Cancer functional genomics; applied genomics; bioinformatics; RNA biology

Postdoctoral

1. Solange Rivas (2020-2023). "Uncovering novel driver mutations in non-small cell lung cancer from Chile, Brazil and Perú patients". Universidad del Desarrollo.

2.. Cesar Echeverria (2016) . "Lipopolysaccharide induces epithelial- mesenchymal transition of the bladder urothelium”. Universidad de Chile.

Graduate

1. Fernanda Morales (2020). Doctoral Program in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Thesis title: "Role of ADAR1 in the progression of breast cancer through the regulation of the Wnt / ?-catenin signaling pathway". Thesis Director. Finished.

2. Pamela Rojas from Santiago (2020). PhD Program in Cellular and Molecular Biology, Pontificia Universidad Católica de Chile. Thesis title: "Role of ADAR1-induced changes of long non-coding RNAs in the breast cancer cell line MDA-MB-436". Thesis Director. Finished.

3. Valentina Garate (2018). Master of Science Program, Faculty of Sciences, University of Chile. Thesis title: "Validation and evaluation of algorithms for the detection of INDELS in the MICA gene in Gastric Cancer". Thesis Director. Finished.

4. Eduardo Sagredo (2018). Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Chile. Thesis title: "Role of the ADAR1 enzyme in the response to DNA damage and cell cycle checkpoints in mammary adenocarcinoma". Thesis Director. Finished.

5. Jalaj Jain (2017). Doctorate Program in Applied Sciences, Universidad de Talca. Thesis title: “Studies on plasma focus devices and characterization of pulsed neutron and x-ray emission: Applied to cancer cells. Co-director of Thesis. Finished.

6. Marcela Morales (2016). Magister Program in Immunology, Faculty of Medicine, University of Chile. Thesis title: "Determination of genetic variations in the promoter of the ligand ULBP4 / RAET1E, which allow explaining its expression after stimulation by Helicobacter pylori, in gastric adenocarcinoma". Co-director. Finished.

7. Claudio Capelli (2016). Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Chile. Thesis title: "Maintenance of epigenetic information during mitosis by the co-repressor Ski". Co-director of Thesis. Finished.

8. Alfredo Sagredo Campos (2015). Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Chile. Thesis title: "The TRPM4 channel promotes cell proliferation and migration through the negative regulation of GSK-3? kinase and consequent increase in the activity of the ?-catenin oncogene". Thesis Director. Finished.

9. Pablo Báez Benavidez (2013). Master's Program in Medical and Biological Sciences, Genetics mention, Faculty of Medicine, University of Chile. Thesis title: "Role of the TRPM4 ion channel in the development of prostate cancer in a transgenic murine model". Thesis Director. Finished.

Undergraduate

1. Valentina Garate (2016). School of Biotechnology, Faculty of Sciences, University of Chile. Professional thesis to qualify for the title of Engineer in Molecular Biotechnology. Thesis title: Analysis of genetic polymorphisms of NKG2D ligands in Chilean patients with gastric cancer. Thesis Director. Finished.

2. Bárbara Avello (2014). School of Medical Technology, Faculty of Medicine, University of Chile. Professional thesis to qualify for the title of Medical Technologist with a mention in Clinical Bioanalysis, Hematology and Blood Bank. Thesis title: "Generation of a protocol to evaluate the clinical relevance of somatic and germline mutations detected by high-depth directed sequencing in 25 patients with breast cancer". Thesis Director. Finished.

3. Carolina Luco (2013). School of Medical Technology, Faculty of Medicine, University of Chile. Professional thesis to qualify for the title of Medical Technologist with a mention in Clinical Bioanalysis, Hematology and Blood Bank. Thesis title: "Determination of the proliferative change in the PC-3 cell line and its effect on the cell cycle according to the differential activity of the TRPM4 channel". Thesis Director. Finished.

CONFERENCES and SEMINARS

1. Conference "Precision Medicine and its role in the therapeutic future of patients in Chile"
PLACE: 2020 Pharmaceutical Week of the Santiago Regional College of Pharmaceutical and Biochemical Chemists of Chile.
DATE: December 2, 2020

2. Conference "Precision Medicine in Lung Cancer"
PLACE: Oncosummit Chile 2020
DATE: November 19, 2020

3. Conference "Access to existing data in research perspective - 2 points of view / case studies: EU and LAC."
PLACE: EULAC-PerMed Virtual Workshop on Ethical, Legal and Social Aspects (ELSA) in Personalized Medicine
DATE: November 18, 2020

4. Conference "Molecular characterization of actionable somatic mutations in Chilean patients with NSCLC"
PLACE: Fourth Latin American Symposium on Thoracic Oncology (SILOT IV), Chile.
DATE: November 5, 6 and 13, 2020

5. Conference "Cancer functional genomics"
VENUE: ACCDIS Cancer Symposium, Santiago, Chile.
DATE: November 3, 2020.

6. Conference “Research made in Chile, what do we have to show? NGS Project "
PLACE: Fourth Latin American Symposium on Thoracic Oncology (SILOT IV), Chile.
DATE: November 5, 6 and 13, 2020

7. Conference "Challenges in Implementing Genomic Medicine in Latin America"
VENUE: 5th G2MC International VIRTUAL Conference Genomic Medicine Implementation in Low Resources Settings
DATE: May 6-8, 2020.

8. Conference "Personalized Medicine Situation in Latin America and the Caribbean: Chile"
PLACE: BUILDING BRIDGES IN PERSONALIZED MEDICINE BETWEEN LATIN AMERICA-CARIBBEAN AND EUROPE, Montevideo, Uruguay.
DATE: December 11-12, 2019.

9. Conference "Edition A> I of RNA in the progression of breast cancer"
PLACE: Doctoral Program in Molecular Biosciences, Andres Bello University, Santiago, Chile.
DATE: December 2, 2019.

10. Conference "Mutational tumor burden and biomarkers of resistance in Lung Cancer"
PLACE: IV Chilean Congress of Medical Oncology, Hotel Santa Cruz Plaza, Santa Cruz, Chile.
DATE: August 21-23, 2019.

11. Seminar "RNA Edition in the progression of breast cancer"
PLACE: Institute of Sciences and Innovation in Medicine, Faculty of German Clinical Medicine, Universidad del Desarrollo, Santiago, Chile.
DATE: July 31, 2019.

12. Conference “Understanding ADAR’s role in shaping the (cancer) transcriptome”.
VENUE: Pfizer Omics Workshop 2018, Target Sciences & Technologies, Cambridge, USA.
DATE: May 18th & 19th 2019.

13. Seminar "Genomics of Lung Cancer in Latin America".
PLACE: Seminars Department of Pathology, Clínica Alemana de Santiago, Chile.
DATE: September 25, 2018.

14. Conference "Genomics of Lung Cancer".
PLACE: Conference of the Respiratory Center and Thoracic Surgery, Las Condes Clinic, Santiago, Chile.
DATE: August 3, 2018.

15. Conference “A-to-I UTR editing by ADAR1 in breast cancer progression”.
VENUE: Pfizer Omics Workshop 2018, Target Sciences & Technologies, Cambridge, USA.
DATE: May 14th & 15th 2018.

16. Conference "Personalized medicine in breast cancer: The role of next generation sequencing".
PLACE: XI Santiago International Breast Cancer Symposium, Clínica Las Condes, Santiago, Chile.
DATE: April 16-18, 2018.

17. Conference "Collaboration in cancer research: External vision".
PLACE: 1st UC Oncology Research Conference 2017, Faculty of Medicine, Pontificia Universidad Catolica. Santiago, Chile.
DATE: December 15 and 16, 2017.

18. Conference “Precision Medicine in Latin America: CEMP and lung cancer genomics”.
PLACE: Workshop on Bioinformatics and Biostatistics in Genomics. Faculty of Mathematics, Astronomy, Physics and Computing. University City. National University of Cordoba. Cordoba Argentina.
DATE: December 4, 5 and 6, 2017.

19. Conference “Next generation sequencing, CEMP data”.
PLACE: Third Latin American Symposium on Thoracic Oncology (SILOT III), Iquique, Chile.
DATE: November 23 to 25, 2017.

20. Talk "Role of RNA editing in the progression of breast cancer".
PLACE: Cycle of talks "Genetics, Genomics and Evolution". Human Genetics Program, ICBM, Faculty of Medicine, U. de Chile, Santiago, Chile.
DATE: November 18, 2017.

21. Conversation "Bioinformatics applied to the study of cancer"
PLACE: Directorate of Technology Transfer, University of Talca, Talca, Chile.
DATE: November 17, 2017.

22. Conference “Molecular Epidemiology of Non-Small Cell Lung Cancer in Chile”.
PLACE: 1st Metting “Cell Differentiation, Signaling and Therapy”. Integrative Center for Applied Chemistry and Biology, Bernardo O'Higgins University, Santiago, Chile.
DATE: November 15, 2017.

23. Conference "New technologies in the identification of mutations".
PLACE: 1st International Course on Genetics in Breast and Ovarian Cancer. Controversies and challenges. Las Condes Clinic, Santiago, Chile.
DATE: 12 of October 13, 2017.

24. Conference "Molecular Epidemiology of Non-Small Cell Lung Cancer in Chile".
PLACE: III Chilean Congress of Oncology: Advances in Medical Oncology and Oncological Care, Chilean Society of Medical Oncology. Santa Cruz, Chile.
DATE: August 24-26, 2017.

25. Inaugural Conference "Precision Medicine and Genomics of Lung Cancer in Chile".
PLACE: Inauguration of the Molecular Pathology Laboratory, Christus Muguerza Hospital, Monterrey, Mexico.
DATE: June 22, 2017.

26. Seminar "Precision Medicine and Genomics of Lung Cancer in Chile".
PLACE: University Hospital of the Autonomous University of Nuevo León, Monterrey, Mexico.
DATE: June 21, 2017.

27. Conference “Precision Medicine in Latin America: CEMP and lung cancer genomics”.
VENUE: Pfizer Omics Workshop 2017, Cambridge, USA.
DATE: May 15, 2017.

28. Inaugural Conference "Edition of RNA in progression of breast cancer".
PLACE: Inauguration of the academic year of the Integrative Genomics Doctorate Program, Universidad Mayor, Santiago, Chile.
DATE: March 27, 2017.

29. Conference “New Frontiers of Health: Human development and major diseases”.
PLACE: Congress of the Future 2017. Senate of Chile, Santiago, Chile.
DATE: January 9-14, 2017

30. Conference “Lung cancer genomics in Chile”.
PLACE: International Symposium in Cancer Genomics and Bioinformatics, Faculty of Medicine, University of Chile. Santiago, Chile.
DATE: January 16, 2017.

31. Seminar "RNA edition in the progression of breast cancer".
PLACE: Seminars of the Department of Biology of the Faculty of Sciences of the University of Chile, Santiago, Chile.
DATE: June 2016.

32. Conference “Challenges in research for the development of Biotechnology in Chile, opportunities and national and international context”.
PLACE: Launch of the Health Technology Nucleus, Universidad San Sebastian, Santiago, Chile.
DATE: May 2016.

33. Inaugural Conference "Precision Medicine in Oncology today".
PLACE: Southern Oncology Society Congress, Villarrica, Chile.
DATE: October 2015.

34. Conference “Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA repair”.
PLACE: Center for Genetics and Genomics, Faculty of German Clinical Medicine, Universidad del Desarrollo, Santiago, Chile.
DATE: September 2015.

35. Conference “Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA repair”.
PLACE: Symposium “When Biology Meets Computers: Oncodomains, Microbiomes and Allosteric Networks”. International Society of Computational Biology (ISCB) & XXXVIII Annual Meeting of the Society for Biochemistry and Molecular Biology of Chile, Puerto Varas, Chile.
DATE: September 2015.

36. Conference "Genomics of cancer in Chile".
PLACE: XLVII Annual Meeting of the Chilean Genetics Society, Puerto Varas, Chile.
DATE: November 2014.

37. Conference "New molecular discoveries in Breast Cancer".
PLACE: First Latin American Congress of Molecular Oncology, Santiago, Chile.
DATE: May 2014

38. Conference "Personalized Medicine".
PLACE: 2nd Meeting of Basic Clinical Research. Biomedical Neuroscience Institute. Faculty of Medicine, U. de Chile, Santiago, Chile.
DATE: November 2013.

39. Conference "Incorporation of ultra-deep gene sequencing in the care of cancer patients".
PLACE: Cycle of Conferences in Oncology 2013, Center for Translational Research in Oncology (CITO), Pontificia Universidad Católica de Chile. Santiago, Chile.
DATE: August 2013.

40. Conference "Genome Study and Computer Integration".
PLACE: 1st Chilean Congress of Medical Oncology. Chilean Society of Medical Oncology, Santa Cruz, Chile.
DATE: August 2013.

41. Conference "Molecular diagnosis in the clinical laboratory: Molecular biology and cancer".
PLACE: XVII Chilean Congress of Clinical Chemistry, Extension Center of the Catholic University, Santiago, Chile.
DATE: May 17, 2012.

42. Conference "Personalized therapy, medicine of tomorrow".
PLACE: I Training Course in Oncology, Scientific Academy of Medical Students, Faculty of Medicine, U of Chile. Santiago, Chile.
DATE: May 3-5, 2012.

43. Conference “University of Chile Cancer Network”.
PLACE: Joint Symposium on Current Health Research in the Faculties of Medicine of the University of Sydney and the University of Chile, Facultad de Medicina, U de Chile. Santiago, Chile.
DATE: September 13, 2012.

44. Conference “Capacities and infrastructure needed for Translational Research in Cancer”.
PLACE: Workshop on "European Collaboration in the Development of Translational Research on Cancer in Chile". Institute of Biomedical Sciences, Faculty of Medicine, U. de Chile. Santiago, Chile.
DATE: January 19 and 20, 2011.

45. Conference “Cancer Center of the Faculty of Medicine: A strategy of Translational Medicine ”.
PLACE: Workshop on Cancer Research and Treatment, Institute of Biomedical Sciences / Moores Cancer Center, Faculty of Medicine, U. de Chile. Santiago, Chile.
DATE: November 28 - 30, 2011.

46. Conference “Role of TRPM4 in the development of prostate cancer”.
PLACE: Department of Internal Medicine, Clinical Hospital of the University of Chile, University of Chile. Santiago, Chile.
DATE: November 2010.

47. Lecture "Participation of TRPM4 in the development of prostate cancer".
PLACE: "First Conference on Cancer Research", Institute of Biomedical Sciences, Faculty of Medicine, University of Chile. Santiago, Chile.
DATE: July 16, 2011.

48. Conference "Mechanisms of subcellular localization of CAMKII in neurons".
PLACE: Center for Molecular Studies of the Cell, Faculty of Medicine, University of Chile. Santiago, Chile.
DATE: July 20, 2006.