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Nelson Miguel Varela Figueroa

Académico

UNIVERSIDAD DE CHILE

Santiago, Chile

FARMACOGENETICA; BIOLOGIA MOLECULAR; ONCOLOGIA

Bioquímica y Biología Molecular, UNIVERSIDAD DE CHILE. Chile, 2004
Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 1999
Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2010

Académico Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2010 - 2015
Académico Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2015 - 2016
Académico Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2017 - At present

Responsable Aseguramiento Calidad / RT-PCR para COVID1919 Part Time

Laboratorio CQF, Facultad de Medicina, Universidad de Chile

Santiago, Chile

2020 - At present

Dirección de 6 tesis conducentes al grado de licenciado en el periodo 2013-2016
Actualmente dirijo 2 tesis de pregado y 1 tesis de magister, además de la co-tutoria de una tesis doctoral.


Addressing genetic diversity and health inequities: RELIVAF’s proposal for Latin American pharmacogenomic guidelines Luis A. Quiñones, Matías F. Martínez, Rodrigo Vargas, Leslie C. Cerpa, Andrés López-Cortés, Farith González-Martínez, Dora Fonseca, Jorge Duconge, Nelson M. Varela, Ismael Lares-Asseff, María Ana Redal, Patricia Esperón, Fabricio Ríos-Santos, Ana Lucía Article ISI FRONTIERS IN PHARMACOLOGY (2026)
Association Between <i>CYP2C9</i> and <i>CYP2C19</i> Genetic Polymorphisms and Antiseizure Medication-Induced Adverse Reactions Among Peruvian Patients with Epilepsy Alvarado, Angel T.; Ignacio-Cconchoy, Felipe L.; Espinoza-Retuerto, Juan C.; Contreras-Macazana, Roxana M.; Quinones, Luis Abel; Garcia, Jorge A.; Bendezu, Maria R.; Chavez, Haydee; Surco-Laos, Felipe; Laos-Anchante, Doris; et al. Article ISI PHARMACEUTICALS (2025)
Association of OPRM1 and OPRD1 Polymorphisms with Pain and Opioid Adverse Reactions in Colorectal Cancer Gutierrez-Cáceres, C; Avila, N; Cerpa, LC; Martínez, MF; Irarrazabal, CE; Torres, B; Barajas, O; Varela, NM; Quiñones, LA Article ISI SCOPUS Pharmaceuticals (2025)
Comparison between optimized bismuth quadruple therapy and standard clarithromycin-based triple therapy for first-line Helicobacter pylori eradication: a double-blind randomized controlled trial Medel-Jara PA, Latorre G, Fuentes-Lopez E, Pizarro M, Viviani P, Chahuán J, Maquilón S, Corsi O, Reyes D, Espino A, Vargas JI, Wichmann IA, Harris P, Serrano C, Buruato I, Sandoval C, Varela NM, Cerpa L, Quiñones L, Megraud F, Huang RJ, Shah SC, Perez Article ISI The Lancet Regional Health – Americas (2025)
CYP1A1 and GSTM1 genes associated with the risk of developing colorectal cancer: a case-control study in the Lima region of Peru Alvarado, AT; Saravia-Bartra, M; Malpartida-Palomino, R; Cárdenas-Guerrero, CC; García, JA; Bendezú, MR; Chávez, H; Laos-Anchante, D; Palomino-Jhong, JJ; Molina-Cabrera, A; et al. Article ISI SCOPUS Pharmacia (2025)
Genetic variants and clinical determinants affecting the response to 5-Fluorouracil-based treatment in Chilean patients with advanced colorectal cancer Cerpa, LC; Sandoval, C; Escalante, P; Cayún, JP; Lavanderos, MA; Alarcón-Concha, C; Kaempfe, G; Moreno-Tapia, D; Quiroz, CS; Gutierrez-Cáceres, C; et al. Article ISI SCOPUS Frontiers in Oncology (2025)
Prevalence of GSTM10 and CYP1A12A (rs4646903) variants in the central Peruvian coastal population: Pilot Study of predictive genetic biomarkers for 4P medicine Alvarado, AT; Salazar-Granara, A; Varela, N; Quiñones, LA; Li-Amenero, C; Bendezú, MR; García, JA; Surco-Laos, F; Chávez, H; Palomino-Jhong, JJ; et al. Article ISI PHARMACIA (2025)
Small-RNA sequencing identifies serum microRNAs associated with abnormal electrocardiography findings in patients with Chagas disease Mueller, M; Blandino, A; Scherer, D; Zulantay, I; Apt, W; Varela, NM; Llancaqueo, M; Garcia, L; Ortiz, L; Nicastri, E; et al. Article ISI SCOPUS Journal of Infection (2025)
The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population Erices, JI; González, E; Salgado, M; Barahona-Ponce, C; Freire, M; Sepúlveda-Hermosilla, G; Ampuero, D; Blanco, A; Gárate-Calderón, V; Báez-Benavides, P; et al. Article ISI SCOPUS Frontiers in Oncology (2025)
Genetic Polymorphisms and Tumoral Mutational Profiles over Survival in Advanced Colorectal Cancer Patients: An Exploratory Study Cayún JP, Cerpa LC, Colombo A, Cáceres DD, Leal JL, Reyes F, Gutiérrez-Cáceres C, Calfunao S, Varela NM, Quiñones LA. Article ISI CURRENT ONCOLOGY (2024)
Parasite Burden of Trypanosoma cruzi in Whole Blood and Buffy Coat Determined by Real-Time PCR in Individuals with Chronic Chagas Disease Liempi, D; Zulantay, I; Varela, NM; Canals, M; Guevara, A; Poulsen, N; Apt, W Article ISI SCOPUS Microorganisms (2024)
An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean. Salas-Hernández A, Galleguillos M, Carrasco M, López-Cortés A, Redal MA, Fonseca-Mendoza D, Esperón P, González-Martínez F, Lares-Asseff I, Lazarowski A, Loera-Castañeda V, Remírez D, Martínez MF, Vargas R, Rios-Santos F, Macho A, Cayún JP, Varela NM and Article ISI FRONTIERS IN PHARMACOLOGY (2023)
Editorial: Pharmacogenetics and pharmacogenomics in Latin America: ethnic variability, new insights in advances and perspectives: a RELIVAFCYTED initiative, Volume II. López-Cortés A, Esperón P, Martínez MF, Redal MA, Lazarowski A, Varela NM, Lares-Asseff I and Quiñones LA Article ISI FRONTIERS IN PHARMACOLOGY (2023)
Editorial: Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative Esperón P, Martínez MF, Redal MA, Lazarowski A, López-Cortés A, Varela NM and Quiñones LA. Article ISI FRONTIERS IN PHARMACOLOGY (2022)
Polymorphism in the pvcrt-o and pvmdr-1 genes of Plasmodium vivax associated with a better prognosis for malaria. Alves-Junior ER, Dombroski TCD, Nakazato L, Dutra V, Neves-Costa JD, Katsuragawa TH, Varela Figueroa NM, Macho A, Fontes CJF, Rios-Santos F. Article TROPICAL BIOMEDICINE (2022)
The close interaction between hypoxia‑related proteins and metastasis in pancarcinomas Andrés López?Cortés, Lavanya Prathap, Esteban Ortiz?Prado, Nikolaos C. Kyriakidis, Ángela León Cáceres, Isaac Armendáriz?Castillo, Antonella Vera?Guapi, Nelson Varela & Santiago Guerrero Article ISI SCIENTIFIC REPORTS (2022)
A new insight for the identification of oncogenic variants in breast and prostate cancers in diverse human populations, with a focus on Latinos Nelson M. Varela, Patricia Guevara, Cristian Acevedo, Tomás Zambrano, Isaac Armendáriz-Castillo, Santiago Guerrero, Andrés López-Cortés and Luis Abel Quiñones. Article ISI FRONTIERS IN PHARMACOLOGY (2021)
Effect of CYP3A4, CYP3A5, MDR1 and POR Genetic Polymorphisms in Immunosuppressive Treatment in Chilean Kidney Transplanted Patients Contreras-Castillo, Stephania; Plaza, Anita; Carmona, Rodolfo; Farias, Nayaret; Llull, Gabriel; Ardiles, Leopoldo; Varela, Nelson; Flores, Claudio; Krall, Paola Article ISI FRONTIERS IN PHARMACOLOGY (2021)
Frequency of <i>CYP1A1*2A</i> polymorphisms and deletion of the <i>GSMT1</i> gene in a Peruvian mestizo population Tito Alvarado, Angel; Maria Munoz, Ana; Saravia Bartra, Maria; Valderrama-Wong, Milton; Gonzalez, Daniela; Abel Quinones, Luis; Varela, Nelson; Rocio Bendezu, Maria; Antonio Garcia, Jorge; Loja-Herrera, Berta Article ISI PHARMACIA (2021)
Frequency of <i>CYP2D63</i> and 4 and metabolizer phenotypes in three mestizo Peruvian populations Alvarado, Angel T.; Ybanez-Julca, Roberto; Maria Munoz, Ana; Tejada-Bechi, Cesar; Cerro, Roberto; Abel Quinones, Luis; Varela, Nelson; Andre Alvarado, Cesar; Alvarado, Erick; Bendezu, Maria R.; et al. Article ISI PHARMACIA (2021)
In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19 Lopez-Cortes, Andres; Kyriakidis, Nikolaos C.; Barba-Ostria, Carlos; Leon Caceres, Angela; Guerrero, Santiago; Ortiz-Prado, Esteban; Tejera, Eduardo; Cevallos-Robalino, Domenica; Gomez-Jaramillo, Ana Maria; Simbana-Rivera, Katherine; et al. Article ISI FRONTIERS IN PHARMACOLOGY (2021)
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori. Patricio Gonzalez-Hormazabal, Diana Pelaez, Maher Musleh, Marco Bustamante, Juan Stambuk, Raul Pisano, Hector Valladares, Enrique Lanzarini, Hector Chiong, Jose Suazo, Luis A. Quiñones, Nelson M. Varela, V. Gonzalo Castro, Lilian Jara and Zoltan Berger. Article ISI BIOLOGICAL RESEARCH (2021)
Novel risk associations between microRNA polymorphisms and gastric cancer. Natalia Landeros, Alejandro H. Corvalan, Maher Musleh, Luis A. Quiñones, Nelson M. Varela, Patricio Gonzalez-Hormazabal. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Pharmacogenetic Associations Between Atazanavir/UGT1A1*28 and Efavirenz/rs3745274 (CYP2B6) Account for Specific Adverse Reactions in Chilean Patients Undergoing Antiretroviral Therapy. Daniela Poblete, Fernando Bernal, Gabriel Llull, Sebastian Archiles, Patricia Vasquez, Leonardo Chanqueo, Nicole Soto, María A. Lavanderos, Luis A. Quiñones, Nelson M. Varela Article ISI FRONTIERS IN PHARMACOLOGY (2021)
Pharmacogenetics-based preliminary algorithm to predict the incidence of infection in patients receiving cytotoxic chemotherapy for hematological malignancies: a discovery cohort. Matias F Martinez , Enzo Alveal, Tomas Gonzalo Soto , Eva I Bustamante, Fernanda Ávila, Shrikant I Bangdiwala, Ivonne Flores, Claudia Benavides, Ricardo Morales, Nelson M Varela, Alison E Fohner and Luis A Quiñones. Article ISI FRONTIERS IN PHARMACOLOGY (2021)
Preliminary pharmacogenomic-based predictive models of tamoxifen response in hormone-dependent Chilean Breast Cancer patients Carla Estefania Miranda, Macarena Galleguillos, Roberto Torres, Karla Tardón, Dante D. Caceres, Kuen Shiou Lee, Nelson Miguel Varela and Luis Abel Quiñones. Article ISI FRONTIERS IN PHARMACOLOGY (2021)
Resolvin D1 reduces expression and secretion of cytokines and monocyte adhesion triggered by Angiotensin II, in rat cardiac fibroblasts Aimeé Salas-Hernández, Felipe Ruz-Cortés, Francisca Bruggendieck, Claudio Espinoza-Perez, Jenaro Espitia-Corredor, Nelson M. Varela, Luis A. Quiñones, Carlos Sánchez-Ferrer, Concepción Peiró, Guillermo Díaz-Araya. Article ISI BIOMEDICINE AND PHARMACOTHERAPY (2021)
Retrospective pharmacogenetic analysis of a pediatric patient under anticoagulant treatment: Clinical case Cavieres, Mirta; Suarez, Marcelo; Veron, Gabriel; Abel Quinones, Luis; Miguel Varela, Nelson Article ISI BIOMEDICA (2021)
Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals Rodrigo M Young, Camila J Solis, Andres Barriga-Fehrman, Carlos Abogabir, María A Lavanderos, Nelson M Varela, Alvaro Santibañez, Ana M Sandino, Felipe Reyes-Lopez, Garth Dixon, Luis A Quiñones Article ELIFE (2021)
As3MT and GST polymorphisms influencing arsenic metabolism in human exposure to drinking groundwater Farith González-Martínez, Daniel Sánchez-Rodas, Nelson M. Varela, Christopher A. Sandoval, Luis A. Quiñones, Boris Johnson-Restrepo Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Functionally Significant Coumarin-Related Variant Alleles and Time to Therapeutic Range in Chilean Cardiovascular Patients Roco, A.M.; Lavanderos, M. A.; VerÃ³n G.; Salas, P; MejÃas F.; VÃ©liz P.; Varela, NM; Llull G. Article ISI SCOPUS CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2020)
Genetic polymorphisms as non-modifiable susceptibility factors to laryngeal cancer Rahal, Maritza; Daniel Caceres, Dante; Abel Quinones, Luis; Miguel Varela, Nelson Article ISI BIOSCIENCE REPORTS (2020)
Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach D’afonseca, Vívian; Arencibia, Ariel D.; ECHEVERRIA-VEGA, ALEX BENJAMIN; Cerpa, Leslie Carol; Cayun, Juan P.; Varela, Nelson Miguel; Salazar, Marcela; QUINONES-SEPULVEDA, LUIS ABEL Article ISI SCOPUS Cancer Informatics (2020)
IL-6 -572C>G and CARD8 304T>A genetic polymorphisms are associated with the absolute neutrophil count in patients with hematological malignancies under chemotherapy: An application of multilevel models to a preliminary pharmacogenetic study. Matias F. Martinez, Enzo Alveal, Tomas Soto, Eva Bustamante, Fernanda Ávila, Shrikant I. Bangdiwala, Ivonne Flores, Claudia Benavides, Ricardo Morales, Nelson M. Varela, Luis A. Quiñones Article ISI PHARMACOGENOMICS AND PERSONALIZED MEDICINE (2020)
Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population. Gonzalez-Hormazabal P, Retamales-Ortega R, Musleh M, Bustamante M, Stambuk J, Pisano R, Valladares H, Lanzarini E, Chiong H, Suazo J, Quiñones LA, Varela NM, Castro VG, Jara L, Verdugo RA, Berger Z. Article ISI MOLECULAR BIOLOGY REPORTS (2020)
The Current State of MicroRNAs as Restenosis Biomarkers Varela N, Lanas F, Salazar LA and Zambrano T. Article ISI FRONTIERS IN GENETICS (2020)
Association Study Among Candidate Genetic Polymorphisms and Chemotherapy-Related Severe Toxicity in Testicular Cancer Patients. Lavanderos, M.A., Cayún, J.P., Roco, A., Sandoval, C., Cerpa, L., Rubilar, J., Varela, N. Quiñones, L.A. Article ISI FRONTIERS IN PHARMACOLOGY (2019)
Study of the allelic variants CYP2C92 and CYP2C93 in the Peruvian mestizo population [Estudio de las variantes alélicas CYP2C92 y CYP2C93 en población mestiza peruana] Alvarado, AT; Loja B.; Miyasato J.M.; Varela, NM Article SCOPUS Biomedica (2019)
The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis. Villanueva, Francisco; Araya, Hector; Briceño, Pedro; Varela, Nelson; Stevenson, Andres; Jerez, Sofia; Tempio, Fabian; Chnaiderman, Jonas; Perez, Carola; Villarroel, Milena; Concha, Emma; Khani, Farzaneh; Thaler, Roman; Salazar-Onfray, Flavio; Stein, Gary S; van Wijnen, Andre J; Galindo, Mario Article Journal of cellular physiology (2019)
The role of phase I and II genetic polymorphisms, smoking, alcohol, and family history in the risk of developing testicular cancer. Roco A, Lavanderos A, Cayún JP, Acevedo C, Celedón C, Rubilar JC, Sandoval C, Cerpa L, García-Martín E, Agúndez JA, Esguevillas G, Amo G, Canepa A, Cerda B, Peña K, Cáceres D, Varela N, Quiñones L. Article ISI PHARMACOGENETICS AND GENOMICS (2019)
Farmacogenética, tabaco, alcohol y su efecto sobre el riesgo de desarrollar cáncer Roco, A; Cerda, B; Cayún, JP; Rubilar, JC; Cerro, R.; Varela, N; Quiñones, LA Article WOS-ESCI SCIELO SCOPUS REVISTA CHILENA DE PEDIATRIA (2018)
Clinical applications of pharmacogenomics Quiñones, L; Roco, Á; Cayún, JP1; Escalante, P; Miranda, C; Varela, N; Meneses, F; Gallegos, B; Zaruma-Torres, F; Lares-Asseff, I. Article REVISTA MEDICA DE CHILE (2017)
Pharmacogenomics of antiretroviral therapy in Latin America Varela, NM Article SCOPUS Pharmacogenomics in Latin America: Challenges and Opportunities (2017)
Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells Varela, N; Aranguiz, A; Lizama, C; Sepulveda, H; Antonelli, M; Thaler, R; Montecino, M; Stein, GS; van Wijnen, AJ; Galindo, M. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2016)
Upregulation of rat liver PPARα-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol Videla LA, Fernández V, Vargas R, Cornejo P, Tapia G, Varela N, Valenzuela R, Arenas A, Fernández J, Hernández-Rodas MC, Riquelme B. Article ISI BIOFACTORS (2016)
Causal role of oxidative stress in unfolded protein response development in the hyperthyroid state Videla, LA; Fernández, V; Cornejo, P; Vargas, R; Carrasco, J; Fernández, J; Varela, N Article ISI SCOPUS Free Radical Biology and Medicine (2015)
Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through polymorphism analyses Varela, N; Quiñones, LA; Stojanova, J; Garay, J; Caceres D.; Céspedes, S; Sasso, J.; Miranda, C Article ISI SCOPUS Pharmacological Research (2015)
Preclinical evaluation of the encelia canescens lam extract: Medicinal properties useful for cancer treatment CayÃºn J.P.; Zamorano, J; QuiÃ±ones L.; Varela, NM; Squicciarini, V; Larenas H.D.; CÃ¡ceres D.D. Article SCOPUS Journal of Natural Remedies (2015)
Bioequivalence of Acenocoumarol in Chilean Volunteers: an Open, Randomized, Double-Blind, Single-Dose, 2-Period, and 2-Sequence Crossover Study for 2 Oral Formulations Sasso, J.; Carmona, P; Quiñones, L; Ortíz, M; Tamayo, E; Varela, N; Caceres D.; Saavedra, I. Article ISI SCOPUS Arzneimittel-Forschung/Drug Research (2012)
Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: Comparison with caucasian and asian populations Roco, A; Quiñones, L; Agúndez, JAG; García-Martín, E; Squicciarini, V; Miranda, C; Garay, J; Farfán, N; Saavedra, I.; Caceres D.; et al. Article SCOPUS FRONTIERS IN GENETICS (2012)
Relative bioavailability of two formulations of rosuvastatin importance in clinical practice Biodisponibilidad relativa de dos formulaciones de rosuvastatina. Importancia en la práctica clínica Saavedra, I.; Quiñones, L; Ortíz, M; Varela, N; Sasso, J.; Tamayo E D.C.D. Article SCOPUS Informe Medico (2012)
A comparative bioavailability study of two formulations of pregabalin in healthy chilean volunteers Saavedra, I.; Quiñones, L; Sasso, J.; Tamayo, E; Catalán, J; Escala, M; Varela, N; Leon, J; CÃ¡ceres D.D. Article SCOPUS Therapeutic Advances in Chronic Disease (2010)
Relative bioavailability study with two oral formulations of topiramate using a validated UPLC-MS/MS method Saavedra, I.; Tamayo, E; Gamboa, A; Sasso, J.; Varela, N; Moreno, I.; Marchant, D; Caceres D.; Quiñones, L Article ISI SCOPUS International Journal of Clinical Pharmacology and Therapeutics (2010)
Impaired Cell Cycle Regulation of the Osteoblast-Related Heterodimeric Transcription Factor Runx2-Cbf beta in Osteosarcoma Cells San Martin, IA; Varela, N; Gaete, M; Villegas, K.; Osorio, M; Antonelli, M; Mancilla, EE; Pereira, BP; Nathan, SS; Lian, JB; et al. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, noalcoholic steatohepatitis obese women Varela, NM; Orellana, M; Rodrigo, R; Poniachik, J; Csendes, A; Smok, G; CÃ¡ceres D.D. Article SCOPUS BIOLOGICAL RESEARCH (2008)
Asociación entre el sistema sanguíneo ABO y los polimorfismos genéticos de enzimas de biotransformación en relación con la susceptibilidad a cancer. Luis Quiñones, Dante Cáceres, Inés Salazar, Katherina Betta, Viviana Villela, Ángela Roco, Nelson Varela, Magdalena Orellana, e Iván Saavedra. Article Revista Chilena de Cancerología y Hematología (2007)
Cytochrome P4501A1 (CYP1A1), glutathione S transferase M1 (GSTM1) polymorphisms and their association with smoking and alcohol consumption as gastric cancer susceptibility biomarkers Lee, K; Caceres D.; Varela, N; Csendes, A; Rios, H; Quiñones, L Article ISI REVISTA MEDICA DE CHILE (2006)
Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study Quiñones, LA; Rojas C.R.; Orellana, CE; Acevedo, C; Huidobro, C; Varela, NE Article ISI SCOPUS ASIAN JOURNAL OF ANDROLOGY (2006)
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrorne P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients Orellana, M; Rodrigo, R; Varela, N; Araya, J; Poniachik, J; Csendes, A; Smok, G; Videla, LA Article ISI SCOPUS HEPATOLOGY RESEARCH (2006)
Relationship among metabolizing genes, smoking and alcohol used as modifier factors on prostate cancer risk: Exploring some gene-gene and gene-environment interactions Iturrieta, J; Acevedo, C; Huidobro, C; Varela, N; Quiñones, L Article ISI SCOPUS EUROPEAN JOURNAL OF EPIDEMIOLOGY (2005)
Chromatin from two classes of platyhelminthes display both protist H1 and higher eukaryote core histones Galindo, M.; Varela, N; Espinoza, I; Toro, GC; Hellman, U; Wernstedt, C; Galanti N. Article ISI SCOPUS FEBS LETTERS (2004)
Gene-gene and gene-environment interactions as modifier factors of prostatic cancer risk: (a case-only) design study Caceres D.; Iturrieta, J; Acevedo, C; Huidobro, C; Varela, N; Escala, M; Quiñones, L Article ISI REVISTA MEDICA DE CHILE (2004)
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients Videla, LA; Rodrigo, R; Orellana, M; Fernández, V; Tapia, G; Quiñones, L; Varela, N; Contreras, J; Lazarte, R; Csendes, A; et al. Article ISI SCOPUS CLINICAL SCIENCE (2004)
Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption Orellana, M; Varela, N; Guajardo, V; Araya, J; Rodrigo, R Article ISI SCOPUS COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2002)
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people Quiñones, L; Lucas D.; Godoy, J; Caceres D.; Berthou, F; Varela, N; Lee, K; Acevedo, C; Martinez, L; Aguilera, AM; et al. Article ISI SCOPUS CANCER LETTERS (2001)
Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations Article Cancer Letters (1999)


Genetic variants and clinical factors affecting the response to 5-fluorouracil-based treatment in Chilean patients with advanced colorectal cancer. Cerpa-Castro, LC; Sandoval, C; Barra, S; Calfunao, S; Cayún, JP; Donoso, G; Barajas, O; Müller, B; Caceres D.; Varela, N; et al. Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2025)
Evaluation of CYP1A1 and GSTM1 as gastric cancer susceptibility biomarkers: Influence of smoking habit and alcohol consumption Caceres D.; Lee, K; Varela, N; Csendes, A; Rios, H; Quiñones, L Abstract ISI EPIDEMIOLOGY (2006)


Pharmacodynamic Polymorphisms Martínez M.F., Cerpa L.C., Varela N.M., Quiñones L.A. BookSection (2021)
Pharmacogenomics: Basis and Milestones Cerpa L.C., Varela N.M., Martínez M.M., Quiñones L.A BookSection (2021)
Pharmacogenomics: Challenges and Future Perspectives Quiñones L.A., Martínez M.M., Cerpa L.C., Varela N.M. BookSection (2021)
Pharmacogenomics: Genetic Polymorphisms Varela N.M., Cerpa L.C., Martínez M.M., Quiñones L.A BookSection (2021)
Pharmacokinetic Polymorphisms Martínez M.M., Cerpa L.C., Varela N.M., Quiñones L.A. BookSection (2021)
Farmacogenetica de la terapia antiretroviral en pacientes que viven con vih, y situación latinoamericana Nelson M. Varela, Fernando Bernal, Gabriel Llull, Sebastian Archiles; Quiñones, LA; Redal, María Ana BookSection (2020)


Pharmacogenetics-based preliminary model improves prediction of infection in patients receiving cytotoxic chemotherapy for hematological malignancies. Matias F. Martinez, Enzo Alveal, Tomas Soto, Eva Bustamante, Ivonne Flores, Claudia Benavides, Fernanda Avila, Scarlette Jara, Ricardo Morales, Nelson M. Varela and Luis A. Quinones ConferencePoster (2020)
GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS AS MODIFIER FACTORS OF PROSTATIC CANCER RISK: “A CASE-ONLY” DESIGN STUDY Dante, L Cáceres; Iturrieta, J; Acevedo, C; Huidobro, Ch; Varela, N F; Escala, M Z.; Quiñones, L S. ConferencePoster (2005)


Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through polymorphism analyses (vol 101, pg 124, 2015) Varela, N; Stojanova, J; Garay, J; Caceres D.; Céspedes, S; Sasso, J.; Miranda, C Errata ISI SCOPUS PHARMACOLOGICAL RESEARCH (2016)


Reply to the commentary: Estimating genotype and allele frequencies of the CYP2D6 gene Varela, NM Letter ISI SCOPUS PHARMACOLOGICAL RESEARCH (2016)


BIOMARCADORES FARMACOGENÉTICOS DE LA TERAPIA ANTI-RETROVIRAL EN PACIENTES QUE VIVEN CON VIH=> BASES PARA UN DIAGNÓSTICO PRE-TERAPÉUTICO. Facultad de Medicina, Universidad de Chile (11-2016) Proyecto 2016-2017 Inv. Responsable
IMPROVING TESTICULAR CANCER RISK EVALUATION AND PHARMACOTHERAPY THROUGH PHARMACOGENOMICS FONDECYT (1140434) Proyecto 2014-2018 Coinvestigador(a)
ESTUDIO DE CALIDAD FARMACEUTICA PARA EL DESARROLLO DE UN EXTRACTO COMO MEDICAMENTO ANTINEOPLASICO INNOVA-CORFO (12IDL2-16208) Proyecto 2013-2015 Director(a)


Pharmacogenetic variants of CYP2C9 and CYP2C19 associated with adverse reactions induced by antiepileptic drugs used in Peru Alvarado, A; Muñoz, AM; Varela, N; Sullón-Dextre, L; Pineda, M; Bolarte-Arteaga, M; Bendezú, MR; García, JA; Chávez, H; Surco-Laos, F; et al. Review ISI SCOPUS Pharmacia (2023)
Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs Quiñones, L; Rosero, M; Roco, A; Moreno, I.; Sasso, J.; Varela, N; Caceres D.; Saavedra, I. Review ISI REVISTA MEDICA DE CHILE (2008)
Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure Quiñones, L; Lee, K; Varela, N; Escala, M; Garcia, K; Godoy, L; Castro, A; Soto, J; Saavedra, I.; Caceres D. Review ISI REVISTA MEDICA DE CHILE (2006)

Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

Carlos Irarrázabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Ramón Rodrigo

PROFESOR TITULAR

INSTITUTO DE CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

DANTE CACERES

Académico

Programa de Salud Ambiental

ESCUELA DE SALUD PUBLICA, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Alexander Gamboa

Profesor Asistente

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

Jana Stojanova

Profesor Auxiliar

Departamento Preclinicas

Universidad de Valparaíso

Viña del Mar, Chile

Carla Miranda

Encargada de estudios Clinicos y preclinicos

Oncología Básico Clínica

Universidad de Chile

Santiago, Chile

Viviana Guajardo

Profesor Asistente

Psiquiatria

Universidad de Chile

Santiago, Chile

juan cayún

Investigador

Departamento de oncología básico-clínico

Universidad de Chile

Santiago, Chile

María Bertoglia

Profesor Adjunto

Escuela de Medicina

Universidad Andrés Bello

Santiago, Chile

Marina Leiva

Directora Técnica Unidad de Hemodiálisis

Nefrología

Hospital Intercultural de Nueva Imperial

Nueva Imperial, Chile

Berta Cerda

Director

Instituto Nacional del Cáncer

Santiago, Chile

Johanna Catalán

Profesor Asistente Regular

Facultad de Medicina y Ciencia

Universidad Central de Chile

Santiago, Chile

María Lavanderos

Académica

Universidad Bernardo O'higgins

Santiago, Chile

Nancy Farfán

Post-doc.

Farmacología

Universidad de Chile

Santiago, Chile

Marcia Gaete

Javier Fernández

Investigador

Fundación COANIQUEM Avances Tecnológicos

Santiago, Chile

Juan Rubilar

MARIO GALINDO

Profesor Asociado

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Nelson Miguel Varela Figueroa

Líneas de Investigación

Educación

Bioquímica y Biología Molecular, UNIVERSIDAD DE CHILE. Chile, 2004

Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 1999

Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2010

Experiencia Académica

Académico Full Time

Académico Full Time

Académico Full Time

Experiencia Profesional

Responsable Aseguramiento Calidad / RT-PCR para COVID1919 Part Time

Formación de Capital Humano

Article (66)

Abstract (2)

BookSection (6)

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Errata (1)

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Proyecto (3)

BIOMARCADORES FARMACOGENÉTICOS DE LA TERAPIA ANTI-RETROVIRAL EN PACIENTES QUE VIVEN CON VIH=> BASES PARA UN DIAGNÓSTICO PRE-TERAPÉUTICO.

IMPROVING TESTICULAR CANCER RISK EVALUATION AND PHARMACOTHERAPY THROUGH PHARMACOGENOMICS

ESTUDIO DE CALIDAD FARMACEUTICA PARA EL DESARROLLO DE UN EXTRACTO COMO MEDICAMENTO ANTINEOPLASICO

Review (3)