecto (2011)
DISCOVERY OF NEURONAL ROLES FOR GENES THAT CAUSE LETHALITY IN C.ELEGANS USING RNA INTERFERENCE. FONDECYT (3100099) Proyecto 2009-2012 Inv. Responsable